Role of SARS-CoV-2 -induced cytokines and growth factors in coagulopathy and thromboembolism


Posted: 2021-11-09 20:00:00
Review Cytokine Growth Factor Rev . 2021 Oct 24;S1359-6101(21)00079-4. doi: 10.1016/j.cytogfr.2021.10.007. Online ahead of print. Affiliations Expand Affiliations 1 College of Medicine, University of Sharjah, Sharjah 27272, UAE; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, UAE. Electronic address: fahmad@sharjah.ac.ae. 2 Blood and Vascular Biology Research Lab, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur 610005, India. 3 Dermatology Institute, Translational Research Institute, Academic Health Systems, Hamad Medical Corporation, PO Box 3050, Doha, Qatar. Item in Clipboard Review Firdos Ahmad et al. Cytokine Growth Factor Rev. 2021. Show details Display options Display options Format Cytokine Growth Factor Rev . 2021 Oct 24;S1359-6101(21)00079-4. doi: 10.1016/j.cytogfr.2021.10.007. Online ahead of print. Affiliations 1 College of Medicine, University of Sharjah, Sharjah 27272, UAE; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, UAE. Electronic address: fahmad@sharjah.ac.ae. 2 Blood and Vascular Biology Research Lab, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur 610005, India. 3 Dermatology Institute, Translational Research Institute, Academic Health Systems, Hamad Medical Corporation, PO Box 3050, Doha, Qatar. Item in Clipboard CiteDisplay options Display options Format Abstract Severe COVID-19 patients frequently present thrombotic complications which commonly lead to multiorgan failure and increase the risk of death. Severe SARS-CoV-2 infection induces the cytokine storm and is often associated with coagulation dysfunction. D-dimer, a hallmark of venous thromboembolism (VTE), is observed at a higher level in the majority of hospitalized COVID-19 patients. The precise molecular mechanism of the disproportionate effect of SARS-CoV-2 infection on the coagulation system is largely undefined. SARS-CoV-2 -induced endotheliopathy and, induction of cytokines and growth factors (GFs) most likely play important roles in platelet activation, coagulopathy, and VTE. Generally, viral infections lead to systemic inflammation and induction of numerous cytokines and GFs and many of them are reported to be associated with increased VTE. Most importantly, platelets play key thromboinflammatory roles linking coagulation to immune mediators in a variety of infections including response to viral infection. Since the pathomechanism of coagulopathy and VTE in COVID-19 is largely undefined, herein we highlight the association of dysregulated inflammatory cytokines and GFs with thrombotic complications and coagulopathy in COVID-19. Keywords: COVID-19; Coagulopathy; Cytokines; Growth factors; Inflammation; Platelet activation; Thromboembolism. Copyright © 2021 Elsevier Ltd. All rights reserved. Publication types [x] Cite Copy Format: Send To [x]

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バイオクイックニュース日本語版:COVID-19特集

バイオクイックニュース日本語版
10月 12, 2020 バイオアソシエイツ

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