Potential for false-positive results with quantitative antigen tests for SARS-CoV-2: A case of a child with acute respiratory infection


Posted: 2021-11-19 20:00:00
J Infect Chemother . 2021 Nov 12;S1341-321X(21)00308-1. doi: 10.1016/j.jiac.2021.10.032. Online ahead of print. Affiliations Expand Affiliations 1 Department of Infectious Diseases, Japanese Red Cross Narita Hospital, 90-1 Iida-cho, Narita, Chiba, 286-8523, Japan; Department of Infectious Diseases, Kameda Medical Center, Kamogawa, Chiba, Japan, 929 Higashi-cho, Kamogawa, Chiba, 296-8602, Japan. Electronic address: hase.ryota@kameda.jp. 2 Department of Infectious Diseases, Japanese Red Cross Narita Hospital, 90-1 Iida-cho, Narita, Chiba, 286-8523, Japan. 3 Department of Clinical Laboratory, Kameda Medical Center, Kamogawa, Chiba, Japan, 929 Higashi-cho, Kamogawa, Chiba, 296-8602, Japan. 4 Department of Pediatrics, Japanese Red Cross Narita Hospital, 90-1 Iida-cho, Narita, Chiba, 286-8523, Japan. Item in Clipboard Ryota Hase et al. J Infect Chemother. 2021. Show details Display options Display options Format J Infect Chemother . 2021 Nov 12;S1341-321X(21)00308-1. doi: 10.1016/j.jiac.2021.10.032. Online ahead of print. Affiliations 1 Department of Infectious Diseases, Japanese Red Cross Narita Hospital, 90-1 Iida-cho, Narita, Chiba, 286-8523, Japan; Department of Infectious Diseases, Kameda Medical Center, Kamogawa, Chiba, Japan, 929 Higashi-cho, Kamogawa, Chiba, 296-8602, Japan. Electronic address: hase.ryota@kameda.jp. 2 Department of Infectious Diseases, Japanese Red Cross Narita Hospital, 90-1 Iida-cho, Narita, Chiba, 286-8523, Japan. 3 Department of Clinical Laboratory, Kameda Medical Center, Kamogawa, Chiba, Japan, 929 Higashi-cho, Kamogawa, Chiba, 296-8602, Japan. 4 Department of Pediatrics, Japanese Red Cross Narita Hospital, 90-1 Iida-cho, Narita, Chiba, 286-8523, Japan. Item in Clipboard CiteDisplay options Display options Format Abstract The quantitative antigen test based on the chemiluminescent enzyme immunoassay for SARS-CoV-2 has been used in international airports for quarantine in Japan. While cases of false-positive rapid antigen tests for SARS-CoV-2 were reported, false-positive cases of the quantitative antigen test with clinical information are rare. Here, we report a case of acute respiratory infection whose quantitative antigen test for SARS-CoV-2 was suspected to be false positive. A 9-month-old boy who presented with fever and rhinorrhea was admitted to our hospital under the Quarantine Act. He was diagnosed with COVID-19 based on the quantitative antigen test for SARS-CoV-2 performed at the quarantine station. None of the accompanying family members were positive for COVID-19. Nucleic acid amplification tests (NAAT) for SARS-CoV-2 were all negative, and multiplex polymerase chain reaction detected human rhinovirus or enterovirus infection. This case suggests that the results of the quantitative antigen test should be interpreted together with clinical information, and NAAT should be performed when false-positive results are suspected to avoid unnecessary isolation. Keywords: COVID-19; False positive; Quantitative antigen test; Quarantine; SARS-CoV-2. Copyright © 2021. Published by Elsevier Ltd. [x] Cite Copy Format: Send To [x]

参考サイト PubMed: covid-19


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