Pediatric asthma control during the COVID-19 pandemic: a systematic review and meta-analysis


Posted: 2021-10-21 19:00:00
Background: With the onset of the COVID-19 pandemic, many experts expected that asthma-associated morbidity because of SARS-CoV-2 infection would dramatically increase. However, some studies suggested that there was no apparent increasing in asthma related morbidity in children with asthma, it is even possible children may have improved outcomes. In order to understand the relationship between the COVID-19 pandemic and asthma outcomes, we performed this article. Methods: We searched PubMed, Embase, and Cochrane Library to find literature from December 2019 to June 2021 related to Covid-19 and children's asthma control, among which results such as abstracts, comments, letters, reviews and case reports were excluded. The level of asthma control during the COVID-19 pandemic was synthesized and discussed by outcomes of asthma exacerbation, emergency room visit, asthma admission and c-ACT. Results: A total of 22159 subjects were included in 10 studies. Random effect model was used to account for the data. Compared to the same period before the COVID-19 pandemic, asthma exacerbation reduced(OR=0.26, 95%CI= [0.14,0.48], Z=4.32, P<0.0001), the odds of emergency room visit decreased as well(OR =0.11, 95%CI= [0.04,0.26], Z=4.98, P<0.00001). The outcome of asthma admission showed no significant difference (OR =0.84, 95%CI= [0.32,2.20], Z=0.36, P=0.72). The outcome of c-ACT scores were not analyzed because of the different manifestations used. Overall, c-ACT scores reduced during the pandemic. Conclusion: Compared to the same period before the COVID-19 pandemic, the level of asthma control has been significantly improved. We need to understand the exact factors leading to these improvements and find methods to sustain it. This article is protected by copyright. All rights reserved. Keywords: COVID-19; asthma control; children; systematic review and meta-analysis.

参考サイト PubMed: covid-19



バイオクイックニュース日本語版:COVID-19特集

バイオクイックニュース日本語版
5月 11, 2020 バイオアソシエイツ

COVID-19治療薬レロンリマブについてのQ&A、リファレンス

2020年5月1日CytoDyn社WEBINARにおけるレロンリマブに関する質問(ログインするとQ&Aを表示):• この薬は COVID-19 の単剤治療に使用できますか?それとも最終的な分析に役立つ併用薬物療法を想定していますか?• FDAがレロンリマブを使用することで何人の命を救うことができるのかを理解するのが難しいのはなぜですか?• レロンリマブは、主に免疫系の回復または何らかの新しいメカニズムによる血漿ウイルス負荷を軽減する能力がありますか?•…

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