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Peculiar Histopathologic Feature of an Erythematous/Morbilliform Eruption in a COVID-19-Positive Patient


Posted: 2021-10-05 19:00:00
Am J Dermatopathol . 2021 Sep 29. doi: 10.1097/DAD.0000000000002034. Online ahead of print. Affiliations Expand Affiliation 1 Unit of Surgical Pathology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy; Department of Dermatology, University of Münster, Münster, Germany; Department of Infectious Diseases Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy; and Unit of Dermatology, Vita-Salute S. Raffaele University, Milan, Italy. Item in Clipboard Valentina Caputo et al. Am J Dermatopathol. 2021. Show details Display options Display options Format Am J Dermatopathol . 2021 Sep 29. doi: 10.1097/DAD.0000000000002034. Online ahead of print. Affiliation 1 Unit of Surgical Pathology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy; Department of Dermatology, University of Münster, Münster, Germany; Department of Infectious Diseases Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy; and Unit of Dermatology, Vita-Salute S. Raffaele University, Milan, Italy. Item in Clipboard CiteDisplay options Display options Format Abstract One of the most common patterns of presentations that have been described in COVID-19 patients includes the erythematous/papular/morbilliform eruptions. However, actually, the diffuse exanthems containing macules and papules were not specific to COVID-19, and even histopathology does not show any specific signs that could help to differentiate COVID-19 skin lesions from non-COVID-19 causes such as drugs or other viral infections. We present the case of a COVID-19-positive woman with a morbilliform rash, whose skin biopsy showed the presence of some peculiar cytopathic epidermal changes that could represent a possible distinctive histopathological feature related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection The presence of viral particles in the keratinocytes with additional positivity of endothelial cells and eccrine glands by immunohistochemistry using an anti-SARS-CoV-2 Spike S1 antibodies supports a causal relation of the lesions with SARS-CoV-2 infection. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. Conflict of interest statement The authors declare no conflicts of interest. [x] Cite Copy Format: Send To [x]

参考サイト PubMed: covid-19



バイオクイックニュース日本語版:COVID-19特集

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