On the importance of physicochemical parameters of copper and aminosilane functionalized mesoporous silica for hydroxychloroquine release


Posted: 2021-10-27 19:00:00
Mater Sci Eng C Mater Biol Appl . 2021 Nov;130:112438. doi: 10.1016/j.msec.2021.112438. Epub 2021 Sep 17. Affiliations Expand Affiliations 1 Adam Mickiewicz University in Poznań, Faculty of Chemistry, Department of Chemical Technology, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland. Electronic address: annamar@amu.edu.pl. 2 Adam Mickiewicz University in Poznań, Faculty of Chemistry, Department of Chemical Technology, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland. Electronic address: asiagosc@amu.edu.pl. Item in Clipboard Anna Olejnik et al. Mater Sci Eng C Mater Biol Appl. 2021 Nov. Show details Display options Display options Format Mater Sci Eng C Mater Biol Appl . 2021 Nov;130:112438. doi: 10.1016/j.msec.2021.112438. Epub 2021 Sep 17. Affiliations 1 Adam Mickiewicz University in Poznań, Faculty of Chemistry, Department of Chemical Technology, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland. Electronic address: annamar@amu.edu.pl. 2 Adam Mickiewicz University in Poznań, Faculty of Chemistry, Department of Chemical Technology, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland. Electronic address: asiagosc@amu.edu.pl. Item in Clipboard CiteDisplay options Display options Format Abstract Recently, great attention has been paid to hydroxychloroquine which after promising in vitro studies has been proposed to treat the severe acute respiratory syndrome caused by SARS-CoV-2. The clinical trials have shown that hydroxychloroquine was not as effective as was expected and additionally, several side effects were observed in patients cured with this medicament. In order to reduce them, it is suggested to deliver hydroxychloroquine in a controlled manner. Therefore, in this study non-modified (SBA-15, SBA-16) and modified with copper and aminosilane mesoporous silica materials were applied as novel nanocarriers for hydroxychloroquine. First, pristine and functionalized samples were synthesized and characterized by X-ray diffraction, low-temperature nitrogen sorption, transmission electron microscopy, X-ray photoelectron spectroscopy, infrared spectroscopy, laser diffraction. Then the influence of physicochemical parameters of materials obtained on the adsorption and release processes of hydroxychloroquine was analyzed. The mechanism of hydroxychloroquine binding to non-modified silicas was based on the formation of hydrogen bonds, while in the case of copper and aminosilane functionalized materials the complexes with drug molecules were generated. The release behavior of hydroxychloroquine from silica samples obtained was determined by different factors including pH conditions, textural parameters, surface charge, and presence of surface functional groups. The greatest differences in hydroxychloroquine release profiles between materials were observed at pH 7.2. The amount of drug desorbed from silica decreased in the following order: functionalized SBA-15 (84%) > functionalized SBA-16 (79%) > SBA-15 (59%) > SBA-16 (33%). It proved that a higher amount of drug was released from materials of hexagonal structure. Keywords: Drug release; Impregnation; Mesoporous materials; Release kinetics; Surface modification. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved. [x] Cite Copy Format: Send To [x]

参考サイト PubMed: covid-19


Powered by Stromvergleich


バイオクイックニュース日本語版:COVID-19特集

バイオクイックニュース日本語版
9月 28, 2020 バイオアソシエイツ

Johnson&Johnsonは6万人の被験者を対象としたCOVID-19ワクチン候補のフェーズ3有効性試験を開始

COVID-19 のほとんどの人は比較的軽度の症状だが、一部の人は重度の肺炎と呼吸不全を発症し、死に至る可能性がある。Beth Israel Deaconess Medical Center(BIDMC)の免疫学者Dan H. Barouch医学博士らは、最近発表されたこれまでの研究で、COVID-19ワクチン候補が中和抗体を産生し、COVID-19を引き起こすウイルスSARS-CoV-2から非ヒト霊長類(NHP)を強力に保護することを示した。2020年9月3日にNature…

ゲスト 525人 と メンバー 6人 がオンラインです