Network analysis of comorbid posttraumatic stress disorder and depression in adolescents across COVID-19 epidemic and Typhoon Lekima


Posted: 2021-09-11 19:00:00
Background: Network analytic studies indicate that posttraumatic stress disorder (PTSD) may be comorbid with depression at the symptom level, but it remains unclear whether these findings are replicable and generalizable across trauma types. Objective: This study aim was to examine and compare PTSD-depression comorbidity networks of two types of trauma related to Typhoon Lekima and COVID-19 epidemic. Methods: Participants were 1605 and 601 adolescents recruited following Typhoon Lekima and the COVID-19 outbreak, respectively. Results: COVID-19 and Lekima PTSD-depression networks had considerable similarities, including adequate stability and accuracy, connected symptoms of PTSD and depression, symptoms with high centralities, and bridge symptoms. PTSD-depression comorbid symptoms were more complicated in the COVID-19 network but may show more persistence in the Lekima network. Distinct bridge symptoms contributed to the heterogeneity of PTSD-depression comorbidity characteristics between the two networks. Specifically, restricted affect and felt down and unhappy were two important bridge symptoms with high centrality unique to the COVID-19 network. Conclusions: PTSD-depression comorbidity network has considerable replicability across trauma types, but specific symptom-level associations and some bridge symptoms may vary across trauma types. These findings also highlight the importance of negative emotions to comorbid PTSD and depression in adolescents following the COVID-19 outbreak compared with Typhoon Lekima. Keywords: COVID-19; Depression: Network analysis; PTSD; Typhoon lekima.

参考サイト PubMed: covid-19


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バイオクイックニュース日本語版:COVID-19特集

バイオクイックニュース日本語版
4月 30, 2020 バイオアソシエイツ

MITの科学者がCOVID-19等におけるサイトカインストームの治療に有用な水溶性改変サイトカイン受容体を設計

Covid-19 の決定的な特徴の1つは、重症例で発生する可能性のある過剰な免疫応答だ。 この免疫過剰反応のバーストは、サイトカインストームとも呼ばれ、肺に損傷を与え、致命的となる可能性がある。MITの研究チームは、これらの過剰なサイトカインを吸収するために、抗体と構造が類似した特殊なタンパク質を開発した。…