Model-driven mitigation measures for reopening schools during the COVID-19 pandemic


Posted: 2021-09-14 19:00:00
Proc Natl Acad Sci U S A . 2021 Sep 28;118(39):e2108909118. doi: 10.1073/pnas.2108909118. Affiliations Expand Affiliations 1 Department of Biology, University of Washington, Seattle, WA 98195; ryansmcgee@gmail.com. 2 Scientific Affairs, Color Health, Burlingame, CA 94010. 3 Department of Biology, University of Washington, Seattle, WA 98195. Item in Clipboard Ryan Seamus McGee et al. Proc Natl Acad Sci U S A. 2021. Show details Display options Display options Format Proc Natl Acad Sci U S A . 2021 Sep 28;118(39):e2108909118. doi: 10.1073/pnas.2108909118. Affiliations 1 Department of Biology, University of Washington, Seattle, WA 98195; ryansmcgee@gmail.com. 2 Scientific Affairs, Color Health, Burlingame, CA 94010. 3 Department of Biology, University of Washington, Seattle, WA 98195. Item in Clipboard CiteDisplay options Display options Format Abstract Reopening schools is an urgent priority as the COVID-19 pandemic drags on. To explore the risks associated with returning to in-person learning and the value of mitigation measures, we developed stochastic, network-based models of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in primary and secondary schools. We find that a number of mitigation measures, alone or in concert, may reduce risk to acceptable levels. Student cohorting, in which students are divided into two separate populations that attend in-person classes on alternating schedules, can reduce both the likelihood and the size of outbreaks. Proactive testing of teachers and staff can help catch introductions early, before they spread widely through the school. In secondary schools, where the students are more susceptible to infection and have different patterns of social interaction, control is more difficult. Especially in these settings, planners should also consider testing students once or twice weekly. Vaccinating teachers and staff protects these individuals and may have a protective effect on students as well. Other mitigations, including mask wearing, social distancing, and increased ventilation, remain a crucial component of any reopening plan. Keywords: SARS-CoV-2; epidemiology; primary schools; secondary schools. Copyright © 2021 the Author(s). Published by PNAS. Conflict of interest statement Competing interest statement: C.T.B. and R.S.M. consult for Color Health. C.T.B. has received honoraria from Novartis. H.E.W. and A.Y.Z. are currently employed by and have equity interest in Color Health. J.R.H. was previously employed by and holds an equity stake in Color Health. J.R.H. is currently employed and has an equity interest in Maze Therapeutics. References United Nations Educational, Scientific and Cultural Organization. Hanushek E., Woessmann L.. The economic impacts of learning losses. Nierenberg A., Pasick A.. Will any more schools reopen in 2020?. NY Times. Leidman E.. COVID-19 trends among persons aged 0–24 years — United States, March 1–December 12, 2020. MMWR Morb. Mortal. Wkly. Rep.. 2021;70:88–94. Walensky R. P., Walke H. T., Fauci A. S.. SARS-CoV-2 variants of concern in the United States challenges and opportunities. JAMA. 2021;325:1037–1038. Show all 77 references [x] Cite Copy Format: Send To [x]

参考サイト PubMed: covid-19



バイオクイックニュース日本語版:COVID-19特集

バイオクイックニュース日本語版
7月 22, 2020 バイオアソシエイツ

新型コロナウイルスがin vitroで心臓細胞に感染することが最近の研究で判明

米国のシーダーズ・サイナイ病院による新しい研究で、 COVID-19 を引き起こすSARS-CoV-2(新型コロナウイルス)が心臓細胞に感染する可能性があり、COVID-19患者の心臓細胞が直接感染する可能性があることが示された。 2020年6月25日にCell Reports Medicineのオンラインで公開されたこの発見は、iPS細胞技術によって生産された心筋細胞を使用して行われた。この論文は、「ヒトiPSC由来の心筋細胞はSARS-CoV-2感染の影響を受けやすい(Human iPSC-Derived…