Methodological challenges for living systematic reviews conducted during the COVID-19 pandemic: a concept paper


Posted: 2021-09-15 19:00:00
J Clin Epidemiol . 2021 Sep 12;S0895-4356(21)00293-6. doi: 10.1016/j.jclinepi.2021.09.013. Online ahead of print. Affiliations Expand Affiliations 1 Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. Electronic address: claire.iannizzi@uk-koeln.de. 2 Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. 3 Institute for Medical Information Processing, Biometry and Epidemiology - IBE, LMU Munich, Marchioninistr. 17, 81377, Munich, Germany; Pettenkofer School of Public Health, Munich, Germany. 4 Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, Germany. 5 Editorial and Methods Department, Cochrane Central Executive, London, UK. 6 Haematology/Transfusion Medicine, NHS Blood and Transplant, John Radcliffe Hospital, Oxford UK, OX3 9BQ. Item in Clipboard Claire Iannizzi et al. J Clin Epidemiol. 2021. Show details Display options Display options Format J Clin Epidemiol . 2021 Sep 12;S0895-4356(21)00293-6. doi: 10.1016/j.jclinepi.2021.09.013. Online ahead of print. Affiliations 1 Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. Electronic address: claire.iannizzi@uk-koeln.de. 2 Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. 3 Institute for Medical Information Processing, Biometry and Epidemiology - IBE, LMU Munich, Marchioninistr. 17, 81377, Munich, Germany; Pettenkofer School of Public Health, Munich, Germany. 4 Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, Germany. 5 Editorial and Methods Department, Cochrane Central Executive, London, UK. 6 Haematology/Transfusion Medicine, NHS Blood and Transplant, John Radcliffe Hospital, Oxford UK, OX3 9BQ. Item in Clipboard CiteDisplay options Display options Format Abstract A living systematic review (LSR) is an emerging review type that makes use of continual updating. In the COVID-19 pandemic, we were confronted with a shifting epidemiological landscape, clinical uncertainties and evolving evidence. These unexpected challenges compelled us to amend standard LSR methodology. Objective and outline: Our primary objective is to discuss some challenges faced when conducting LSRs in the context of the COVID-19 pandemic, and to provide methodological guidance for others doing similar work. Based on our experience and lessons learned from two Cochrane LSRs and challenges identified in several non-Cochrane LSRs, we highlight methodological considerations, particularly with regards to the study design, interventions and comparators, changes in outcome measure, and the search strategy. We discuss when to update, or rather when not to update the review, and the importance of transparency when reporting changes. Lessons learned and conclusions: We learned that a LSR is a very suitable review type for the pandemic context, even in the face of new methodological and clinical challenges. Our experience showed that the decision for updating a LSR depends not only on the evolving disease or emerging evidence, but also on the individual review question and the review teams' resources. Keywords: COVID-19 pandemic; emerging disease; experience report; experiences during pandemic; lessons learned; living systematic review. Copyright © 2021. Published by Elsevier Inc. Conflict of interest statement Declaration of interest There are no declarations of interest. [x] Cite Copy Format: Send To [x]

参考サイト PubMed: covid-19



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MIT主導の研究チームがSARS-CoV-2ゲノムの包括的マップを作成

COVID-19 パンデミックが始まってから数カ月後の2020年初頭、科学者らはCOVID-19感染症の原因ウイルスであるSARS-CoV-2の全ゲノム配列を決定することができた。その時点で、その遺伝子の多くはすでに判明していたが、タンパク質をコードする遺伝子の全容は解明されていなかった。今回、MITの研究者らが広範な比較ゲノム研究を行った結果、SARS-CoV-2のゲノムについて、最も正確で完全な遺伝子アノテーションを作成した。 この研究結果は、2021年5月11日にNature…

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