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Lipid profile as an indicator of COVID-19 severity: A systematic review and meta-analysis


Posted: 2021-10-08 19:00:00
Background: Coronavirus disease-2019 (COVID-19) is a global pandemic. Studies reported dyslipidemia in patients with COVID-19. Herein, we conducted a systematic review and meta-analysis of published articles to evaluate the association of the lipid profile with the severity and mortality in COVID-19 patients. Methods: PubMed/Medline, Europe PMC, and Google Scholar were searched for studies published between January 1, 2020 and January 13, 2021. Random or Fixed effects models were used to calculate the mean difference (MD) and 95% confidence intervals (CIs). Statistical heterogeneity was assessed using Cochran's Q test and I2 statistics. Results: This meta-analysis included 19 studies. Of which, 12 studies were categorized by severity, 04 studies by mortality, and 03 studies by both severity and mortality. Our findings revealed significantly decreased levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) in the severe group when compared with the non-severe group in a random effect model. Similarly, random effect model results demonstrated significantly lower levels of HDL-C and LDL-C in the non-survivor group when compared with the survivor group. The level of TC was also found to be decreased in the non-survivor group when compared to the survivor group in a fixed-effect model. Conclusion: In conclusion, the lipid profile is associated with both the severity and mortality in COVID-19 patients. Hence, the lipid profile may be used for assessing the severity and prognosis of COVID-19. Prospero registration number: CRD42021216316. Keywords: COVID-19; High-density lipoprotein cholesterol; Low-density lipoprotein cholesterol; SARS-CoV-2; Total cholesterol.

参考サイト PubMed: covid-19



バイオクイックニュース日本語版:COVID-19特集

バイオクイックニュース日本語版
7月 18, 2021 バイオアソシエイツ

COVID-19モノクローナル抗体療法は、高リスク患者に早期投与することで医療システムの負担を軽減することができるとの報告

南フロリダ大学(USF Health)とタンパ総合病院(Tampa General Hospital)が新たに発表した研究によると、モノクローナル抗体は、リスクの高い患者に早期に投与することで、 COVID-19 に関連する救急外来の受診や入院を減少させる効果があることがわかった。FDAのガイドラインに沿って使用すれば、この治療法は、パンデミックによる患者や限られた医療資源への継続的な負担を軽減することができる、と研究者らは提案している。この共同研究は、2021年6月4日にOpen Forum…

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