Learning through a Pandemic: The Current State of Knowledge on COVID-19 and Cancer

Review Cancer Discov . 2021 Dec 10;candisc.1368.2021. doi: 10.1158/2159-8290.CD-21-1368. Online ahead of print. Arielle Elkrief 1 , Julie T Wu 2 , Chinmay Jani 3 , Kyle T Enriquez 4 , Michael Glover 5 , Mansi R Shah 6 , Hira Ghazal Shaikh 7 , Alicia Beeghly-Fadiel 8 , Benjamin French 9 , Sachin R Jhawar 10 , Douglas B Johnson 11 , Rana R McKay 12 , Donna R Rivera 13 , Daniel Y Reuben 14 , Surbhi Shah 15 , Stacey L Tinianov 16 , Donald Cuong Vinh 17 , Sanjay Mishra 18 , Jeremy L Warner 19 Affiliations Expand Affiliations 1 Hemato-Oncology, University of Montreal Research Center (CRCHUM). 2 Oncology, Stanford University. 3 Internal Medicine, Mount Auburn Hospital. 4 Medical Scientist Training Program, Vanderbilt University School of Medicine. 5 Internal Medicine, Stanford University. 6 Division of Blood Disorders, Rutgers Cancer Institute of New Jersey. 7 Hemaoology Oncology, University of Cincinnati Cancer Center. 8 Department of Medicine, Vanderbilt University Medical Center. 9 Vanderbilt University Medical Center. 10 Radiation Oncology, The Ohio State University Comprehensive Cancer Center. 11 Department of Medicine, Vanderbilt-Ingram Cancer Center. 12 Medicine, University of California, San Diego. 13 Oncology Center of Excellence, US FDA. 14 Hematology and Oncology, Medical University of South Carolina. 15 Mayo Clinic Hospital. 16 founder, Advocates for Collaborative Education. 17 McGill University Health Centre. 18 Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center. 19 Medicine and Biomedical Informatics, Vanderbilt University Medical Center jeremy.warner@vumc.org. Item in Clipboard Review Arielle Elkrief et al. Cancer Discov. 2021. Show details Display options Display options Format Cancer Discov . 2021 Dec 10;candisc.1368.2021. doi: 10.1158/2159-8290.CD-21-1368. Online ahead of print. Authors Arielle Elkrief 1 , Julie T Wu 2 , Chinmay Jani 3 , Kyle T Enriquez 4 , Michael Glover 5 , Mansi R Shah 6 , Hira Ghazal Shaikh 7 , Alicia Beeghly-Fadiel 8 , Benjamin French 9 , Sachin R Jhawar 10 , Douglas B Johnson 11 , Rana R McKay 12 , Donna R Rivera 13 , Daniel Y Reuben 14 , Surbhi Shah 15 , Stacey L Tinianov 16 , Donald Cuong Vinh 17 , Sanjay Mishra 18 , Jeremy L Warner 19 Affiliations 1 Hemato-Oncology, University of Montreal Research Center (CRCHUM). 2 Oncology, Stanford University. 3 Internal Medicine, Mount Auburn Hospital. 4 Medical Scientist Training Program, Vanderbilt University School of Medicine. 5 Internal Medicine, Stanford University. 6 Division of Blood Disorders, Rutgers Cancer Institute of New Jersey. 7 Hemaoology Oncology, University of Cincinnati Cancer Center. 8 Department of Medicine, Vanderbilt University Medical Center. 9 Vanderbilt University Medical Center. 10 Radiation Oncology, The Ohio State University Comprehensive Cancer Center. 11 Department of Medicine, Vanderbilt-Ingram Cancer Center. 12 Medicine, University of California, San Diego. 13 Oncology Center of Excellence, US FDA. 14 Hematology and Oncology, Medical University of South Carolina. 15 Mayo Clinic Hospital. 16 founder, Advocates for Collaborative Education. 17 McGill University Health Centre. 18 Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center. 19 Medicine and Biomedical Informatics, Vanderbilt University Medical Center jeremy.warner@vumc.org. Item in Clipboard CiteDisplay options Display options Format Abstract The ongoing COVID-19 pandemic has left patients with current or past history of cancer facing disparate consequences at every stage of the cancer trajectory. This comprehensive review offers a landscape analysis of the current state of the literature on COVID-19 and cancer including the immune response to COVID-19, risk factors for severe disease, and impact of anticancer therapies. We also review the latest data on treatment of COVID-19 and vaccination safety and efficacy in patients with cancer, as well as impact of the pandemic on cancer care, including the urgent need for rapid evidence generation and real-world study designs. Copyright ©2021, American Association for Cancer Research. Publication types [x] Cite Copy Format: Send To [x]