Kawasaki Disease- Management Strategies Given Symptoms Overlap to COVID-19: A Review


Posted: 2021-09-11 19:00:00
Kawasaki disease is an acute, self-limiting vasculitis in children. Early treatment is necessary to prevent cardiovascular complications. The acute phase of Kawasaki disease may present with hemodynamic instability. An association between viral respiratory infections and Kawasaki disease has been reported. Studies have shown that Kawasaki and Kawasaki-like disease may be associated with and have symptoms overlapping COVID-19. Children with COVID-19 may present as Kawasaki-like disease with pediatric inflammatory multisystem syndrome, or macrophage activation syndrome. Clinicians need to be aware of the early diagnosis and management of Kawasaki disease to prevent the development of coronary artery aneurysms. The symptoms overlap of multisystem inflammatory disease seen in COVID-19 adds to the difficulties in timely diagnosis and treatment. Children with Kawasaki disease require regular follow-up plans for coronary artery aneurysms. This adds to the difficulties during the changed environment of COVID-19 for control and prevention. Missed diagnosis and early treatment of Kawasaki disease with immunoglobulin and aspirin results in the development of coronary artery aneurysm in up to 25% of cases, with grave consequences. Here, we briefly review the management of typical and atypical Kawasaki disease which has symptoms overlapping with the multisystem inflammatory disease as seen in COVID-19.

参考サイト PubMed: covid-19


7月 22, 2020 bioassociates2

新型コロナウイルスがin vitroで心臓細胞に感染することが最近の研究で判明

米国のシーダーズ・サイナイ病院による新しい研究で、 COVID-19 を引き起こすSARS-CoV-2(新型コロナウイルス)が心臓細胞に感染する可能性があり、COVID-19患者の心臓細胞が直接感染する可能性があることが示された。 2020年6月25日にCell Reports Medicineのオンラインで公開されたこの発見は、iPS細胞技術によって生産された心筋細胞を使用して行われた。この論文は、「ヒトiPSC由来の心筋細胞はSARS-CoV-2感染の影響を受けやすい(Human iPSC-Derived…

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