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Effects of cardiac toxicity of combination therapy with hydroxychloroquine and azithromycin in COVID-19 patients


Posted: 2021-10-09 19:00:00
J Infect Public Health . 2021 Sep 23;14(11):1668-1670. doi: 10.1016/j.jiph.2021.09.013. Online ahead of print. Affiliations Expand Affiliations 1 Department of Internal Medicine, Huntsville Hospital, AL, USA. Electronic address: ushachowdhary.y@gmail.com. 2 Department of Infectious Disease, Huntsville Hospital, AL, USA. Electronic address: ali_hasoun@yahoo.com. 3 Department of Cardiology, Huntsville Hospital, AL, USA. 4 Department of Pharmacology, Huntsville Hospital, AL, USA. Item in Clipboard Usha Yendrapalli et al. J Infect Public Health. 2021. Show details Display options Display options Format J Infect Public Health . 2021 Sep 23;14(11):1668-1670. doi: 10.1016/j.jiph.2021.09.013. Online ahead of print. Affiliations 1 Department of Internal Medicine, Huntsville Hospital, AL, USA. Electronic address: ushachowdhary.y@gmail.com. 2 Department of Infectious Disease, Huntsville Hospital, AL, USA. Electronic address: ali_hasoun@yahoo.com. 3 Department of Cardiology, Huntsville Hospital, AL, USA. 4 Department of Pharmacology, Huntsville Hospital, AL, USA. Item in Clipboard CiteDisplay options Display options Format Abstract Coronavirus disease 2019 (COVID-19), which began in China, caused a global pandemic. Few studies have shown the benefit of hydroxychloroquine (HY) ± azithromycin (AZ) for treating COVID-19. Concerns of QT prolongation and increased risks of torsade's de pointes (TdP) with this combination have been raised since each agent can individually prolong the QT interval. This retrospective, observational study included hospitalized patients treated with HY and AZ from March 2020 to May 2020 at a large community hospital. Serial assessments of the QT interval were performed. Our aim is to evaluate the safety and characterize the change in QTc interval and arrhythmic events in COVID-19 patients treated with HY/AZ. A total of 21 COVID patients who received at least four days of HY and AZ were included in this study. Mean baseline was QTc 403 ms, mean maximum QTc was 440 ms, mean change in QTc was 36 ms. Only one patient (4.8%) developed prolonged QTc > 500 ms. No patient had a change in QTc of 60 ms or more. No patient developed TdP. Fifteen patients (71.4%) had hypoxia on admission, with only two patients (9.5%) required oxygen of 1-2 L at discharge. 80.9% of patients have been discharged home or inpatient rehabilitation. Keywords: Azithromycin; COVID-19; Hydroxychloroquine; QT interval; Torsade de pointes. Copyright © 2021. Published by Elsevier Ltd. Figures Fig. 1 Primary and secondary outcomes. Fig. 1 Primary and secondary outcomes. Fig. 1 Primary and secondary outcomes. References Epidemiology Working Group for NCIP Epidemic Response Chinese center for disease control and prevention. Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41(2):145–151. doi: 10.3760/cma.j.issn.0254-6450.2020.02.003. - DOI - PubMed Arshad S., Kilgore P., Chaudhry Z.S. Treatment with hydroxychloroquine, azithromycin, and combination in patients hospitalized with COVID-19. Int J Infect Dis. 2020;97:396–403. doi: 10.1016/j.ijid.2020.06.099. - DOI - PMC - PubMed Andreani J., Bideau M.L., Duflot I., Jardot P., Rolland C., Boxberger M. In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect. Microb Pathog. 2020;145 doi: 10.1016/j.micpath.2020.104228. - DOI - PMC - PubMed Chen J., Liu D., Liu L., Liu P., Xu Q., Xia L. A pilot study of hydroxychloroquine in treatment of patients with common coronavirus disease-19 (COVID-19) J Zhejiang Univ (Med Sci) 2020;49(1) Gautret P., Lagier J.-C., Parola P., Hoang V.T., Meddeb L., Sevestre J. Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: a pilot observational study. Travel Med Infect Dis. 2020;34 doi: 10.1016/j.tmaid.2020.101663. - DOI - PMC - PubMed Show all 13 references LinkOut - more resources Full Text Sources [x] Cite Copy Format: Send To [x]

参考サイト PubMed: covid-19



バイオクイックニュース日本語版:COVID-19特集

バイオクイックニュース日本語版
9月 18, 2020 バイオアソシエイツ

COVID-19の病原性は、宿主MicroRNAの枯渇によるものという仮説が発表された

なぜ COVID-19 ウイルスは致命的であるのに、他の多くのコロナウイルスは無害で風邪をひくだけなのか? ポーランドとアメリカのアラバマ大学バーミンガム校(UAB)の研究チームがその答えを提案した。COVID-19ウイルスはマイクロRNAの「スポンジ」として機能するという。ポーランドのグダニスク医科大学の Rafal Bartoszewski 博士らによるこの仮説は、American Journal of Physiology-Lung Cellular and Molecular…

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