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Effect of ORF7 of SARS-CoV-2 on the Chemotaxis of Monocytes and Neutrophils In Vitro


Posted: 2021-10-04 19:00:00
Dis Markers . 2021 Sep 28;2021:6803510. doi: 10.1155/2021/6803510. eCollection 2021. Gang Wang 1 , Jun Guan 1 , Guojun Li 2 , Fengtian Wu 1 , Qin Yang 1 , Chunhong Huang 1 , Junwei Shao 1 , Lichen Xu 1 , Zixuan Guo 1 , Qihui Zhou 1 , Haihong Zhu 1 , Zhi Chen 1 Affiliations Expand Affiliations 1 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. 2 Department of Liver Diseases, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, 518000 Guangdong, China. Item in Clipboard Gang Wang et al. Dis Markers. 2021. Show details Display options Display options Format Dis Markers . 2021 Sep 28;2021:6803510. doi: 10.1155/2021/6803510. eCollection 2021. Authors Gang Wang 1 , Jun Guan 1 , Guojun Li 2 , Fengtian Wu 1 , Qin Yang 1 , Chunhong Huang 1 , Junwei Shao 1 , Lichen Xu 1 , Zixuan Guo 1 , Qihui Zhou 1 , Haihong Zhu 1 , Zhi Chen 1 Affiliations 1 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. 2 Department of Liver Diseases, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, 518000 Guangdong, China. Item in Clipboard CiteDisplay options Display options Format Abstract Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently the most significant public health threat worldwide. Patients with severe COVID-19 usually have pneumonia concomitant with local inflammation and sometimes a cytokine storm. Specific components of the SARS-CoV-2 virus trigger lung inflammation, and recruitment of immune cells to the lungs exacerbates this process, although much remains unknown about the pathogenesis of COVID-19. Our study of lung type II pneumocyte cells (A549) demonstrated that ORF7, an open reading frame (ORF) in the genome of SARS-CoV-2, induced the production of CCL2, a chemokine that promotes the chemotaxis of monocytes, and decreased the expression of IL-8, a chemokine that recruits neutrophils. A549 cells also had an increased level of IL-6. The results of our chemotaxis Transwell assay suggested that ORF7 augmented monocyte infiltration and reduced the number of neutrophils. We conclude that the ORF7 of SARS-CoV-2 may have specific effects on the immunological changes in tissues after infection. These results suggest that the functions of other ORFs of SARS-CoV-2 should also be comprehensively examined. Copyright © 2021 Gang Wang et al. Conflict of interest statement The authors declare no conflict of interest. [x] Cite Copy Format: Send To [x]

参考サイト PubMed: covid-19



バイオクイックニュース日本語版:COVID-19特集

バイオクイックニュース日本語版
4月 07, 2020 バイオアソシエイツ

米国の2人の感染症専門家がCOVID-19生存者からの抗体を、患者治療と医療従事者保護の応急措置として使用すべきと主張。 このアプローチは100年間に渡り致命的な病原体の大発生で成功を収めている。

新型コロナウイルス( COVID-19 )と闘う国々は、感染から回復した人々の抗体を使用して症例を治療し、重要な医療従事者に短期免疫(数週間から数ヶ月)を提供することを検討する必要があると米国の2人の感染症専門家が主張している。 ボルティモアにあるジョンズホプキンスブルームバーグ公衆衛生学校の分子微生物学および免疫学科の部長であるArturo Casadevall医学博士とニューヨーク市にあるアルバートアインシュタイン医科大学の感染症部門の責任者であるLiise-anne Pirofski医学博士である。…

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