Diagnostic performance of rapid antigen tests (RATs) for SARS-CoV-2 and their efficacy in monitoring the infectiousness of COVID-19 patients


Posted: 2021-11-25 20:00:00
The most widely used test for the diagnosis of SARS-CoV-2 infection is a PCR test. PCR has very high sensitivity and is able to detect very low amounts of RNA. However, many individuals receiving a positive test result in a context of a PCR-based surveillance might be infected with SARS-CoV-2, but they are not contagious at the time of the test. The question arises regards if the cost effective, portable rapid antigen tests (RATs) have a better performance than PCR in identification of infectious individuals. In this direction, we examined the diagnostic performance of RATs from 14 different manufacturers in 400 clinical samples with known rRT-PCR cycles threshold (cT) and 50 control samples. Substantial variability was observed in the limit of detection (LOD) of different RATs (cT = 26.8-34.7). The fluorescence-based RAT exhibited a LOD of cT = 34.7. The use of the most effective RATs leads to true positive rates (sensitivities) of 99.1% and 90.9% for samples with cT ≤ 30 and cT ≤ 33, respectively, percentages that can guarantee a sensitivity high enough to identify contagious patients. RAT testing may also substantially reduce the quarantine period for infected individuals without compromising personal or public safety.

参考サイト PubMed: covid-19


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バイオクイックニュース日本語版:COVID-19特集

バイオクイックニュース日本語版
10月 14, 2020 バイオアソシエイツ

ヒトY染色体遺伝子によって制御される非性器機能が発見された。なぜ特定の病気が男性と女性に異なる影響を与えるのか?その理由を解明できるかもしれない。

男性特有のY染色体遺伝子のあまり知られていない役割に新たな光が当てられ、 COVID-19 を含むさまざまな病気で、男性が女性とは異なる重症化を示すのか理由を説明することができるかもしれない。この研究成果は、モントリオール大学・モントリオール臨床研究所の実験的心臓血管生物学研究ユニットのディレクターであるChristian Deschepper医学博士によって、Scientific Reports…

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