Demographic, clinical, and laboratory characteristics of patients with COVID-19 during the second and third waves of the pandemic in Egypt


Posted: 2021-09-13 19:00:00
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel virus that belongs to the coronaviruses and causes coronavirus disease 2019 (COVID-19). In this study, we explored the demographic details, clinical features, and routinely conducted laboratory investigations of patients with COVID-19 during the second and third waves of the pandemic to understand their possible diagnostic and prognostic values in Egypt. Methods: In this retrospective cohort study, the demographic characteristics, detailed medical history, laboratory findings, and symptoms of all enrolled patients with SARS-CoV-2 were collected from the medical records of Beni Suef University Hospitals between December 15, 2020, and April 15, 2021. Results: This retrospective study included 473 patients, almost all of whom were elderly. The median age of the patients was 48 years, and those with moderate and severe disease were older than those with mild infections. The proportion of females was higher (63.4%) than males (36.6%). Diabetes mellitus (DM) was the most common comorbidity (17.3%), and fever was the most typical manifestation of COVID-19 (62.6%). Those with severe disease showed a higher C-reactive protein level (CRP) than those with moderate (p-value 0.009) or mild (p-value 0.01) diseases. Serum ferritin levels were significantly higher in patients with severe disease than in those with moderate disease (p-value 0.018). In contrast, d-dimer and serum creatinine were normal and showed no significant difference in all comparisons (p-value overall 0.21). Conclusion: This study observed several variations in COVID-19 patients' characteristics. The new manifestations included skin rash, bone and low back pains, and rigors. In contrast to females, most males had moderate-to-severe illness. Old age and higher body mass index was associated with increasing severity. d-dimer and complete blood count were normal and could not identify potential COVID-19 patients. Patients who had mild illness were still at risk of developing post-COVID complications. Keywords: COVID-19; Clinical characteristics; Demographic details; Egypt; Laboratory findings; SARS-CoV-2.

参考サイト PubMed: covid-19


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バイオクイックニュース日本語版:COVID-19特集

バイオクイックニュース日本語版
9月 06, 2021 バイオアソシエイツ

COVID-19ウイルスの広範な変異種から防御する抗体を発見。変異種間で変化の少ない受容体結合ドメイン(RBD)を標的としている。

現在のCOVID-19を引き起こすウイルスは、はるか昔の2019年12月に最初に人々を病気にしたウイルスと同じではない。現在流行している亜種の多くは、元のウイルスに基づいて開発された抗体ベースの治療薬の一部に部分的に耐性を持っている。パンデミックが続くと、必然的にさらに多くの亜種が発生し、耐性の問題は大きくなる一方だ。ワシントン大学医学部(セントルイス)の研究者らは、広範囲のウイルス亜種に対して低用量で高い保護効果を示す抗体を発見した。さらに、この抗体は、ウイルスの亜種間でほとんど違いのない部分に結合するため、この…