Coronavirus disease 2019-associated immunoglobulin A vasculitis/Henoch-Schonlein purpura: A case report and review


Posted: 2021-11-06 19:00:00
J Dermatol . 2021 Nov 5. doi: 10.1111/1346-8138.16211. Online ahead of print. Affiliations Expand Affiliation 1 Division of Dermatology, University of Arizona College of Medicine, Tucson, Arizona, USA. Item in Clipboard Patrick M Jedlowski et al. J Dermatol. 2021. Show details Display options Display options Format J Dermatol . 2021 Nov 5. doi: 10.1111/1346-8138.16211. Online ahead of print. Affiliation 1 Division of Dermatology, University of Arizona College of Medicine, Tucson, Arizona, USA. Item in Clipboard CiteDisplay options Display options Format Abstract Immunoglobulin A (IgA) vasculitis or Henoch-Schönlein purpura is a predominantly pediatric disease occurring after a triggering viral or bacterial infection. Conversely, drug exposure is the most common inciting event in adult cases of IgA vasculitis. Recently, data has suggested a temporal association between coronavirus disease 2019 (COVID-19) and the development of IgA vasculitis in children and adults. Here, we describe a case of IgA vasculitis with nephritis in a 70-year-old man with COVID-19 and perform a comprehensive review of eight reported cases of suspected COVID-19-associated IgA vasculitis. When compared to classical IgA vasculitis, COVID-19-associated IgA vasculitis exclusively affects males (p < 0.00002) and is more common in adults (p < 0.005). Among cases of COVID-19-associated IgA vasculitis, adult cases were associated with significantly more arthralgia than pediatric cases (p = 0.04). In cases where skin biopsy was obtained, direct immunofluorescence (DIF) was negative for IgA in 50% of cases; thereafter, kidney biopsy DIF was positive for IgA in all cases. With this study, we provide support for an association between IgA vasculitis and severe acute respiratory syndrome coronavirus 2 infection and provide clinical information differentiating its manifestations from classical IgA vasculitis. Keywords: Henoch-Schönlein Purpura; coronavirus disease 2019; cutaneous small vessel vasculitis; immunoglobulin A vasculitis; severe acute respiratory syndrome coronavirus 2. © 2021 Japanese Dermatological Association. References REFERENCES Fervenza FC. Henoch-Schonlein purpura nephritis. Int J Dermatol. 2003;42:170-7. Kang Y, Park JS, Ha YJ, Kang MI, Park HJ, Lee SW, et al. Differences in clinical manifestations and outcomes between adult and child patients with Henoch-Schonlein purpura. J Korean Med Sci. 2014;29:198-203. Allez M, Fleshner P, Gearry R, Lakatos PL, Rubin DT. Care of the patient With IBD requiring hospitalisation during the COVID-19 pandemic. J Crohns Colitis. 2020;14:S774-9. AlGhoozi DA, AlKhayyat HM. A child with Henoch-Schonlein purpura secondary to a COVID-19 infection. BMJ Case Rep. 2021;14:e239910. Hoskins B, Keeven N, Dang M, Keller E, Nagpal R. A child with COVID-19 and immunoglobulin A vasculitis. Pediatr Ann. 2021;50:e44-7. Show all 15 references [x] Cite Copy Format: Send To [x]

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バイオクイックニュース日本語版:COVID-19特集

バイオクイックニュース日本語版
10月 14, 2020 バイオアソシエイツ

ヒトY染色体遺伝子によって制御される非性器機能が発見された。なぜ特定の病気が男性と女性に異なる影響を与えるのか?その理由を解明できるかもしれない。

男性特有のY染色体遺伝子のあまり知られていない役割に新たな光が当てられ、 COVID-19 を含むさまざまな病気で、男性が女性とは異なる重症化を示すのか理由を説明することができるかもしれない。この研究成果は、モントリオール大学・モントリオール臨床研究所の実験的心臓血管生物学研究ユニットのディレクターであるChristian Deschepper医学博士によって、Scientific Reports…

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