Convalescent plasma therapy in B-cell-depleted and B-cell sufficient patients with life-threatening COVID-19 - A case series

Posted: 2021-09-22 19:00:00
Objective: To investigate the effect of convalescent plasma therapy (CPT) on clinical courses of B-cell-sufficient and B-cell-depleted patients with life-threatening COVID-19. Patients and methods: In this case series, we retrospectively analysed clinical, laboratory and cardiopulmonary parameters of six patients with life-threatening COVID-19 receiving convalescent plasma (CP) as rescue therapy between April 11, 2020 to October 10, 2020. Clinical and laboratory parameters before and after transfusion were compared in two B-cell-depleted patients and four B-cell sufficient patients (control group). Results: Both B-cell-depleted patients cleared SARS-CoV-2 virus and survived, while all other patients died within 14 days from intervention despite maximal therapeutic efforts. D-dimer levels increased in both cohorts subsequent to CPT. In control patients, mean Interleukin-6 increased and platelet levels decreased as opposed to decreasing and stable levels in B-cell-depleted patients, respectively. Control patients required increased doses of vasopressor compared to decreasing doses in B-cell depleted patients subsequent to CPT. PO2/FiO2 decrease was more pronounced and respiratory deterioration required postinterventional extracorporeal membrane oxygenation in two control patients. Transpulmonary thermodilution revealed a further increase of the Extravascular Lung Water Index upon CPT in control patients. Conclusion: Use of CP in late stages of life-threatening COVID-19 should be used with caution but may be beneficial in B-cell-depleted patients. Further studies are necessary to assess factors predicting potential therapeutic benefits as well as possible hazards. Keywords: B-cell depletion; Convalescent plasma; Life-threatening COVID-19; SARS-CoV-2.

参考サイト PubMed: covid-19


8月 05, 2020 バイオアソシエイツ


コウモリは、ヒトに影響を与える多くの致命的なウイルス(エボラ出血熱、狂犬病、そして最近では COVID-19 を引き起こすコロナウイルスのSARS-CoV-2など)に対し、耐性があると考えられている。 ヒトはこれらの病原体で有害な症状を経験するが、コウモリはウイルスに著しく耐えることができ、さらに、同じサイズの陸上哺乳類よりもはるかに長く生きる。コウモリの寿命とウイルス耐性の秘密は何か?…

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