Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines

Posted: 2021-10-26 19:00:00
Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in COVID-19 patients, suggesting that vaccination mimicked an infection. Single-cell mRNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) before and 28 days after the first inoculation also revealed consistent alterations in gene expression of many different immune cell types. Reduction of CD8+ T cells and increase in classic monocyte contents were exemplary. Moreover, scRNA-seq revealed increased NF-κB signaling and reduced type I interferon responses, which were confirmed by biological assays and also had been reported to occur after SARS-CoV-2 infection with aggravating symptoms. Altogether, our study recommends additional caution when vaccinating people with pre-existing clinical conditions, including diabetes, electrolyte imbalances, renal dysfunction, and coagulation disorders.

参考サイト PubMed: covid-19

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8月 05, 2020 バイオアソシエイツ


コウモリは、ヒトに影響を与える多くの致命的なウイルス(エボラ出血熱、狂犬病、そして最近では COVID-19 を引き起こすコロナウイルスのSARS-CoV-2など)に対し、耐性があると考えられている。 ヒトはこれらの病原体で有害な症状を経験するが、コウモリはウイルスに著しく耐えることができ、さらに、同じサイズの陸上哺乳類よりもはるかに長く生きる。コウモリの寿命とウイルス耐性の秘密は何か?…

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