C-Reactive protein and SOFA scale: A simple score as early predictor of critical care requirement in patients with COVID-19 pneumonia in Spain


Posted: 2021-11-08 20:00:00
Rev Esp Anestesiol Reanim (Engl Ed) . 2021 Nov 4;S2341-1929(21)00146-3. doi: 10.1016/j.redare.2020.11.008. Online ahead of print. Affiliations Expand Affiliations 1 Departamento de Anestesiología y Reanimación, Hospital Universitario de Salamanca-IBSAL, Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain. 2 Departamento de Anestesiología y Reanimación, Hospital Universitario de Salamanca-IBSAL, Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain. Electronic address: mesanchezba@saludcastillayleon.es. 3 Departamento de Anestesiología y Reanimación, Hospital Universitario de León, Universidad de León, León, Spain. 4 Departamento de Hematología, Hospital Universitario de Salamanca-IBSAL, Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain. Item in Clipboard L M Vaquero-Roncero et al. Rev Esp Anestesiol Reanim (Engl Ed). 2021. Show details Display options Display options Format Rev Esp Anestesiol Reanim (Engl Ed) . 2021 Nov 4;S2341-1929(21)00146-3. doi: 10.1016/j.redare.2020.11.008. Online ahead of print. Affiliations 1 Departamento de Anestesiología y Reanimación, Hospital Universitario de Salamanca-IBSAL, Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain. 2 Departamento de Anestesiología y Reanimación, Hospital Universitario de Salamanca-IBSAL, Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain. Electronic address: mesanchezba@saludcastillayleon.es. 3 Departamento de Anestesiología y Reanimación, Hospital Universitario de León, Universidad de León, León, Spain. 4 Departamento de Hematología, Hospital Universitario de Salamanca-IBSAL, Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain. Item in Clipboard CiteDisplay options Display options Format Abstract Objective: To identify potential markers at admission predicting the need for critical care in patients with COVID-19 pneumonia. Material and methods: An approved, observational, retrospective study was conducted between March 15 to April 15, 2020. 150 adult patients aged less than 75 with Charlson comorbidity index ≤6 diagnosed with COVID-19 pneumonia were included. Seventy-five patients were randomly selected from those admitted to the critical care units (critical care group [CG]) and seventy-five hospitalized patients who did not require critical care (non-critical care group [nCG]) represent the control group. One additional cohort of hospitalized patients with COVID-19 were used to validate the score. Measurements and main results: Multivariable regression showed increasing odds of in-hospital critical care associated with increased C-reactive protein (CRP) (odds ratio 1.052 [1.009-1.101]; P = 0.0043) and higher Sequential Organ Failure Assessment (SOFA) score (1.968 [1.389-2.590]; P < 0.0001), both at the time of hospital admission. The AUC-ROC for the combined model was 0.83 (0.76-0.90) (vs AUC-ROC SOFA P < 0.05). The AUC-ROC for the validation cohort was 0.89 (0.82-0.95) (P > 0.05 vs AUC-ROC development). Conclusion: Patients COVID-19 presenting at admission SOFA score ≥ 2 combined with CRP ≥ 9.1 mg/mL could be at high risk to require critical care. Keywords: C-reactive protein; COVID-19 pneumonia; Critical care; Cuidados críticos; Neumonía por COVID-19; Proteína C reactiva; SOFA - evaluación de fallo orgánico secuencial; Sequential organ failure assessment - SOFA. Copyright © 2021 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Publicado por Elsevier España, S.L.U. All rights reserved. [x] Cite Copy Format: Send To [x]

参考サイト PubMed: covid-19



バイオクイックニュース日本語版:COVID-19特集

バイオクイックニュース日本語版
4月 07, 2021 バイオアソシエイツ

超音波はコロナウイルスに損傷を与える可能性があることをMITのシミュレーションが示唆

コロナウイルスは、いばらの冠に似た密集した表面受容体を備えた構造をしている。 これらのスパイク状タンパク質は健康な細胞をしっかり掴み、ウイルスRNAの侵入を引き起こす。 ウイルスの形状と感染戦略は一般的に理解されているが、その物理的完全性についてはほとんど知られていない。MITの機械工学科の研究者による新研究は、コロナウイルスが医用画像診断で使用される周波数内で超音波振動に対して脆弱である可能性があることを示唆している。…

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