Burdens of post-acute sequelae of COVID-19 by severity of acute infection, demographics and health status


Posted: 2021-11-13 20:00:00
Nat Commun . 2021 Nov 12;12(1):6571. doi: 10.1038/s41467-021-26513-3. Affiliations Expand Affiliations 1 Clinical Epidemiology Center, Research and Development Service, VA Saint Louis Health Care System, Saint Louis, MO, USA. 2 Veterans Research and Education Foundation of Saint Louis, Saint Louis, MO, USA. 3 Department of Epidemiology and Biostatistics, College for Public Health and Social Justice, Saint Louis University, Saint Louis, MO, USA. 4 Clinical Epidemiology Center, Research and Development Service, VA Saint Louis Health Care System, Saint Louis, MO, USA. zalaly@gmail.com. 5 Veterans Research and Education Foundation of Saint Louis, Saint Louis, MO, USA. zalaly@gmail.com. 6 Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA. zalaly@gmail.com. 7 Institute for Public Health, Washington University in Saint Louis, Saint Louis, MO, USA. zalaly@gmail.com. 8 Nephrology Section, Medicine Service, VA Saint Louis Health Care System, Saint Louis, MO, USA. zalaly@gmail.com. Item in Clipboard Yan Xie et al. Nat Commun. 2021. Show details Display options Display options Format Nat Commun . 2021 Nov 12;12(1):6571. doi: 10.1038/s41467-021-26513-3. Affiliations 1 Clinical Epidemiology Center, Research and Development Service, VA Saint Louis Health Care System, Saint Louis, MO, USA. 2 Veterans Research and Education Foundation of Saint Louis, Saint Louis, MO, USA. 3 Department of Epidemiology and Biostatistics, College for Public Health and Social Justice, Saint Louis University, Saint Louis, MO, USA. 4 Clinical Epidemiology Center, Research and Development Service, VA Saint Louis Health Care System, Saint Louis, MO, USA. zalaly@gmail.com. 5 Veterans Research and Education Foundation of Saint Louis, Saint Louis, MO, USA. zalaly@gmail.com. 6 Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA. zalaly@gmail.com. 7 Institute for Public Health, Washington University in Saint Louis, Saint Louis, MO, USA. zalaly@gmail.com. 8 Nephrology Section, Medicine Service, VA Saint Louis Health Care System, Saint Louis, MO, USA. zalaly@gmail.com. Item in Clipboard CiteDisplay options Display options Format Abstract The Post-Acute Sequelae of SARS-CoV-2 infection (PASC) have been characterized; however, the burden of PASC remains unknown. Here we used the healthcare databases of the US Department of Veterans Affairs to build a cohort of 181,384 people with COVID-19 and 4,397,509 non-infected controls and estimated that burden of PASC-defined as the presence of at least one sequela in excess of non-infected controls-was 73.43 (72.10, 74.72) per 1000 persons at 6 months. Burdens of individual sequelae varied by demographic groups (age, race, and sex) but were consistently higher in people with poorer baseline health and in those with more severe acute infection. In sum, the burden of PASC is substantial; PASC is non-monolithic with sequelae that are differentially expressed in various population groups. Collectively, our results may be useful in informing health systems capacity planning and care strategies of people with PASC. © 2021. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. References Al-Aly, Z., Xie, Y. & Bowe, B. High-dimensional characterization of post-acute sequelae of COVID-19. Nature 594, 259–264 (2021). WHO. In the Wake of the Pandemic: Preparing for Long COVID (World Health Organization, 2021). Greenhalgh, T., Knight, M., A’Court, C., Buxton, M. & Husain, L. Management of post-acute covid-19 in primary care. BMJ 370, m3026 (2020). - DOI Ayoubkhani, D. et al. Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study. BMJ 372, n693 (2021). - DOI Dennis, A. et al. Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study. BMJ Open 11, e048391 (2021). - DOI Show all 42 references [x] Cite Copy Format: Send To [x]

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