Association and predictive value of biomarkers with severe outcomes in hospitalized patients with SARS-CoV-2 infection


Posted: 2021-11-13 20:00:00
. 2021 Nov 6;149:155755. doi: 10.1016/j.cyto.2021.155755. Online ahead of print. Affiliations Expand Affiliations 1 Department of Pathology & Laboratory Medicine, University of Louisville, Louisville, KY, United States. Electronic address: rafael@louisville.edu. 2 Division of Infectious Diseases and Center of Excellence for Research on Infectious Diseases (CERID), University of Louisville, Louisville, KY, United States. 3 Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY, United States. Item in Clipboard Rafael Fernandez-Botran et al. Cytokine. 2021. Show details Display options Display options Format . 2021 Nov 6;149:155755. doi: 10.1016/j.cyto.2021.155755. Online ahead of print. Affiliations 1 Department of Pathology & Laboratory Medicine, University of Louisville, Louisville, KY, United States. Electronic address: rafael@louisville.edu. 2 Division of Infectious Diseases and Center of Excellence for Research on Infectious Diseases (CERID), University of Louisville, Louisville, KY, United States. 3 Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY, United States. Item in Clipboard CiteDisplay options Display options Format Abstract This study analyzed the levels at admission of biomarkers for their association with and ability to predict risk of severe outcomes, including admission to the ICU, need for invasive mechanical ventilation (IMV), need for vasopressor use (VU), and in-hospital mortality (IHM) in 700 patients hospitalized with COVID-19. Biomarker data split by outcomes was compared using Mann-Whitney U tests; frequencies of biomarker values were compared using Chi-square tests and multivariable logistic regression analysis was performed to look at the impact of biomarkers by outcome. Patients that suffered IHM were more likely to have reduced platelet numbers and high blood urea nitrogen (BUN) levels among patients admitted to the ICU. Risk factors for mortality were related to hyper-coagulability (low platelet count and increased D-dimer) and decreased respiratory (PaO2/FiO2 ratio) and kidney function (BUN). Association with risks of other severe outcomes were as follows: ICU with hyper-inflammation (IL-6) and decreased respiratory function; IMV with low platelet count, abnormal neutrophil-lymphocyte ratio with reduced respiratory function, VU with inflammatory markers (IL-6), and low platelet count with respiratory function. Our studies confirmed the association of biomarkers of hematological, inflammatory, coagulation, pulmonary and kidney functions with disease severity. Whether these biomarkers have any mechanistic or causal role in the disease progress requires further investigation. Keywords: COVID-19; Critical care; Cytokines and inflammatory mediators; Growth factors; Inflammation; Intensive care; Mechanical ventilation. Copyright © 2021 Elsevier Ltd. All rights reserved. [x] Cite Copy Format: Send To [x]

参考サイト PubMed: covid-19



バイオクイックニュース日本語版:COVID-19特集

バイオクイックニュース日本語版
11月 13, 2020 バイオアソシエイツ

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