An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment


Posted: 2022-01-07 20:00:00
The COVID-19 pandemic is one of the greatest threats to human health in the 21st century with more than 257 million cases and over 5.17 million deaths reported worldwide (as of November 23, 2021. Various agents were initially proclaimed to be effective against SARS-CoV-2, the etiological agent of COVID-19. Hydroxychloroquine, lopinavir/ritonavir, and ribavirin are all examples of therapeutic agents, whose efficacy against COVID-19 was later disproved. Meanwhile, concentrated efforts of researchers and clinicians worldwide have led to the identification of novel therapeutic options to control the disease including PAXLOVID™ (PF-07321332). Although COVID-19 cases are currently treated using a comprehensive approach of anticoagulants, oxygen, and antibiotics, the novel Pfizer agent PAXLOVID™ (PF-07321332), an investigational COVID-19 oral antiviral candidate, significantly reduced hospitalization time and death rates, based on an interim analysis of the phase 2/3 EPIC-HR (Evaluation of Protease Inhibition for COVID-19 in High-Risk Patients) randomized, double-blind study of non-hospitalized adult patients with COVID-19, who are at high risk of progressing to severe illness. The scheduled interim analysis demonstrated an 89 % reduction in risk of COVID-19-related hospitalization or death from any cause compared to placebo in patients treated within three days of symptom onset (primary endpoint). However, there still exists a great need for the development of additional treatments, as the recommended therapeutic options are insufficient in many cases. Thus far, mRNA and vector vaccines appear to be the most effective modalities to control the pandemic. In the current review, we provide an update on the progress that has been made since April 2020 in clinical trials concerning the effectiveness of therapies available to combat COVID-19. We focus on currently recommended therapeutic agents, including steroids, various monoclonal antibodies, remdesivir, baricitinib, anticoagulants and PAXLOVID™ summarizing the latest original studies and meta-analyses. Moreover, we aim to discuss other currently and previously studied agents targeting COVID-19 that either show no or only limited therapeutic activity. The results of recent studies report that hydroxychloroquine and convalescent plasma demonstrate no efficacy against SARS-CoV-2 infection. Lastly, we summarize the studies on various drugs with incoherent or insufficient data concerning their effectiveness, such as amantadine, ivermectin, or niclosamide. Keywords: Baricitinib; COVID-19; Casirivimab; Dexamethasone; Imdevimab; Omicron; Paxlovid; Remdesivir; SARS-CoV-2; Sotrovimab; Tocilizumab.

参考サイト PubMed: covid-19


4月 14, 2020 bioassociates2


メルボルンの研究者らは、オーストラリアで最初の新型コロナウイルス(COVID-19)患者の1人から免疫反応をマッピングし、ウイルスと戦って感染から回復する人体の能力を示した。 メルボルン大学とロイヤルメルボルン病院の合弁会社であるピータードハティ感染症研究所(ドハティ研究所)の研究者らは、COVID-19を呈し、入院を必要とする軽度から中程度の症状があった 40代の健康な女性の4つの異なる時点での血液サンプルをテストすることができた。2020年3月16日にNature…

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