Advances in aggregation induced emission (AIE) materials in biosensing and imaging of bacteria


Posted: 2021-11-09 20:00:00
Prog Mol Biol Transl Sci . 2021;184:61-79. doi: 10.1016/bs.pmbts.2021.06.015. Epub 2021 Jul 21. Affiliations Expand Affiliations 1 Department of Biochemistry, Central University of Haryana, Mahendergarh, India. 2 Amity Stem cell Institute, Amity Medical School, Amity University Haryana, Amity Education Valley Pachgaon, Gurugram, India. Electronic address: skkalangi@ggn.amity.edu. Item in Clipboard Mulaka Maruthi et al. Prog Mol Biol Transl Sci. 2021. Show details Display options Display options Format Prog Mol Biol Transl Sci . 2021;184:61-79. doi: 10.1016/bs.pmbts.2021.06.015. Epub 2021 Jul 21. Affiliations 1 Department of Biochemistry, Central University of Haryana, Mahendergarh, India. 2 Amity Stem cell Institute, Amity Medical School, Amity University Haryana, Amity Education Valley Pachgaon, Gurugram, India. Electronic address: skkalangi@ggn.amity.edu. Item in Clipboard CiteDisplay options Display options Format Abstract With their ubiquitous nature, bacteria have had a significant impact on human health and evolution. Though as commensals residing in/on our bodies several bacterial communities support our health in many ways, bacteria remain one of the major causes of infectious diseases that plague the human world. Adding to this, emergence of antibiotic resistant strains limited the use of available antibiotics. The current available techniques to prevent and control such infections remain insufficient. This has been proven during one of greatest pandemic of our generation, COVID-19. It has been observed that bacterial coinfections were predominantly observed in COVID-19 patients, despite antibiotic treatment. Such higher rates of coinfections in critical patients even after antibiotic treatment is a matter of concern. Owing to many reasons across the world drug resistance in bacteria is posing a major problem i. According to Center for Disease control (CDC) antibiotic report threats (AR), 2019 more than 2.8 million antibiotic resistant cases were reported, and more than 35,000 were dead among them in USA alone. In both normal and pandemic conditions, failure of identifying infectious agent has played a major role. This strongly prompts the need to improve upon the existing techniques to not just effective identification of an unknown bacterium, but also to discriminate normal Vs drug resistant strains. New techniques based on Aggregation Induced Emission (AIE) are not only simple and rapid but also have high accuracy to visualize infection and differentiate many strains of bacteria based on biomolecular variations which has been discussed in this chapter. Keywords: Aggregation induced emission; Bacteria; Bio sensing; Cell labelling; Differentiating pathogenic and non pathogenic bacteria; Drug resistant bacteria; Imaging; Live imaging; Nanomaterials; Rapid detection. Copyright © 2021 Elsevier Inc. All rights reserved. [x] Cite Copy Format: Send To [x]

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