Adenocarcinoma mucinosum of extrophy bladder: A rare case report


Posted: 2021-10-30 19:00:00
Introduction: Bladder exstrophy is a rare congenital anomaly while, bladder adenocarcinoma mucinous type is a rare type of bladder cancer, with aggressive behavior and inadequate response to radiation and chemotherapy. In extremely rare cases, untreated bladder exstrophy could transform into bladder mucinous adenocarcinoma. Case presentation: We report a case of a 41-year-old male with untreated bladder exstrophy that transformed into mucinous adenocarcinoma. The patient also had epispadias and a right inguinal hernia. Joint procedures were conducted to perform radical cystectomy, total penectomy and W-Pouch continent urostomy, inguinal hernia repair, osteotomy, and keystone and scrotal flap by split-thickness skin graft (STSG) for wound closure. The patient progressed well after surgery, two months after initial procedure, nephrostomies were conducted due to pouches stenosis. Due to the government's limited transportation and lockdown policy, as the Covid-19 pandemic occurred, the patient could not come to the hospital for routine follow-up and died nine-month after surgery. Clinical discussion: Bladder exstrophy is one of the risk factors of bladder cancer. Transformation of bladder exstrophy into mucinous adenocarcinoma is extremely rare, as the case is the first case to be discovered in Indonesia. Surgery, followed with a strict follow-up regime, is mainstay of treatment in this type of malignancy. Conclusion: Adenocarcinoma of mucinous type is a scarce type of bladder exstrophy malignancies. A multidiscipline approach is mandatory in these cases. Strict and regular follow up are suggested for these cases. Keywords: Bladder exstrophy; Epispadias; Inguinal hernia; Mucinous adenocarcinoma.

参考サイト PubMed: covid-19



バイオクイックニュース日本語版:COVID-19特集

バイオクイックニュース日本語版
8月 05, 2020 バイオアソシエイツ

コウモリのウイルス耐性と長寿命が、新型コロナウイルスへのヒントを提供するとの展望が発表された

コウモリは、ヒトに影響を与える多くの致命的なウイルス(エボラ出血熱、狂犬病、そして最近では COVID-19 を引き起こすコロナウイルスのSARS-CoV-2など)に対し、耐性があると考えられている。 ヒトはこれらの病原体で有害な症状を経験するが、コウモリはウイルスに著しく耐えることができ、さらに、同じサイズの陸上哺乳類よりもはるかに長く生きる。コウモリの寿命とウイルス耐性の秘密は何か?…

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