ACE2 in the Gut: The Center of the 2019-nCoV Infected Pathology


Posted: 2021-10-11 19:00:00
Review Front Mol Biosci . 2021 Sep 21;8:708336. doi: 10.3389/fmolb.2021.708336. eCollection 2021. Affiliations Expand Affiliations 1 Department of Oral Medicine "5+3" Program, Basic Medical College, Capital Medical University, Beijing, China. 2 Undergraduate Student of 2018 Eight Program of Clinical Medicine, Peking University Health Science Center, Beijing, China. 3 Department of Physiology and Pathophysiology, Basic Medical College, Capital Medical University, Beijing, China. 4 Department of Bioinformatics, School of Biomedical Engineering, Capital Medical University, Beijing, China. 5 Department of Clinical Medicine "5+3" Program, Basic Medical College, Capital Medical University, Beijing, China. Item in Clipboard Review Yuexin Guo et al. Front Mol Biosci. 2021. Show details Display options Display options Format Front Mol Biosci . 2021 Sep 21;8:708336. doi: 10.3389/fmolb.2021.708336. eCollection 2021. Affiliations 1 Department of Oral Medicine "5+3" Program, Basic Medical College, Capital Medical University, Beijing, China. 2 Undergraduate Student of 2018 Eight Program of Clinical Medicine, Peking University Health Science Center, Beijing, China. 3 Department of Physiology and Pathophysiology, Basic Medical College, Capital Medical University, Beijing, China. 4 Department of Bioinformatics, School of Biomedical Engineering, Capital Medical University, Beijing, China. 5 Department of Clinical Medicine "5+3" Program, Basic Medical College, Capital Medical University, Beijing, China. Item in Clipboard CiteDisplay options Display options Format Abstract The 2019-nCoV is a rapidly contagious pneumonia caused by the recently discovered coronavirus. Although generally the most noticeable symptoms are concentrated in the lungs, the disorders in the gastrointestinal tract are of great importance in the diagnosis of 2019-nCoV. The angiotensin-converting enzyme 2 (ACE2), an important regulator of many physiological functions, including blood pressure and nutrients absorption, is recently identified as a vital entry for 2019-nCoV to enter host cells. In this review, we summarize its functions both physiologically and pathologically. We also elaborate its conflicting roles from the clews of contemporary researches, which may provide significant indications for pharmacological investigations and clinical uses. Keywords: 2019-nCoV; ACE2; biological actions; function; gut. Copyright © 2021 Guo, Wang, Gao, Gao, Hua and Xu. Conflict of interest statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publication types [x] Cite Copy Format: Send To [x]

参考サイト PubMed: covid-19


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