A Meta-Analysis of Association between Remdesivir and Mortality among Critically-Ill COVID-19 Patients


Posted: 2021-09-11 19:00:00
Background: The World Health Organization guidelines did not make a recommendation on use of remdesivir based on disease severity. Little is known regarding effectiveness of remdesivir in critically ill coronavirus disease 2019 (COVID-19) patients. This has led to a state of dilemma for doctors leaving them skeptical of whether they should continue to recommend the drug or not. Materials and methods: A systematic search adhering to preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines was conducted from inception until February 20, 2020. Electronic bibliographic databases (PubMed, Cochrane database, Scopus, Embase) were included. Using dichotomous data for select values, the unadjusted odds ratios (ORs) were calculated applying Mantel Haenszel (M-H) using random-effects model. The primary outcome of interest was all-cause mortality in ventilated and non-ventilated patients. Results: The Remdesivir arm was associated with similar rates of 28-day all-cause mortality (OR: 0.93, 95% CI: 0.80 - 1.08; P = 0.33). Remdesivir was not found to be favorable for ventilated patients. Non ventilated COVID-19 patients showed a significant lower in-hospital mortality rate as compared with patients requiring mechanical ventilatory support (OR: 6.86, 95% CI: 5.39 - 268.74; P <0.0001). Conclusion: Non-ventilated patients were associated with significant lower all-cause mortality rates. Prudent use of Remdesivir is recommended in critically ill COVID-19 patients. Keywords: Antiviral therapy; COVID-19; Critical care; Remdesivir.

参考サイト PubMed: covid-19



バイオクイックニュース日本語版:COVID-19特集

バイオクイックニュース日本語版
9月 18, 2020 バイオアソシエイツ

COVID-19の病原性は、宿主MicroRNAの枯渇によるものという仮説が発表された

なぜ COVID-19 ウイルスは致命的であるのに、他の多くのコロナウイルスは無害で風邪をひくだけなのか? ポーランドとアメリカのアラバマ大学バーミンガム校(UAB)の研究チームがその答えを提案した。COVID-19ウイルスはマイクロRNAの「スポンジ」として機能するという。ポーランドのグダニスク医科大学の Rafal Bartoszewski 博士らによるこの仮説は、American Journal of Physiology-Lung Cellular and Molecular…