http://biomarket.jp/ バイオ研究支援インターネットモール Wed, 08 Sep 2010 21:15:14 +0900 Sun, 05 Sep 2010 01:00:06 +0900 http://backend.userland.com/rss/ XOOPS rssc RSS Center noreply@biomarket.jp (bioassociates) noreply@biomarket.jp (bioassociates) Copyright (c) 2010, bioassociates ja http://biomarket.jp/modules/pubmed_sugarcomposition/article-360.html Related Articles The grand challenge to decipher the cancer proteome. Nat Rev Cancer. 2010 Sep;10(9):652-60 Authors: Hanash S, Taguchi A The quest to decipher protein alterations in cancer has spanned well over half a century. The vast dynamic range of protein abundance coupled with a plethora of isoforms and disease heterogeneity have been formidable challenges. Progress in cancer proteomics has substantially paralleled technological developments. Advances in analytical techniques and the impl ... Sun, 05 Sep 2010 01:00:06 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-360.html http://biomarket.jp/modules/pubmed_fluidigm/article-422.html Epigenetics, copy number variation, and other molecular mechanisms underlying neurodevelopmental disabilities: new insights and diagnostic approaches. J Dev Behav Pediatr. 2010 Sep;31(7):582-91 Authors: Gropman AL, Batshaw ML The diagnostic evaluation of children with intellectual disability (ID) and other neurodevelopmental disabilities (NDD) has become increasingly complex in recent years owing to a number of newly recognized genetic mechanisms and sophisticated methods to diagnose them. Prev ... Sun, 05 Sep 2010 01:00:06 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-422.html http://biomarket.jp/modules/pubmed_seldi/article-232.html Serum pattern profiling for analyzing different types of stress by protein chip technology: a preliminary study. Eur J Mass Spectrom (Chichester, Eng). 2010;16(5):619-23 Authors: Liu H, Hou D, Wu D, Yin H, Wu X ProteinChip is a widely accepted tool for exploring serum pattern profile to evaluate the risk of somatic diseases from different stressors. In this study, by using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF), the serum proteome from mice unde ... Sun, 05 Sep 2010 01:00:05 +0900 http://biomarket.jp/modules/pubmed_seldi/article-232.html http://biomarket.jp/modules/pubmed_fluidigm/article-413.html Disruption of the SCN2A and SCN3A genes in a patient with mental retardation, neurobehavioral and psychiatric abnormalities, and a history of infantile seizures. Clin Genet. 2010 Aug 2; Authors: Bartnik M, Chun-Hui Tsai A, Xia Z, Cheung SW, Stankiewicz P Bartnik M, Chun-Hui Tsai A, Xia Z, Cheung SW, Stankiewicz P. Disruption of the SCN2A and SCN3A genes in a patient with mental retardation, neurobehavioral and psychiatric abnormalities, and a history of infantile seizures. Mutations in genes en ... Sat, 04 Sep 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-413.html http://biomarket.jp/modules/pubmed_fluidigm/article-414.html Subtelomeric rearrangements and copy number variations in people with intellectual disabilities. J Intellect Disabil Res. 2010 Aug 30; Authors: Christofolini DM, de Paula Ramos MA, Kulikowski LD, da Silva Bellucco FT, Belangero SI, Brunoni D, Melaragno MI Abstract Background The most prevalent type of structural variation in the human genome is represented by copy number variations that can affect transcription levels, sequence, structure and function of genes. Method In the present study, we u ... Sat, 04 Sep 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-414.html http://biomarket.jp/modules/pubmed_fluidigm/article-421.html Integrating common and rare genetic variation in diverse human populations. Nature. 2010 Sep 2;467(7311):52-58 Authors: , , Altshuler DM, Gibbs RA, Peltonen L, , Altshuler DM, Gibbs RA, Peltonen L, Dermitzakis E, , Schaffner SF, Yu F, Peltonen L, Dermitzakis E, Bonnen PE, Altshuler DM, Gibbs RA, , de Bakker PI, Deloukas P, Gabriel SB, Gwilliam R, Hunt S, Inouye M, Jia X, Palotie A, Parkin M, Whittaker P, , Yu F, Chang K, Hawes A, Lewis LR, Ren Y, Wheeler D, Gibbs RA, Marie Muzny D, , Barnes C, ... Sat, 04 Sep 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-421.html http://biomarket.jp/modules/pubmed_fluidigm/article-415.html Phenotypic variability and genetic susceptibility to genomic disorders. Hum Mol Genet. 2010 Aug 31; Authors: Girirajan S, Eichler EE The duplication architecture of the human genome predisposes our species to recurrent copy number variation and disease. Emerging data suggest that this mechanism of mutation contributes to both common and rare diseases. Two features regarding this form of mutation have emerged. First, common structural polymorphisms create susceptible and protective chromosomal a ... Sat, 04 Sep 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-415.html http://biomarket.jp/modules/pubmed_fluidigm/article-417.html POD-FISH: A New Technique for Parental Origin Determination Based on Copy Number Variation Polymorphism. Methods Mol Biol. 2010;659:291-8 Authors: Weise A, Gross M, Hinreiner S, Witthuhn V, Mkrtchyan H, Liehr T With the progress of array technologies and the enabled screening of individual human genomes, a new kind of polymorphism has been described - the so-called copy number variation (CNV) polymorphism. Copy number variants can be found in around 12% of the human genome sequence and have a s ... Sat, 04 Sep 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-417.html http://biomarket.jp/modules/pubmed_fluidigm/article-419.html Variable Tandem Repeats Accelerate Evolution of Coding and Regulatory Sequences. Annu Rev Genet. 2010 Aug 25; Authors: Gemayel R, Vinces MD, Legendre M, Verstrepen KJ Genotype-to-phenotype mapping commonly focuses on two major classes of mutations: single nucleotide polymorphisms (SNPs) and copy number variation (CNV). Here, we discuss an underestimated third class of genotypic variation: changes in microsatellite and minisatellite repeats. Such tandem repeats (TRs) are ubiquitous, unstable gen ... Sat, 04 Sep 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-419.html http://biomarket.jp/modules/pubmed_fluidigm/article-416.html Novel association strategy with copy number variation for identifying new risk Loci of human diseases. PLoS One. 2010;5(8): Authors: Chen X, Li X, Wang P, Liu Y, Zhang Z, Zhao G, Xu H, Zhu J, Qin X, Chen S, Hu L, Kong X BACKGROUND: Copy number variations (CNV) are important causal genetic variations for human disease; however, the lack of a statistical model has impeded the systematic testing of CNVs associated with disease in large-scale cohort. METHODOLOGY/PRINCIPAL FINDINGS: Here, we develop ... Sat, 04 Sep 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-416.html http://biomarket.jp/modules/pubmed_fluidigm/article-420.html Simple Copy Number Determination with Reference Query Pyrosequencing (RQPS). Cold Spring Harb Protoc. 2010;2010:pdb.prot5491 Authors: Liu Z, Schneider DL, Kornfeld K, Kopan R INTRODUCTION The accurate measurement of the copy number (CN) for an allele is often desired. We have developed a simple pyrosequencing-based method, reference query pyrosequencing (RQPS), to determine the CN of any allele in any genome by taking advantage of the fact that pyrosequencing can accurately measure the molar ra ... Sat, 04 Sep 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-420.html http://biomarket.jp/modules/pubmed_fluidigm/article-418.html A rare novel deletion of tyrosine hydroxylase gene in Parkinson disease. Hum Mutat. 2010 Aug 31; Authors: Bademci G, Edwards TL, Torres AL, Scott WK, ZÃ?chner S, Martin ER, Vance JM, Wang L Tyrosine hydroxylase (TH) enzyme is a rate limiting enzyme in dopamine biosynthesis. Missense mutation in both alleles of the TH gene is known to cause dopamine-related phenotypes, including dystonia and infantile Parkinsonism. However, it is not clear if single allele mutation in TH modifies the susceptib ... Sat, 04 Sep 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-418.html http://biomarket.jp/modules/pubmed_seldi/article-231.html Vandetanib alters the protein pattern in malignant glioma and normal brain in the BT4C rat glioma model. Int J Oncol. 2010 Oct;37(4):879-90 Authors: Wibom C, Sandström M, Henriksson R, Antti H, Johansson M, Bergenheim AT The treatment of glioblastoma is unsatisfactory. Improved understanding of the biological effects of treatment, together with development of new tools to predict outcome of the initiated treatment are therefore of great need. Vandetanib (ZD6474) is mainly a vascular endothel ... Sat, 04 Sep 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-231.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-358.html Related Articles Applications of synthetic carbohydrates to chemical biology. Curr Opin Chem Biol. 2010 Jun;14(3):404-11 Authors: Lepenies B, Yin J, Seeberger PH Access to synthetic carbohydrates is an urgent need for the development of carbohydrate-based drugs, vaccines, adjuvants as well as novel drug delivery systems. Besides traditional synthesis in solution, synthetic carbohydrates have been generated by chemoenzymatic methods as well as automated solid-phase synthesis. Synthetic oligosacc ... Fri, 03 Sep 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-358.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-359.html Inverting character of family GH115 alpha-glucuronidases. FEBS Lett. 2010 Aug 27; Authors: Kolenová K, Ryabova O, VrÅ¡anská M, Biely P alpha-Glucuronidases of glycoside hydrolase family 115 of the xylose-fermenting yeast Pichia stipitis and wood-destroying fungus Schizophyllum commune liberate 4-O-methyl-D-glucuronic acid residues from aldouronic acids and glucuronoxylan. The specific activities of both enzymes increased with polymerization degree of the acidic xylooligosaccharides ... Fri, 03 Sep 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-359.html http://biomarket.jp/modules/pubmed_fluidigm/article-412.html Detecting copy number variation with mated short reads. Genome Res. 2010 Aug 30; Authors: Medvedev P, Fiume M, Dzamba M, Smith T, Brudno M The development of high-throughput sequencing (HTS) technologies has opened the door to novel methods for detecting copy number variants (CNVs) in the human genome. While in the past CNVs have been detected based on array CGH data, recent studies have shown that depth-of-coverage information from HTS technologies can also be used for the reliable identificat ... Fri, 03 Sep 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-412.html http://biomarket.jp/modules/pubmed_fluidigm/article-410.html Complete mtDNA of Meretrix lusoria (Bivalvia: Veneridae) reveals the presence of an atp8 gene, length variation and heteroplasmy in the control region. Comp Biochem Physiol Part D Genomics Proteomics. 2010 Aug 3; Authors: Wang H, Zhang S, Li Y, Liu B The complete nucleotide sequence of the mitochondrial genome of the clam Meretrix lusoria (Bivalvia: Veneridae) was determined. It comprises 20,268 base pairs (bp) and contains 13 protein-coding genes, including ATPase subunit 8 (atp8), two ribosom ... Sun, 29 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-410.html http://biomarket.jp/modules/pubmed_fluidigm/article-409.html A case-control study and meta-analysis of association between a common copy number variation of the glutathione S-transferase mu 1 (GSTM1) gene and schizophrenia. Schizophr Res. 2010 Aug 24; Authors: Watanabe Y, Nunokawa A, Kaneko N, Someya T PMID: 20797839 [PubMed - as supplied by publisher] Sun, 29 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-409.html http://biomarket.jp/modules/pubmed_fluidigm/article-408.html Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT. BMB Rep. 2010 Aug;43(8):547-53 Authors: Kim HY, Cho S, Yu J, Sung S, Kim H Biochemical tests such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are useful for diagnosing patients with liver disease. In this study, we tested the association between copy number variation and the hepatic biomarkers AST and ALT based on 8,842 samples from population ... Sun, 29 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-408.html http://biomarket.jp/modules/pubmed_fluidigm/article-411.html Related Articles Gender-Specific Reduction in Contraction is Associated with Increased Estrogen Receptor Expression in Single Vascular Smooth Muscle Cells of Female Rat. Cell Physiol Biochem. 2010;26(3):457-470 Authors: Ma Y, Qiao X, Falone AE, Reslan OM, Sheppard SJ, Khalil RA Gender differences in the incidence of cardiovascular disease have been related to plasma estrogen levels; however, the role of vascular estrogen receptor (ER) subtypes in these sex differences is less clear. We tested wh ... Sun, 29 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-411.html http://biomarket.jp/modules/pubmed_bmp/article-153.html Related Articles Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study. J Bone Miner Res. 2009 Oct;24(10):1719-27 Authors: Freedman BI, Bowden DW, Ziegler JT, Langefeld CD, Lehtinen AB, Rudock ME, Lenchik L, Hruska KA, Register TC, Carr JJ Inverse relationships have been observed between BMD and vascular calcification (VC), suggesting an underlying metabolic pathway linking these processe ... Sat, 28 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-153.html http://biomarket.jp/modules/pubmed_bmp/article-129.html Related Articles PI3K/Akt-dependent transcriptional regulation and activation of BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells. Prostate. 2009 Feb 1;69(2):168-80 Authors: Graham TR, Odero-Marah VA, Chung LW, Agrawal KC, Davis R, Abdel-Mageed AB BACKGROUND: Bone morphogenetic proteins (BMPs) exert osteoinductive effects in prostate cancer (PC) via uncharacterized mechanisms. In this study, we investigated whether the nuclear transcription factor NF-kappaB, implicated in P ... Sat, 28 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-129.html http://biomarket.jp/modules/pubmed_bmp/article-145.html Related Articles The positive correlation between gene expression of the two angiogenic factors: VEGF and BMP-2 in lung cancer patients. Lung Cancer. 2009 Dec;66(3):319-26 Authors: Bieniasz M, Oszajca K, Eusebio M, Kordiak J, Bartkowiak J, Szemraj J Lung cancer is a particular challenge in oncology. More than 1 million new cases occur worldwide every year and despite many clinical trials and modern diagnostic techniques, long-term survival rate has only marginally improved. The aim of the curre ... Sat, 28 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-145.html http://biomarket.jp/modules/pubmed_bmp/article-121.html Related Articles BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling. Blood. 2008 Oct 15;112(8):3154-63 Authors: Jeanpierre S, Nicolini FE, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, Maguer-Satta V Activin A, BMP2, and BMP4, 3 members of the transforming growth factor-beta family, are involved in the regulation of hematopoiesis. Here, we explored the role of these molecules in human megakaryopoiesis using an in vitro serum-free assay. Our results ... Sat, 28 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-121.html http://biomarket.jp/modules/pubmed_bmp/article-137.html Related Articles In the limb AER Bmp2 and Bmp4 are required for dorsal-ventral patterning and interdigital cell death but not limb outgrowth. Dev Biol. 2009 Mar 15;327(2):516-23 Authors: Maatouk DM, Choi KS, Bouldin CM, Harfe BD The apical ectodermal ridge (AER) in the vertebrate limb is required for limb outgrowth and patterning. To investigate the role BMP ligands expressed in the AER play in limb development we selectively inactivated both Bmp2 and Bmp4 in this tissue. The autopods of mice l ... Sat, 28 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-137.html http://biomarket.jp/modules/pubmed_bmp/article-205.html Changes in expression of bone morphogenetic proteins, their receptors and inhibin co-receptor betaglycan during bovine antral follicle development: inhibin can antagonise the suppressive effect of BMPs on thecal androgen production. Reproduction. 2010 Aug 25; Authors: Glister C, Satchell L, Knight PG We reported previously that BMPs potently suppress CYP17 expression and androgen production by bovine theca interna cells (TC) in vitro. In this study, real-time PCR was used to analyse gene express ... Sat, 28 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-205.html 200-fold (P<0.001) while co-treatment with inhibin-A reversed the suppressive action of BMP in each case (P<0.001). Results support a physiological role for granulosa-derived inhibin as an antagonist of BMP action on thecal androgen synthesis. A shift in intrafollicular balance between thecal BMP signalling (inhibitory for androgen synthesis) and betaglycan-dependent inhibin signalling (stimulatory for androgen synthesis) accords with the physiological requirement to deliver an adequate supply of aromatase substrate to GC of developing follicles. PMID: 20739376 [PubMed - as supplied by publisher]（【斜め読み用】機械翻訳：） ]]> http://biomarket.jp/modules/pubmed_fluidigm/article-407.html Identification of epistatic effects using a protein-protein interaction database. Hum Mol Genet. 2010 Aug 24; Authors: Sun YV, Kardia SL Epistasis (i.e. gene-gene interactions) has long been recognized as an important mechanism underlying the complexity of the genetic architecture of human traits. Definitions of epistasis range from the purely molecular to the traditional statistical measures of interaction. The statistical detection of epistasis usually does not map onto or easily relate to th ... Fri, 27 Aug 2010 01:00:11 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-407.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-357.html Related Articles Concanavalin A-immobilized magnetic nanoparticles for selective enrichment of glycoproteins and application to glycoproteomics in hepatocelluar carcinoma cell line. Proteomics. 2010 May;10(10):2000-14 Authors: Tang J, Liu Y, Yin P, Yao G, Yan G, Deng C, Zhang X Protein glycosylation is one of the most important PTMs in biological organism. Lectins such as concanavalin A (Con A) have been widely applied to N-glycosylated protein investigation. In this study, we developed Con A-i ... Thu, 26 Aug 2010 01:00:12 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-357.html http://biomarket.jp/modules/pubmed_fluidigm/article-404.html {alpha}-Synuclein gene duplication impairs reward learning. Proc Natl Acad Sci U S A. 2010 Aug 23; Authors: Kéri S, Moustafa AA, Myers CE, Benedek G, Gluck MA alpha-Synuclein (SNCA) plays an important role in the regulation of dopaminergic neurotransmission and neurodegeneration in Parkinson disease. We investigated reward and punishment learning in asymptomatic carriers of a rare SNCA gene duplication who were healthy siblings of patients with Parkinson disease. Results revealed that heal ... Thu, 26 Aug 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-404.html http://biomarket.jp/modules/pubmed_fluidigm/article-405.html Somatic mosaicism for chromosome X and Y aneuploidies in monozygotic twins heterozygous for sickle cell disease mutation. Am J Med Genet A. 2010 Aug 23; Authors: Razzaghian HR, Shahi MH, Forsberg LA, de StÃ?hl TD, Absher D, Dahl N, Westerman MP, Dumanski JP Somatic genetic variation in health and disease is poorly explored. Monozygotic (MZ) twins are a suitable model for studies of somatic mosaicism since genetic differences in twins derived from the same zygote represent an irrefutable examp ... Thu, 26 Aug 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-405.html http://biomarket.jp/modules/pubmed_fluidigm/article-406.html Related Articles TLR2 expression and signaling-dependent inflammation impair wound healing in diabetic mice. Lab Invest. 2010 Aug 23; Authors: Dasu MR, Thangappan RK, Bourgette A, Dipietro LA, Isseroff R, Jialal I Toll-like receptor-2 (TLR2) is a pivotal pathogen recognition receptor that has a key role in inflammation, diabetes, and injury. Hyperglycemia, inflammation, and oxidative stress induce TLR2-myeloid differentiation factor-88 (MyD88) expression and signaling, and are major pathophysiol ... Thu, 26 Aug 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-406.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-356.html The RINGS Resource for Glycome Informatics Analysis and Data Mining on the Web. OMICS. 2010 Aug;14(4):475-86 Authors: Akune Y, Hosoda M, Kaiya S, Shinmachi D, Aoki-Kinoshita KF Abstract In the bioinformatics field, many computer algorithmic and data mining technologies have been developed for gene prediction, protein-protein interaction analysis, sequence analysis, and protein folding predictions, to name a few. This kind of research has branched off from the genomics field, creating the transcr ... Wed, 25 Aug 2010 01:00:11 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-356.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-354.html Glycomics: technologies taming a frontier omics field. OMICS. 2010 Aug;14(4):385-7 Authors: Turnbull JE, Sasisekharan R PMID: 20726798 [PubMed - in process]（【斜め読み用】機械翻訳： Glycomics: フロンティアのomicsを飼いならす技術は守備につく。 OMICS. 8月2010日; 14 (4): 385-7書く: Turnbull JE、Sasisekharan R PMID: 20726798 [PubMed -プロセスの…） Wed, 25 Aug 2010 01:00:10 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-354.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-355.html Lectin microarrays for glycomic analysis. OMICS. 2010 Aug;14(4):419-36 Authors: Gupta G, Surolia A, Sampathkumar SG Abstract Glycomics is the study of comprehensive structural elucidation and characterization of all glycoforms found in nature and their dynamic spatiotemporal changes that are associated with biological processes. Glycocalyx of mammalian cells actively participate in cell-cell, cell-matrix, and cell-pathogen interactions, which impact embryogenesis, growth and development, homeost ... Wed, 25 Aug 2010 01:00:10 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-355.html http://biomarket.jp/modules/pubmed_bmp/article-152.html Related Articles Functional mode of FoxD1/CBF2 for the establishment of temporal retinal specificity in the developing chick retina. Dev Biol. 2009 Jul 15;331(2):300-10 Authors: Takahashi H, Sakuta H, Shintani T, Noda M Two winged-helix transcription factors, FoxG1 (previously called chick brain factor1, CBF1) and FoxD1 (chick brain factor2, CBF2), are expressed specifically in the nasal and temporal regions of the developing chick retina, respectively. We previously demonstrated that FoxG1 con ... Wed, 25 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-152.html http://biomarket.jp/modules/pubmed_bmp/article-128.html Related Articles Evidence for an inhibitory role of bone morphogenetic protein(s) in the follicular-luteal transition in cattle. Reproduction. 2009 Jan;137(1):67-78 Authors: Kayani AR, Glister C, Knight PG Bone morphogenetic proteins (BMPs) and their receptors are expressed in ovarian theca cells (TC) and granulosa cells (GC) and BMPs have been implicated in the regulation of several aspects of follicle development including thecal androgen production and granulosal oestrogen production. Their ... Wed, 25 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-128.html http://biomarket.jp/modules/pubmed_bmp/article-144.html Related Articles Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development. 2009 Apr;136(8):1387-96 Authors: Lan Y, Jiang R The mammalian secondary palate arises by outgrowth from the oral side of the paired maxillary processes flanking the primitive oral cavity. Palatal growth depends on reciprocal interactions between the oral ectoderm and the underlying neural-crest-derived mesenchyme. Previous studies have implicated sonic h ... Wed, 25 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-144.html http://biomarket.jp/modules/pubmed_bmp/article-136.html Related Articles A late role for bmp2b in the morphogenesis of semicircular canal ducts in the zebrafish inner ear. PLoS One. 2009;4(2):e4368 Authors: Hammond KL, Loynes HE, Mowbray C, Runke G, Hammerschmidt M, Mullins MC, Hildreth V, Chaudhry B, Whitfield TT BACKGROUND: The Bone Morphogenetic Protein (BMP) genes bmp2 and bmp4 are expressed in highly conserved patterns in the developing vertebrate inner ear. It has, however, proved difficult to elucidate the function of BMPs during ear developm ... Wed, 25 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-136.html http://biomarket.jp/modules/pubmed_bmp/article-120.html Related Articles Molecular determinants of Xolloid action in vivo. J Biol Chem. 2008 Oct 3;283(40):27057-63 Authors: Geach TJ, Dale L Xld (Xolloid) is a member of the Tolloid family of metalloproteases found in embryos of the frog Xenopus laevis. It cleaves Chordin, an inhibitory binding protein for BMP2/4, releasing fragments with reduced affinity for these important ventralizing signals. As a consequence, increasing Xld activity ventralizes Xenopus embryos. We have used this phenotype as an a ... Wed, 25 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-120.html http://biomarket.jp/modules/pubmed_bmp/article-204.html Related Articles Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. Dev Biol. 2010 Aug 18; Authors: He F, Xiong W, Wang Y, Matsui M, Yu X, Chai Y, Klingensmith J, Chen Y BMP signaling plays many important roles during organ development, including palatogenesis. Loss of BMP signaling leads to cleft palate formation. During development, BMP activities are finely tuned by a number of modulators at the extracellular and intrace ... Wed, 25 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-204.html http://biomarket.jp/modules/pubmed_fluidigm/article-403.html Variable Numbers of Tandem Repeats in Plasmodium falciparum Genes. J Mol Evol. 2010 Aug 22; Authors: Tan JC, Tan A, Checkley L, Honsa CM, Ferdig MT Genome variation studies in Plasmodium falciparum have focused on SNPs and, more recently, large-scale copy number polymorphisms and ectopic rearrangements. Here, we examine another source of variation: variable number tandem repeats (VNTRs). Interspersed low complexity features, including the well-studied P. falciparum microsatellite sequences, are ... Wed, 25 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-403.html http://biomarket.jp/modules/pubmed_seldi/article-230.html Related Articles Targeting phosphoprotein profiling by combination of hydroxyapatite-based phosphoprotein enrichment and SELDI-TOF MS. Arch Physiol Biochem. 2010 Aug 23; Authors: Vormbrock I, Kaber G, Hartwig S, Eckel J, Schrör K, Lehr S Over the last decade surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) has evolved as a versatile tool in the field of proteomic research. Although the chromatographic matrices on the currently provided SELDI affini ... Wed, 25 Aug 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-230.html http://biomarket.jp/modules/pubmed_fluidigm/article-402.html Related Articles Amplification of CyclinL1 in uterine cervical carcinoma has prognostic implications. Mol Carcinog. 2010 Aug 18; Authors: Mitra S, Mazumder ' Indra ' D, Basu PS, Mondal RK, Roy A, Roychoudhury S, Panda CK The chromosomal 3q25.31 region was consistently amplified in primary cancer of cervix (CACX). CyclinL1 is a candidate gene of this region and already have been implicated as an oncogene in head and neck cancers. In this study, we aimed to investigate the involvement of CyclinL1 ... Sun, 22 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-402.html /=5) CACX patients with amplified CyclinL1 locus along with advanced tumor stage (III/IV) had worst prognosis. Our data suggest importance of CyclinL1 in cervical carcinogenesis with its associated pathways viz: pre-mRNA splicing, cell-cycle regulation (G(0)/G(1) and G(2)/M) being potential targets of therapeutic interventions in CACX. (c) 2010 Wiley-Liss, Inc. PMID: 20721974 [PubMed - as supplied by publisher] ]]> http://biomarket.jp/modules/pubmed_fluidigm/article-401.html Related Articles Genomics and Pharmacogenomics of Schizophrenia. CNS Neurosci Ther. 2010 Aug 16; Authors: Cacabelos R, MartÃ?nez-Bouza R SUMMARY Schizophrenia (SCZ) is among the most disabling of mental disorders. Several neurobiological hypotheses have been postulated as responsible for SCZ pathogenesis: polygenic/multifactorial genomic defects, intrauterine and perinatal environment-genome interactions, neurodevelopmental defects, dopaminergic, cholinergic, serotonergic, gamma-aminobutiric a ... Sun, 22 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-401.html http://biomarket.jp/modules/pubmed_fluidigm/article-400.html Amelioration of excess collagen IalphaI, fibrosis, and smooth muscle growth in TNBS-induced colitis in IGF-I(+/-) mice. Inflamm Bowel Dis. 2010 Aug 18; Authors: Mahavadi S, Flynn RS, Grider JR, Qiao LY, Murthy KS, Hazelgrove KB, Kuemmerle JF BACKGROUND:: Strictures occur in approximately 30% of patients with Crohn's disease (CD) and are characterized by intestinal smooth muscle hyperplasia, hypertrophy, and fibrosis due to excess extracellular matrix production including collagen. Insulin-like g ... Sat, 21 Aug 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-400.html http://biomarket.jp/modules/pubmed_fluidigm/article-399.html Related Articles The influence of different land uses on the structure of archaeal communities in Amazonian anthrosols based on 16S rRNA and amoA genes. Microb Ecol. 2010 May;59(4):734-43 Authors: Taketani RG, Tsai SM Soil from the Amazonian region is usually regarded as unsuitable for agriculture because of its low organic matter content and low pH; however, this region also contains extremely rich soil, the Terra Preta Anthrosol. A diverse archaeal community usually inhabits acidic soils, suc ... Fri, 20 Aug 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-399.html http://biomarket.jp/modules/pubmed_bmp/article-151.html Related Articles The Drosophila DPP signal is produced by cleavage of its proprotein at evolutionary diversified furin-recognition sites. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8501-6 Authors: KÃ?nnapuu J, Björkgren I, Shimmi O Maturation of bone morphogenetic proteins (BMPs) requires cleavage of their precursor proteins by furin-type proprotein convertases. Here, we find that cleavage sites of the BMP2/4/decapentaplegic (DPP) subfamily have been evolutionary diversified and can be ... Thu, 19 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-151.html http://biomarket.jp/modules/pubmed_bmp/article-127.html Related Articles Msx and dlx homeogene expression in epithelial odontogenic tumors. J Histochem Cytochem. 2009 Jan;57(1):69-78 Authors: Ruhin-Poncet B, Ghoul-Mazgar S, Hotton D, Capron F, Jaafoura MH, Goubin G, Berdal A Epithelial odontogenic tumors are rare jaw pathologies that raise clinical diagnosis and prognosis dilemmas notably between ameloblastomas and clear cell odontogenic carcinomas (CCOCs). In line with previous studies, the molecular determinants of tooth development-amelogenin, Ms ... Thu, 19 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-127.html http://biomarket.jp/modules/pubmed_bmp/article-143.html Related Articles NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development. J Cell Sci. 2009 Apr 15;122(Pt 8):1145-54 Authors: Hu Z, Wang C, Xiao Y, Sheng N, Chen Y, Xu Y, Zhang L, Mo W, Jing N, Hu G Heparan sulfate proteoglycans (HSPGs) are required for various signaling pathways, one of which is the bone morphogenetic protein (BMP) signaling pathway. N-deacetylase/N-sulfotransferase-1 (NDST1) participates in synthesizing heparan sulfate (HS) chains of HSP ... Thu, 19 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-143.html http://biomarket.jp/modules/pubmed_bmp/article-119.html Related Articles Bmp signaling is necessary and sufficient for ventrolateral endoderm specification in Xenopus. Dev Dyn. 2008 Aug;237(8):2177-86 Authors: Wills A, Dickinson K, Khokha M, Baker JC Here we show that Bmp signaling is necessary and sufficient for the specification of ventral endoderm in Xenopus embryos. Overexpression of Bmp4 in ectoderm induces markers of endoderm, including Sox17beta, Mixer, and VegT, but cannot induce the expression of the dorsoanterior markers, Xhex and Cerberus ... Thu, 19 Aug 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_bmp/article-119.html http://biomarket.jp/modules/pubmed_bmp/article-135.html Related Articles Temporomandibular joint ankylosis caused by chondroid hyperplasia from the callus of condylar neck fracture. J Craniofac Surg. 2009 Jan;20(1):240-2 Authors: Kim SM, Park JM, Kim JH, Kwon KJ, Park YW, Lee JH, Lee SS, Lee SK A patient who complained of difficulty in opening his mouth after condylar neck fracture 1 year ago presented typical features of temporomandibular joint ankylosis in clinical and radiologic examinations. To demonstrate a possible pathogenesis of temporomandi ... Thu, 19 Aug 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_bmp/article-135.html http://biomarket.jp/modules/pubmed_bmp/article-203.html Involvement of cytoskeleton-associated proteins in the commitment of C3H10T1/2 pluripotent stem cells to adipocyte lineage induced by BMP2/4. Mol Cell Proteomics. 2010 Aug 16; Authors: Huang HY, Hu LL, Song TJ, Li X, He Q, Sun X, Li YM, Lu HJ, Yang PY, Tang QQ The developmental pathway that gives rise to mature adipocytes involves two distinct stages: commitment and terminal differentiation. Although the important proteins/factors contributing to terminal adipocyte differentiation have been well ... Thu, 19 Aug 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_bmp/article-203.html http://biomarket.jp/modules/pubmed_seldi/article-229.html Related Articles A proteomic analysis reveals differential regulation of the {sigma}S-dependent yciGFE(katN) locus by YncC and H-NS in Salmonella and Escherichia coli K-12. Mol Cell Proteomics. 2010 Aug 16; Authors: Beraud M, Kolb A, Monteil V, D'Alayer J, Norel F The stationary phase sigma factor sigmaS (RpoS) controls a regulon required for general stress resistance of the closely related enterobacteria Salmonella and Escherichia coli. The sigmaS-dependent yncC gene encodes a putative DNA bind ... Thu, 19 Aug 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-229.html http://biomarket.jp/modules/pubmed_seldi/article-227.html Effects of Post-Mortem Intervals on Regional Brain Protein Profiles in Rats using SELDI-TOF MS Analysis. Neurochem Int. 2010 Aug 10; Authors: Machaalani R, Gozal E, Berger F, Waters KA, Dematteis M Identification of disease-associated proteins is critical for elucidating CNS disease mechanisms and elaborating novel treatment strategies. It requires post-mortem tissue analysis which can be significantly affected by the collection process, post-mortem intervals (PMI), and storage conditions. To as ... Wed, 18 Aug 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-227.html http://biomarket.jp/modules/pubmed_seldi/article-228.html Is SELDI-TOF a valid tool for diagnostic biomarkers? Trends Parasitol. 2010 Aug 12; Authors: Ndao M, Rainczuk A, Rioux MC, Spithill TW, Ward J The genome revolution is providing fresh insights into host and parasite genomes, and new tools are becoming available for examining host-parasite interactions at the proteome level. Technologies such as surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry (MS) can be applied to discover biomarkers (alterations in both ... Wed, 18 Aug 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-228.html http://biomarket.jp/modules/bulletin/index.php?page=article&storyid=32 バイオ創薬研究・特集コラム「機能性食品開発：自然免疫賦活素材の評価と免疫食品の開発」に新規コンテンツ「自然免疫研究の再出発：TLR (toll like receptor: トル様受容体)の発見」が追加されました。 Tue, 17 Aug 2010 11:30:56 +0900 http://biomarket.jp/modules/bulletin/index.php?page=article&storyid=32 General http://biomarket.jp/modules/pubmed_sugarcomposition/article-353.html Related Articles Serum N-glycome biomarker for monitoring development of DENA-induced hepatocellular carcinoma in rat. Mol Cancer. 2010 Aug 12;9(1):215 Authors: Fang M, Dewaele S, Zhao YP, Starkel P, Vanhooren V, Chen YM, Ji X, Luo M, Sun BM, Horsmans Y, Dell A, Haslam SM, Grassi P, Libert C, Gao CF, Chen CC ABSTRACT: BACKGROUND: There is a demand for serum markers for the routine assessment of the progression of liver cancer. We previously found that serum N-linked sugar chains are altered in h ... Sun, 15 Aug 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-353.html http://biomarket.jp/modules/pubmed_fluidigm/article-398.html Related Articles Selected summaries from the XVII World Congress of Psychiatric Genetics, San Diego, California, USA, 4-8 November 2009. Psychiatr Genet. 2010 Aug 11; Authors: Amstadter AB, Balachandar V, Bergen SE, Ceulemans S, Christensen JH, Cole J, De Luca V, Ducci F, Tee SF, Hartz S, Keers R, Medland S, Melas PA, MÃ?hleisen TW, Ozomaro U, Pidsley R, Scott AP, Sha L, Talati A, Teltsh O, VidetiÄ? A, Wang K, Wong CC, Delisi LE The XVII World Congress of Psychiatric Genetics, sponsored by T ... Sun, 15 Aug 2010 01:00:06 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-398.html http://biomarket.jp/modules/pubmed_seldi/article-226.html Proteomic Analysis of Pichindé virus Infection Identifies Differential Expression of Prothymosin-alpha. J Biomed Biotechnol. 2010;2010: Authors: Bowick GC, Soman KV, Wang H, Aronson JF, Luxon BA, Lomas LO, Gorenstein DG, Herzog NK The arenaviruses include a number of important pathogens including Lassa virus and Junin virus. Presently, the only treatment is supportive care and the antiviral Ribavirin. In the event of an epidemic, patient triage may be required to more effectively manage res ... Sun, 15 Aug 2010 01:00:06 +0900 http://biomarket.jp/modules/pubmed_seldi/article-226.html http://biomarket.jp/modules/pubmed_fluidigm/article-397.html Related Articles Genome-wide association analysis of copy number variations in subarachnoid aneurysmal hemorrhage. J Hum Genet. 2010 Aug 12; Authors: Bae JS, Cheong HS, Park BL, Kim LH, Park TJ, Kim JY, Pasaje CF, Lee JS, Cui T, Inoue I, Shin HD Subarachnoid aneurysmal hemorrhage (SAH) due to cerebral aneurysm rupture is a very serious disease resulting in high mortality rate. It has been known that genetic factors are involved in the risk of SAH. A recent breakthrough in genomic variation calle ... Sat, 14 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-397.html 1%). From a total of 4574 individual CNVs identified in this study (9.7 CNVs per individual), we were able to discover 1644 unique CNV regions containing 1232 genes. The identified variations were validated using visual examination of the genoplot image, overlapping analysis with the Database of Genomic Variants (73.2%), CNVpartition (72.4%) and quantitative PCR. Interestingly, two CNV regions, chr4:153210505-153212191 (deletion, 4q31.3, P=0.0005, P(corr) (corrected P-value)=0.04) and chr10:6265006-6267388 (duplication, 10p15.1, P=0.0006, P(corr)=0.05), were significantly associated with the risk of SAH after multiple testing corrections. Our results suggest that the newly identified CNV regions may contribute to SAH disease susceptibility.Journal of Human Genetics advance online publication, 12 August 2010; doi:10.1038/jhg.2010.97. PMID: 20703242 [PubMed - as supplied by publisher] ]]> http://biomarket.jp/modules/pubmed_fluidigm/article-395.html Related Articles Difference in larval type explains patterns of nonsynonymous substitutions in two ancient paralogs of the histone H3 gene in sea stars. Evol Dev. 2010 Mar;12(2):222-30 Authors: Foltz DW, Mah CL Paralogous genes frequently show differences in patterns and rates of substitution that are typically attributed to different selection regimes, mutation rates, or local recombination rates. Here, two anciently diverged paralogous copies of the histone H3 gene in sea stars, the tandem-re ... Sat, 14 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-395.html http://biomarket.jp/modules/pubmed_fluidigm/article-396.html Related Articles Reconstructing CNV genotypes using segregation analysis: combining pedigree information with CNV assay. Genet Sel Evol. 2010 Aug 12;42(1):34 Authors: Henshall JM, Whan VA, Norris BJ ABSTRACT: BACKGROUND: Repeated blocks of genome sequence have been shown to be associated with genetic diversity and disease risk in humans, and with phenotypic diversity in model organisms and domestic animals. Reliable tests are desirable to determine whether individuals are carriers of copy number ... Sat, 14 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-396.html http://biomarket.jp/modules/pubmed_seldi/article-225.html Graphene-Based SELDI Probe with Ultrahigh Extraction and Sensitivity for DNA Oligomer. J Am Chem Soc. 2010 Aug 18;132(32):10976-7 Authors: Tang LA, Wang J, Loh KP We demonstrate that graphene can be used as an ultrahigh efficiency preconcentration and detection platform for ssDNA. DNA-adsorbed graphene can be used directly for Surface Enhanced Laser Desorption Ionization-Time of Flight-Mass Spectrometry (SELDI-TOF-MS). The rapid enrichment of biomolecules and direct, label-free detection are pot ... Fri, 13 Aug 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-225.html http://biomarket.jp/modules/pubmed_fluidigm/article-393.html Related Articles Long-term conservation vs high sequence divergence: the case of an extraordinarily old satellite DNA in bivalve mollusks. Heredity. 2010 Jun;104(6):543-51 Authors: Plohl M, PetroviÄ? V, Luchetti A, Ricci A, SatoviÄ? E, Passamonti M, Mantovani B The ubiquity of satellite DNA (satDNA) sequences has raised much controversy over the abundance of divergent monomer variants and the long-time nucleotide sequence stability observed for many satDNA families. In this work, we describ ... Thu, 12 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-393.html http://biomarket.jp/modules/pubmed_fluidigm/article-394.html Related Articles Atorvastatin as a potential anti-malarial drug: in vitro synergy in combinational therapy with quinine against Plasmodium falciparum. Malar J. 2010;9:139 Authors: Parquet V, Henry M, Wurtz N, Dormoi J, Briolant S, Gil M, Baret E, Amalvict R, Rogier C, Pradines B BACKGROUND: Quinine (QN) remains the first line anti-malarial drug for the treatment of complicated malaria in Europe and Africa. The emergence of QN resistance has been documented. QN resistance is not yet a significan ... Thu, 12 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-394.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-352.html The N-Glycome of Human Plasma. J Proteome Res. 2010 Aug 6; Authors: Stumpo KA, Reinhold VN N-linked glycans isolated from human plasma proteins have been profiled and sequenced by mass spectrometry using an ion trap instrument (ITMS(n)). The released glycans were prepared as reduced, methylated analogues and directly infused into a chip-based nanoelectrospray ionization system and analyzed by ITMS(n). The resulting mass profiles (MS(1)) of IgG-depleted and nondepleted plasma samples were contras ... Wed, 11 Aug 2010 01:00:11 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-352.html http://biomarket.jp/modules/pubmed_bmp/article-150.html Related Articles Hesperetin stimulates differentiation of primary rat osteoblasts involving the BMP signalling pathway. J Nutr Biochem. 2010 May;21(5):424-31 Authors: Trzeciakiewicz A, Habauzit V, Mercier S, Lebecque P, Davicco MJ, Coxam V, Demigne C, Horcajada MN Hesperidin found in citrus fruits has been reported to be a promising bioactive compound for maintaining an optimal bone status in ovariectomized rodent models. In this study, we examined the capacity of hesperetin (Hp) to affect the ... Wed, 11 Aug 2010 01:00:10 +0900 http://biomarket.jp/modules/pubmed_bmp/article-150.html http://biomarket.jp/modules/pubmed_bmp/article-126.html Related Articles Bone morphogenetic proteins 2 and 4 are selectively expressed by late outgrowth endothelial progenitor cells and promote neoangiogenesis. Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2137-43 Authors: Smadja DM, Bièche I, Silvestre JS, Germain S, Cornet A, Laurendeau I, Duong-Van-Huyen JP, Emmerich J, Vidaud M, Aiach M, Gaussem P OBJECTIVE: Endothelial progenitor cells are currently identified either by their surface antigen expression or by their generation of early colon ... Wed, 11 Aug 2010 01:00:10 +0900 http://biomarket.jp/modules/pubmed_bmp/article-126.html http://biomarket.jp/modules/pubmed_bmp/article-142.html Related Articles A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol. 2009;10:20 Authors: Herrera B, Inman GJ BACKGROUND: Bone morphogenetic proteins (BMPs) are pleiotropic members of the TGF-beta superfamily which regulate many biological processes during development and adult tissue homeostasis and are implicated in the pathogenesis of a number ... Wed, 11 Aug 2010 01:00:10 +0900 http://biomarket.jp/modules/pubmed_bmp/article-142.html http://biomarket.jp/modules/pubmed_bmp/article-118.html Related Articles Unique and shared gene expression patterns in Atlantic salmon (Salmo salar) tooth development. Dev Genes Evol. 2008 Aug;218(8):427-37 Authors: Huysseune A, Takle H, Soenens M, Taerwe K, Witten PE To validate the use of Atlantic salmon (Salmo salar L.) as a model species in research on the mechanism of continuous tooth replacement, we have started to collect data on the molecular control underlying tooth formation in this species. This study reports expression patterns in the lo ... Wed, 11 Aug 2010 01:00:10 +0900 http://biomarket.jp/modules/pubmed_bmp/article-118.html http://biomarket.jp/modules/pubmed_bmp/article-134.html Related Articles Histone deacetylase inhibitor, trichostatin A, affects gene expression patterns during morphogenesis of chicken limb buds in vivo. Cells Tissues Organs. 2009;190(3):121-34 Authors: Zhao W, Dai F, Bonafede A, Schafer S, Jung M, Yusuf F, Gamel AJ, Wang J, Brand-Saberi B Acetylation is one of the key chromatin modifications that control gene transcription during embryonic development and tumorigenesis. The types of genes sensitive to such modifications in vivo are not known to dat ... Wed, 11 Aug 2010 01:00:10 +0900 http://biomarket.jp/modules/pubmed_bmp/article-134.html http://biomarket.jp/modules/pubmed_bmp/article-202.html Highly efficient osteogenic differentiation of human mesenchymal stem cells by eradication of STAT3 signaling. Int J Biochem Cell Biol. 2010 Aug 3; Authors: Levy O, Ruvinov E, Reem T, Granot Y, Cohen S Human bone marrow-derived mesenchymal stem cells (hMSCs) are promising candidates for cellular therapy owing to their multipotency to differentiate into several cell lineages. Elucidating the signaling events involved in the response of hMSCs to diverse stimulants affecting their differentiation m ... Wed, 11 Aug 2010 01:00:10 +0900 http://biomarket.jp/modules/pubmed_bmp/article-202.html http://biomarket.jp/modules/pubmed_fluidigm/article-391.html RankProdIt : A web-interactive Rank Products analysis tool. BMC Res Notes. 2010 Aug 6;3(1):221 Authors: Laing E, Smith CP ABSTRACT: BACKGROUND: The first objective of a DNA microarray experiment is typically to generate a list of genes or probes that are found to be differentially expressed or represented (in the case of comparative genomic hybridizations and/or copy number variation) between two conditions or strains. Rank Products analysis comprises a robust algorithm for deriving such lists ... Wed, 11 Aug 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-391.html http://biomarket.jp/modules/pubmed_fluidigm/article-392.html Microdeletions of 3q29 Confer High Risk for Schizophrenia. Am J Hum Genet. 2010 Aug 4; Authors: Mulle JG, Dodd AF, McGrath JA, Wolyniec PS, Mitchell AA, Shetty AC, Sobreira NL, Valle D, Rudd MK, Satten G, Cutler DJ, Pulver AE, Warren ST Schizophrenia (SZ) is a severe psychiatric illness that affects approximately 1% of the population and has a strong genetic underpinning. Recently, genome-wide analysis of copy-number variation (CNV) has implicated rare and de novo events as important in SZ. Her ... Wed, 11 Aug 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-392.html http://biomarket.jp/modules/pubmed_fluidigm/article-390.html Related Articles Prenatal diagnosis of fetal aneuploidies: post-genomic developments. Genome Med. 2010 Aug 5;2(8):50 Authors: Hahn S, Jackson LG, Zimmermann BG ABSTRACT: Prenatal diagnosis of fetal aneuploidies and chromosomal anomalies is likely to undergo a profound change in the near future. On the one hand this is mediated by new technical developments, such as chromosomal microarrays, which allow a much more precise delineation of minute sub-microscopic chromosomal aberrancies than the clas ... Mon, 09 Aug 2010 01:00:06 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-390.html http://biomarket.jp/modules/pubmed_fluidigm/article-388.html Related Articles Single integration and spread of a Copia-like sequence nested in rDNA intergenic spacers of Allium cernuum (Alliaceae). Cytogenet Genome Res. 2010 Jul;129(1-3):35-46 Authors: Chester M, Sykorova E, Fajkus J, Leitch AR The 35S ribosomal DNA (rDNA) intergenic spacer (IGS) of Allium cernuum is examined. Initial sequencing of IGS clones revealed that some rDNA units contain a truncated retrotransposon sequence most similar to members of the Copia superfamily. Fluorescence in situ h ... Sun, 08 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-388.html http://biomarket.jp/modules/pubmed_fluidigm/article-389.html Related Articles Diversity of chromosomal karyotypes in maize and its relatives. Cytogenet Genome Res. 2010 Jul;129(1-3):6-16 Authors: Albert PS, Gao Z, Danilova TV, Birchler JA Maize is a highly diverse species on the gene sequence level. With the recent development of methods to distinguish each of the 10 pairs of homologues in somatic root tip spreads, a wide collection of maize lines was subjected to karyotype analysis to serve as a reference for the community and to examine the spectrum of ... Sun, 08 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-389.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-351.html High-Throughput Profiling of the Serum N-Glycome on Capillary Electrophoresis Microfluidics Systems: Toward Clinical Implementation of GlycoHepatoTest. Anal Chem. 2010 Aug 4; Authors: Vanderschaeghe D, SzekreÌ?nyes A, Wenz C, Gassmann M, Naik N, Bynum M, Yin H, Delanghe J, Guttman A, Callewaert N We developed a 3 h procedure for preparing serum N-glycans and labeling them with 8-aminopyrene-1,3,6-trisulfonic acid (APTS) by sequential addition of reagents to the serum and incubation in a polyme ... Sat, 07 Aug 2010 01:00:11 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-351.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-350.html Related Articles [N-glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus] Zhonghua Gan Zang Bing Za Zhi. 2008 Jan;16(1):74-5 Authors: Liu XE, Desmyter L, Gao CF, Laroy W, Dewaele S, Vanhooren V, Wang L, Zhuang H, Callewaert N, Libert C, Contreras R, Chen CY PMID: 18226355 [PubMed - indexed for MEDLINE]（【斜め読み用】機械翻訳：記事の[N-glycomicは肝炎のウイルスが引き起こす肝硬変のhepatocellular癌腫の患者で変わる] Zhonghua関連のGan ZangビングZa Zh ... Sat, 07 Aug 2010 01:00:11 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-350.html http://biomarket.jp/modules/pubmed_seldi/article-224.html Comparison of three methods for fractionation and enrichment of low molecular weight proteins for SELDI-TOF-MS differential analysis. Talanta. 2010 Jun 30;82(1):245-254 Authors: De Bock M, de Seny D, Meuwis MA, Servais AC, Minh TQ, Closset J, Chapelle JP, Louis E, Malaise M, Merville MP, Fillet M In most diseases, the clinical need for serum/plasma markers has never been so crucial, not only for diagnosis, but also for the selection of the most efficient therapies, as well as exclusion of ineffe ... Sat, 07 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-224.html http://biomarket.jp/modules/pubmed_fluidigm/article-385.html A sequence-based approach to identify reference genes for gene expression analysis. BMC Med Genomics. 2010 Aug 3;3(1):32 Authors: Chari R, Lonergan KM, Pikor LA, Coe BP, Zhu CQ, Chan TH, Macaulay CE, Tsao MS, Lam S, Ng RT, Lam WL ABSTRACT: BACKGROUND: An important consideration when analyzing both microarray and quantitative PCR expression data is the selection of appropriate genes as endogenous controls or reference genes. This step is especially critical when identifying genes differentially e ... Fri, 06 Aug 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-385.html http://biomarket.jp/modules/pubmed_fluidigm/article-387.html Copy number variation analysis in single-suture craniosynostosis: Multiple rare variants including RUNX2 duplication in two cousins with metopic craniosynostosis. Am J Med Genet A. 2010 Aug 3; Authors: Mefford HC, Shafer N, Antonacci F, Tsai JM, Park SS, Hing AV, Rieder MJ, Smyth MD, Speltz ML, Eichler EE, Cunningham ML Little is known about genes that underlie isolated single-suture craniosynostosis. In this study, we hypothesize that rare copy number variants (CNV) in patients with isolated s ... Fri, 06 Aug 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-387.html http://biomarket.jp/modules/pubmed_fluidigm/article-386.html Genetic variability at the PARK16 locus. Eur J Hum Genet. 2010 Aug 4; Authors: Tucci A, Nalls MA, Houlden H, Revesz T, Singleton AB, Wood NW, Hardy J, Paisán-Ruiz C Parkinson's disease (PD) is a complex neurodegenerative disease which is clinically heterogeneous and pathologically consists of loss of dopaminergic neurons in the substantia nigra and intracytoplasmic neuronal inclusions containing alpha-synuclein aggregations known as Lewy bodies. Although the majority of PD is idiopathic, p ... Fri, 06 Aug 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-386.html http://biomarket.jp/modules/pubmed_bmp/article-149.html Related Articles Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood. 2009 Jul 2;114(1):181-6 Authors: Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, Bhupatiraju A, Lee YT, Goodnough JB, Harandi O, Ganz T, Paulson RF, Miller JL In thalassemia and other iron loading anemias, ineffective erythropoiesis and erythroid signaling molecules are thought to cause inappropriate suppression of a small peptide produced by hepatocytes n ... Thu, 05 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-149.html http://biomarket.jp/modules/pubmed_bmp/article-125.html Related Articles Bone morphogenetic protein 6 (BMP6) and BMP7 inhibit estrogen-induced proliferation of breast cancer cells by suppressing p38 mitogen-activated protein kinase activation. J Endocrinol. 2008 Dec;199(3):445-55 Authors: Takahashi M, Otsuka F, Miyoshi T, Otani H, Goto J, Yamashita M, Ogura T, Makino H, Doihara H Estrogen is involved in the development and progression of breast cancer. Here, we investigated the effects of bone morphogenetic proteins (BMPs) on breast cancer cell prol ... Thu, 05 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-125.html http://biomarket.jp/modules/pubmed_bmp/article-141.html Related Articles The expression and crucial roles of BMP signaling in development of smooth muscle progenitor cells in the mouse embryonic gut. Differentiation. 2009 Mar;77(3):277-89 Authors: Torihashi S, Hattori T, Hasegawa H, Kurahashi M, Ogaeri T, Fujimoto T Bone morphogenetic protein (BMP) signaling is essential for normal development of the gastrointestinal (GI) tract. BMPs also play multiple roles in vascular smooth muscle cells; however, the BMP signaling in the development of the GI mus ... Thu, 05 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-141.html http://biomarket.jp/modules/pubmed_bmp/article-117.html Related Articles Histone deacetylases control neurogenesis in embryonic brain by inhibition of BMP2/4 signaling. PLoS One. 2008;3(7):e2668 Authors: Shakèd M, WeissmÃ?ller K, Svoboda H, Hortschansky P, Nishino N, Wölfl S, Tucker KL BACKGROUND: Histone-modifying enzymes are essential for a wide variety of cellular processes dependent upon changes in gene expression. Histone deacetylases (HDACs) lead to the compaction of chromatin and subsequent silencing of gene transcription, and they ... Thu, 05 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-117.html http://biomarket.jp/modules/pubmed_bmp/article-200.html Related Articles Investigation of the association of BMP gene variants with nephropathy in Type 1 diabetes mellitus. Diabet Med. 2010 Jun;27(6):624-30 Authors: McKnight AJ, Pettigrew KA, Patterson CC, Kilner J, Sadlier DM, Maxwell AP, AIMS: Diabetic nephropathy is a leading cause of end-stage renal disease. The transforming growth factor beta-bone morphogenic protein (BMP) pathway is implicated in the pathogenesis of diabetic nephropathy. The BMP2, BMP4 and BMP7 genes are located near linkage p ... Thu, 05 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-200.html T). No significant differences (P > 0.2) were observed when comparing genotype or allele or haplotype frequencies between 864 individuals with Type 1 diabetes and nephropathy compared with 944 individuals with Type 1 diabetes without nephropathy, stratified by recruitment centre. CONCLUSIONS: Common polymorphisms in these BMP genes do not strongly influence genetic susceptibility to diabetic nephropathy in White individuals with Type 1 diabetes mellitus. PMID: 20546278 [PubMed - in process]（【斜め読み用】機械翻訳： タイプ1の糖尿病mellitusのネフロパシーを用いるBMPの遺伝子の変形の連合の関連の記事の調査。 Diabet Med。 6月2010日; 27 (6): 624-30書く: 、PettigrewのKA AJ、McKnight Patterson CC、Kilner J、Sadlier DMのマックスウェルAPは、向ける: 糖尿病性のネフロパシーは末期の腎臓病の一流の原因である。 形質転換成長因子のベータ骨morphogenic蛋白質(BMP)の細道は糖尿病性のネフロパシーの病因で関係する。 BMP2、BMP4およびBMP7遺伝子は腎臓の機能障害のための連結ピーク近くにあり、これらの生物的および定位置候補者の遺伝子の遺伝の多形が糖尿病性の腎臓病のための危険率であるかもしれないことを私達は仮定する。 方法: BMP7遺伝子は選別された、変形および二方向に札SNPsの選択を促進するために46人の個人を配列することによって定められた対立遺伝子の頻度は識別された(n = 4)。 BMP2およびBMP4遺伝子のために、データはHapMapの国際的なプロジェクトからの19の単一のヌクレオチドの多形(SNPs)のためにダウンロードされ、6札SNPsは選んだ。 結果: BMP7遺伝子は新しい遺伝の多形、haplotypesのために識別された選別された、共通の遺伝の危険率の調査に、およびBMP2選ばれた、変形の適切なサブセットBMP4およびBMP7遺伝子は1808人の個人の糖尿病性のネフロパシーを用いる連合のために査定された。 11が新しかった32 SNPsはSNP (+63639C>を変えるアミノ酸を含んで識別された; T)。 重要な相違無し(Pの> 0.2は)遺伝子型を比較するとき観察されたまたはタイプ1の糖尿病を持つ864人の個人とネフロパシー間の対立遺伝子またはhaplotypeの頻度は募集の中心によって成層化したネフロパシーなしでタイプ1の糖尿病を持つ944人の個人と比較した。 結論: これらのBMPの遺伝子の共通の多形は強くタイプ1の糖尿病mellitusの白い個人の糖尿病性のネフロパシーへの遺伝の感受性に影響を及ぼさない。 PMID: 20546278 [PubMed -プロセスの…） ]]> http://biomarket.jp/modules/pubmed_bmp/article-133.html Related Articles The bone morphogenetic protein antagonist gremlin promotes vascular smooth muscle cell apoptosis. J Vasc Res. 2009;46(4):325-32 Authors: Maciel TT, Melo RS, Campos AH BACKGROUND: Previous studies from our laboratory demonstrated that gremlin significantly increases vascular smooth muscle cell (VSMC) proliferation and migration. The present study investigates gremlin expression in the initial stages of rat carotid balloon injury and its effects on VSMC apoptosis. METHODS: Gremli ... Thu, 05 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-133.html http://biomarket.jp/modules/pubmed_bmp/article-201.html Divergent Modulation of Adipose-Derived Stromal Cell Differentiation by TGF-beta1 Based on Species of Derivation. Plast Reconstr Surg. 2010 Aug;126(2):412-25 Authors: Levi B, James AW, Xu Y, Commons GW, Longaker MT BACKGROUND:: Adipose-derived stromal cells hold promise for skeletal tissue engineering. However, various studies have observed that adipose-derived stromal cells differ significantly in their biology depending on species of derivation. In the following study, the authors sought to de ... Thu, 05 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-201.html http://biomarket.jp/modules/pubmed_fluidigm/article-383.html NU-IN: Nucleotide evolution and input module for the EvolSimulator genome simulation platform. BMC Res Notes. 2010 Aug 2;3(1):217 Authors: Dlugosch KM, Barker MS, Rieseberg LH ABSTRACT: BACKGROUND: There is increasing demand to test hypotheses that contrast the evolution of genes and gene families among genomes, using simulations that work across these levels of organization. The EvolSimulator program was developed recently to provide a highly flexible platform for forward simulations of amino ... Thu, 05 Aug 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-383.html http://biomarket.jp/modules/pubmed_fluidigm/article-384.html A large-scale survey of the novel 15q24 microdeletion syndrome in autism spectrum disorders identifies an atypical deletion that narrows the critical region. Mol Autism. 2010;1(1):5 Authors: McInnes LA, Nakamine A, Pilorge M, Brandt T, Jiménez González P, Fallas M, Manghi ER, Edelmann L, Glessner J, Hakonarson H, Betancur C, Buxbaum JD ABSTRACT: BACKGROUND: The 15q24 microdeletion syndrome has been recently described as a recurrent, submicroscopic genomic imbalance found in individuals ... Thu, 05 Aug 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-384.html http://biomarket.jp/modules/pubmed_fluidigm/article-382.html A domain insertion in Escherichia coli GyrB adopts a novel fold that plays a critical role in gyrase function. Nucleic Acids Res. 2010 Jul 31; Authors: Schoeffler AJ, May AP, Berger JM DNA topoisomerases manage chromosome supercoiling and organization in all forms of life. Gyrase, a prokaryotic heterotetrameric type IIA topo, introduces negative supercoils into DNA by an ATP-dependent strand passage mechanism. All gyrase orthologs rely on a homologous set of catalytic domains for function; howe ... Wed, 04 Aug 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-382.html http://biomarket.jp/modules/pubmed_fluidigm/article-380.html Useful genetic variation databases for oncologists investigating the genetic basis of variable treatment response and survival in cancer. Acta Oncol. 2010 Jul 29; Authors: Savas S Abstract Identification of the genetic basis of variable treatment response, prognosis and survival in cancer patients (i.e. personalized medicine) is an important aim in current medicine. Millions of genetic variations exist in the human genome, some of which are already found to be directly involved in variable trea ... Sun, 01 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-380.html http://biomarket.jp/modules/pubmed_fluidigm/article-381.html Varietas: a functional variation database portal. Database (Oxford). 2010;2010:baq016 Authors: Paananen J, Ciszek R, Wong G Current high-throughput technologies for investigating genomic variation in large population based samples produce data on a scale of millions of variations. Browsing through these results and identifying relevant functional variations is a major hurdle in these genome-wide association studies. In order to help researchers locate the most promising associations, we have de ... Sun, 01 Aug 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-381.html http://biomarket.jp/modules/pubmed_seldi/article-223.html URINE PROTEOME ANALYSIS MAY ALLOW NON-INVASIVE DIFFERENTIAL DIAGNOSIS OF DIABETIC NEPHROPATHY. Diabetes Care. 2010 Jul 29; Authors: Papale M, Di Paolo S, Magistroni R, Lamacchia O, De Mattia A, Teresa Rocchetti M, Furci L, Pasquali S, De Cosmo S, Cignarelli M, Gesualdo L AbstractObjective: Chronic renal insufficiency and/or proteinuria in type 2 diabetes may stem from chronic renal diseases (CKD) other than classic diabetic nephropathy (DN) in over one third of cases. We interrogated urine prote ... Sun, 01 Aug 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-223.html http://biomarket.jp/modules/pubmed_fluidigm/article-379.html A genomewide scan for common alleles affecting risk for autism. Hum Mol Genet. 2010 Jul 27; Authors: Anney R, Klei L, Pinto D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Sykes N, Pagnamenta AT, Almeida J, Bacchelli E, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Carson AR, Casallo G, Casey J, Chu S, Cochrane L, Corsello C, Crawford EL, Crossett A, Dawson G, de Jonge M, Delorme R, Drmic I, Duketis E, Duque F, Este ... Fri, 30 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-379.html http://biomarket.jp/modules/pubmed_seldi/article-221.html ProteoMiner() and SELDI-TOF-MS: A robust and highly reproducible combination for biomarker discovery from whole blood serum. Arch Physiol Biochem. 2010 Jul 22; Authors: Fröbel J, Hartwig S, PaÃ?lack W, Eckel J, Haas R, Czibere A, Lehr S Surface-enhanced laser desorption ionization time of flight mass spectrometry (SELDI-TOF-MS) has been recognized as an appropriate technology for biomarker discovery. Nevertheless, whenever human blood serum is studied, its sensitivity is restricted due to ... Fri, 30 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-221.html http://biomarket.jp/modules/pubmed_seldi/article-222.html Detection of nasopharyngeal carcinoma using surface-enhanced laser desorption and ionization mass spectrometry profiles of the serum proteome. Chin J Cancer. 2010 Aug;29(8):721-8 Authors: Cao SM, Yu JK, Chen QY, Li NW, Xiang YQ, Qian CN, Hu X, Zhang CQ, Xie D, Guo X Background and Objective: Early diagnosis of nasopharyngeal carcinoma (NPC) is difficult due to the insufficient specificity of the conventional examination method. This study was to investigate potential and consistent biomarkers fo ... Fri, 30 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-222.html http://biomarket.jp/modules/pubmed_fluidigm/article-378.html Copy number variation in chemokine superfamily: the complex scene of CCL3L-CCL4L genes in health and disease. Clin Exp Immunol. 2010 Jul 23; Authors: Colobran R, Pedrosa E, Carretero-Iglesia L, Juan M Summary Genome copy number changes (copy number variations: CNVs) include inherited, de novo and somatically acquired deviations from a diploid state within a particular chromosomal segment. CNVs are frequent in higher eukaryotes and associated with a substantial portion of inherited and acquired ... Thu, 29 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-378.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-348.html Red blood cell proteomics. Transfus Clin Biol. 2010 Jul 22; Authors: Pasini EM, Mann M, Thomas AW Since its discovery in the 17th century, the red blood cell, recognized in time as the critical cell component for survival, has been the focus of much attention. Its unique role in gas exchange (oxygen/CO(2) transport) and its distinct characteristics (absence of nucleus; biconcave cell shape) together with an - in essence - unlimited supply lead to extensive targeted biochemical, molecular and str ... Wed, 28 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-348.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-349.html Involvement of ST6Gal I in the biosynthesis of a unique human colon cancer biomarker candidate, {alpha}2,6-sialylated blood group type 2 H (ST2H) antigen. J Biochem. 2010 Jul 23; Authors: Korekane H, Matsumoto A, Ota F, Hasegawa T, Misonou Y, Shida K, Miyamoto Y, Taniguchi N The alpha2,6-sialylated blood group type 2 H (ST2H) antigen (Fucalpha 1-2(NeuAcalpha2-6)Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc-Cer) is a fucoganglioside found in human colon cancer tissues. To elucidate an enzyme responsible f ... Wed, 28 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-349.html http://biomarket.jp/modules/pubmed_fluidigm/article-377.html Seal capability of interim post and core crown with temporary cements. Braz Oral Res. 2010 Jun;24(2):238-44 Authors: Bönecker-Valverde G, Maniglia-Ferreira C, Abi-Rached GP, Gomes BP, Mesquita MF The purpose of the present study was to evaluate the in vitro seal capability of interim post and core crown restorations. Eighty teeth were selected and divided into 8 groups. Four experimental groups received interim posts and core crowns. Half of each group was decoronated at the cementum-enamel ... Wed, 28 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-377.html http://biomarket.jp/modules/pubmed_seldi/article-219.html [Study on proteomics of inhibitory effects of elemene on proliferation of human lens epithelial cell.] Zhonghua Yan Ke Za Zhi. 2010 May;46(5):427-31 Authors: Hu YH, Huang XR, Qi MX, Hou BY OBJECTIVE: To investigate the inhibitory effects of natural medicinal monomer elemene (Ele) on proliferation of human lens epithelial cells B3 (HLE-B3) inducing by recombinant human basic fibroblast growth factor(rhbFGF) and to pursue the proteomics regularity of the inhibitory effects of Ele on proliferation ... Wed, 28 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-219.html http://biomarket.jp/modules/pubmed_seldi/article-220.html Effect of contact lenses on the protein composition in tear film: a ProteinChip study. Graefes Arch Clin Exp Ophthalmol. 2010 Jul 26; Authors: Kramann C, Boehm N, Lorenz K, Wehrwein N, Stoffelns BM, Pfeiffer N, Grus FH BACKGROUND: The aim of this study was to analyze and compare the effects of rigid gas permeable and soft contact lenses on the protein composition in the tear film of contact lens wearers. METHODS: Wearers of soft contact lenses (CL_S, n = 13) and rigid gas permeable contact lense ... Wed, 28 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-220.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-347.html Related Articles Involvement of aberrant glycosylation in thyroid cancer. J Oncol. 2010;2010:816595 Authors: Miyoshi E, Ito Y, Miyoshi Y Glycosylation is one of the most common posttranslational modification reactions and nearly half of all known proteins in eukaryotes are glycosylated. In fact, changes in oligosaccharides structures are associated with many physiological and pathological events, including cell growth, migration and differentiation, and tumor invasion. Therefore, functional glyc ... Sun, 25 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-347.html http://biomarket.jp/modules/pubmed_fluidigm/article-376.html The basis for haplotype complexity in VCBPs, an immune-type receptor in amphioxus. Immunogenetics. 2010 Jul 22; Authors: Dishaw LJ, Ota T, Mueller MG, Cannon JP, Haire RN, Gwatney NR, Litman RT, Litman GW Innate immune gene repertoires are restricted primarily to germline variation. Adaptive immunity, by comparison, relies on somatic variation of germline-encoded genes to generate extraordinarily large numbers of non-heritable antigen recognition motifs. Invertebrates lack the key features of v ... Sun, 25 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-376.html http://biomarket.jp/modules/pubmed_fluidigm/article-375.html Serum Free Circulating DNA Is a Useful Biomarker to Distinguish Benign versus Malignant Prostate Disease. Cancer Epidemiol Biomarkers Prev. 2010 Jul 20; Authors: Gordian E, Ramachandran K, Reis IM, Manoharan M, Soloway MS, Singal R BACKGROUND: Free circulating DNA (fcDNA) has been shown to be elevated in serum of prostate cancer patients compared with benign controls. However, studies evaluating the role of fcDNA as a biomarker in a "representative" patient group who have undergone prostate canc ... Fri, 23 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-375.html 4 ng/mL and/or abnormal digital rectal exam. fcDNA levels in serum before prostate biopsy were quantitated by real-time PCR amplification of the glutathione S-transferase, pi, gene. RESULTS: Patients with PSA 180 ng/mL were at increased risk for prostate cancer compared with those with fcDNA http://biomarket.jp/modules/pubmed_fluidigm/article-371.html Ethical issues raised by common copy number variants and single nucleotide polymorphisms of certain and uncertain significance in general medical practice. Genome Med. 2010 Jul 17;2(7):42 Authors: Beaudet AL ABSTRACT: The ethical issues surrounding genotyping for single nucleotide polymorphisms (SNPs) or for copy number variation (CNV) are very different. SNP genotyping can focus on ancestry, risk probability, single gene diagnosis, pharmacogenetics, and carrier testing, and the combination of ... Thu, 22 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-371.html http://biomarket.jp/modules/pubmed_fluidigm/article-372.html Genetic bottlenecks and the hazardous game of population reduction in cell line based research. Exp Cell Res. 2010 Jul 16; Authors: Gisselsson D, Lindgren D, Mengelbier LH, Ora I, Yeger H Established tumour cell lines are ubiquitous tools in research, but their representativity is often debated. One possible caveat is that many cell lines are derived from cells with genomic instability, potentially leading to genotype changes in vitro. We applied SNP-array analysis to an established tumour cell ... Thu, 22 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-372.html http://biomarket.jp/modules/pubmed_fluidigm/article-373.html Toward a more uniform sampling of human genetic diversity: A survey of worldwide populations by high-density genotyping. Genomics. 2010 Jul 16; Authors: Xing J, Watkins WS, Shlien A, Walker E, Huff CD, Witherspoon DJ, Zhang Y, Simonson TS, Weiss RB, Schiffman JD, Malkin D, Woodward SR, Jorde LB High-throughput genotyping data are useful for making inferences about human evolutionary history. However, the populations sampled to date are unevenly distributed, and some areas (e.g., South and Centr ... Thu, 22 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-373.html http://biomarket.jp/modules/pubmed_fluidigm/article-374.html Clinically detectable copy number variations in a Canadian catchment population of schizophrenia. J Psychiatr Res. 2010 Jul 17; Authors: Bassett AS, Costain G, Alan Fung WL, Russell KJ, Pierce L, Kapadia R, Carter RF, Chow EW, Forsythe PJ Copy number variation (CNV) is a highly topical area of research in schizophrenia, but the clinical relevance is uncertain and the translation to clinical practice is under-studied. There is a paucity of research involving truly community-based samples of schi ... Thu, 22 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-374.html http://biomarket.jp/modules/pubmed_seldi/article-207.html Related Articles High-abundance proteins depletion for serum proteomic analysis: concomitant removal of non-targeted proteins. Amino Acids. 2010 May 22; Authors: Bellei E, Bergamini S, Monari E, Fantoni LI, Cuoghi A, Ozben T, Tomasi A In clinical and pharmaceutical proteomics, serum and plasma are frequently used for detection of early diagnostic biomarkers for therapeutic targets. Although obtaining these body fluid samples is non-invasive and easy, they contain some abundant proteins that mas ... Thu, 22 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-207.html http://biomarket.jp/modules/pubmed_seldi/article-217.html Related Articles Proteomic profiling of cerebrospinal fluid in parkinsonian disorders. Parkinsonism Relat Disord. 2010 Jul 8; Authors: Constantinescu R, Andreasson U, Li S, Podust VN, Mattsson N, Anckarsäter R, Anckarsäter H, Rosengren L, Holmberg B, Blennow K, Wikkelsö C, RÃ?etschi U, Zetterberg H Parkinson's disease (PD) and atypical parkinsonian disorders (APD), including multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), ... Thu, 22 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-217.html http://biomarket.jp/modules/pubmed_seldi/article-218.html Depicting the Spatial Distribution of Proteins in Human Tumor Tissue Combining SELDI, MALDI Imaging, and Immunohistochemistry. J Histochem Cytochem. 2010 Jul 19; Authors: Wehder L, Ernst G, Crecelius AC, Guntinas-Lichius O, Melle C, Schubert US, von Eggeling F Carcinoma tissue does not only consist of tumor cells but also of fibroblasts, endothelial cells or vascular structures, and inflammatory cells forming the supportive tumor stroma. Therefore, the spatial distribution of proteins which prom ... Thu, 22 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-218.html http://biomarket.jp/modules/pubmed_fluidigm/article-370.html R-Gada: a fast and flexible pipeline for copy number analysis in association studies. BMC Bioinformatics. 2010 Jul 16;11(1):380 Authors: Pique-Regi R, Caceres A, Gonzalez JR ABSTRACT: BACKGROUND: Genome-wide association studies (GWAS) using Copy Number Variation (CNV) are becoming a central focus of genetic research. CNVs have successfully provided target genome regions for some disease conditions where simple genetic variation (i.e., SNPs) has previously failed to provide a clear association. ... Wed, 21 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-370.html http://biomarket.jp/modules/pubmed_fluidigm/article-369.html Related Articles Molecular analysis of germline t(3;6) and t(3;12) associated with conventional renal cell carcinomas indicates their rate-limiting role and supports the three-hit model of carcinogenesis. Cancer Genet Cytogenet. 2010 Aug;201(1):15-23 Authors: Yusenko MV, Nagy A, Kovacs G We describe the molecular analysis of chromosomal rearrangements in familial t(3;6)(p12.3;q24.3) and t(3;12)(q13.13;q24.23) associated with the development of conventional renal cell carcinomas (RCC). We mapped ... Tue, 20 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-369.html http://biomarket.jp/modules/pubmed_fluidigm/article-360.html Related Articles Repetitive sequences in the lamprey mitochondrial DNA control region and speciation of Lethenteron. Gene. 2010 Jun 25; Authors: Okada K, Yamazaki Y, Yokobori S, Wada H The sequence of the mitochondrial DNA control region was examined in four species of lamprey in the genus Lethenteron. The 3' half of the control region contains highly variable repeat sequences, showing variation in both copy number and nucleotide sequence, even within local populations. Detailed analyses of the ... Sat, 17 Jul 2010 01:00:10 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-360.html http://biomarket.jp/modules/pubmed_fluidigm/article-368.html Related Articles R2 dynamics in Triops cancriformis (Bosc, 1801) (Crustacea, Branchiopoda, Notostraca): turnover rate and 28S concerted evolution. Heredity. 2010 Jul 14; Authors: Mingazzini V, Luchetti A, Mantovani B The R2 retrotransposon is here characterized in bisexual populations of the European crustacean Triops cancriformis. The isolated element matches well with the general aspects of the R2 family and it is highly differentiated from that of the congeneric North American Triops longicau ... Sat, 17 Jul 2010 01:00:10 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-368.html http://biomarket.jp/modules/pubmed_fluidigm/article-366.html Related Articles Identification of gene copy number variations in patients with mental retardation using array-CGH: Novel syndromes in a large French series. Eur J Med Genet. 2010 Mar-Apr;53(2):66-75 Authors: Jaillard S, Drunat S, Bendavid C, Aboura A, Etcheverry A, Journel H, Delahaye A, Pasquier L, Bonneau D, Toutain A, Burglen L, Guichet A, Pipiras E, Gilbert-Dussardier B, Benzacken B, Martin-Coignard D, Henry C, David A, Lucas J, Mosser J, David V, Odent S, Verloes A, Dubourg C Array-CGH ha ... Sat, 17 Jul 2010 01:00:10 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-366.html http://biomarket.jp/modules/pubmed_fluidigm/article-367.html Related Articles Rice structural variation: a comparative analysis of structural variation between rice and three of its closest relatives in the genus Oryza. Plant J. 2010 Jul 8; Authors: Hurwitz BL, Kudrna D, Yu Y, Sebastian A, Zuccolo A, Jackson SA, Ware D, Wing RA, Stein L SUMMARY Rapid progress in comparative genomics among the grasses has revealed similar gene content and order despite exceptional differences in chromosome size and number. Large and small-scale genomic variations are of pa ... Sat, 17 Jul 2010 01:00:10 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-367.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-345.html Related Articles 8th HUPO World Congress: The Human Disease Glycomics/Proteomics Initiative (HGPI) Session 26 September 2009, Toronto, Canada. Proteomics. 2010 May;10(10):1899-902 Authors: Narimatsu H The Human Disease Glycomics/Proteomics Initiative (HGPI) Session at the HUPO World Congress was held in Toronto on 26 September 2009. In this report, we summarize the presentation of the HGPI workshop as follows: (i) The results of the past HGPI pilot studies (first and second) in which we analyzed ... Thu, 15 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-345.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-346.html Towards Functional Glycomics by Lectin Histochemistry: Strategic Probe Selection to Monitor Core and Branch-end Substitutions and Detection of Cell-type and Regional Selectivity in Adult Mouse Testis and Epididymis. Anat Histol Embryol. 2010 Jul 7; Authors: Lohr M, Kaltner H, Schwartz-Albiez R, Sinowatz F, Gabius HJ With 2 figures and 3 tables Summary The emerging insights into glycan functionality direct increasing attention to monitor core modifications of N-glycans and branch-end structures. ... Thu, 15 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-346.html http://biomarket.jp/modules/pubmed_fluidigm/article-365.html Related Articles The impact of CpG island on defining transcriptional activation of the mouse L1 retrotransposable elements. PLoS One. 2010;5(6):e11353 Authors: Lee SH, Cho SY, Shannon MF, Fan J, Rangasamy D BACKGROUND: L1 retrotransposable elements are potent insertional mutagens responsible for the generation of genomic variation and diversification of mammalian genomes, but reliable estimates of the numbers of actively transposing L1 elements are mostly nonexistent. While the human and mouse ... Thu, 15 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-365.html http://biomarket.jp/modules/pubmed_fluidigm/article-361.html Related Articles Mapping candidate regions and genes for congenital anomalies of the kidneys and urinary tract (CAKUT) by array-based comparative genomic hybridization. Nephrol Dial Transplant. 2010 Jul 5; Authors: Weber S, Landwehr C, Renkert M, Hoischen A, WÃ?hl E, Denecke J, Radlwimmer B, Haffner D, Schaefer F, Weber RG BACKGROUND: Congenital anomalies of the kidneys and urinary tract (CAKUT) are frequently associated with malformations of other organs. METHODS: In order to explore the role ... Thu, 15 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-361.html http://biomarket.jp/modules/pubmed_fluidigm/article-358.html Related Articles Insights into the Role of Fc Gamma Receptors (FcgammaRs) Genetic Variations in Monoclonal Antibody-Based Anti-Cancer Therapy. Recent Pat Anticancer Drug Discov. 2010 Apr 30; Authors: Concetti F, Napolioni V Recently, the field of oncology has witnessed the introduction of several effective chemotherapeutic agents. Still, not all cancers respond to the use of conventional chemotherapy and thus combination therapy is an emerging weapon in the battle against cancer. There is emergi ... Thu, 15 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-358.html http://biomarket.jp/modules/pubmed_fluidigm/article-362.html Related Articles CNVineta: A data mining tool for large case-control copy number variation data sets. Bioinformatics. 2010 Jul 6; Authors: Wittig M, Helbig I, Schreiber S, Franke A MOTIVATION: Copy number variation (CNV), a major contributor to human genetic variation, comprises 1 kb or longer genomic deletions and insertions. Yet, the identification of CNVs from microarray data is still hampered by high false negative and positive prediction rates due to the noisy nature of the raw data. Here, ... Thu, 15 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-362.html http://biomarket.jp/modules/pubmed_fluidigm/article-353.html Related Articles A de novo 4q34 interstitial deletion of at least 9.3 Mb with no discernible phenotypic effect. Am J Med Genet A. 2010 Jul;152A(7):1764-9 Authors: Bateman MS, Mehta SG, Willatt L, Selkirk E, Bedwell C, Zwolinski S, Sparnon L, Simonic I, Abbott K, Barber JC Cytogenetically visible imbalances without phenotypic effect are still rare despite the extent of large-scale copy number variation in the normal population revealed by array CGH. Here we report on a phenotypically normal 30-y ... Thu, 15 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-353.html http://biomarket.jp/modules/pubmed_fluidigm/article-363.html Related Articles Genetic variation of copia suppression in Drosophila melanogaster. Heredity. 2010 Jul 7; Authors: Vu W, Nuzhdin S Transposable elements (TEs) are genomic parasites that propagate by exploiting its host reproductive machinery. However, some hosts have evolved the ability to silence TE activity, whereas others have not. We are investigating the population dynamics of TE host-silencing pathways, particularly copia long terminal repeat retrotransposon in Drosophila melanogaster. He ... Thu, 15 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-363.html http://biomarket.jp/modules/pubmed_fluidigm/article-357.html Related Articles Gene copy-number polymorphism in nature. Proc Biol Sci. 2010 Jun 30; Authors: Schrider DR, Hahn MW Differences between individuals in the copy-number of whole genes have been found in every multicellular species examined thus far. Such differences result in unique complements of protein-coding genes in all individuals, and have been shown to underlie adaptive phenotypic differences. Here, we review the evidence for copy-number variants (CNVs), focusing on the methods used to de ... Thu, 15 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-357.html http://biomarket.jp/modules/pubmed_fluidigm/article-364.html Related Articles A novel microdeletion/microduplication syndrome of 19p13.13. Genet Med. 2010 Jul 6; Authors: Dolan M, Mendelsohn NJ, Pierpont ME, Schimmenti LA, Berry SA, Hirsch B PURPOSE:: Whole genome interrogation by array-based comparative genomic hybridization has led to a rapidly increasing number of discoveries of novel microdeletion and/or microduplication syndromes. We here describe the clinical and cytogenomic correlates of a novel microdeletion/microduplication of 19p13.13. METHODS:: ... Thu, 15 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-364.html http://biomarket.jp/modules/pubmed_fluidigm/article-355.html Related Articles Copy number variation and transposable elements feature in recent, ongoing adaptation at the Cyp6g1 locus. PLoS Genet. 2010;6(6):e1000998 Authors: Schmidt JM, Good RT, Appleton B, Sherrard J, Raymant GC, Bogwitz MR, Martin J, Daborn PJ, Goddard ME, Batterham P, Robin C The increased transcription of the Cyp6g1 gene of Drosophila melanogaster, and consequent resistance to insecticides such as DDT, is a widely cited example of adaptation mediated by cis-regulatory change. A fragm ... Thu, 15 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-355.html http://biomarket.jp/modules/pubmed_fluidigm/article-359.html Related Articles Mosaic uniparental disomies and aneuploidies as large structural variants of the human genome. Am J Hum Genet. 2010 Jul 9;87(1):129-38 Authors: RodrÃ?guez-Santiago B, Malats N, Rothman N, Armengol L, Garcia-Closas M, Kogevinas M, Villa O, Hutchinson A, Earl J, Marenne G, Jacobs K, Rico D, TardÃ?n A, Carrato A, Thomas G, Valencia A, Silverman D, Real FX, Chanock SJ, Pérez-Jurado LA Mosaicism is defined as the coexistence of cells with different genetic composition withi ... Thu, 15 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-359.html http://biomarket.jp/modules/pubmed_seldi/article-212.html Related Articles [The screening and identification of Apolipoprotein A-II from serum differential proteins in hepatocellular carcinoma patients.] Zhonghua Gan Zang Bing Za Zhi. 2010 Jun;18(6):445-9 Authors: Jiang ZH, Zhang ZY, He M, Qin J, Wang Q, Wei X, Nong BJ, Liu F To screen differential proteins in serum from hepatocellular carcinoma (HCC) patients by Proteomic Technology and to purify and identify them. Surface enhanced laser desorption Ionization time of flight-mass spectrum (SELDI-TOF-MS ... Thu, 15 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-212.html http://biomarket.jp/modules/pubmed_seldi/article-209.html Related Articles Detection of pancreatic adenocarcinoma using circulating fragments of fibrinogen. Eur J Gastroenterol Hepatol. 2010 Jun 15; Authors: Ward DG, Wei W, Buckels J, Taha AM, Hegab B, Tariciotti L, Salih R, Qi YQ, Martin A, Johnson PJ BACKGROUND: There is an urgent need for biomarkers to detect pancreatic cancer in the early, potentially curable, stages. METHODS: We have used SELDI profiling to analyze serum from 75 patients with pancreatic cancer and 61 patients with nonmalignant pan ... Thu, 15 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-209.html http://biomarket.jp/modules/pubmed_seldi/article-213.html Related Articles Discovery of serum biomarkers for pancreatic adenocarcinoma using proteomic analysis. Br J Cancer. 2010 Jun 29; Authors: Xue A, Scarlett CJ, Chung L, Butturini G, Scarpa A, Gandy R, Wilson SR, Baxter RC, Smith RC Background and aims:The serum/plasma proteome was explored for biomarkers to improve the diagnostic ability of CA19-9 in pancreatic adenocarcinoma (PC).Methods:A Training Set of serum samples from 20 resectable and 18 stage IV PC patients, 54 disease controls (DCs) and ... Thu, 15 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-213.html http://biomarket.jp/modules/pubmed_seldi/article-211.html Related Articles Characterization of a diverse secretome generated by the mouse preimplantation embryo in vitro. Reprod Biol Endocrinol. 2010;8:71 Authors: Beardsley AJ, Li Y, O'Neill C ABSTRACT: This study investigates the suitability of surface-enhanced laser desorption and ionization time-of-flight (SELDI-TOF) and electrospray ionization (ESI) mass spectrometry for analysis of the proteins released by the mouse preimplantation embryo in vitro. SELDI-TOF analysis with CM10 or IMAC30 (but not ... Thu, 15 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-211.html http://biomarket.jp/modules/pubmed_seldi/article-214.html Related Articles Probing the dynamic nature of signalling pathways by IMAC and SELDI-tof MS. Arch Physiol Biochem. 2010 Jun 30; Authors: Foucher AL, Späth GF, Pemberton IK One major obstacle to the analysis of signalling pathways is the dynamic nature of signalling response to environmental stimuli. To overcome this limitation we applied immobilized metal affinity chromatography (IMAC) in combination with SELDI-tof MS to investigate the temporal variation of protein phosphorylation. We ana ... Thu, 15 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-214.html http://biomarket.jp/modules/pubmed_seldi/article-208.html Related Articles Identification of a 17-protein signature in the serum of lung cancer patients. Oncol Rep. 2010 Jul;24(1):263-70 Authors: Sreseli RT, Binder H, Kuhn M, Digel W, Veelken H, Sienel W, Passlick B, Schumacher M, Martens UM, Zimmermann S Early detection of lung cancer may potentially help to improve the outcome of this fatal disease. Currently, no satisfactory laboratory tests are available to screen for this type of cancer. The aim of this study was to improve diagnostic procedures f ... Thu, 15 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-208.html http://biomarket.jp/modules/pubmed_seldi/article-215.html Related Articles Proteomic investigations of the ventriculo-lumbar gradient in human CSF. J Neurosci Methods. 2010 Jun 25; Authors: Simonsen AH, Bech S, Laursen I, Salvesen L, Winge K, Waldemar G, Werdelin L, Nielsen JE, McGuire JN, Hjermind LE Cerebrospinal fluid (CSF) is an ideal biological material in which to search for new biomarkers for improved diagnosis of neurological diseases. During a lumbar puncture between 5 and 15mL of CSF are obtained. Previous studies have assessed the ventricul ... Thu, 15 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/pubmed_seldi/article-215.html http://biomarket.jp/modules/pubmed_seldi/article-206.html Related Articles Identification of a beta-casein-like peptide in breast nipple aspirate fluid that is associated with breast cancer. Biomark Med. 2009 Oct;3(5):577-88 Authors: Sauter ER, Davis W, Qin W, Scanlon S, Mooney B, Bromert K, Folk WR AIMS: Nipple aspirate fluid was collected prospectively from women scheduled for diagnostic breast surgery in order to determine protein masses associated with breast cancer, subsets of women with a unique proteomic profile and a breast cancer predictive mo ... Thu, 15 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/pubmed_seldi/article-206.html 87%) or 3592 (best specificity: >94%) peak. MALDI-TOF mass spectrometry demonstrated the 3592 peak, which was most discriminating in many of our cancer prediction models, to be a beta-casein-like peptide. CONCLUSION: Differential nipple aspirate fluid proteomic expression exists between women with/without breast cancer. The most discriminating protein identified is a beta-casein-like peptide not previously described. Combining proteomic and clinical information, which are available before surgery, optimizes the prediction of which women have breast cancer. PMID: 20477526 [PubMed]（【斜め読み用】機械翻訳：） ]]> http://biomarket.jp/modules/pubmed_seldi/article-216.html Related Articles Specific protein and miRNA patterns characterise tumour-associated fibroblasts in bladder cancer. J Cancer Res Clin Oncol. 2010 Jul 4; Authors: Enkelmann A, Heinzelmann J, von Eggeling F, Walter M, Berndt A, Wunderlich H, Junker K PURPOSE: Tumour development and progression are strongly affected by interaction of tumour cells and tumour stroma. Different tumour models demonstrate a supportive effect of tumour-associated fibroblasts (TAF) on the tumour genesis. Aims of the prese ... Thu, 15 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/pubmed_seldi/article-216.html http://biomarket.jp/modules/pubmed_seldi/article-210.html Related Articles [Isolation and characterization of pigment-protein complexes from Rhodobacter azotoformans] Wei Sheng Wu Xue Bao. 2010 Apr 4;50(4):500-5 Authors: Zhao G, Yang S, Qu Y, Jiao N OBJECTIVE: In order to reveal the relationships of compositions and content of pigment in pigment-protein complexes (PPC) and hydrogen photoevolution from anoxygenic phototrophic bacteria. METHODS: We isolated and identified pigment-protein complexes using a separation strategy of subsequent fractionated am ... Thu, 15 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/pubmed_seldi/article-210.html http://biomarket.jp/modules/pubmed_bmp/article-114.html Related Articles Bone morphogenetic protein regulation of enteric neuronal phenotypic diversity: relationship to timing of cell cycle exit. J Comp Neurol. 2008 Aug 10;509(5):474-92 Authors: Chalazonitis A, Pham TD, Li Z, Roman D, Guha U, Gomes W, Kan L, Kessler JA, Gershon MD The effects of bone morphogenetic protein (BMP) signaling on enteric neuron development were examined in transgenic mice overexpressing either the BMP inhibitor, noggin, or BMP4 under control of the neuron specific enolase ... Wed, 14 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-114.html http://biomarket.jp/modules/pubmed_bmp/article-196.html Related Articles Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system. J Bone Miner Metab. 2010 Apr 8; Authors: Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI To effectively treat degenerative joint diseases including osteoarthritis (OA), small chemical compounds need to be developed that can potently induce chondrogenic differentiation without promoting terminal ... Wed, 14 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-196.html http://biomarket.jp/modules/pubmed_bmp/article-130.html Related Articles Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness. Blood. 2009 Jan 15;113(3):688-95 Authors: Truksa J, Lee P, Beutler E Hepcidin plays a major role in the regulation of iron homeostasis. Several bone morphogenetic proteins (BMPs) are strong inducers of hepcidin (Hamp1, HAMP) expression. Hemojuvelin, a protein critical for maintaining appropriate levels of hepcidin, acts as a coreceptor for B ... Wed, 14 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-130.html http://biomarket.jp/modules/pubmed_bmp/article-197.html Related Articles The expression of twisted gastrulation in postnatal mouse brain and functional implications. Neuroscience. 2010 May 21; Authors: Sun M, Forsman C, Sergi C, Gopalakrishnan R, O'Connor MB, Petryk A Twisted gastrulation (TWSG1), an extracellular regulator of bone morphogenetic protein (BMP) signaling, is critical for embryonic brain development. Mice deficient in TWSG1 have abnormal forebrain development manifesting as holoprosencephaly. The expression and potential roles of TWSG1 ... Wed, 14 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-197.html http://biomarket.jp/modules/pubmed_bmp/article-146.html Related Articles Daily low-intensity pulsed ultrasound stimulates production of bone morphogenetic protein in ROS 17/2.8 cells. J Oral Sci. 2009 Mar;51(1):29-36 Authors: Suzuki A, Takayama T, Suzuki N, Kojima T, Ota N, Asano S, Ito K Although daily low-intensity pulsed ultrasound (LIPUS) can accelerate osteogenic differentiation of the rat clonal cell line ROS 17/2.8, the molecular mechanism that underlies this phenomenon is unclear. The purpose of this study was to determine which molecules ex ... Wed, 14 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-146.html http://biomarket.jp/modules/pubmed_bmp/article-198.html Related Articles Agrin binds BMP2, BMP4 and TGFbeta1. PLoS One. 2010;5(5):e10758 Authors: Bányai L, Sonderegger P, Patthy L The C-terminal 95 kDa fragment of some isoforms of vertebrate agrins is sufficient to induce clustering of acetylcholine receptors but despite two decades of intense agrin research very little is known about the function of the other isoforms and the function of the larger, N-terminal part of agrins that is common to all isoforms. Since the N-terminal part of agrins c ... Wed, 14 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-198.html http://biomarket.jp/modules/pubmed_bmp/article-122.html Related Articles Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium. BMC Dev Biol. 2008;8:75 Authors: Chen YH, Ishii M, Sucov HM, Maxson RE BACKGROUND: Msx1 and Msx2, which belong to the highly conserved Nk family of homeobox genes, display overlapping expression patterns and redundant functions in multiple tissues and organs during vertebrate development. Msx1 and Msx2 have well-documented rol ... Wed, 14 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-122.html http://biomarket.jp/modules/pubmed_bmp/article-199.html Related Articles BMP Signalling in the Human Fetal Ovary is Developmentally-regulated and Promotes Primordial Germ Cell Apoptosis. Stem Cells. 2010 May 6; Authors: Childs AJ, Kinnell HL, Collins CS, Hogg K, Bayne RA, Green SJ, McNeilly AS, Anderson RA Primordial Germ Cells (PGCs) are the embryonic precursors of gametes in the adult organism, and their development, differentiation and survival is regulated by a combination of growth factors collectively known as the germ cell niche. Although man ... Wed, 14 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-199.html http://biomarket.jp/modules/pubmed_bmp/article-106.html Related Articles A distinct cohort of the TGFbeta superfamily members expressed in human endometrium regulate decidualization. Hum Reprod. 2008 Jun;23(6):1447-56 Authors: Stoikos CJ, Harrison CA, Salamonsen LA, Dimitriadis E BACKGROUND: Successful blastocyst implantation requires the differentiation of human endometrial stromal cells (HESC), a process known as decidualization. Activin A, a transforming growth factor beta (TGFbeta) superfamily member, enhances HESC decidualization and localizes ... Wed, 14 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-106.html http://biomarket.jp/modules/pubmed_bmp/article-138.html Related Articles BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet. 2009 Apr;41(4):482-7 Authors: Andriopoulos B, Corradini E, Xia Y, Faasse SA, Chen S, Grgurevic L, Knutson MD, Pietrangelo A, Vukicevic S, Lin HY, Babitt JL Juvenile hemochromatosis is an iron-overload disorder caused by mutations in the genes encoding the major iron regulatory hormone hepcidin (HAMP) and hemojuvelin (HFE2). We have previously shown that hemojuvelin is a co-receptor for bon ... Wed, 14 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_bmp/article-138.html http://biomarket.jp/modules/pubmed_fluidigm/article-308.html Related Articles Detection of increased amounts of cell-free fetal DNA with short PCR amplicons. Clin Chem. 2010 Jan;56(1):136-8 Authors: Sikora A, Zimmermann BG, Rusterholz C, Birri D, Kolla V, Lapaire O, Hoesli I, Kiefer V, Jackson L, Hahn S AIM: A digital PCR approach has recently been suggested to detect greater amounts of cell-free fetal DNA in maternal plasma than conventional real-time quantitative PCR (qPCR). Because the digital qPCR approach uses shorter PCR amplicons than the real-tim ... Wed, 14 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-308.html http://biomarket.jp/modules/pubmed_fluidigm/article-343.html Related Articles PCA3: a new tool to diagnose prostate cancer (PCa) and a guidance in biopsy decisions. Preliminary report of the UrOP study. Arch Ital Urol Androl. 2010 Mar;82(1):5-9 Authors: Galasso F, Giannella R, Bruni P, Giulivo R, Barbini VR, Disanto V, Leonardi R, Pansadoro V, Sepe G OBJECTIVES: PCA3 is a prostate specific non-coding mRNA that is significantly overexpressed in prostate cancer tissue. Urinary PCA3 levels have been associated with prostate cancer grade suggesting a signific ... Wed, 14 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-343.html /= 35 (cut-off) whereas the remaining 472 patients (51.58%) presented a PCA3 score lower the cut-off limit (< 35). Of the 443 patients with PCA3 score >/= 35, 105 (23.70%) underwent biopsy or rebiopsy. We found that 27 patients (25.71%) had no tumour at biopsy, 37 (35.24%) had HGPIN or ASAP and 41 (39.05%) had a cancer. Moreover, including the additonal 9 patients with PCA3 < 35, who underwent biopsy post PCA3 results, our data indicate that patients with negative biopsy (n = 31) show lower PCA3 score (mean = 54.9) compared with patients with positive biopsy (n = 45) (mean = 141.6) (p = 0.000183; two-tailed t-student test). The mean PCA3 score (79.6)for the patients diagnosed with HGPIN/ASAP at biopsy (n = 38) was intermediate between patients with negative and positive biopsy. Conclusions: Our results indicate that the PCA3 score is a valid tool for prostate cancer detection and its role in making better biopsy decisions. This marker consents to discriminate patients who have to undergo biopsy from patients who only need be actively surveilled: Quantitative PCA3 score is correlated with the probability of a positive result at biopsy. PMID: 20593708 [PubMed - in process]（【斜め読み用】機械翻訳：） ]]> http://biomarket.jp/modules/pubmed_fluidigm/article-314.html Related Articles [Noninvasive prenatal diagnosis of single gene disorders through cell-free fetal DNA in maternal blood] Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009 Aug;26(4):410-3 Authors: Guo QW, Zhou YL The discovery of cell-free fetal DNA (cff-DNA) in maternal plasma offered a new way to noninvasive prenatal diagnosis for single gene disorders. In the past decade, many techniques such as real-time PCR, pyrophosphorolysis-activated polymerization, mass spectrum and digital PCR have been develop ... Wed, 14 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-314.html http://biomarket.jp/modules/pubmed_fluidigm/article-344.html Related Articles Digital PCR on a SlipChip. Lab Chip. 2010 Jul 1; Authors: Shen F, Du W, Kreutz JE, Fok A, Ismagilov RF This paper describes a SlipChip to perform digital PCR in a very simple and inexpensive format. The fluidic path for introducing the sample combined with the PCR mixture was formed using elongated wells in the two plates of the SlipChip designed to overlap during sample loading. This fluidic path was broken up by simple slipping of the two plates that removed the overlap among ... Wed, 14 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-344.html http://biomarket.jp/modules/pubmed_fluidigm/article-296.html Related Articles High-throughput quantitative polymerase chain reaction in picoliter droplets. Anal Chem. 2008 Dec 1;80(23):8975-81 Authors: Kiss MM, Ortoleva-Donnelly L, Beer NR, Warner J, Bailey CG, Colston BW, Rothberg JM, Link DR, Leamon JH Limiting dilution PCR has become an increasingly useful technique for the detection and quantification of rare species in a population, but the limit of detection and accuracy of quantification are largely determined by the number of reactions that can b ... Wed, 14 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-296.html http://biomarket.jp/modules/pubmed_fluidigm/article-345.html Related Articles Identification by a Digital Gene Expression Displayer (DGED) and test by RT-PCR analysis of new mRNA candidate markers for colorectal cancer in peripheral blood. Int J Oncol. 2010 Aug;37(2):519-525 Authors: Lauriola M, Ugolini G, Rosati G, Zanotti S, Montroni I, Manaresi A, Zattoni D, Rivetti S, Mattei G, Coppola D, Strippoli P, Taffurelli M, Solmi R Evidence from the literature widely supports the efficacy of screening for colorectal cancer (CRC) in reducing mortality. A blood- ... Wed, 14 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-345.html http://biomarket.jp/modules/pubmed_fluidigm/article-318.html Related Articles Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma. Neoplasia. 2010 Jan;12(1):20-7 Authors: Nakahara Y, Northcott PA, Li M, Kongkham PN, Smith C, Yan H, Croul S, Ra YS, Eberhart C, Huang A, Bigner D, Grajkowska W, Van Meter T, Rutka JT, Taylor MD Although medulloblastoma is the most common pediatric malignant brain tumor, its molecular underpinnings are largely unknown. We have identified rare, recurrent homozygous deletions of Kruppel-like Factor 4 ... Wed, 14 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-318.html http://biomarket.jp/modules/pubmed_fluidigm/article-304.html Related Articles Noninvasive prenatal diagnosis of fetal aneuploidies and Mendelian disorders: new innovative strategies. Expert Rev Mol Diagn. 2009 Sep;9(6):613-21 Authors: Hahn S, Jackson LG, Kolla V, Mahyuddin AP, Choolani M The application of recent technical developments, such as digital PCR or shot-gun sequencing, for the analysis of cell-free fetal DNA, have indicated that the long-sought goal of the noninvasive detection of Down syndrome may finally be attained. Although these methods ar ... Wed, 14 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-304.html http://biomarket.jp/modules/pubmed_fluidigm/article-347.html Related Articles Development of unigene-derived SSR markers in cowpea (Vigna unguiculata) and their transferability to other Vigna species. Genome. 2010 Jul;53(7):508-23 Authors: Gupta SK, Gopalakrishna T Unigene sequences available in public databases provide a cost-effective and valuable source for the development of molecular markers. In this study, the identification and development of unigene-based SSR markers in cowpea (Vigna unguiculata (L.) Walp.) is presented. A total of 1071 SSRs were ... Wed, 14 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-347.html http://biomarket.jp/modules/pubmed_fluidigm/article-346.html Related Articles Copy number variation of the SELENBP1 gene in schizophrenia. Behav Brain Funct. 2010 Jul 8;6(1):40 Authors: Amar S, Ovadia O, Maier W, Ebstein R, Belmaker RH, Mishmar D, Agam G ABSTRACT: BACKGROUND: Schizophrenia is associated with rare copy-number (CN) mutations. Screening for such alleles genome-wide, though comprehensive, cannot study in-depth the causality of particular loci, therefore cannot provide the functional interpretation for the disease etiology. We hypothesized tha ... Wed, 14 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-346.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-328.html Related Articles Chiral-auxiliary-mediated 1,2-cis-glycosylations for the solid-supported synthesis of a biologically important branched alpha-glucan. Nat Chem. 2010 Jul;2(7):552-7 Authors: Boltje TJ, Kim JH, Park J, Boons GJ Solid-phase oligosaccharide synthesis offers the promise of providing libraries of oligosaccharides for glycomics research. A major stumbling block to solid-phase oligosaccharide synthesis has been a lack of general methods for the stereoselective installation of 1,2-cis-gl ... Tue, 13 Jul 2010 01:01:18 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-328.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-329.html Related Articles Central Role of Manganese in Regulation of Stress Responses, Physiology and Metabolism in Streptococcus pneumoniae. J Bacteriol. 2010 Jul 2; Authors: Ogunniyi AD, Mahdi LK, Jennings MP, McEwan AG, McDevitt CA, Van der Hoek MB, Bagley CJ, Hoffmann P, Gould KA, Paton JC The importance of Mn(2+) for pneumococcal physiology and virulence has been studied extensively. However, the specific cellular role(s) for which Mn(2+) is required are yet to be fully elucidated. Here, we analyzed ... Tue, 13 Jul 2010 01:01:18 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-329.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-326.html Related Articles Lectin Glycoarrays technologies for Nanoscale Biomedical Detection. Protein Pept Lett. 2010 Jun 3; Authors: Chan K, Ng TB Microarray technologies have begun to feature widely in biomedical science. These techniques, allow for high throughput and quantitative analysis of protein-carbohydrate interactions. Lectin and antibody have been evaluated with these new techniques which extend to the detection of viruses and bacteria. This review outlines some of the basic principles of 'gl ... Tue, 13 Jul 2010 01:01:18 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-326.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-324.html Related Articles Site-mapping and characterization of O-glycan structures on alpha-dystroglycan isolated from rabbit skeletal muscle. J Biol Chem. 2010 May 27; Authors: Stalnaker SH, Hashmi S, Lim JM, Aoki K, Porterfield M, Gutierrez-Sanchez G, Wheeler J, Ervasti JM, Bergmann C, Tiemeyer M, Wells L The main extracellular matrix binding component of the dystrophin-glycoprotein complex (DGC), alpha-dystroglycan (alpha-DG), which was originally isolated from rabbit skeletal muscle, is an extensivel ... Tue, 13 Jul 2010 01:01:18 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-324.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-325.html Related Articles Precision mapping of an in vivo N-glycoproteome reveals rigid topological and sequence constraints. Cell. 2010 May 28;141(5):897-907 Authors: Zielinska DF, Gnad F, Wi Tue, 13 Jul 2010 01:01:18 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-325.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-323.html Related Articles Chip-based reversed-phase liquid chromatography-mass spectrometry of permethylated N-linked glycans: a potential methodology for cancer-biomarker discovery. Anal Chem. 2010 Jun 15;82(12):5095-106 Authors: Alley WR, Madera M, Mechref Y, Novotny MV The study of protein glycosylation in biological fluids and tissues has substantial medical importance, as changes in glycan structures have now been associated with a number of diseases. Quantification of glycomic-profile changes is b ... Tue, 13 Jul 2010 01:01:18 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-323.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-321.html Related Articles Preparation of regioselectively feruloylated p-nitrophenyl alpha-L-arabinofuranosides and beta-D-xylopyranosides-convenient substrates for study of feruloyl esterase specificity. Carbohydr Res. 2010 Jun 16;345(9):1094-8 Authors: Mastihubov Tue, 13 Jul 2010 01:01:18 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-321.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-319.html Related Articles Platform technology to identify potential disease markers and establish heritability and environmental determinants of the human serum N-glycome. Carbohydr Res. 2010 Apr 18; Authors: Tharmalingam T, Mari Tue, 13 Jul 2010 01:01:18 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-319.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-322.html Related Articles Enzymatic synthesis of new oligosaccharides using mannosyltransferases from Candida species and their NMR assignments. Biol Pharm Bull. 2010;33(5):895-9 Authors: Shibata N, Okawa Y The outer layer of the cell wall of pathogenic fungi, Candida species, consists of mannan, which plays an important role in infection. In this study, we synthesized several oligosaccharides using mannosyltransferases obtained from Candida parapsilosis and Candida albicans. Namely, we synthesized mann ... Tue, 13 Jul 2010 01:01:18 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-322.html 2Manalpha1-->3Manalpha1-->2Man and Manalpha1-->3(Manalpha1-->6)Manalpha1-->2Man] from mannotriose, Manalpha1-->3Manalpha1--> 2Man, and mannohexaoses [Manalpha1-->2Manalpha1-->3Manalpha1-->3Manalpha1-->2Manalpha1-->2Man and Manalpha1-->3(Manalpha1-->6)Manalpha1-->3Manalpha1-->2Manalpha1-->2Man] from mannopentaose, Manalpha1-->3Manalpha1-->3Manalpha1-->2Manalpha1-->2Man. The linkage sequence of these oligosaccharides was identified by a sequential (1)H-NMR assignment method combined with rotating frame nuclear Overhauser enhancement spectroscopy and relayed coherence transfer spectroscopy. The steric effect by the alpha-1,6-linked branching mannose residue to the H-1 proton chemical shift of the neighboring 3-O-substituted mannose residue was different from that of the 2-O-substituted mannose residue. These oligosaccharides having novel structures seem to be useful as the substrate or ligand for glycomics. PMID: 20460773 [PubMed - in process] ]]> http://biomarket.jp/modules/pubmed_sugarcomposition/article-318.html Related Articles Mass Spectrometry and Glycomics. OMICS. 2010 May 5; Authors: Zaia J Abstract Glycosylation defines the adhesive properties of animal cell surfaces and the surrounding extracellular environments. Because cells respond to stimuli by altering glycan expression, glycan structures vary according to spatial location in tissue and temporal factors. These dynamic structural expression patterns, combined with the essential roles glycans play in physiology, drive the need for analytical m ... Tue, 13 Jul 2010 01:01:18 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-318.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-320.html Related Articles Proteoglycomics: Recent Progress and Future Challenges. OMICS. 2010 May 7; Authors: Ly M, Laremore TN, Linhardt RJ Abstract Proteoglycomics is a systematic study of structure, expression, and function of proteoglycans, a posttranslationally modified subset of a proteome. Although relying on the established technologies of proteomics and glycomics, proteoglycomics research requires unique approaches for elucidating structure-function relationships of both proteoglycan components, ... Tue, 13 Jul 2010 01:01:18 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-320.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-317.html Related Articles Glycopeptidome of a heavily N-glycosylated cell surface glycoprotein of Dictyostelium implicated in cell adhesion. J Proteome Res. 2010 Jul 2;9(7):3495-510 Authors: Feasley CL, Johnson JM, West CM, Chia CP Genetic analysis has implicated the cell surface glycoprotein gp130 in cell interactions of the social amoeba Dictyostelium, and information about the utilization of the 18 N-glycosylation sequons present in gp130 is needed to identify critical molecular determinants of its a ... Tue, 13 Jul 2010 01:01:18 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-317.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-315.html Related Articles Rescue of Drosophila Melanogaster l(2)35Aa lethality is only mediated by polypeptide GalNAc-transferase pgant35A, but not by the evolutionary conserved human ortholog GalNAc-transferase-T11. Glycoconj J. 2010 May;27(4):435-44 Authors: Bennett EP, Chen YW, Schwientek T, Mandel U, Schjoldager KB, Cohen SM, Clausen H The Drosophila l(2)35Aa gene encodes a UDP-N-acetylgalactosamine: Polypeptide N-acetylgalactosaminyltransferase, essential for embryogenesis and development (J. Biol. ... Tue, 13 Jul 2010 01:01:18 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-315.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-310.html Related Articles Generating heparan sulfate saccharide libraries for glycomics applications. Nat Protoc. 2010;5(5):821-33 Authors: Powell AK, Ahmed YA, Yates EA, Turnbull JE Natural and semi-synthetic heparan sulfate (HS) saccharide libraries are a valuable resource for investigating HS structure-function relationships, enabling high-throughput glycomics studies. Owing to the difficulty of chemical or in vitro enzymatic synthesis of HS saccharides, the structural diversity displayed in sacchari ... Tue, 13 Jul 2010 01:01:18 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-310.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-313.html Related Articles Developing high-affinity boron-based receptors for cell-surface carbohydrates. Chembiochem. 2010 May 3;11(7):954-7 Authors: Houston TA PMID: 20391454 [PubMed - in process] Tue, 13 Jul 2010 01:01:18 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-313.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-309.html Related Articles Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC. Glycobiology. 2010 Jul;20(7):865-71 Authors: Nakajima K, Kitazume S, Angata T, Fujinawa R, Ohtsubo K, Miyoshi E, Taniguchi N Nucleotide sugars are important in determining cell surface glycoprotein glycosylation, which can modulate cellular properties such as growth and arrest. We have developed a conventional HPLC method for simultaneous determination of nucleotide sugars. A mixture of nucleotid ... Tue, 13 Jul 2010 01:01:18 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-309.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-311.html Related Articles Chemical approaches to glycobiology. Annu Rev Biochem. 2010;79:619-53 Authors: Kiessling LL, Splain RA Glycans are ubiquitous components of all organisms. Efforts to elucidate glycan function and to understand how they are assembled and disassembled can reap benefits in fields ranging from bioenergy to human medicine. Significant advances in our knowledge of glycan biosynthesis and function are emerging, and chemical biology approaches are accelerating the pace of discovery. No ... Tue, 13 Jul 2010 01:01:18 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-311.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-308.html Related Articles Synthesis of alkyl and cycloalkyl alpha-d-mannopyranosides and derivatives thereof and their evaluation in the mycobacterial mannosyltransferase assay. Carbohydr Res. 2010 Mar 15; Authors: Pol Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-308.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-314.html Related Articles Comparative glycomic profiling in esophageal adenocarcinoma. J Thorac Cardiovasc Surg. 2010 May;139(5):1216-23 Authors: Hammoud ZT, Mechref Y, Hussein A, Bekesova S, Zhang M, Kesler KA, Novotny MV OBJECTIVE: Aberrant glycosylation has been implicated in various types of cancers. Cancerous cells with altered glycosylation of their surface proteins shed such proteins into the circulating fluids. Glycomic profiling of such fluids shows the altered glycosylation. We performed glyco ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-314.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-307.html Related Articles Carbohydrate vaccines: developing sweet solutions to sticky situations? Nat Rev Drug Discov. 2010 Apr;9(4):308-24 Authors: Astronomo RD, Burton DR Recent technological advances in glycobiology and glycochemistry are paving the way for a new era in carbohydrate vaccine design. This is enabling greater efficiency in the identification, synthesis and evaluation of unique glycan epitopes found on a plethora of pathogens and malignant cells. Here, we review the progress being made i ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-307.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-316.html Related Articles Altered Serum Glycomics in Alzheimer Disease: A Potential Blood Biomarker? Rejuvenation Res. 2010 Apr 28; Authors: Chen CC, Engelborghs S, Dewaele S, Le Bastard N, Martin JJ, Vanhooren V, Libert C, De Deyn PP Abstract We investigated whether blood N-glycan changes can be used as a diagnostic biomarker for Alzheimer disease (AD). We used DNA sequencer-assisted, fluorophore-assisted carbohydrate electrophoresis (DSA-FACE) technology to assay N-glycans in sera from 79 autopsy-confi ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-316.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-306.html Related Articles Glycomic Analysis of Sialic Acid Linkages in Glycans Derived from Blood Serum Glycoproteins. J Proteome Res. 2010 May 5; Authors: Alley WR, Novotny MV A number of alterations to the normal glycomic profile have been previously described for a number of diseases and disorders, thus underscoring the medical importance of studying the glycans associated with proteins present in biological samples. An important alteration in cancer progression is an increased level of alpha2,6-sial ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-306.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-312.html Related Articles Marine glycobiology: current status and future perspectives. Mar Biotechnol (NY). 2010 Jun;12(3):241-52 Authors: Caldwell GS, Pagett HE Glycobiology, which is the study of the structure and function of carbohydrates and carbohydrate containing molecules, is fundamental to all biological systems.Progress in glycobiology has shed light on a range of complex biological processes associated with, for example,disease and immunology, molecular and cellular communication,and developme ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-312.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-305.html Related Articles Enzymatic Oxidation and Separation of Various Saccharides with Immobilized Glucose Oxidase. Appl Biochem Biotechnol. 2010 Mar 27; Authors: Mislovi Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-305.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-303.html Related Articles Coencapsulation of oxygen carriers and glucose oxidase in polyelectrolyte complex capsules for the enhancement of D-gluconic acid and delta-gluconolactone production. Artif Cells Blood Substit Immobil Biotechnol. 2010 Apr;38(2):90-8 Authors: Bucko M, Gemeiner P, Vikartovsk Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-303.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-292.html Related Articles Glycome profiling using modern glycomics technology: technical aspects and applications. Biol Chem. 2010 Feb-Mar;391(2-3):149-61 Authors: Vanderschaeghe D, Festjens N, Delanghe J, Callewaert N Glycomics research has become indispensable in many research fields such as immunity, signal transduction and development. Moreover, changes in the glycosylation of proteins and lipids have been reported in several diseases including cancer. The analysis of a complex post-translational mod ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-292.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-301.html Related Articles Comprehensive analysis of N-linked oligosaccharides from eggs of the family Phasianidae. Biosci Biotechnol Biochem. 2010 Mar 23;74(3):606-13 Authors: Sumiyoshi W, Nakakita S, Hasehira K, Miyanishi N, Kubo Y, Kita T, Hirabayashi J We have reported a strategic procedure for the preparation of human-type N-linked oligosaccharides targeting hen egg white and yolk. To determine whether the technique is applicable to other avian species, we performed comparative analysis of N-linked ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-301.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-291.html Related Articles Cancer biomarkers defined by autoantibody signatures to aberrant O-glycopeptide epitopes. Cancer Res. 2010 Feb 15;70(4):1306-13 Authors: Wandall HH, Blixt O, Tarp MA, Pedersen JW, Bennett EP, Mandel U, Ragupathi G, Livingston PO, Hollingsworth MA, Taylor-Papadimitriou J, Burchell J, Clausen H Autoantibodies to cancer antigens hold promise as biomarkers for early detection of cancer. Proteins that are aberrantly processed in cancer cells are likely to present autoantibody target ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-291.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-299.html Related Articles Special Issue on Carbohydrate Recognition and Applications. Preface. Med Res Rev. 2010 Mar;30(2):169-70 Authors: Sun XL PMID: 20175191 [PubMed - indexed for MEDLINE] Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-299.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-290.html Related Articles Glyco-Forum section Obituary: Alan D. Elbein (1933-2009). Glycobiology. 2010 Jan;20(4):404-5 Authors: Drake RR PMID: 20124191 [PubMed - indexed for MEDLINE] Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-290.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-297.html Related Articles Xyloglucan endotransglycosylases (XETs) from germinating nasturtium (Tropaeolum majus) seeds: isolation and characterization of the major form. Plant Physiol Biochem. 2010 Apr;48(4):207-15 Authors: Stratilov Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-297.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-289.html Related Articles Antibody-lectin sandwich arrays for biomarker and glycobiology studies. Expert Rev Proteomics. 2010 Feb;7(1):9-11 Authors: Haab BB PMID: 20121469 [PubMed - indexed for MEDLINE] Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-289.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-295.html Related Articles GlycoExtractor: a web-based interface for high throughput processing of HPLC-glycan data. J Proteome Res. 2010 Apr 5;9(4):2037-41 Authors: Artemenko NV, Campbell MP, Rudd PM Recently, an automated high-throughput HPLC platform has been developed that can be used to fully sequence and quantify low concentrations of N-linked sugars released from glycoproteins, supported by an experimental database (GlycoBase) and analytical tools (autoGU). However, commercial packages that suppor ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-295.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-288.html Related Articles Glycan and lectin microarrays for glycomics and medicinal applications. Med Res Rev. 2010 Mar;30(2):394-418 Authors: Katrl Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-288.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-293.html Related Articles The phasevarion: phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes. Nat Rev Microbiol. 2010 Mar;8(3):196-206 Authors: Srikhanta YN, Fox KL, Jennings MP In several host-adapted pathogens, phase variation has been found to occur in genes that encode methyltransferases associated with type III restriction-modification systems. It was recently shown that in the human pathogens Haemophilus influenzae, Neisseria gonorrhoeae and Neisse ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-293.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-287.html Related Articles N-glycomic changes in human breast carcinoma MCF-7 and T-lymphoblastoid cells after treatment with herceptin and herceptin/Lipoplex. J Proteome Res. 2010 Mar 5;9(3):1533-40 Authors: Lattov Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-287.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-302.html Related Articles Software utilities for the interpretation of mass spectrometric data of glycoconjugates: application to glycosphingolipids of human serum. Rapid Commun Mass Spectrom. 2010 Apr 15;24(7):1039-48 Authors: Souady J, Dadimov D, Kirsch S, Bindila L, Peter-Katalini Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-302.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-286.html Related Articles Akira Kobata: a man who established the structural basis for glycobiology of N-linked sugar chains. J Biochem. 2010 Jan;147(1):9-17 Authors: Endo T Akira Kobata is a pioneer of the glycobiology of N-linked sugar chains. He established the basis of glycobiology by developing a series of reliable methods to analyse the structures of N-linked sugar chains. The sensitive methods established by him greatly contributed to our understanding of the structural characteristics of the sug ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-286.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-298.html Related Articles Biochemical analysis of Lgt3, a glycosyltransferase of the bacterium Moraxella catarrhalis. Biochem Biophys Res Commun. 2010 Mar 19;393(4):609-13 Authors: Faglin I, Tiralongo J, Wilson JC, Collins PM, Peak IR The lipooligosaccharide (LOS) of Moraxella catarrhalis is unusual in that it lacks heptose. The sugar linking oligosaccharide to Lipid A is a trisubstituted glucose. A single enzyme, Lgt3, is suggested to trisubstitute this core sugar. The lgt3 gene encodes two distinct do ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-298.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-285.html Related Articles Alpha2,6-sialic acid on platelet endothelial cell adhesion molecule (PECAM) regulates its homophilic interactions and downstream antiapoptotic signaling. J Biol Chem. 2010 Feb 26;285(9):6515-21 Authors: Kitazume S, Imamaki R, Ogawa K, Komi Y, Futakawa S, Kojima S, Hashimoto Y, Marth JD, Paulson JC, Taniguchi N Antiangiogenesis therapies are now part of the standard repertoire of cancer therapies, but the mechanisms for the proliferation and survival of endothelial cells are not ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-285.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-294.html Related Articles The promise of glycomics, glycan arrays and carbohydrate-based vaccines. Immunopharmacol Immunotoxicol. 2010 Jun;32(2):196-207 Authors: Lepenies B, Seeberger PH Carbohydrates and glycoconjugates are involved in a number of biological processes including host-pathogen interactions, cell communication, proliferation and differentiation as well as the initiation of immune responses. However, access to synthetic oligosaccharide structures has been limited for long time since no sta ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-294.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-284.html Related Articles Isolation of bioactive compounds that relate to the anti-platelet activity of Cymbopogon ambiguus. Evid Based Complement Alternat Med. 2010 Jan 4; Authors: Grice ID, Rogers KL, Griffiths LR Infusions and decoctions of Cymbopogon ambiguus have been used traditionally in Australia for the treatment of headache, chest infections and muscle cramps. The aim of the present study was to screen and identify bioactive compounds from C. ambiguus that could explain this plant's anti-heada ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-284.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-300.html Related Articles A weighted q-gram method for glycan structure classification. BMC Bioinformatics. 2010;11 Suppl 1:S33 Authors: Li L, Ching WK, Yamaguchi T, Aoki-Kinoshita KF BACKGROUND: Glycobiology pertains to the study of carbohydrate sugar chains, or glycans, in a particular cell or organism. Many computational approaches have been proposed for analyzing these complex glycan structures, which are chains of monosaccharides. The monosaccharides are linked to one another by glycosidic bonds, w ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-300.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-283.html Related Articles N-Glycosylation profiling of turtle egg yolk: expression of galabiose structure. Carbohydr Res. 2010 Feb 11;345(3):442-8 Authors: Yagi H, Yamamoto M, Yu SY, Takahashi N, Khoo KH, Lee YC, Kato K To understand the roles of species-specific carbohydrates, systematic studies of interspecific glycan analyses are imperative. An extensive series of glycomics studies on approximately 180 kinds of bird eggs have demonstrated that 60-70% of the birds, which are closely related in phyloge ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-283.html 4)-Galp structure on their egg glycoproteins. This prompted us to investigate the glycosylation profiles of eggs from an evolutionarily related organism, a sea turtle (reptilian). We performed N-glycosylation profiling of turtle egg yolk by using HPLC mapping in conjunction with mass spectrometric methods and thereby demonstrated that the alpha-Galp-(1-->4)-Galp groups are displayed on approximately 38% of total N-glycans. Our findings suggest that the ability to express the galabiose structure was acquired at an early stage of diversification in amniotes. PMID: 20044081 [PubMed - indexed for MEDLINE] ]]> http://biomarket.jp/modules/pubmed_sugarcomposition/article-304.html Related Articles Comparative glycomics using a tetraplex stable-isotope coded tag. Anal Chem. 2010 Apr 1;82(7):3023-31 Authors: Bowman MJ, Zaia J This study illustrates the utility of tetraplex stable isotope coded tags in mass spectrometric glycomics using three carbohydrate classes. The teteraplex tags allow for the direct comparison of glycan compositions within four samples using capillary scale hydrophilic interaction chromatography with online mass spectrometry. In addition, the ability t ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-304.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-282.html Related Articles Comparison of methods for profiling O-glycosylation: Human Proteome Organisation Human Disease Glycomics/Proteome Initiative multi-institutional study of IgA1. Mol Cell Proteomics. 2010 Apr;9(4):719-27 Authors: Wada Y, Dell A, Haslam SM, Tissot B, Canis K, Azadi P, B Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-282.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-296.html Related Articles Never take candy from a stranger: the role of the bacterial glycome in host-pathogen interactions. Future Microbiol. 2010 Feb;5(2):267-88 Authors: Reid CW, Fulton KM, Twine SM With the comprehensive study and complete sequencing of the Haemophilus influenzae genome in 1995 came the term 'genomics' and the beginning of the 'omics' era. Since this time, several analogous fields, such as transcriptomics and proteomics, have emerged. While growth and advancement in these fields have ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-296.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-281.html Related Articles Identification and characterization of the aspartate chemosensory receptor of Campylobacter jejuni. Mol Microbiol. 2010 Feb;75(3):710-30 Authors: Hartley-Tassell LE, Shewell LK, Day CJ, Wilson JC, Sandhu R, Ketley JM, Korolik V Campylobacter jejuni is a highly motile bacterium that responds via chemotaxis to environmental stimuli to migrate towards favourable conditions. Previous in silico analysis of the C. jejuni strain NCTC11168 genome sequence identified 10 open reading fra ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-281.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-279.html Related Articles Sequential enrichment of sulfated glycans by strong anion-exchange chromatography prior to mass spectrometric measurements. J Am Soc Mass Spectrom. 2010 Mar;21(3):348-57 Authors: Lei M, Novotny MV, Mechref Y Structural characterization of sulfated glycans through mass spectrometry (MS) has been often limited by their low abundance in biological materials and inefficient ionization in the positive-ion mode. Here, we describe a microscale method for sequentially enriching sulfate ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-279.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-255.html Related Articles Profiling LPS glycoforms of non-typeable Haemophilus influenzae by multiple-stage tandem mass spectrometry. Methods Mol Biol. 2010;600:79-92 Authors: Schweda EK, Richards JC Non-typeable (acapsular) Haemophilus influenzae (NTHi) is a major cause of otitis media accounting for 25-30% of all cases of the disease. Lipopolysaccharide (LPS) is an essential and exposed component of the H. influenzae cell wall. A characteristic feature of H. influenzae LPS is the extensive inter-strai ... Tue, 13 Jul 2010 01:01:17 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-255.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-277.html Related Articles Threshold in stage-specific embryonic glycotypes uncovered by a full portrait of dynamic N-glycan expression during cell differentiation. Mol Cell Proteomics. 2010 Mar;9(3):523-37 Authors: Amano M, Yamaguchi M, Takegawa Y, Yamashita T, Terashima M, Furukawa J, Miura Y, Shinohara Y, Iwasaki N, Minami A, Nishimura S Although various glycoforms appear to participate independently in multiple molecular interactions in cellular adhesion that contribute to embryogenesis and organogen ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-277.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-254.html Related Articles Quantitative glycomics. Methods Mol Biol. 2010;600:31-49 Authors: Orlando R The ability to quantitatively determine changes is an essential component of comparative glycomics. Multiple strategies are available by which this can be accomplished. These include label-free approaches and strategies where an isotopic label is incorporated into the glycans prior to analysis. The focus of this chapter is to describe each of these approaches while providing insight into their strengths ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-254.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-275.html Related Articles Neisseria meningitidis serogroup B polysialyltransferase: insights into substrate binding. Chembiochem. 2010 Jan 25;11(2):170-4 Authors: B Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-275.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-253.html Related Articles Historical overview of glycoanalysis. Methods Mol Biol. 2010;600:9-30 Authors: Bielik AM, Zaia J More than half of all human proteins are glycosylated. Glycosylation defines the adhesive properties of glycoconjugates and it is largely through glycan-protein interactions that cell-cell and cell-pathogen contacts occur. Not surprisingly, considering the central role they play in molecular encounters, glycoprotein and carbohydrate-based drugs and therapeutics represent a greater t ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-253.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-273.html Related Articles Glycomics profiling of Chinese hamster ovary cell glycosylation mutants reveals N-glycans of a novel size and complexity. J Biol Chem. 2010 Feb 19;285(8):5759-75 Authors: North SJ, Huang HH, Sundaram S, Jang-Lee J, Etienne AT, Trollope A, Chalabi S, Dell A, Stanley P, Haslam SM Identifying biological roles for mammalian glycans and the pathways by which they are synthesized has been greatly facilitated by investigations of glycosylation mutants of cultured cell lines and model ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-273.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-252.html Related Articles Functional glycomics and glycobiology: an overview. Methods Mol Biol. 2010;600:1-8 Authors: Li J, Richards JC Glycomics is the study of the biological role of glycans and glycoconjugates, including glycoproteins, glycolipids, proteoglycans, and of protein-glycan interactions. This chapter outlines the scope of functional glycomics, from biological/biomedical significance to technology development. PMID: 19882117 [PubMed - indexed for MEDLINE] Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-252.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-271.html Related Articles A comprehensive HPLC analytical system for the identification and quantification of hexoses that employs 2-aminobenzamide coupling. J Biochem. 2010 Apr;147(4):501-9 Authors: Hasehira K, Nakakita S, Miyanishi N, Sumiyoshi W, Hayashi S, Takegawa K, Hirabayashi J Rare sugars are defined as monosaccharides with extremely low natural abundances. Their natural distributions and biological functions remain to be clarified. To establish a robust analytical system that can separate, ide ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-271.html 75%) for both aldohexoses and ketohexoses. The calibration curve determined for the rare ketohexose, d-psicose (Psi), was linear between 1 pmol and 1 micromol and had a correlation coefficient of 0.9999. Using the developed method, the psicose content in a leaf of Itea virginica, in which the presence of psicose has previously been reported, was found to be 2.7 mg psicose/g leaf. The result proved feasibility of the method even for natural products. Because the system is a comprehensive tool, it should help answer questions concerning the biosyntheses and functions of rare hexose sugars. PMID: 19948774 [PubMed - in process] ]]> http://biomarket.jp/modules/pubmed_sugarcomposition/article-251.html Related Articles The plasma von Willebrand factor O-glycome comprises a surprising variety of structures including ABH antigens and disialosyl motifs. J Thromb Haemost. 2010 Jan;8(1):137-45 Authors: Canis K, McKinnon TA, Nowak A, Panico M, Morris HR, Laffan M, Dell A BACKGROUND: von Willebrand factor (VWF) is a key component for maintenance of normal hemostasis. Its glycan moieties, accounting for about 20% of its molecular weight, have been shown to affect many of its properties. Previous stud ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-251.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-269.html Related Articles Chemo-enzymatic synthesis and functional analysis of natural and modified glycostructures. Nat Prod Rep. 2009 Dec;26(12):1555-71 Authors: Homann A, Seibel J The advancing field of glycomics is driven by the development of new analysis and synthesis techniques and novel strategies such as metabolic glyco-labeling. In this review we will present strategies for tailoring chemo-enzymatic glycosyltransfer reactions, screening methods such as carbohydrate-based micro-arrays, and meta ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-269.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-250.html Related Articles Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles. Org Biomol Chem. 2009 Nov 21;7(22):4715-25 Authors: Andr Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-250.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-267.html Related Articles A strategy for discovery of cancer glyco-biomarkers in serum using newly developed technologies for glycoproteomics. FEBS J. 2010 Jan;277(1):95-105 Authors: Narimatsu H, Sawaki H, Kuno A, Kaji H, Ito H, Ikehara Y Detection of cancer at early stages that can be treated through surgery is a difficult task. One methodology for cancer biomarker discovery exploits the fact that glycoproteins produced by cancer cells have altered glycan structures, although the proteins themselves ar ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-267.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-249.html Related Articles Characterisation of oxidized recombinant human galectin-1. Protein Pept Lett. 2009;16(10):1249-55 Authors: Scott SA, Bugarcic A, Blanchard H Oxidized human galectin-1 plays a role in the immune response to injured axons. Over-expression of galectin-1 by cancer, in combination with cancer associated oxidative stress suggests oxidized human galectin-1 may also play a role(s) in tumourigenesis. Here we generate milligram quantities of oxidized human galectin-1 and undertake biophys ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-249.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-265.html Related Articles Photoimmobilization of unmodified carbohydrates on activated surface. J Colloid Interface Sci. 2010 Feb 1;342(1):202-4 Authors: Sharma P, Basir SF, Nahar P Herein, we demonstrate a simple, versatile and efficient method for immobilization of unmodified carbohydrates onto a solid surface. The method employs a photoreactive-cellulose membrane which is prepared by the introduction of a photoreactive group to a cellulose membrane through 1-fluoro-2-nitro-4-azidobenzene (FNAB). Upon ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-265.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-248.html Related Articles Glycome and transcriptome regulation of vasculogenesis. Circulation. 2009 Nov 10;120(19):1883-92 Authors: Harfouche R, Hentschel DM, Piecewicz S, Basu S, Print C, Eavarone D, Kiziltepe T, Sasisekharan R, Sengupta S BACKGROUND: Therapeutic vasculogenesis is an emerging concept that can potentially be harnessed for the management of ischemic pathologies. The present study elucidates the potential coregulation of vasculogenesis by the heparan sulfate glycosaminoglycan-rich cell-su ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-248.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-263.html Related Articles Fungal glucuronoyl esterases and substrate uronic acid recognition. Biosci Biotechnol Biochem. 2009 Nov;73(11):2483-7 Authors: Duranov Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-263.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-247.html Related Articles From the gamma-glutamyl cycle to the glycan cycle: a road with many turns and pleasant surprises. J Biol Chem. 2009 Dec 11;284(50):34469-78 Authors: Taniguchi N PMID: 19840938 [PubMed - indexed for MEDLINE] Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-247.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-261.html Related Articles Bioinformatics in glycomics: glycan characterization with mass spectrometric data using SimGlycan. Methods Mol Biol. 2010;600:269-81 Authors: Apte A, Meitei NS Mass spectrometry (MS), with its low sample requirement and high sensitivity, has been the predominantly used methodology for characterization and elucidation of glycan structures. However, manual interpretation of MS data is complex and tedious due to large number of product ions observed and also due to the variation i ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-261.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-246.html Related Articles The glycobiology of brain tumors: disease relevance and therapeutic potential. Expert Rev Neurother. 2009 Oct;9(10):1529-45 Authors: Moskal JR, Kroes RA, Dawson G The oligosaccharides that decorate cell surface glycoconjugates play important roles in intercellular recognition and cell-extracellular matrix interactions, and thus the regulation of cellular migration, metastasis and invasivity. Virtually all tumor cells display aberrant cell-surface glycosylation patterns brought a ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-246.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-259.html Related Articles A glycomics approach to the discovery of potential cancer biomarkers. Methods Mol Biol. 2010;600:199-213 Authors: An HJ, Lebrilla CB Glycosylation is highly sensitive to the biochemical environment and plays a key role in development and disease manifestation. Moreover, glycan biosynthesis depends on several highly competitive processes; thus, variations in the concentration of specific glycosyltransferases produce different products. For this reason, monitoring changes in glyc ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-259.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-245.html Related Articles Determination of sulfation pattern in brain glycosaminoglycans by chip-based electrospray ionization ion trap mass spectrometry. Anal Bioanal Chem. 2009 Dec;395(8):2489-98 Authors: Flangea C, Schiopu C, Sisu E, Serb A, Przybylski M, Seidler DG, Zamfir AD Chondroitin sulfate (CS) and dermatan sulfate (DS) glycosaminoglycans display variability of sulfation in their constituent disaccharide repeats during chain elongation. Since a large proportion of the extracellular matrix of t ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-245.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-257.html Related Articles Metabolomics in glycomics. Methods Mol Biol. 2010;600:175-86 Authors: Soo EC, Hui JP Metabolomics is essentially the study of all low molecular weight molecules in a biological system under defined conditions. In glycomics, there is much potential to gain insight into the biosynthesis of novel glycoconjugate structures by probing the metabolome for substrates that are suspected, or known, to be involved in the biosynthetic processes. Recently, we employed the use of hydrophilic ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-257.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-244.html Related Articles Glycans on influenza hemagglutinin affect receptor binding and immune response. Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18137-42 Authors: Wang CC, Chen JR, Tseng YC, Hsu CH, Hung YF, Chen SW, Chen CM, Khoo KH, Cheng TJ, Cheng YS, Jan JT, Wu CY, Ma C, Wong CH Recent cases of avian influenza H5N1 and the swine-origin 2009 H1N1 have caused a great concern that a global disaster like the 1918 influenza pandemic may occur again. Viral transmission begins with a critical intera ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-244.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-327.html Related Articles Alteration of N-glycome in diethylnitrosamine-induced hepatocellular carcinoma mice: a non-invasive monitoring tool for liver cancer. Liver Int. 2010 May 26; Authors: Liu XE, Dewaele S, Vanhooren V, Fan YD, Wang L, Van Huysse J, Zhuang H, Contreras R, Libert C, Chen CC Abstract Background and aims: There is a demand for serum markers that can routinely assess the progression of liver cancer. DENA (diethylnitrosamine), a hepatocarcinogen, is commonly used in an experimental mous ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-327.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-243.html Related Articles Vibrio cholerae O1 Ogawa detoxified lipopolysaccharide structures as inducers of cytokines and oxidative species in macrophages. J Med Microbiol. 2010 Feb;59(Pt 2):158-64 Authors: Paulovicov Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-243.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-276.html Related Articles Improved hydrophilic interaction chromatography LC/MS of heparinoids using a chip with postcolumn makeup flow. Anal Chem. 2010 Jan 15;82(2):516-22 Authors: Staples GO, Naimy H, Yin H, Kileen K, Kraiczek K, Costello CE, Zaia J Heparan sulfate (HS) and heparin are linear, heterogeneous carbohydrates of the glycosaminoglycan (GAG) family that are modified by N-acetylation, N-sulfation, O-sulfation, and uronic acid epimerization. HS interacts with growth factors in the extracellula ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-276.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-242.html Related Articles OMICS-rooted studies of milk proteins, oligosaccharides and lipids. J Proteomics. 2009 Dec 1;73(2):196-208 Authors: Casado B, Affolter M, Kussmann M Milk has co-evolved with mammals and mankind to nourish their offspring and is a biological fluid of unique complexity and richness. It contains all necessary nutrients for the growth and development of the newborn. Structure and function of biomolecules in milk such as the macronutrients (glyco-) proteins, lipids, and oligosacchar ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-242.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-272.html Related Articles Altered serum N-glycomics in chronic hepatitis B patients. Liver Int. 2010 Feb;30(2):259-67 Authors: Gui HL, Gao CF, Wang H, Liu XE, Xie Q, Dewaele S, Wang L, Zhuang H, Contreras R, Libert C, Chen C BACKGROUND: We previously reported on serum N-glycans as markers for the diagnosis of cirrhosis in patients with chronic hepatitis C infection. Our present study aimed to evaluate the use of serum glycan markers for the diagnosis of liver fibrosis in patients with chronic hepatitis ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-272.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-241.html Related Articles Carbohydrate cluster microarrays fabricated on three-dimensional dendrimeric platforms for functional glycomics exploration. J Proteome Res. 2009 Nov;8(11):5031-40 Authors: Zhou X, Turchi C, Wang D We reported here a novel, ready-to-use bioarray platform and methodology for construction of sensitive carbohydrate cluster microarrays. This technology utilizes a three-dimensional (3-D) poly(amidoamine) starburst dendrimer monolayer assembled on glass surface, which is functionaliz ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-241.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-268.html Related Articles Glycan array: a powerful tool for glycomics studies. Expert Rev Proteomics. 2009 Dec;6(6):631-45 Authors: Liang CH, Wu CY Glycan arrays have become a powerful tool for the high-throughput elucidation of interactions of different carbohydrate structures with a wide variety of biological targets, including antibodies, proteins, viruses and cells. This technique is especially suitable for glycomics studies, because arrays present carbohydrate ligands in a manner that mimics interac ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-268.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-240.html Related Articles Mechanistic investigation of the endo-alpha-N-acetylgalactosaminidase from Streptococcus pneumoniae R6. Biochemistry. 2009 Nov 3;48(43):10334-41 Authors: Willis LM, Zhang R, Reid A, Withers SG, Wakarchuk WW The large (1767-amino acid) endo-alpha-N-acetylgalactosaminidase from Streptococcus pneumoniae (SpGH101) specifically removes an O-linked disaccharide Gal-beta-1,3-GalNAc-alpha from glycoproteins. While the enzyme from natural sources has been used as a reagent for many year ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-240.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-264.html Related Articles Symbol nomenclature for glycan representation. Proteomics. 2009 Dec;9(24):5398-9 Authors: Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Marth JD, Bertozzi CR, Hart GW, Etzler ME The glycan symbol nomenclature proposed by Harvey et al. in these pages has relative advantages and disadvantages. The use of symbols to depict glycans originated from Kornfeld in 1978, was systematized in the First Edition of "Essentials of Glycobiology" and updated for the second edition, with ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-264.html 200 illustrations in the second edition have already been published using our nomenclature and are available for download at PubMed. PMID: 19902428 [PubMed - indexed for MEDLINE] ]]> http://biomarket.jp/modules/pubmed_sugarcomposition/article-239.html Related Articles Glycomics and disease markers. Curr Opin Chem Biol. 2009 Dec;13(5-6):601-7 Authors: An HJ, Kronewitter SR, de Leoz ML, Lebrilla CB Glycomics is the comprehensive study of all glycans expressed in biological systems. The biosynthesis of glycan relies on a number of highly competitive processes involving glycosyl transferases. Glycosylation is therefore highly sensitive to the biochemical environment and has been implicated in many diseases including cancer. Recently, interest in ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-239.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-260.html Related Articles N-linked protein glycosylation in a bacterial system. Methods Mol Biol. 2010;600:227-43 Authors: Nothaft H, Liu X, McNally DJ, Szymanski CM N-Linked protein glycosylation is conserved throughout the three domains of life and influences protein function, stability, and protein complex formation. N-Linked glycosylation is an essential process in Eukaryotes; however, although N-glycosylation affects multiple cellular processes in Archaea and Bacteria, it is not needed for cell sur ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-260.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-238.html Related Articles Analysis of bacterial lipid-linked oligosaccharide intermediates using porous graphitic carbon liquid chromatography-electrospray ionization mass spectrometry: heterogeneity in the polyisoprenyl carrier revealed. Anal Chem. 2009 Oct 15;81(20):8472-8 Authors: Reid CW, Stupak J, Szymanski CM, Li J N-glycosylation of proteins is recognized as one of the most common post-translational modifications. It was believed that N-glycosylation occurred exclusively in eukaryotes until the r ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-238.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-256.html Related Articles The application of NMR spectroscopy to functional glycomics. Methods Mol Biol. 2010;600:155-73 Authors: Brisson JR, Vinogradov E, McNally DJ, Khieu NH, Schoenhofen IC, Logan SM, Jarrell H Glycomics which is the study of saccharides and genes responsible for their formation requires the continuous development of rapid and sensitive methods for the identification of glycan structures. It involves glycoanalysis which relies upon the development of methods for determining the struc ... Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-256.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-237.html Related Articles Iodine-promoted ribosylation leads to a facile acetonide-forming reaction. Carbohydr Res. 2009 Nov 2;344(16):2240-4 Authors: Houston TA, Koreeda M Iodine not only promotes smooth beta-selective glycosylation of ribose tetra-acetate under exceptionally mild conditions, it also catalyzes an expedient acetonide-forming reaction in this system when dry acetone is used as a solvent. PMID: 19765691 [PubMed - indexed for MEDLINE] Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-237.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-274.html Related Articles Polysaccharide microarrays for high-throughput screening of transglycosylase activities in plant extracts. Glycoconj J. 2010 Jan;27(1):79-87 Authors: Kos Tue, 13 Jul 2010 01:01:16 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-274.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-236.html Related Articles Fluorescent glycan derivatives: their use for natural glycan microarrays. ACS Chem Biol. 2009 Sep 18;4(9):699-701 Authors: Park S, Sung JW, Shin I Glycan microarrays have become powerful tools in the investigation of biological systems because they enable fast, quantitative, and simultaneous analysis of glycan-protein interactions with small quantities of samples. One hurdle in the construction of glycan microarrays is to obtain a diverse set of glycans for immobilization on su ... Tue, 13 Jul 2010 01:01:15 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-236.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-266.html Related Articles Chemoenzymatic synthesis and lectin array characterization of a class of N-glycan clusters. J Am Chem Soc. 2009 Dec 16;131(49):17963-71 Authors: Huang W, Wang D, Yamada M, Wang LX N-Glycans are major components of many glycoproteins. These sugar moieties are frequently involved in important physiological and disease processes via their interactions with a variety of glycan-binding proteins (GBP). Clustering effect is an important feature in many glycan-lectin interactions. We de ... Tue, 13 Jul 2010 01:01:15 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-266.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-235.html Related Articles A Glyco-mix of Approaches To Studying Carbohydrates. ACS Chem Biol. 2009 Sep 18;4(9):685-6 Authors: Martens E PMID: 19761247 [PubMed - indexed for MEDLINE] Tue, 13 Jul 2010 01:01:15 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-235.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-258.html Related Articles Characterization of lipid-linked oligosaccharides by mass spectrometry. Methods Mol Biol. 2010;600:187-97 Authors: Reid CW, Stupak J, Szymanski CM N- Glycosylation of proteins is recognized as one of the most common post-translational modifications. Until recently it was believed that N-glycosylation occurred exclusively in eukaryotes until the discovery of the general protein glycosylation pathway (Pgl) in Campylobacter jejuni. We have developed a new glycomics strategy based ... Tue, 13 Jul 2010 01:01:15 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-258.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-234.html Related Articles Glycome-DB.org: a portal for querying across the digital world of carbohydrate sequences. Glycobiology. 2009 Dec;19(12):1563-7 Authors: Ranzinger R, Frank M, von der Lieth CW, Herget S Despite ongoing harmonization efforts, the major carbohydrate sequence databases following the first initiative in this field, CarbBank, are still isolated islands, with mechanisms for automatic structure exchange and comparison largely missing. This unfavorable situation has been overcome with a ... Tue, 13 Jul 2010 01:01:15 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-234.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-270.html Related Articles Preparation of synthetic polyoxazoline based carrier and Vibrio cholerae O-specific polysaccharide conjugate vaccine. Eur J Med Chem. 2010 Feb;45(2):795-9 Authors: Farkas P, Korcov Tue, 13 Jul 2010 01:01:15 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-270.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-233.html Related Articles The repertoire of glycan determinants in the human glycome. Mol Biosyst. 2009 Oct;5(10):1087-104 Authors: Cummings RD The number of glycan determinants that comprise the human glycome is not known. This uncertainty arises from limited knowledge of the total number of distinct glycans and glycan structures in the human glycome, as well as limited information about the glycan determinants recognized by glycan-binding proteins (GBPs), which include lectins, receptors, toxins, micr ... Tue, 13 Jul 2010 01:01:15 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-233.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-278.html Related Articles Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and -IVb double deficient mice. Glycobiology. 2010 Jan;20(4):485-97 Authors: Takamatsu S, Antonopoulos A, Ohtsubo K, Ditto D, Chiba Y, Le DT, Morris HR, Haslam SM, Dell A, Marth JD, Taniguchi N N-Acetylglucosaminyltransferase-IV (GnT-IV) has two isoenzymes, GnT-IVa and GnT-IVb, which initiate the GlcNAcbeta1-4 branch synthesis on the Manalpha1-3 arm of the N-glycan core thereby increasing N-glyca ... Tue, 13 Jul 2010 01:01:15 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-278.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-262.html Related Articles How does a medical doctor become a glycobiologist. Biochim Biophys Acta. 2009 Sep;1792(9):824 Authors: Hennet T PMID: 19894337 [PubMed - indexed for MEDLINE] Tue, 13 Jul 2010 01:01:15 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-262.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-280.html Related Articles Programmable nano-bio-chips: multifunctional clinical tools for use at the point-of-care. Nanomedicine (Lond). 2010 Jan;5(1):143-55 Authors: Jokerst JV, McDevitt JT A new generation of programmable diagnostic devices is needed to take advantage of information generated from the study of genomics, proteomics, metabolomics and glycomics. This report describes the 'programmable nano-bio-chip' with potential to bridge the significant scientific, technology and clinical gaps through ... Tue, 13 Jul 2010 01:01:15 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-280.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-232.html Related Articles Quantitative glycomics from fluidic glycan microarrays. J Am Chem Soc. 2009 Sep 30;131(38):13646-50 Authors: Zhu XY, Holtz B, Wang Y, Wang LX, Orndorff PE, Guo A A hallmark of cell-surface processes involving glycans is their multivalent interaction with glycan binding proteins (GBPs). Such a multivalent interaction depends critically on the mobility and density of signaling molecules on the membrane surface. While glycan microarrays have been used in exploring multivalent inter ... Tue, 13 Jul 2010 01:01:15 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-232.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-231.html Related Articles Development of a microtiter plate-based glycosaminoglycan array for the investigation of glycosaminoglycan-protein interactions. Glycobiology. 2009 Dec;19(12):1537-46 Authors: Marson A, Robinson DE, Brookes PN, Mulloy B, Wiles M, Clark SJ, Fielder HL, Collinson LJ, Cain SA, Kielty CM, McArthur S, Buttle DJ, Short RD, Whittle JD, Day AJ The interactions of glycosaminoglycans (GAGs) with proteins underlie a wide range of important biological processes. However, the study of such ... Tue, 13 Jul 2010 01:01:15 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-231.html http://biomarket.jp/modules/pubmed_seldi/article-105.html Related Articles SELDI-TOF serum proteomics and colorectal cancer: A current overview. Arch Physiol Biochem. 2010 Jul 8; Authors: Gemoll T, Roblick UJ, Auer G, Jörnvall H, Habermann JK Surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) is a widely used technology platform for diagnostic biomarker discovery in tissue, plasma and serum. High-throughput and simplicity of experimental procedures have allowed this technology to become an important researc ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-105.html http://biomarket.jp/modules/pubmed_seldi/article-155.html Related Articles Discovery and identification of potential biomarkers of papillary thyroid carcinoma. Mol Cancer. 2009;8:79 Authors: Fan Y, Shi L, Liu Q, Dong R, Zhang Q, Yang S, Fan Y, Yang H, Wu P, Yu J, Zheng S, Yang F, Wang J ABSTRACT: BACKGROUND: Thyroid carcinoma is the most common endocrine malignancy and a common cancer among the malignancies of head and neck. Noninvasive and convenient biomarkers for diagnosis of papillary thyroid carcinoma (PTC) as early as possible remain an urgent n ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-155.html http://biomarket.jp/modules/pubmed_seldi/article-107.html Related Articles Targeted serum glycoproteomics for the discovery of lung cancer-associated glycosylation disorders using lectin-coupled ProteinChip arrays. Proteomics. 2009 Apr;9(8):2182-92 Authors: Ueda K, Fukase Y, Katagiri T, Ishikawa N, Irie S, Sato TA, Ito H, Nakayama H, Miyagi Y, Tsuchiya E, Kohno N, Shiwa M, Nakamura Y, Daigo Y To screen for glycoproteins showing aberrant sialylation patterns in sera of cancer patients and apply such information for biomarker identification, we performe ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-107.html http://biomarket.jp/modules/pubmed_seldi/article-156.html Related Articles Detection of breast cancer by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry tissue and serum protein profiling. Int J Biol Markers. 2009 Jul-Sep;24(3):130-41 Authors: Gast MC, van Dulken EJ, van Loenen TK, Kingma-Vegter F, Westerga J, Flohil CC, Knol JC, Jimenez CR, van Gils CH, Wessels LF, Schellens JH, Beijnen JH AIM: Novel diagnostic breast cancer markers have been extensively searched for in the proteome, using, among others, surface-enhanced ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-156.html http://biomarket.jp/modules/pubmed_seldi/article-109.html Related Articles Evaluation of two different albumin depletion strategies for improved analysis of human CSF by SELDI-TOF-MS. Clin Biochem. 2009 Jul;42(10-11):1136-43 Authors: Siegmund R, Kiehntopf M, Deufel T OBJECTIVES: Two different depletion strategies for removing albumin from human cerebrospinal fluid (CSF), Microcon Centrifugal Filter vs. Montage Albumin Deplete kit, were evaluated for improving protein profiling pattern and reproducibility in SELDI analysis. DESIGN AND METHODS: Pooled C ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-109.html http://biomarket.jp/modules/pubmed_seldi/article-157.html Related Articles Cytokeratin 8/18 as a new marker of mouse liver preneoplastic lesions. Toxicol Appl Pharmacol. 2010 Jan 1;242(1):47-55 Authors: Kakehashi A, Kato A, Inoue M, Ishii N, Okazaki E, Wei M, Tachibana T, Wanibuchi H To search for a reliable biomarker of preneoplastic lesions arising early in mouse hepatocarcinogenesis the proteomes of microdissected basophilic foci, hepatocellular adenomas (HCAs), carcinomas (HCCs) and normal-appearing liver of B6C3F1 mice initiated with diethylnitro ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-157.html http://biomarket.jp/modules/pubmed_seldi/article-111.html Related Articles Identification of biomarkers for risk stratification of cardiovascular events using genetic algorithm with recursive local floating search. Proteomics. 2009 Apr;9(8):2286-94 Authors: Zhou X, Wang H, Wang J, Wang Y, Hoehn G, Azok J, Brennan ML, Hazen SL, Li K, Chang SF, Wong ST Conventional biomarker discovery focuses mostly on the identification of single markers and thus often has limited success in disease diagnosis and prognosis. This study proposes a method to identify an o ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-111.html http://biomarket.jp/modules/pubmed_seldi/article-158.html Related Articles Serum proteomics of glioma: methods and applications. Expert Rev Mol Diagn. 2009 Oct;9(7):695-707 Authors: Somasundaram K, Nijaguna MB, Kumar DM The prognosis of patients with glioblastoma, the most malignant adult glial brain tumor, remains poor in spite of advances in treatment procedures, including surgical resection, irradiation and chemotherapy. Genetic heterogeneity of glioblastoma warrants extensive studies in order to gain a thorough understanding of the biology of this ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-158.html http://biomarket.jp/modules/pubmed_seldi/article-113.html Related Articles Analysis of serum proteome profiles of non-Hodgkin lymphoma for biomarker identification. J Proteomics. 2009 Aug 20;72(6):952-9 Authors: Zhang MZ, Sun ZC, Fu XR, Nan FF, Fan QX, Wu XA, Geng L, Ma W, Wang RL Serum samples from non-Hodgkin lymphoma (NHL) patients who had not undergone chemotherapy, lymphnoditis patients, and healthy adults were analyzed using surface-enhanced laser desorption-ionization time-of-flight mass spectrometry (SELDI-TOF MS) to detect the differentially ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-113.html http://biomarket.jp/modules/pubmed_seldi/article-159.html Related Articles [Classification and diagnostic prediction of colorectal cancer using protein profiling of serum and bioinformatics] Zhejiang Da Xue Xue Bao Yi Xue Ban. 2009 Sep;38(5):470-7 Authors: Chen YD, Xie PP, Yu JW, Zhou J, Zheng S OBJECTIVE: To develop a bioinformatic tool and to use it to identify proteomic patterns in serum, distinguishing colorectal cancer from colorectal adenoma and healthy individuals. METHODS: 182 serum samples including 55 colorectal cancer patients, 35 colorectal ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-159.html http://biomarket.jp/modules/pubmed_seldi/article-115.html Related Articles Can serum apolipoprotein C-I demonstrate metabolic abnormality early in women with polycystic ovary syndrome? Fertil Steril. 2010 Jun;94(1):205-10 Authors: Huang S, Qiao J, Li R, Wang L, Li M OBJECTIVE: To evaluate the role of apolipoprotein C-I (apoC-I) levels and assess relationships between apoC-I and clinical features in women with polycystic ovary syndrome (PCOS). DESIGN: Prospective study. SETTING: Reproductive Center of Peking University Third Hospital. PATIENT(S): Thirt ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-115.html http://biomarket.jp/modules/pubmed_seldi/article-160.html Related Articles Proteomic profiling in distinct cellular compartments of tumor cells reveals p53-dependent upregulation of S100A6 upon induction of telomere dysfunction. Proteomics. 2009 Nov;9(22):5175-87 Authors: Zimmermann S, Biniossek ML, Maurer C, MÃ?nzer P, Pantic M, Veelken H, Martens UM Telomere dysfunction is evoking a DNA damage response which leads to replicative senescence or apoptosis. Tumor cells feature telomerase, a ribonucleoprotein complex counteracting telomere shortening a ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-160.html http://biomarket.jp/modules/pubmed_seldi/article-117.html Related Articles SELDI-TOF MS detection of urinary hepcidin. Biochimie. 2009 Oct;91(10):1335-8 Authors: Altamura S, Kiss J, Blattmann C, Gilles W, Muckenthaler MU Hepcidin is a 25-residue hepatic peptide that regulates iron absorption from the diet and tissue iron distribution. Inappropriately low Hepcidin expression is implicated in the pathogenesis of hereditary hemochromatosis and iron-loading anemias, like the thalassemias. Increased hepcidin expression mediates iron retention in the anemia ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-117.html http://biomarket.jp/modules/pubmed_seldi/article-161.html Related Articles SELDI-TOF biomarker signatures for cystic fibrosis, asthma and chronic obstructive pulmonary disease. Clin Biochem. 2010 Jan;43(1-2):168-77 Authors: Gomes-Alves P, Imrie M, Gray RD, Nogueira P, Ciordia S, Pacheco P, Azevedo P, Lopes C, de Almeida AB, Guardiano M, Porteous DJ, Albar JP, Boyd AC, Penque D OBJECTIVES: The aim of this work was to establish protein profiles in serum and nasal epithelial cells of cystic fibrosis individuals in comparison with controls, asthma and chr ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-161.html http://biomarket.jp/modules/pubmed_seldi/article-119.html Related Articles The use of laser microdissection and SELDI-TOF MS in ovarian cancer tissue to identify protein profiles. Anticancer Res. 2009 Apr;29(4):1039-45 Authors: Cadron I, Van Gorp T, Amant F, Vergote I, Moerman P, Waelkens E, Daemen A, Van De Plas R, De Moor B, Zeillinger R BACKGROUND: There is a strong need for prognostic biomarkers in ovarian cancer patients due to the heterogeneous responses on current treatment modalities. MATERIALS AND METHODS: This study investigates the feasibil ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-119.html http://biomarket.jp/modules/pubmed_seldi/article-162.html Related Articles Ubiquitin as potential cerebrospinal fluid marker of Creutzfeldt-Jakob disease. Proteomics. 2010 Jan;10(1):81-9 Authors: Steinacker P, Rist W, Swiatek-de-Lange M, Lehnert S, Jesse S, Pabst A, Tumani H, von Arnim CA, Mitrova E, Kretzschmar HA, Lenter M, Wiltfang J, Otto M Until today, a definite diagnosis of Creutzfeldt-Jakob disease (CJD) can only be made neuropathologically. At lifetime the early and differential diagnosis is often a problem. With SELDI we analyzed cerebrospin ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-162.html http://biomarket.jp/modules/pubmed_seldi/article-121.html Related Articles Evaluation of relaxin's antifibrotic action by SELDI-TOF mass spectrometry-based profiling of relaxin knockout mice, a model of progressive fibrosis. Ann N Y Acad Sci. 2009 Apr;1160:350-2 Authors: Giannakis E, Macris M, Chan L, Tregear GW, Samuel CS, Wade JD Surface-enhanced laser desorption ionization-time-of-flight mass spectrometry was employed to identify potential biomarkers for early-onset fibrosis. These biomarkers were then used to evaluate the efficacy of relaxin to re ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-121.html http://biomarket.jp/modules/pubmed_seldi/article-163.html Related Articles [Profiles of low-molecular proteome spectrum obtained through SELDI-TOF mass spectrometry in the sera of patients with metastatic malignant melanoma: pilot study] Klin Onkol. 2009;22(5):228-32 Authors: LakomÃ? R, Greplová K, PilnÃ? R, Budinská E, ValÃ?k D, Poprach A, Nemecek R, Vyzula R BACKGROUNDS: Recently, research at genetic and molecular levels has extensively accelerated due to advances in new technologies. Since the mid-90s, a relatively new discipline--cl ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-163.html http://biomarket.jp/modules/pubmed_seldi/article-123.html Related Articles SELDI protein chip technology for the detection of serum biomarkers for liver disease. Protein Pept Lett. 2009;16(5):467-72 Authors: Chen L, Fatima S, Peng J, Leng X The need to identify disease biomarkers is critical to ensure fast diagnosis and timely treatment. Surface enhanced laser desorption/ionization time-of-fight mass spectrometry (SELDI-TOF-MS) is a widely used technology platform for diagnostic biomarker discovery. This short review provides an overview of how it func ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-123.html http://biomarket.jp/modules/pubmed_seldi/article-164.html Related Articles Protein biomarker analysis of primary Peyronie's disease cells. J Sex Med. 2010 Jan;7(1 Pt 1):99-106 Authors: De Young LX, Bella AJ, O'Gorman DB, Gan BS, Lim KB, Brock GB INTRODUCTION: The molecular pathogenesis of Peyronie's Disease (PD) remains unclear more than 250 years after its initial description. Because of this, no test is currently available to accurately predict PD progression among those affected. AIM: To investigate the expression of wound healing and fibrosis-asso ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-164.html http://biomarket.jp/modules/pubmed_seldi/article-125.html Related Articles SELDI-TOF-MS-based serum proteomic screening in combination with CT scan distinguishes renal cell carcinoma from benign renal tumors and healthy persons. Technol Cancer Res Treat. 2009 Jun;8(3):225-30 Authors: Xu G, Xiang CQ, Lu Y, Wang WJ, Kang XN, Liao P, Ding Q, Zhang YF In order to identify the proteomic differences between renal cell carcinoma (RCC) and benign renal tumors, we analyzed 168 serum samples from 65 RCC patients, 34 patients with benign renal tumors, and 69 heal ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-125.html http://biomarket.jp/modules/pubmed_seldi/article-165.html Related Articles Identification of a truncated cystatin SA-I as a saliva biomarker for oral squamous cell carcinoma using the SELDI ProteinChip platform. Int J Oral Maxillofac Surg. 2010 Jan;39(1):68-74 Authors: Shintani S, Hamakawa H, Ueyama Y, Hatori M, Toyoshima T New and more consistent biomarkers of oral squamous cell carcinoma (OSCC) are needed to improve early detection of the disease and to monitor patient management. The aim of this study was to detect new OSCC tumor markers in saliva. ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-165.html http://biomarket.jp/modules/pubmed_seldi/article-127.html Related Articles Surface-enhanced Laser Desorption/Ionisation Time-of-flight Mass Spectrometry to Detect Breast Cancer Markers in Tears and Serum. Cancer Genomics Proteomics. 2009 Mar-Apr;6(2):75-83 Authors: Lebrecht A, Boehm D, Schmidt M, Koelbl H, Grus FH BACKGROUND: New biomarkers are needed to improve the early detection of breast cancer. This study describes the use of surface-enhanced laser desorption/ionisation time-of-flight mass spectroscopy (SELDI-TOF-MS) in serum and tear fluid. MATE ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-127.html http://biomarket.jp/modules/pubmed_seldi/article-166.html Related Articles A computational platform for MALDI-TOF mass spectrometry data: application to serum and plasma samples. J Proteomics. 2010 Jan 3;73(3):562-70 Authors: Mantini D, Petrucci F, Pieragostino D, Del Boccio P, Sacchetta P, Candiano G, Ghiggeri GM, Lugaresi A, Federici G, Di Ilio C, Urbani A BACKGROUND: Mass spectrometry (MS) is becoming the gold standard for biomarker discovery. Several MS-based bioinformatics methods have been proposed for this application, but the divergence of the ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-166.html http://biomarket.jp/modules/pubmed_seldi/article-129.html Related Articles Detection of growth hormone responsive proteins using SELDI-TOF mass spectrometry. Growth Horm IGF Res. 2009 Aug;19(4):383-7 Authors: Chung L, Baxter RC The detection of growth hormone (GH) doping is a significant problem in elite sports. GH is secreted in a pulsatile pattern from the anterior pituitary, influenced by a variety of normal and pathophysiological conditions. Exogenous recombinant hGH is virtually indistinguishable from the predominant naturally occurring isoform a ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-129.html http://biomarket.jp/modules/pubmed_seldi/article-167.html Related Articles Detection and identification of potential biomarkers of non-small cell lung cancer. Technol Cancer Res Treat. 2009 Dec;8(6):455-66 Authors: Yang Y, Zhao S, Fan Y, Zhao F, Liu Q, Hu W, Liu D, Fan K, Wang J, Wang J The aim of this study was to discover and identify potential protein biomarkers specific for non-small cell lung cancer (NSCLC). Two hundred and thirty five (235) Serum samples with 112 NSCLC and 123 controls were randomly divided into a training set and a blind testing ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-167.html http://biomarket.jp/modules/pubmed_seldi/article-131.html Related Articles Proteomic analysis of archival breast cancer serum. Cancer Genomics Proteomics. 2009 May-Jun;6(3):141-7 Authors: Zeidan BA, Cutress RI, Murray N, Coulton GR, Hastie C, Packham G, Townsend PA Large cohorts of archival samples are stored in tissue banks worldwide yet their contribution to biomarker discovery is limited. Proteomic profiling technologies have potential for early screening and diagnosis of cancer, and data from such samples can be the answer for many clinical questi ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-131.html http://biomarket.jp/modules/pubmed_seldi/article-168.html Related Articles Differential protein profiling as a potential multi-marker approach for TSE diagnosis. BMC Infect Dis. 2009;9:188 Authors: Barr JB, Watson M, Head MW, Ironside JW, Harris N, Hogarth C, Fraser JR, Barron R BACKGROUND: Transmissible spongiform encephalopathy describes a family of diseases affecting both man and animals. Current tests for the diagnosis of these diseases are based on the detection of an abnormal misfolded form of the host protein PrP which is found within the centr ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-168.html http://biomarket.jp/modules/pubmed_seldi/article-133.html Related Articles Proteomic profiling of growth hormone-responsive proteins in human peripheral blood leukocytes. J Clin Endocrinol Metab. 2009 Aug;94(8):3038-43 Authors: Chung L, Nelson AE, Ho KK, Baxter RC CONTEXT: GH is a known modulator of the immune system, but the effect of exogenous GH administration on white blood cell proteins has not been investigated. Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) is a powerful platform for the study of GH ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-133.html http://biomarket.jp/modules/pubmed_seldi/article-169.html Related Articles Feature selection and machine learning with mass spectrometry data. Methods Mol Biol. 2010;593:205-29 Authors: Datta S, Pihur V Mass spectrometry has been used in biochemical research for a long time. However, its potential for discovering proteomic biomarkers using protein mass spectra has aroused tremendous interest in the last few years. In spite of its potential for biomarker discovery, it is recognized that the identification of meaningful proteomic features from mass spec ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-169.html http://biomarket.jp/modules/pubmed_seldi/article-135.html Related Articles Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry: serum protein profiling in seminoma patients. World J Urol. 2010 Apr;28(2):193-7 Authors: Strenziok R, Hinz S, Wolf C, Conrad T, Krause H, Miller K, Schrader M PURPOSE: Surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF MS) allows rapid protein profiling of complex biological mixtures. We analyzed testicular germ cell cancer serum samples to differentiate between ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-135.html http://biomarket.jp/modules/pubmed_seldi/article-170.html Related Articles Inflammatory biomarker profiling in elderly patients with acute hip fracture treated with heparins. Clin Appl Thromb Hemost. 2010 Feb;16(1):42-50 Authors: Knesek MJ, Litinas E, Adiguzel C, Hopkinson W, Hoppensteadt D, Lassen M, Fareed J Hip fracture is common in the elderly patients with associated high risk of venous thromboembolic complications. Pathogenic activation results in the generation of various surrogate markers in plasma. This study is designed to identify unique bio ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-170.html http://biomarket.jp/modules/pubmed_seldi/article-137.html Related Articles Applications of Surface-Enhanced Laser Desorption/Ionization Time-Of-Flight (SELDI-TOF) Mass Spectrometry in Defining Salivary Proteomic Profiles. Open Dent J. 2009;3:74-79 Authors: Al-Tarawneh SK, Bencharit S Recent advancement in mass spectrometry leads us to a new era of proteomic analysis. Human saliva can be easily collected; however, the complexity of the salivary proteome in the past prevented the use of saliva for proteomic analysis. Here we review the development of pr ... Tue, 13 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed_seldi/article-137.html http://biomarket.jp/modules/pubmed_seldi/article-171.html Related Articles [Establishment of endometriosis diagnostic model using plasma protein profiling] Zhonghua Fu Chan Ke Za Zhi. 2009 Aug;44(8):601-4 Authors: Liu HY, Zheng YH, Zhang JZ, Leng JH, Sun DW, Liu ZF, Zhu L, Lang JH OBJECTIVE: To establish the diagnostic model for endometriosis by screening the plasma biomarkers of endometriosis using surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS)coupled with bioinformatics. METHODS: Plasma samples from 36 pa ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-171.html http://biomarket.jp/modules/pubmed_seldi/article-139.html Related Articles Identification of macrophage migration inhibitory factor and human neutrophil peptides 1-3 as potential biomarkers for gastric cancer. Br J Cancer. 2009 Jul 21;101(2):295-302 Authors: Mohri Y, Mohri T, Wei W, Qi YJ, Martin A, Miki C, Kusunoki M, Ward DG, Johnson PJ BACKGROUND: Proteomic methods have the potential to meet the urgent need for better cancer biomarkers. We have used a range of proteomic analyses of serum and tissue from gastric cancer patients and relevant controls ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-139.html http://biomarket.jp/modules/pubmed_seldi/article-172.html Related Articles Serum protein profiling of smear-positive and smear-negative pulmonary tuberculosis using SELDI-TOF mass spectrometry. Lung. 2010 Jan-Feb;188(1):15-23 Authors: Liu Q, Chen X, Hu C, Zhang R, Yue J, Wu G, Li X, Wu Y, Wen F The focus of this study was to detect novel sera biomarkers for smear-positive and smear-negative pulmonary tuberculosis and to establish respective diagnostic models using the surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-172.html http://biomarket.jp/modules/pubmed_seldi/article-141.html Related Articles Identification of two new serum protein profiles for renal cell carcinoma. Oncol Rep. 2009 Aug;22(2):401-8 Authors: Engwegen JY, Mehra N, Haanen JB, Schellens JH, Voest EE, Beijnen JH Renal cell carcinoma (RCC) is the most lethal urological cancer, and survival greatly depends on early diagnosis. Therefore, reliable, new biomarkers for detection of RCC are required. We assessed serum protein profiles of samples from two institutes with SELDI-TOF MS in duplicate on CM10 chips at ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-141.html http://biomarket.jp/modules/pubmed_seldi/article-173.html Related Articles The complement component C3a fragment is a potential biomarker for hepatitis C virus-related hepatocellular carcinoma. J Gastroenterol. 2010 Apr;45(4):459-67 Authors: Kanmura S, Uto H, Sato Y, Kumagai K, Sasaki F, Moriuchi A, Oketani M, Ido A, Nagata K, Hayashi K, Stuver SO, Tsubouchi H BACKGROUND: Hepatocellular carcinoma (HCC) has a high mortality rate, and early detection of HCC improves patient survival. However, the molecular diagnostic markers for early HCC have not been ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-173.html http://biomarket.jp/modules/pubmed_seldi/article-143.html Related Articles [Study for drug-resistance of epithelial ovarian cancer by serum protein profiling] Zhonghua Yi Xue Za Zhi. 2009 May 19;89(19):1326-9 Authors: Zhang WY, Zhu LR, Zheng YH, Zhou L, Zhang JZ, Wu JH, Liao QP OBJECTIVE: To develop the rationales for ovarian cancer-specific protein profiles in serum and to analyze the protein profiles of multidrug resistance P-glucoprotein (MDR1) and multidrug resistance-associated protein (MRP) positive and negative expression sets for a rapid and se ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-143.html http://biomarket.jp/modules/pubmed_seldi/article-174.html Related Articles Proteomic profiling of the rat cerebral cortex in sleep and waking. Arch Ital Biol. 2009 Sep;147(3):59-68 Authors: Cirelli C, Pfister-Genskow M, McCarthy D, Woodbury R, Tononi G Transcriptomic studies have shown that hundreds of genes change their expression levels across the sleep/waking cycle, and found that waking-related and sleep-related mRNAs belong to different functional categories. Proteins, however, rather than DNA or RNA, carry out most of the cellular functions, and ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-174.html http://biomarket.jp/modules/pubmed_seldi/article-145.html Related Articles Profiling MS proteomics data using smoothed non-linear energy operator and Bayesian additive regression trees. Proteomics. 2009 Sep;9(17):4176-91 Authors: He S, Li X, Viant MR, Yao X This paper proposes a novel profiling method for SELDI-TOF and MALDI-TOF MS data that integrates a novel peak detection method based on modified smoothed non-linear energy operator, correlation-based peak selection and Bayesian additive regression trees. The peak detection and classification perfor ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-145.html http://biomarket.jp/modules/pubmed_seldi/article-175.html Related Articles Regulation of CXCR/IL-8 in human airway epithelial cells. Int Arch Allergy Immunol. 2010;152(2):140-50 Authors: Gras D, Tiers L, Vachier I, de Senneville LD, Bourdin A, Godard P, Lehman S, Chanez P BACKGROUND: Severe asthma is characterized by neutrophilic inflammation and high levels of interleukin (IL)-8. Airway epithelial cells play a pivotal role in the pathogenesis and chronicity of asthma. The objective of this work was to determine whether CXC receptors were involved in ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-175.html http://biomarket.jp/modules/pubmed_seldi/article-147.html Related Articles Laser-capture microdissection and protein extraction for protein fingerprint of OSCC and OLK. Artif Cells Blood Substit Immobil Biotechnol. 2009;37(5):208-13 Authors: He H, Sun G, Ping F To find new biomarkers and establish histopathology protein fingerprint models for early detection of oral squamous cell carcinoma (OSCC), laser capture microdissection (LCM) technology was utilized in 21 OSCC tissues and 7 oral leukoplaque (OLK) tissues as well as their adjacent normal tissues ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-147.html http://biomarket.jp/modules/pubmed_seldi/article-176.html Related Articles Challenges for biomarker discovery in body fluids using SELDI-TOF-MS. J Biomed Biotechnol. 2010;2010:906082 Authors: De Bock M, de Seny D, Meuwis MA, Chapelle JP, Louis E, Malaise M, Merville MP, Fillet M Protein profiling using SELDI-TOF-MS has gained over the past few years an increasing interest in the field of biomarker discovery. The technology presents great potential if some parameters, such as sample handling, SELDI settings, and data analysis, are strictly controlled. ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-176.html http://biomarket.jp/modules/pubmed_seldi/article-149.html Related Articles Protein profiling of pleural effusions to identify malignant pleural mesothelioma using SELDI-TOF MS. Technol Cancer Res Treat. 2009 Oct;8(5):323-32 Authors: Hegmans JP, Veltman JD, Fung ET, Verch T, Glover C, Zhang F, Allard WJ, T'Jampens D, Hoogsteden HC, Lambrecht BN, Aerts J Diagnosis of malignant pleural mesothelioma (MM) is limited. Novel proteomic techno_logies can be utilized to discover changes in expression of pleural proteins that might have diagnostic value. The obje ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-149.html http://biomarket.jp/modules/pubmed_seldi/article-177.html Related Articles Identification biomarkers of eutopic endometrium in endometriosis using artificial neural networks and protein fingerprinting. Fertil Steril. 2010 May 1;93(7):2460-2 Authors: Wang L, Zheng W, Ding XY, Yu JK, Jiang WZ, Zhang SZ Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) protein chip array technology was used to detect biomarkers of eutopic endometrium in endometriosis patients. Five potential biomarkers (6,898 m/z, 5,891 m/z, 5,3 ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-177.html http://biomarket.jp/modules/pubmed_seldi/article-151.html Related Articles Identification of a novel potential biomarker in a model of hemorrhagic shock and valproic acid treatment. J Surg Res. 2010 Mar;159(1):474-81 Authors: Li Y, Liu B, Dillon ST, Fukudome EY, Kheirbek T, Sailhamer EA, Velmahos G, deMoya M, Libermann TA, Alam HB BACKGROUND: The initial management of a poly-trauma patient requires evaluation for potential hemorrhage and ongoing monitoring to assess the efficacy of treatment and avoid complications related to massive blood loss. Certa ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-151.html http://biomarket.jp/modules/pubmed_seldi/article-178.html Related Articles [Application of saliva protein fingerprints in the diagnosis of oral squamous cell cancer by surface enhanced laser desorption ionization time of flight mass.] Zhonghua Kou Qiang Yi Xue Za Zhi. 2009 Nov;44(11):664-7 Authors: Sun G, Ping FY OBJECTIVE: To screen proteomic markers of oral precancerous lesion, local and metastatic squamous cell cancer from human saliva. METHODS: Seventeen patients with oral squamous cell carcinoma, six cases with leukoplakia, seven cases with local ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-178.html http://biomarket.jp/modules/pubmed_seldi/article-153.html Related Articles Identification of serum biomarkers for pancreatic adenocarcinoma by proteomic analysis. Cancer Sci. 2009 Dec;100(12):2292-301 Authors: Guo J, Wang W, Liao P, Lou W, Ji Y, Zhang C, Wu J, Zhang S Diagnosis of pancreatic adenocarcinoma (PaCa) at an early stage is important for successful treatment and improving the prognosis of patients. Serum samples were applied to strong anionic exchange chromatography (SAX) protein chips for protein profiling by surface enhanced laser desorpti ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-153.html http://biomarket.jp/modules/pubmed_seldi/article-179.html Related Articles [Proteomics studies on arthritis by SELDI-TOF-MS: identification of the S100 proteins family as proteins of interest] Rev Med Liege. 2009;64 Spec No:29-35 Authors: De Seny D, Ribbens C, Cobraiville G, Meuwis MA, Marée R, Geurts P, Wehenkel L, Louis E, Merville MP, Fillet M, Malaise MG Clinical proteomics is a technical approach studying the entire proteome expressed by cells, tissues or organs. It describes the dynamics of cell regulation by detecting molecular events relat ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-179.html http://biomarket.jp/modules/pubmed_seldi/article-204.html Related Articles Proteomic Identification of Early Biomarkers of Acute Kidney Injury After Cardiac Surgery in Children. Am J Kidney Dis. 2010 Jul 2; Authors: Devarajan P, Krawczeski CD, Nguyen MT, Kathman T, Wang Z, Parikh CR BACKGROUND: Serum creatinine is a delayed marker of acute kidney injury (AKI). Our purpose is to discover and validate novel early urinary biomarkers of AKI after cardiac surgery. STUDY DESIGN: Diagnostic test study. SETTING &amp; PARTICIPANTS: Children undergoing cardiopu ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-204.html /=50% increase in serum creatinine level from baseline within 3 days of surgery. RESULTS: Proteomic profiling using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) showed 3 protein peaks that appeared consistently within 2 hours in children who developed AKI after cardiopulmonary bypass surgery. The proteins were identified as alpha(1)-microglobulin, alpha(1)-acid glycoprotein, and albumin. Using clinical assays, results were confirmed in a test set and validated in an independent prospective cohort. In the validation set, 135 (37%) developed AKI, in whom there was a progressive increase in urinary biomarker concentrations with severity of AKI. Areas under the curve for urinary alpha(1)-microglobulin, alpha(1)-acid glycoprotein, and albumin at 6 hours after cardiac surgery were 0.84 (95% CI, 0.79-0.89), 0.87 (95% CI, 0.83-0.91), and 0.76 (95% CI, 0.71-0.81), respectively. Participants with increasing quartiles of biomarkers showed increasing lengths of hospital stays and durations of AKI (P < 0.001). LIMITATIONS: Single-center study of children with normal kidney function at recruitment. The SELDI-TOF MS technique has limited sensitivity for the detection of proteins greater than the 20-kDa range. CONCLUSIONS: Urinary alpha(1)-microglobulin, alpha(1)-acid glycoprotein, and albumin represent early, accurate, inexpensive, and widely available biomarkers of AKI after cardiac surgery. They also offer prognostic information about the duration of AKI and length of hospitalization after cardiac surgery. PMID: 20599305 [PubMed - as supplied by publisher]（【斜め読み用】機械翻訳：） ]]> http://biomarket.jp/modules/pubmed_seldi/article-180.html Related Articles Five serum proteins identified using SELDI-TOF-MS as potential biomarkers of gastric cancer. Jpn J Clin Oncol. 2010 Apr;40(4):336-42 Authors: Lu HB, Zhou JH, Ma YY, Lu HL, Tang YL, Zhang QY, Zhao CH OBJECTIVE: The aims of this study were to detect serum proteomic patterns in gastric cancer serum samples using Surface-enhanced Laser Desorption/ionization-Time-of-flight-Mass Spectrometry ProteinChip array technology, to screen biomarker candidates, to build diagnostic models and ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-180.html http://biomarket.jp/modules/pubmed_seldi/article-108.html Related Articles Biomarker discovery in asthma-related inflammation and remodeling. Proteomics. 2009 Apr;9(8):2163-70 Authors: Calvo FQ, Fillet M, de Seny D, Meuwis MA, Maree R, Crahay C, Paulissen G, Rocks N, Gueders M, Wehenkel L, Merville MP, Louis R, Foidart JM, NoÃ?l A, Cataldo D Asthma is a complex inflammatory disease of airways. A network of reciprocal interactions between inflammatory cells, peptidic mediators, extracellular matrix components, and proteases is thought to be involved ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-108.html http://biomarket.jp/modules/pubmed_seldi/article-181.html Related Articles Comparison of normalization methods for the identification of biomarkers using MALDI-TOF and SELDI-TOF mass spectra. OMICS. 2010 Feb;14(1):115-26 Authors: Borgaonkar SP, Hocker H, Shin H, Markey MK Proteomic profiling by mass spectrometry has tremendous potential for identifying disease biomarkers. A key limitation of mass spectrometry is that the information provided on the abundance of the various peptides is only relative. Thus, normalization is typically employed. Several no ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-181.html http://biomarket.jp/modules/pubmed_seldi/article-112.html Related Articles Proteomic analysis of human papillomavirus-related oral squamous cell carcinoma: identification of thioredoxin and epidermal-fatty acid binding protein as upregulated protein markers in microdissected tumor tissue. Proteomics. 2009 Apr;9(8):2193-201 Authors: Melle C, Ernst G, Winkler R, Schimmel B, Klussmann JP, Wittekindt C, Guntinas-Lichius O, von Eggeling F Human papillomavirus (HPV) infection has been identified as an etiologic agent for a subset of oral squamous cell carci ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-112.html http://biomarket.jp/modules/pubmed_seldi/article-182.html Related Articles Use of SELDI MS to discover and identify potential biomarkers of toxicity in InnoMed PredTox: a multi-site, multi-compound study. Proteomics. 2010 Apr;10(8):1592-608 Authors: Collins BC, Sposny A, McCarthy D, Brandenburg A, Woodbury R, Pennington SR, Gautier JC, Hewitt P, Gallagher WM A serious bottleneck in the drug development pipeline is the inability of current pre-clinical toxicology evaluation methods to predict early on, and with good accuracy, that a drug candidate will ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-182.html http://biomarket.jp/modules/pubmed_seldi/article-116.html Related Articles Proteomic toolbox for autoimmunity research. Autoimmun Rev. 2009 Jun;8(7):595-8 Authors: Wu T, Mohan C Autoimmune diseases are genetically complex and poorly understood, and may lead to clinically severe consequences including end-organ damage. Given this scenario, early biomarker discovery is becoming increasingly important for early diagnosis and treatment in these diseases. Among the different approaches tried, the application of proteomic analysis of body fluids has great p ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-116.html http://biomarket.jp/modules/pubmed_seldi/article-183.html Related Articles Culture of human cells and synthesis of extracellular matrix on materials compatible with direct analysis by mass spectrometry. Analyst. 2010 Mar;135(3):503-11 Authors: Lavigne D, Guerrier L, Gueguen V, Michel JB, Boschetti E, Meilhac O, Letourneur D The extracellular matrix (ECM) is a complex three-dimensional network of macromolecules synthesized by cells and is essential for the structure and the function of a tissue. The aim of our approach was to propose a surface allowing ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-183.html http://biomarket.jp/modules/pubmed_seldi/article-120.html Related Articles Influence of sample storage duration on serum protein profiles assessed by surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry (SELDI-TOF MS). Clin Chem Lab Med. 2009;47(6):694-705 Authors: Gast MC, van Gils CH, Wessels LF, Harris N, Bonfrer JM, Rutgers EJ, Schellens JH, Beijnen JH BACKGROUND: Issues have been raised concerning the robustness and validity of alleged serum markers discovered by surface-enhanced laser desorption/ionisation time-of-flight ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-120.html http://biomarket.jp/modules/pubmed_seldi/article-184.html Related Articles Ovarian cancer classification based on dimensionality reduction for SELDI-TOF data. BMC Bioinformatics. 2010;11:109 Authors: Tang KL, Li TH, Xiong WW, Chen K BACKGROUND: Recent advances in proteomics technologies such as SELDI-TOF mass spectrometry has shown promise in the detection of early stage cancers. However, dimensionality reduction and classification are considerable challenges in statistical machine learning. We therefore propose a novel approach for dimensionality red ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-184.html http://biomarket.jp/modules/pubmed_seldi/article-124.html Related Articles Proteomic identification of serum biomarkers for head and neck cancer surveillance. Laryngoscope. 2009 Jul;119(7):1291-302 Authors: Gourin CG, Zhi W, Adam BL OBJECTIVES/HYPOTHESIS: Serum protein profiling by SELDI-TOF-MS distinguishes pretreatment and post-treatment samples from patients with head and neck squamous cell cancer (HNSCC) by disease status (disease-free or recurrence) with a high degree of sensitivity and specificity. We sought to identify biomarkers for recurrence ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-124.html http://biomarket.jp/modules/pubmed_seldi/article-185.html Related Articles [Application of serum protein profiling in diagnosis, prognosis and evaluation of curative effect of pancreatic adenocarcinoma] Zhonghua Zhong Liu Za Zhi. 2010 Jan;32(1):33-6 Authors: Guo JH, Wang WJ, Liao P, Zhang CY, Jin DY, Lou WH, Zhang SC OBJECTIVE: To establish decision tree and logistic regression classification models for diagnosing pancreatic adenocarcinoma (PaCa) and for screening serum biomarkers related to evaluation of different stages and curative effects. METHODS: ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-185.html http://biomarket.jp/modules/pubmed_seldi/article-128.html Related Articles [Detection of differentially expressed proteins in the semen of oligospermia patients by SELDI-TOF-MS technology] Zhonghua Nan Ke Xue. 2009 Mar;15(3):232-6 Authors: Liu CB, Liang Y, Pan CQ, Zhang J OBJECTIVE: To analyze the spectrometric semen protein profiling of oligospermia patients and healthy controls by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS), and to establish a semen marker pattern for the diagnosis of oligospermia. MET ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-128.html http://biomarket.jp/modules/pubmed_seldi/article-186.html Related Articles Plasma proteome to look for diagnostic biomarkers of early bacterial sepsis after liver transplantation: a preliminary study. Anesthesiology. 2010 Apr;112(4):926-35 Authors: Paugam-Burtz C, Albuquerque M, Baron G, Bert F, Voitot H, Delefosse D, Dondero F, Sommacale D, Francoz C, Hanna N, Belghiti J, Ravaud P, Bedossa P, Mantz J, Paradis V BACKGROUND: While outcome continuously improves after liver transplantation, sepsis remains the leading cause of early postoperative mortalit ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-186.html http://biomarket.jp/modules/pubmed_seldi/article-132.html Related Articles [Detection of tissue protein biomarkers by surface enhanced laser desorption/ionization-time of flight-mass spectrometry in patients with mycosis fungoides] Zhonghua Yi Xue Za Zhi. 2009 Jan 13;89(2):100-4 Authors: Liu J, Zheng YH, Zhou YF, Zhang JZ, Wang BX OBJECTIVE: To search the tissue biomarker in mycosis fungoides (MF) patients by surface enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS). METHODS: Skin specimens were collected from 12 MF p ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-132.html http://biomarket.jp/modules/pubmed_seldi/article-187.html Related Articles Detection and identification of potential biomarkers of breast cancer. J Cancer Res Clin Oncol. 2010 Aug;136(8):1243-54 Authors: Fan Y, Wang J, Yang Y, Liu Q, Fan Y, Yu J, Zheng S, Li M, Wang J PURPOSE: Noninvasive and convenient biomarkers for early diagnosis of breast cancer remain an urgent need. The aim of this study was to discover and identify potential protein biomarkers specific for breast cancer. METHODS: Two hundred and eighty-two (282) serum samples with 124 breast c ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-187.html http://biomarket.jp/modules/pubmed_seldi/article-136.html Related Articles SELDI-TOF MS profiling of serum for detection of nasopharyngeal carcinoma. J Exp Clin Cancer Res. 2009;28:85 Authors: Huang YJ, Xuan C, Zhang BB, Liao M, Deng KF, He M, Zhao JM BACKGROUND: No satisfactory biomarkers are currently available to screen for nasopharyngeal carcinoma (NPC). We have developed and evaluated surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) for detection and analysis of multiple proteins for distinguishing indi ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-136.html http://biomarket.jp/modules/pubmed_seldi/article-188.html Related Articles [A diagnostic model of cerebrospinal protein fingerprint pattern for brain metastases of non-small cell lung cancer] Nan Fang Yi Ke Da Xue Xue Bao. 2010 Mar;30(3):498-501 Authors: Xie SX, Li WX, Huang YJ, Chen JG, Wu YL OBJECTIVE: To establish a diagnostic model of protein fingerprint pattern in the cerebrospinal fluid (CSF) for non-small-cell lung cancer (NSCLC) patients with brain metastases. METHODS: The CSF samples were obtained from 29 NSCLC patients with brain metastasis, ... Tue, 13 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed_seldi/article-188.html http://biomarket.jp/modules/pubmed_seldi/article-140.html Related Articles New potential biomarkers in the diagnosis of esophageal squamous cell carcinoma. Biomarkers. 2009 Aug;14(5):340-6 Authors: Xu SY, Liu Z, Ma WJ, Sheyhidin I, Zheng ST, Lu XM OBJECTIVE: To analyse the alterations of serum proteins in cases of esophageal squamous cell carcinoma (ESCC) in order to screen and validate serum marker patterns for the diagnosis of ESCC in the high-risk populations of Xinjiang, China. METHODS: The serum proteomic patterns of 188 cases, including 139 pati ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-140.html http://biomarket.jp/modules/pubmed_seldi/article-189.html Related Articles Discovery of serum protein biomarkers for prostate cancer progression by proteomic analysis. Cancer Genomics Proteomics. 2010 Mar-Apr;7(2):93-103 Authors: Al-Ruwaili JA, Larkin SE, Zeidan BA, Taylor MG, Adra CN, Aukim-Hastie CL, Townsend PA BACKGROUND: The incidence of prostate cancer (PCa) has increased in recent years due to the aging of the population and increased testing; however, mortality rates have remained largely unchanged. Studies have shown deficiencies in predictin ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-189.html http://biomarket.jp/modules/pubmed_seldi/article-144.html Related Articles Limitations in SELDI-TOF MS whole serum proteomic profiling with IMAC surface to specifically detect colorectal cancer. BMC Cancer. 2009;9:287 Authors: Wang Q, Shen J, Li ZF, Jie JZ, Wang WY, Wang J, Zhang ZT, Li ZX, Yan L, Gu J BACKGROUND: Surface enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF-MS) analysis on serum samples was reported to be able to detect colorectal cancer (CRC) from normal or control patients. We carried out a validation ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-144.html http://biomarket.jp/modules/pubmed_seldi/article-190.html Related Articles Identification of candidate molecular markers predicting chemotherapy resistance in non-small cell lung cancer. Clin Chem Lab Med. 2010 Jun;48(6):863-7 Authors: Han M, Liu Q, Yu J, Zheng S BACKGROUND: Empirical chemotherapy for patients with non-small cell lung cancer (NSCLC) is recommended, even without knowledge of the tumor's specific biological characteristics, and many patients may not benefit. The goal of this study was to identify potential serum biomarkers that influence ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-190.html http://biomarket.jp/modules/pubmed_seldi/article-148.html Related Articles Mining novel biomarkers for prognosis of gastric cancer with serum proteomics. J Exp Clin Cancer Res. 2009;28:126 Authors: Qiu FM, Yu JK, Chen YD, Jin QF, Sui MH, Huang J BACKGROUND: Although gastric cancer (GC) remains the second cause of cancer-related death, useful biomarkers for prognosis are still unavailable. We present here the attempt of mining novel biomarkers for GC prognosis by using serum proteomics. METHODS: Sera from 43 GC patients and 41 controls with gastritis a ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-148.html http://biomarket.jp/modules/pubmed_seldi/article-191.html Related Articles Enhanced Detection of Early Hepatocellular Carcinoma by Serum SELDI-TOF Proteomic Signature Combined with Alpha-Fetoprotein Marker. Ann Surg Oncol. 2010 Mar 31; Authors: Chen L, Ho DW, Lee NP, Sun S, Lam B, Wong KF, Yi X, Lau GK, Ng EW, Poon TC, Lai PB, Cai Z, Peng J, Leng X, Poon RT, Luk JM BACKGROUND: Biomarkers for accurate diagnosis of early hepatocellular carcinoma (HCC) are limited in number and clinical validation. We applied SELDI-TOF-MS ProteinChip technology to identi ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-191.html http://biomarket.jp/modules/pubmed_seldi/article-152.html Related Articles Serum protein profiles in myasthenia gravis. Ann Thorac Surg. 2009 Oct;88(4):1118-23 Authors: Cheng C, Wu G, Yeung SC, Li R, Bella AE, Pang J, Zhong FT, Luo H, Jin Y, Pan J BACKGROUND: The diagnosis of myasthenia gravis (MG) remains challenging. We performed a proteome-wide search for potential serum protein diagnostic markers for MG using surface-enhanced laser desorption/ionization (SELDI) time-of-flight mass spectrometry (TOFMS). METHODS: Proteomic spectra from 80 MG patient ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-152.html http://biomarket.jp/modules/pubmed_seldi/article-192.html Related Articles [Analysis of proteomic spectra in serum from patients with laryngeal carcinoma by SELDI-TOF-MS technology] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Dec;23(24):1116-9 Authors: Xu Y, Qiao S, Huangfu H, Wang B OBJECTIVE: To screen the tumor markers of laryngeal carcinoma and to investigate their expression in preoperative and postoperative serum. METHOD: The distinct protein in serum was detected in 32 cases of laryngeal carcinoma and 38 healthy people by IMAC-Cu protei ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-192.html http://biomarket.jp/modules/pubmed_seldi/article-106.html Related Articles [Screening of serum protein biomarkers by surface-enhanced laser desorption and ionization with time-of-flight detection mass spectrometry in patients with mycosis fungoides] Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2009 Feb;31(1):13-6 Authors: Liu J, Zheng YH, Zhang JZ, Wang BX OBJECTIVE: To screen serum biomarkers in patients with mycosis fungoides (MF) using surface-enhanced laser desorption and ionization with time-of-flight detection mass spectrometry (SELDI-TOF-MS) technique. ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-106.html http://biomarket.jp/modules/pubmed_seldi/article-193.html Related Articles Serum proteomic profiling analysis of chronic arsenic exposure by using SELDI-TOF-MS technology. Toxicol Lett. 2010 Jun 2;195(2-3):155-60 Authors: Zhao L, Gao Y, Yang Y, Wei Y, Li Y, Feng H, Wei W, Ding Y, Sun D This study was to investigate the differences in serum proteomic profiling among subjects exposed to different levels of arsenic in drinking water and to identify proteins related to arsenicosis. A total of 148 subjects from endemic regions of China were selected and di ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-193.html http://biomarket.jp/modules/pubmed_seldi/article-114.html Related Articles Application of SELDI-TOF-MS to identify serum biomarkers for renal cell carcinoma. Cancer Lett. 2009 Sep 18;282(2):205-13 Authors: Xu G, Xiang CQ, Lu Y, Kang XN, Liao P, Ding Q, Zhang YF PURPOSE: Early diagnosis is critical for improving the outcome of patients with renal cell carcinoma (RCC). In this study, we applied a proteomic approach to identify serum biomarkers associated with different stages of renal tumor development. MATERIALS AND METHODS: The protein expression prof ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-114.html http://biomarket.jp/modules/pubmed_seldi/article-194.html Related Articles Identification of beta2-microgloblin as a candidate for early diagnosis of imaging-invisible hepatocellular carcinoma in patient with liver cirrhosis. Oncol Rep. 2010 May;23(5):1325-30 Authors: Saito Y, Oba N, Nishinakagawa S, Mizuguchi Y, Kojima T, Nomura K, Nakatsura T Glypican-3 (GPC3) is overexpressed in hepatocellular carcinoma (HCC) but not in chronic hepatitis (CH) and liver cirrhosis (LC). We have reported the possibility of GPC3-specific cytotoxic T lymphocytes (CTLs) s ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-194.html http://biomarket.jp/modules/pubmed_seldi/article-122.html Related Articles Pancreatic cancer biomarkers discovery by surface-enhanced laser desorption and ionization time-of-flight mass spectrometry. Clin Chem Lab Med. 2009;47(6):713-23 Authors: Navaglia F, Fogar P, Basso D, Greco E, Padoan A, Tonidandel L, Fadi E, Zambon CF, Bozzato D, Moz S, Seraglia R, Pedrazzoli S, Plebani M BACKGROUND: Surface-enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF/MS), a laboratory-friendly technique, is used to identify biomarkers fo ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-122.html http://biomarket.jp/modules/pubmed_seldi/article-195.html Related Articles The promise of bone cancer proteomics. Ann N Y Acad Sci. 2010 Mar;1192(1):222-9 Authors: Byrum S, Montgomery CO, Nicholas RW, Suva LJ Mass spectrometric analysis of the low-molecular-weight (LMW) range of the serum/plasma proteome is revealing the existence of large numbers of previously unknown peptides and protein fragments, predicted to be derived from circulating low-abundance proteins. While genomics and proteomics are the primary discovery research tool, recent innovation ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-195.html http://biomarket.jp/modules/pubmed_seldi/article-130.html Related Articles Characterization of apolipoprotein A-I as a potential biomarker for cholangiocarcinoma. Eur J Cancer Care (Engl). 2009 Nov;18(6):625-35 Authors: Wang X, Dai S, Zhang Z, Liu L, Wang J, Xiao X, He D, Liu B Serum samples from 60 cholangiocarcinoma (CC), 60 benign diseases of hepatobiliary and 53 normal individuals were analysed by SELDI-TOF-MS (Surface Enhanced Laser Desorption/Ionization Time of Flight Mass Spectrometry). It was found that a 28 k m/z peak was significantly decrea ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-130.html http://biomarket.jp/modules/pubmed_seldi/article-196.html Related Articles A review of experimental design best practices for proteomics based biomarker discovery: focus on SELDI-TOF. Methods Mol Biol. 2010;641:167-83 Authors: Caffrey RE Surface Enhanced Laser/Desorption Ionization-time of flight (SELDI-TOF) mass spectrometry is a technique uniquely suited to the study of the urine proteome due to its salt tolerance, high-throughput, and small sample requirements. However, due to the extreme sensitivity of the technique, sample collection and storage ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-196.html http://biomarket.jp/modules/pubmed_seldi/article-138.html Related Articles The isolation and identification of a secreted biomarker associated with cell stress in serum-free CHO cell culture. Biotechnol Bioeng. 2009 Oct 15;104(3):590-600 Authors: Woolley JF, Al-Rubeai M One approach to improving mammalian culture productivity has been to reduce cell stress and cell death in the bioreactor, thus enhancing productivity through a longer phase of viability. Here we describe the isolation and identification of a biomarker for stress and viability loss in C ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-138.html http://biomarket.jp/modules/pubmed_seldi/article-197.html Related Articles Changes in protein expression profiles between a low phytic acid rice ( Oryza sativa L. Ssp. japonica) line and its parental line: a proteomic and bioinformatic approach. J Agric Food Chem. 2010 Jun 9;58(11):6912-22 Authors: Emami K, Morris NJ, Cockell SJ, Golebiowska G, Shu QY, Gatehouse AM The seed proteome of a low phytic acid (lpa) rice line (Os-lpa-XS110-1), developed as a novel food source, was compared to that of its parental line, Xiushui 110 (XS-110). Analysis by surfa ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-197.html http://biomarket.jp/modules/pubmed_seldi/article-146.html Related Articles Tumor proteomic profiling predicts the susceptibility of breast cancer to chemotherapy. Int J Oncol. 2009 Oct;35(4):683-92 Authors: He J, Shen D, Chung DU, Saxton RE, Whitelegge JP, Faull KF, Chang HR Chemotherapy is often used for breast cancer treatment, but individual outcome varies widely. We hypothesized that tumor proteomic profiles obtained prior to chemotherapy may predict the individual tumor response to treatment. The goal of our study was to explore feasibility of usi ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-146.html http://biomarket.jp/modules/pubmed_seldi/article-198.html Related Articles Blood-borne amyloid-beta dimer correlates with clinical markers of Alzheimer's disease. J Neurosci. 2010 May 5;30(18):6315-22 Authors: Villemagne VL, Perez KA, Pike KE, Kok WM, Rowe CC, White AR, Bourgeat P, Salvado O, Bedo J, Hutton CA, Faux NG, Masters CL, Barnham KJ Alzheimer's disease (AD) is the most common age-related dementia. Unfortunately due to a lack of validated biomarkers definitive diagnosis relies on the histological demonstration of amyloid-beta (Abeta) plaques ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-198.html http://biomarket.jp/modules/pubmed_seldi/article-154.html Related Articles Cancer-specific MALDI-TOF profiles of blood serum and plasma: biological meaning and perspectives. J Proteomics. 2010 Jan 3;73(3):537-51 Authors: Karpova MA, Moshkovskii SA, Toropygin IY, Archakov AI MALDI-TOF mass-spectrometry has become a popular tool of cancer research during the last decade. High throughput and relative simplicity of this technology have made it attractive for biomarker discovery and validation across various platforms in blood serum/plasma. Many technical ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-154.html http://biomarket.jp/modules/pubmed_seldi/article-199.html Related Articles [Effect of amygdlin on serum proteinic biomarker in pulmonary fibrosis of bleomycin-induced rat] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2010 Apr;28(4):260-3 Authors: Du HK, Song FC, Zhou X, Li H, Zhang JP OBJECTIVE: To evaluate effect of amygdlin on expression of four biomarkers in the animal model of pulmonary fibrosis induced by bleomycin. METHODS: Rats were given one dose (5 mg/kg) of bleomycin in bleomycin-treated groups, amygdlin-treated groups and saline in contro ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-199.html 2 in bleomycin-treated groups. Compared with amygdlin-treated groups, protein peaks intensity with mass/charge ratio of 3530.7 at 7, 14, 28 d had no change almost, but protein peaks intensity ratio with mass/charge ratio of 7043.5 at 7 d, 8332.6 on 28 d and 9068.0 on 14 d was > 2 in bleomycin-tread groups. All the four protein peaks intensity had no change almost at other point. CONCLUSION: Amygdlin may reduce the bleomycin-induced increase of differentially expressed protein peak intensities in rat serum. PMID: 20465950 [PubMed - in process]（【斜め読み用】機械翻訳：） ]]> http://biomarket.jp/modules/pubmed_seldi/article-118.html Related Articles Detection of elevated proteins in peritoneal dissemination of gastric cancer by analyzing mass spectra data of serum proteins. J Surg Res. 2009 Jul;155(1):13-7 Authors: Kojima T, Yoshikawa K, Saga S, Yamada T, Kure S, Matsui T, Uemura T, Fujimitsu Y, Sakakibara M, Kodera Y, Kojima H BACKGROUND: Recently, several authors reported on the Protein Chip approach to analyze serum. They used SELDI-TOF-MS (surface enhanced laser desorption/ionization-time of flight-mass spectrometry) t ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-118.html http://biomarket.jp/modules/pubmed_seldi/article-200.html Related Articles The Lucid Proteomics System for top-down biomarker research. Arch Physiol Biochem. 2010 May 28; Authors: Jourdain S, Bulman A, Dalmasso E Advances have been made in recent years for both "top-down" and "bottom-up" profiling approaches to biomarker discovery. Top-down protein profiling via SELDI-TOF mass spectrometry has been used by researchers in many fields of study to discover native protein biomarker candidates from a variety of sample types, but has been limited without a ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-200.html http://biomarket.jp/modules/pubmed_seldi/article-134.html Related Articles Serum protein profiling for diagnosis of breast cancer using SELDI-TOF MS. Oncol Rep. 2009 Jul;22(1):205-13 Authors: Gast MC, Van Gils CH, Wessels LF, Harris N, Bonfrer JM, Rutgers EJ, Schellens JH, Beijnen JH In search for novel markers for breast cancer, we aimed to identify and validate novel serum protein profiles specific for breast cancer, and assess the influence of clinical (subjects age) and pre-analytical (sample storage duration) variables on the constructed classifie ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-134.html http://biomarket.jp/modules/pubmed_seldi/article-201.html Related Articles Identification of serum proteins as prognostic and predictive markers of colorectal cancer using surface enhanced laser desorption ionization-time of flight mass spectrometry. Oncol Rep. 2010 Jul;24(1):57-64 Authors: Helgason HH, Engwegen JY, Zapatka M, Vincent A, Cats A, Boot H, Beijnen JH, Schellens JH Colorectal cancer (CRC) is the second most common cause of cancer related death. Prognosis is highly dependent on stage at diagnosis making early detection mandatory. This study ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-201.html http://biomarket.jp/modules/pubmed_seldi/article-150.html Related Articles Identification of potential serum markers for endometrial cancer using protein expression profiling. J Cancer Res Clin Oncol. 2010 Mar;136(3):475-81 Authors: Takano M, Kikuchi Y, Asakawa T, Goto T, Kita T, Kudoh K, Kigawa J, Sakuragi N, Sakamoto M, Sugiyama T, Yaegashi N, Tsuda H, Seto H, Shiwa M OBJECTIVES: Screening method of endometrial cancer (EC) has not been established yet. Our study was to explore serum biomarkers of EC patients using surface-enhanced laser desorption a ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-150.html http://biomarket.jp/modules/pubmed_seldi/article-202.html Related Articles Hepcidin is not useful as a biomarker for iron needs in haemodialysis patients on maintenance erythropoiesis-stimulating agents. Nephrol Dial Transplant. 2010 Jun 10; Authors: Tessitore N, Girelli D, Campostrini N, Bedogna V, Pietro Solero G, Castagna A, Melilli E, Mantovani W, De Matteis G, Olivieri O, Poli A, Lupo A BACKGROUND: It has been suggested that hepcidin may be useful as a tool for managing iron therapy in haemodialysis (HD) patients on erythropoiesis-stimulating agen ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-202.html http://biomarket.jp/modules/pubmed_seldi/article-126.html Related Articles An integrative multi-platform analysis for discovering biomarkers of osteosarcoma. BMC Cancer. 2009;9:150 Authors: Li G, Zhang W, Zeng H, Chen L, Wang W, Liu J, Zhang Z, Cai Z BACKGROUND: SELDI-TOF-MS (Surface Enhanced Laser Desorption/Ionization-Time of Flight-Mass Spectrometry) has become an attractive approach for cancer biomarker discovery due to its ability to resolve low mass proteins and high-throughput capability. However, the analytes from mass spectrometry are describ ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-126.html http://biomarket.jp/modules/pubmed_seldi/article-203.html Related Articles [Application of SELDI-TOF-MS in establishing a model for predicting radiotherapy response of hypopharyngeal cancers.] Nan Fang Yi Ke Da Xue Xue Bao. 2010 Jun;30(6):1282-7 Authors: Tian WD, Zeng ZY, Yu WB, Li XP OBJECTIVE: To detect the serum proteomic fingerprints in patients with hypopharyngeal squamous cell carcinoma (HPSCC) by surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS) protein chip array technique. METHODS: The serum samples w ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-203.html 0.05), and the difference between well differentiated and poorly differentiated HPSCC was only minor. No significant difference was found in the serum proteins between chemotherapy-sensitive patients and the insensitive patients (P>0.05), but 5 proteins were identified to be overexpressed in the sensitive patients (P http://biomarket.jp/modules/pubmed_seldi/article-110.html Related Articles Proteomic Helicobacter pylori biomarkers discriminating between duodenal ulcer and gastric cancer. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Apr 15;877(11-12):1193-9 Authors: Khoder G, Yamaoka Y, Fauchère JL, Burucoa C, Atanassov C Protein patterns of 129 Helicobacter pylori strains isolated from Korean and Colombian patients suffering from duodenal ulcer or gastric cancer were analyzed by the high-throughput methodology SELDI-TOF-MS. Eighteen statistically signif ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-110.html http://biomarket.jp/modules/pubmed_seldi/article-142.html Related Articles [Screening and identification analysis of serum protein biomarkers in nephroblastoma] Zhonghua Yi Xue Za Zhi. 2009 May 12;89(18):1259-63 Authors: Wang JX, Yang SB, Liu QL, Dong R, Fan YX, Zhang Q, Yang FQ, Wu P, Yu JK, Zheng S OBJECTIVE: To screen and characterize the serum protein biomarkers in nephroblastoma so as to establish the proteins as the specific serum biomarkers for diagnosis and prognosis monitoring. METHODS: The differential protein peaks were located by detecting ... Tue, 13 Jul 2010 01:00:07 +0900 http://biomarket.jp/modules/pubmed_seldi/article-142.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-221.html Related Articles Measurement of waist circumference at four different sites in children, adolescents, and young adults: concordance and correlation with nutritional status as well as cardiometabolic risk factors. Obes Facts. 2008;1(5):243-9 Authors: Hitze B, Bosy-Westphal A, Bielfeldt F, Settler U, Mönig H, MÃ?ller MJ BACKGROUND: This study investigates the concordance of four waist circumference (WC) measurement sites, and examines their relationships with nutritional status and cardiome ... Sun, 11 Jul 2010 01:00:31 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-221.html 90th age-/sex-specific percentile. Pubertal stage was assessed according to Tanner. Body composition (air-displacement plethysmography), blood pressure, lipid profile, glucose/insulin levels, and HOMA-IR (homeostasis model assessment of insulin resistance) were measured. RESULTS: Medians of WCs (cm) for females/males were WCR (64.4/69.5) < WC4 (64.6/70.2) < WCM (67.1/71.2) < WCC (71.5/ 74.2). Although closely related to each other (all r > 0.93; p < 0.001), paired comparisons revealed differences between WCs in their magnitudes which was stronger for females than males. Prevalence of 'overwaist' differed according to measurement site in females/males: WCR (13.2/15.7%) < WC4 (14.3/ 19.1%) < WCM (18.7/22.5%) < WCC (37.4/30.3%). After adjusting for age and pubertal status, WCs were closely related to body mass index (BMI) (all r > 0.86; p < 0.001), percent fat mass (%FM; all r > 0.61; p < 0.001), and comparably associated with cardiometabolic risk factors. However, stronger correlations were found for i) WCR vs. WC4 with BMI in males (r = 0.93 vs. 0.91; p < 0.05), ii) WCC vs. WC4 with %FM in females (r = 0.67 vs. 0.61; p < 0.05), iii) WCC vs. WCR with triglycerides in females (r = 0.29 vs. r = 0.22; p < 0.05), and iv) WCC (r = 0.36) vs. other WCs (r = 0.30-0.32) with low-density lipoprotein cholesterol (LDL-C) in males (p < 0.05). CONCLUSION: WCs measured at different sites were closely correlated with BMI and %FM as well as comparably associated with cardiometabolic risk factors. However, different WCs had different magnitudes, which was more obvious in females and led to discordant results with respect to 'overwaist' and risk assessment. PMID: 20054185 [PubMed - indexed for MEDLINE] ]]> http://biomarket.jp/modules/pubmed_sugarcomposition/article-226.html Related Articles Doxorubicin attached to HPMA copolymer via amide bond modifies the glycosylation pattern of EL4 cells. Tumour Biol. 2010 Aug;31(4):233-42 Authors: Kovar L, Etrych T, Kabesova M, Subr V, Vetvicka D, Hovorka O, Strohalm J, Sklenar J, Chytil P, Ulbrich K, Rihova B To avoid the side effects of the anti-cancer drug doxorubicin (Dox), we conjugated this drug to a N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer backbone. Dox was conjugated via an amide bond (Dox-HPMA(AM), PK1) or a ... Sun, 11 Jul 2010 01:00:31 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-226.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-223.html Related Articles Adiposity measures as indicators of metabolic risk factors in adolescents. Obes Facts. 2009;2(5):294-301 Authors: Neovius M, Rossner SM, VÃ?gstrand K, von Hausswolff-Juhlin YL, Hoffstedt J, Ekelund U AIM: To examine the relation between adiposity assessment methods (percentage body fat (%BF), BMI, and waist circumference (WC)) and individual metabolic risk factors (f-insulin, HDL cholesterol, triglycerides) and a combined measure of metabolic risk. METHODS: Crosssectional stu ... Sun, 11 Jul 2010 01:00:31 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-223.html or =2 metabolic risk factors (AUCs 0.76-0.91, p < 0.001) in both sexes. CONCLUSION: %BF was not superior to BMI and WC for detecting metabolic risk in the general adolescent population. PMID: 20057196 [PubMed - indexed for MEDLINE] ]]> http://biomarket.jp/modules/pubmed_sugarcomposition/article-225.html Related Articles Co-distribution of glycoconjugates and H(+), K(+)-ATPase in the parietal cells of the greater horseshoe bat, Rhinolophus ferrumequinum (Schreber, 1774). Zoolog Sci. 2010 May;27(5):433-9 Authors: Scillitani G, Mastrodonato M, Liquori GE, Ferri D Histochemical, lectin-histochemical, and immunohistochemical analyses were performed on parietal cells of the greater horseshoe bat, Rhinolophus ferrumequinum, to clarify the composition and distribution of oligosaccharide chains in the b ... Sun, 11 Jul 2010 01:00:31 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-225.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-222.html Related Articles Effect of amniotic membrane transplantation on corneal healing and proteoglycan expression in an experimental model of limbal deficiency in rabbits. Eur J Ophthalmol. 2010 Mar-Apr;20(2):290-9 Authors: Andrade AL, Campos MQ, Gomes JA, Berto AG, Michelacci YM PURPOSE: Amniotic membrane transplantation (AMT) has been used as a graft or as a dressing in ocular surface reconstruction, facilitating epithelization, maintaining normal epithelial phenotype, and reducing inflammation, vas ... Sun, 11 Jul 2010 01:00:31 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-222.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-224.html Related Articles Phagocytic activity of macrophages against liposomes with conjugates of oxidized dextrans and isonicotinic acid hydrazide during modeling of phagocytosis disturbances in vitro. Bull Exp Biol Med. 2009 Oct;148(4):689-91 Authors: Arkhipov SA, Shkurupy VA, Troitsky AV, Luzgina NG, Ufimceva EG, Zaikovskaja MV, Iljine DA, Akhramenko ES, Gulyaeva EP, Bistrova TN We studied phagocytic activity of macrophages against molecular-liposome hybrid compositions consisting of liposomes (diamet ... Sun, 11 Jul 2010 01:00:31 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-224.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-230.html Related Articles Biochemical analysis and quantification of hematopoietic stem cells by infrared spectroscopy. J Biomed Opt. 2010 May-Jun;15(3):037008 Authors: Zelig U, Dror Z, Iskovich S, Zwielly A, Ben-Harush M, Nathan I, Mordechai S, Kapelushnik J Identification of hematopoietic stem cells (HSCs) in different stages of maturation is one of the major issues in stem cell research and bone marrow (BM) transplantation. Each stage of maturation of HSCs is characterized by a series of distinct glyc ... Sun, 11 Jul 2010 01:00:31 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-230.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-227.html Related Articles Regulation of growth response to water stress in the soybean primary root. I. Proteomic analysis reveals region-specific regulation of phenylpropanoid metabolism and control of free iron in the elongation zone. Plant Cell Environ. 2010 Feb;33(2):223-43 Authors: Yamaguchi M, Valliyodan B, Zhang J, Lenoble ME, Yu O, Rogers EE, Nguyen HT, Sharp RE In water-stressed soybean primary roots, elongation was maintained at well-watered rates in the apical 4 mm (region 1), but was progres ... Sun, 11 Jul 2010 01:00:31 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-227.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-229.html Related Articles Increased cell and matrix accumulation during atherogenesis in mice with vessel wall-specific deletion of discoidin domain receptor 1. Circ Res. 2010 Jun 11;106(11):1775-83 Authors: Franco C, Ahmad PJ, Hou G, Wong E, Bendeck MP RATIONALE: Discoidin domain receptor (DDR)1 is a collagen receptor expressed on both smooth muscle cells (SMCs) and macrophages, where it plays important roles regulating cell and matrix accumulation during atherogenesis. Systemic deletion of DDR1 result ... Sun, 11 Jul 2010 01:00:31 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-229.html -/-)) or control mice (Ddr1(+/+-->+/+)) were fed an atherogenic diet for 12 weeks. We observed a 3.8-fold increase in the size of aortic sinus plaques in Ddr1(+/+-->-/-) compared to Ddr1(+/+-->+/+) mice. This was attributed to pronounced accumulation of collagen, elastin, proteoglycans, and fibronectin and resulted in a thickened fibrous cap. The enhanced matrix accumulation decreased the proportion of plaque area occupied by cells but was associated with a shift in the cellular composition of the lesions toward increased numbers of vessel wall-derived SMCs compared to bone marrow-derived macrophages. In vitro studies confirmed that Ddr1(-/-) SMCs expressed more matrix, proliferated more, and migrated farther than Ddr1(+/+) SMCs. CONCLUSIONS: DDR1 expression on resident vessel wall SMCs limits proliferation, migration and matrix accumulation during atherogenesis. PMID: 20448217 [PubMed - indexed for MEDLINE] ]]> http://biomarket.jp/modules/pubmed_sugarcomposition/article-228.html Related Articles Impact of acute biochemical castration on insulin sensitivity in healthy adult men. Endocr Res. 2010 May;35(2):71-84 Authors: Rabiee A, Dwyer AA, Caronia LM, Hayes FJ, Yialamas MA, Andersen DK, Thomas B, Torriani M, Elahi D INTRODUCTION: Evidence supports an inverse relationship between serum testosterone (T) and insulin resistance in men. However, data with respect to causality are limited. The aim of this study was to explore the impact of acute biochemical castration on insu ... Sun, 11 Jul 2010 01:00:31 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-228.html http://biomarket.jp/modules/pubmed_fluidigm/article-226.html Related Articles The impact of CpG island on defining transcriptional activation of the mouse l1 retrotransposable elements. PLoS One. 2010;5(6):e11353 Authors: Lee SH, Cho SY, Shannon MF, Fan J, Rangasamy D BACKGROUND: L1 retrotransposable elements are potent insertional mutagens responsible for the generation of genomic variation and diversification of mammalian genomes, but reliable estimates of the numbers of actively transposing L1 elements are mostly nonexistent. While the human and mouse ... Sun, 11 Jul 2010 01:00:21 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-226.html http://biomarket.jp/modules/pubmed_fluidigm/article-225.html Related Articles A novel microdeletion/microduplication syndrome of 19p13.13. Genet Med. 2010 Jul 6; Authors: Dolan M, Mendelsohn NJ, Pierpont ME, Schimmenti LA, Berry SA, Hirsch B PURPOSE:: Whole genome interrogation by array-based comparative genomic hybridization has led to a rapidly increasing number of discoveries of novel microdeletion and/or microduplication syndromes. We here describe the clinical and cytogenomic correlates of a novel microdeletion/microduplication of 19p13.13. METHODS:: ... Sun, 11 Jul 2010 01:00:21 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-225.html http://biomarket.jp/modules/pubmed_fluidigm/article-228.html Related Articles Development of unigene-derived SSR markers in cowpea (Vigna unguiculata) and their transferability to other Vigna species. Genome. 2010 Jul;53(7):508-23 Authors: Gupta SK, Gopalakrishna T Unigene sequences available in public databases provide a cost-effective and valuable source for the development of molecular markers. In this study, the identification and development of unigene-based SSR markers in cowpea (Vigna unguiculata (L.) Walp.) is presented. A total of 1071 SSRs were ... Sun, 11 Jul 2010 01:00:21 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-228.html http://biomarket.jp/modules/pubmed_fluidigm/article-227.html Related Articles Copy number variation of the SELENBP1 gene in schizophrenia. Behav Brain Funct. 2010 Jul 8;6(1):40 Authors: Amar S, Ovadia O, Maier W, Ebstein R, Belmaker RH, Mishmar D, Agam G ABSTRACT: BACKGROUND: Schizophrenia is associated with rare copy-number (CN) mutations. Screening for such alleles genome-wide, though comprehensive, cannot study in-depth the causality of particular loci, therefore cannot provide the functional interpretation for the disease etiology. We hypothesized tha ... Sun, 11 Jul 2010 01:00:21 +0900 http://biomarket.jp/modules/pubmed_fluidigm/article-227.html http://biomarket.jp/modules/pubmed_seldi/article-104.html Related Articles SELDI-TOF serum proteomics and colorectal cancer: A current overview. Arch Physiol Biochem. 2010 Jul 8; Authors: Gemoll T, Roblick UJ, Auer G, Jörnvall H, Habermann JK Surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) is a widely used technology platform for diagnostic biomarker discovery in tissue, plasma and serum. High-throughput and simplicity of experimental procedures have allowed this technology to become an important researc ... Sun, 11 Jul 2010 01:00:13 +0900 http://biomarket.jp/modules/pubmed_seldi/article-104.html http://biomarket.jp/modules/pubmed/article-24449.html Plakophilin-1 Localizes to the Nucleus and Interacts with Single-Stranded DNA. J Invest Dermatol. 2010 Jul 8; Authors: Sobolik-Delmaire T, Reddy R, Pashaj A, Roberts BJ, Wahl JK Plakophilins (Pkp-1, -2, and -3) comprise a family of armadillo repeat-containing proteins first identified as desmosomal plaque components, in which they link desmoplakin to the desmosomal cadherins. In addition to their role in desmosomal cell-cell adhesion, Pkps also localize to the nucleus, where they perform unknow ... Sun, 11 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24449.html http://biomarket.jp/modules/pubmed/article-24448.html UV-Induced Tolerance to a Contact Allergen Is Impaired in Polymorphic Light Eruption. J Invest Dermatol. 2010 Jul 8; Authors: Koulu LM, Laihia JK, Peltoniemi HH, Jansén CT Polymorphic light eruption (PLE) is a common skin disorder provoked by exposure to UVR. Its clinical symptoms resemble those of a contact allergic reaction. PLE is generally considered a T-cell-mediated autoimmune reaction toward a yet unidentified antigen formed in UVR-exposed skin. Predisposition to such an immune reac ... Sun, 11 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24448.html http://biomarket.jp/modules/pubmed/article-24450.html Epigenetic Silencing of Lysyl Oxidase-Like-1 through DNA Hypermethylation in an Autosomal Recessive Cutis Laxa Case. J Invest Dermatol. 2010 Jul 8; Authors: Debret R, Cenizo V, Aimond G, André V, Devillers M, Rouvet I, Mégarbané A, Damour O, Sommer P We have recently reported a case of cutis laxa caused by a fibulin-5 missense mutation (p.C217R). Skin fibroblasts from this individual showed an abnormal pattern of expression of several genes coding for elastic fiber-related protei ... Sun, 11 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24450.html http://biomarket.jp/modules/pubmed/article-24451.html Dermatology: a multi-faceted field with many chances of expedient interdisciplinary cooperation. Dtsch Med Wochenschr. 2010 Jul;135(28/29):1417 Authors: Berking C, Ruzicka T PMID: 20614401 [PubMed - as supplied by publisher] Sun, 11 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24451.html http://biomarket.jp/modules/pubmed/article-24452.html Interventions for melasma. Cochrane Database Syst Rev. 2010;7:CD003583 Authors: Rajaratnam R, Halpern J, Salim A, Emmett C BACKGROUND: Melasma is an acquired symmetrical pigmentary disorder where confluent grey-brown patches typically appear on the face. Available treatments for melasma are unsatisfactory. OBJECTIVES: To assess interventions used in the management of all types of melasma: epidermal, dermal, and mixed. SEARCH STRATEGY: In May 2010 we searched the Cochrane Skin Group Specialised ... Sun, 11 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24452.html http://biomarket.jp/modules/pubmed/article-24453.html A novel metagenome-derived beta-galactosidase: gene cloning, overexpression, purification and characterization. Appl Microbiol Biotechnol. 2010 Jul 8; Authors: Wang K, Li G, Yu SQ, Zhang CT, Liu YH A novel beta-galactosidase gene, zd410, was isolated by screening a soil metagenomic library. Sequence analysis revealed that zd410 encodes a protein of 672 amino acids with a predicted molecular weight of 78.6 kDa. The recombinant ZD410 was expressed and purified in Pichia pastoris, with a yield of ... Sun, 11 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24453.html http://biomarket.jp/modules/pubmed/article-24455.html Related Articles Mechanical Assist Device as a Bridge to Heart Transplantation in Children Less Than 10 Kilograms. Ann Thorac Surg. 2010 Jul;90(1):58-62 Authors: Brancaccio G, Amodeo A, Ricci Z, Morelli S, Gagliardi MG, Iacobelli R, Michielon G, Picardo S, Parisi F, Pongiglione G, Di Donato RM BACKGROUND: Despite the remarkable advances with the use of ventricular assist devices (VAD) in adults, pneumatic pulsatile support in children is still limited. We report a retrospective review of our exp ... Sun, 11 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24455.html 60%) panel reactive antibody by enzyme-linked immunosorbent assay, confirmed by Luminex (Luminex Corp, Austin, TX). All 3 experienced at least one acute episode of rejection in the first month after heart transplant, needing plasmapheresis. The survival rate after heart transplantation was 100% with a median follow-up of 7.5 months. CONCLUSIONS: Mechanical support in very small children with end-stage heart failure is an effective strategy of bridge to heart transplantation with a reasonable mortality rate. The high rate of complications suggests to optimize indications and timing of VAD implantation. PMID: 20609748 [PubMed - as supplied by publisher] ]]> http://biomarket.jp/modules/pubmed/article-24454.html Related Articles Morphological characteristics of the interface between resin composite and glass-ionomer cement to thin-walled roots: a microscopic investigation. Am J Dent. 2010 Apr;23(2):103-7 Authors: Ayad MF, Bahannan SA, Rosenstiel SF PURPOSE: To identify how different treatments of the root dentin surface affect the microscopic appearance of the resin composite/glass-ionomer cement-to-dentin interface. METHODS: The root canals of 70 extracted human single-rooted teeth were enlarged to red ... Sun, 11 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24454.html http://biomarket.jp/modules/pubmed/article-24456.html Related Articles Tools for analyzing intraflagellar transport in trypanosomes. Methods Cell Biol. 2009;93:59-80 Authors: Julkowska D, Bastin P African trypanosomes are evolutionary-divergent eukaryotes responsible for sleeping sickness. They duplicate their single flagellum while maintaining the old one, providing a unique model to examine mature and elongating flagella in the same cell. Like in most eukaryotes, the trypanosome flagellum is constructed by addition of novel subunits at its dista ... Sun, 11 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24456.html http://biomarket.jp/modules/pubmed/article-24457.html Related Articles Development and characterization of promoterless helper RNAs for the production of alphavirus replicon particle. J Gen Virol. 2010 Jul;91(Pt 7):1723-7 Authors: Kamrud KI, Alterson K, Custer M, Dudek J, Goodman C, Owens G, Smith JF Alphavirus-based replicon systems are frequently used as preclinical vectors and as antigen discovery tools, and they have recently been assessed in clinical vaccine trials. Typically, alphavirus replicon RNAs are delivered within virus-like replicon ... Sun, 11 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24457.html http://biomarket.jp/modules/pubmed/article-24458.html Related Articles Cancer cell specific gene delivery by laminin-derived peptide AG73-labeled liposomes. Bioorg Med Chem Lett. 2010 Apr 14; Authors: Iijima H, Negishi Y, Omata D, Nomizu M, Aramaki Y We developed laminin-derived AG73 peptide labeled liposomes for cancer specific gene therapy. AG73 peptide is well known as a ligand for syndecan-2 which is highly expressed in various cancer cells. Liposomes labeled with AG73 showed high efficient transfection efficiency in syndecan-2 overexpressing c ... Sun, 11 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24458.html http://biomarket.jp/modules/pubmed/article-24464.html Related Articles Role of Peroxiredoxin-1 and -4 in Protection of RSV-induced Cysteinyl-oxidation of Nuclear Cytoskeletal Proteins. J Virol. 2010 Jul 7; Authors: Jamaluddin M, Wiktorowicz JE, Soman KV, Boldogh I, Forbus JD, Spratt H, Garofalo RP, Brasier AR The respiratory epithelium plays a central role in innate immunity by secreting networks of inflammatory mediators in response to Respiratory Syncytial Virus (RSV) infection. Previous proteomic studies focusing on the host cellular response to ... Sun, 11 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24464.html 1.2-fold in the Prdx-knockdowns in response to RSV, including Annexin A2 and desmoplakin. Our results suggest that Prdx-1 and -4 are essential for preventing RSV-induced oxidative damage in a subset of nuclear intermediate filament and actin binding proteins in epithelial cells. PMID: 20610706 [PubMed - as supplied by publisher] ]]> http://biomarket.jp/modules/pubmed/article-24463.html Related Articles Inhibition of STAT3 and ErbB2 suppresses tumor growth, enhances radiosensitivity, and induces mitochondria-dependent apoptosis in glioma cells. Int J Radiat Oncol Biol Phys. 2010 Jul 15;77(4):1223-31 Authors: Gao L, Li F, Dong B, Zhang J, Rao Y, Cong Y, Mao B, Chen X PURPOSE: Constitutively activated signal transducer and activator of transcription 3 (STAT3) and ErbB2 are involved in the pathogenesis of many tumors, including astrocytoma. Inactivation of these molecules is repor ... Sun, 11 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24463.html http://biomarket.jp/modules/pubmed/article-24461.html Related Articles Atheroprone hemodynamics regulate fibronectin deposition to create positive feedback that sustains endothelial inflammation. Circ Res. 2010 Jun 11;106(11):1703-11 Authors: Feaver RE, Gelfand BD, Wang C, Schwartz MA, Blackman BR RATIONALE: The extracellular matrix protein fibronectin (FN) is focally deposited in regions of atherosclerosis, where it contributes to inflammatory signaling. OBJECTIVE: To elucidate the mechanism by which FN deposition is regulated by local shear stre ... Sun, 11 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24461.html http://biomarket.jp/modules/pubmed/article-24465.html Related Articles Survivin is a key factor in the differential susceptibility of gastric endothelial and epithelial cells to alcohol-induced injury. J Physiol Pharmacol. 2010 Jun;61(3):253-64 Authors: Jones MK, Padilla OR, Zhu E We previously demonstrated that the anti-apoptosis protein, survivin, plays a protective role against alcohol-induced gastric injury. Since the endothelium is a primary target of alcohol-induced gastric damage, we investigated whether survivin expression is a key factor i ... Sun, 11 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24465.html http://biomarket.jp/modules/pubmed/article-24462.html Related Articles Visfatin is induced by peroxisome proliferator-activated receptor gamma in human macrophages. FEBS J. 2010 Jul 1; Authors: Mayi TH, Duhem C, Copin C, Bouhlel MA, Rigamonti E, Pattou F, Staels B, Chinetti-Gbaguidi G Obesity is a low-grade chronic inflammatory disease associated with an increased number of macrophages (adipose tissue macrophages) in adipose tissue. Within the adipose tissue, adipose tissue macrophages are the major source of visfatin/pre-B-cell colony-enhancing fa ... Sun, 11 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24462.html http://biomarket.jp/modules/pubmed/article-24467.html Related Articles Electromagnetic-Guided Dynamic Multileaf Collimator Tracking Enables Motion Management for Intensity-Modulated Arc Therapy. Int J Radiat Oncol Biol Phys. 2010 Jul 7; Authors: Keall PJ, Sawant A, Cho B, Ruan D, Wu J, Poulsen P, Petersen J, Newell LJ, Cattell H, Korreman S PURPOSE: Intensity-modulated arc therapy (IMAT) is attractive because of high-dose conformality and efficient delivery. However, managing intrafraction motion is challenging for IMAT. The purpose of this researc ... Sun, 11 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24467.html http://biomarket.jp/modules/pubmed/article-24466.html Related Articles Small Molecule Inhibitors of Mitochondrial Division: Tools that Translate Basic Biological Research into Medicine. Chem Biol. 2010 Jun 25;17(6):578-583 Authors: Lackner LL, Nunnari J Mitochondria do not exist as discrete static entities; rather, mitochondria form a network that continuously moves, divides, and fuses. The structure of this dynamic network is in part maintained by a balance of division and fusion events (Hoppins et al., 2007). The ratio of division to fusion event ... Sun, 11 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24466.html http://biomarket.jp/modules/pubmed/article-24468.html 960の新しいpubmed参照はあなたの調査のために取り出された。完全な調査の結果を表示するために次調査のハイパーリンクをつけなさい:癌これらのpubmed結果は50年代に戻って生物医学的な記事のための15,000,000の参照に2010/07/10 PubMedの薬の国立図書館のサービスで、含んでいる発生した。これらの参照はMEDLINEおよび付加的な生命科学ジャーナルからある。 PubMedはフルテキストの記事および他の関連資源を提供する多くの場所にリンクを含んでいる。(原文:960 new pubmed citations were retrieved for your search.Click on the search ... Sun, 11 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24468.html http://biomarket.jp/modules/pubmed/article-24550.html 960 new pubmed citations were retrieved for your search.Click on the search hyperlink below to display the complete search results:cancerThese pubmed results were generated on 2010/07/10PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's.These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. Sun, 11 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24550.html http://biomarket.jp/modules/pubmed/article-24545.html Related Articles TNF{alpha}-induced IP3R1 expression through TNFR1/PC-PLC/PKC{alpha} and TNFR2 signalling pathways in human mesangial cell. Nephrol Dial Transplant. 2010 Jul 7; Authors: Wang YR, Li ZG, Fu JL, Wang ZH, Wen Y, Liu P BACKGROUND: Little information is available regarding the mechanisms involved in cytokine-induced type 1 inositol 1,4,5-trisphosphate receptor (IP(3)R1) expression in human mesangial cells (HMCs) in the occurrence of hepatorenal syndrome (HRS). Over-expression of IP(3) ... Sun, 11 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24545.html http://biomarket.jp/modules/pubmed/article-24549.html Related Articles Establishment of recombinant cannabinoid receptor assays and characterization of several natural and synthetic ligands. Naunyn Schmiedebergs Arch Pharmacol. 2010 Jul 9; Authors: Geiger S, Nickl K, Schneider EH, Seifert R, Heilmann J Cannabinoid receptors (CBR) are important drug targets for the treatment of various inflammatory, metabolic and neurological diseases. Therefore, sensitive test systems for the assessment of ligands are needed. In this study, a steady-state GTPase as ... Sun, 11 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24549.html http://biomarket.jp/modules/pubmed/article-24546.html Related Articles Dramatic Change in Function and Expression Pattern of a Gene Duplicated by Polyploidy Created a Paternal Effect Gene in the Brassicaceae. Mol Biol Evol. 2010 Jul 8; Authors: Liu SL, Adams KL New gene formation by polyploidy has been an ongoing process during the evolution of various eukaryotes that has contributed greatly to the large number of genes in their genomes. After duplication, some genes that are retained can acquire new functions or expression patterns, or subdivide t ... Sun, 11 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24546.html http://biomarket.jp/modules/pubmed/article-24548.html Related Articles Ontogenomic Study of the Relationship Between Number of Gene Splice Variants and Go Categorization. Bioinformatics. 2010 Jul 8; Authors: Kahn AB, Zeeberg BR, Ryan MC, Jamison DC, Rockoff DM, Pommier Y, Weinstein JN MOTIVATION: Splice variation plays important roles in evolution and cancer. Different splice variants of a gene may be characteristic of particular cellular processes, subcellular locations, or organs. Although several genomics projects have identified splice variants ... Sun, 11 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24548.html b (b = 1,,10). Then we used GoMiner to determine whether any GO categories are enriched in genes with particular numbers of splice variants. Since there was no a priori "appropriate" partition boundary, we studied those "robust" categories whose enrichment did not depend on the selection of a particular partition boundary. Furthermore, because the distribution of splice variant number was a snapshot taken at a particular point in time, we confirmed that those observations were stable across successive versions of the human genome and GenBank. A small number of categories were found for genes in the lower partitions. Those categories were associated exclusively with sensory perception. A larger number of categories were found for genes in the higher partitions. Those categories were largely associated with cell death and signal transduction. Apoptotic genes tended to have a large repertoire of splice variants, and genes with splice variants exhibited a distinctive "apoptotic island" in CIMs. PMID: 20616384 [PubMed - as supplied by publisher] ]]> http://biomarket.jp/modules/pubmed/article-24547.html Related Articles Sumoylation and regulation of cardiac gene expression. Circ Res. 2010 Jul 9;107(1):19-29 Authors: Wang J, Schwartz RJ Abstract: Sumoylation is a posttranslational modification process in which SUMO proteins are covalently and reversibly conjugated to their targets via enzymatic cascade reactions. Since the discovery of SUMO-1 in 1996, the SUMO pathway has garnered increased attention due to its role in a number of important biological activities such as cell cycle progression, e ... Sun, 11 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24547.html http://biomarket.jp/modules/pubmed/article-24551.html 449 new pubmed citations were retrieved for your search.Click on the search hyperlink below to display the complete search results:biological chemistryThese pubmed results were generated on 2010/07/10PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's.These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. Sun, 11 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24551.html http://biomarket.jp/modules/pubmed/article-24552.html 160 new pubmed citations were retrieved for your search.Click on the search hyperlink below to display the complete search results:single cellThese pubmed results were generated on 2010/07/10PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's.These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. Sun, 11 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24552.html http://biomarket.jp/modules/d3pipes/article-10798.html Related Articles miR-214 Regulates Lactoferrin Expression and Pro-Apoptotic Function in Mammary Epithelial Cells. J Nutr. 2010 Jul 7; Authors: Liao Y, Du X, Lönnerdal B Lactoferrin (Lf) is an abundantly expressed protein in human milk. Lactoferrin exhibits several important biological functions, and its expression is regulated by multiple environmental factors. Cellular endogenous factors, however, have not been extensively studied with regard to lactoferrin gene expression. In this study, w ... Sun, 11 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10798.html http://biomarket.jp/modules/d3pipes/article-10795.html Related Articles Efficient method for production of high yields of Fab fragments in Drosophila S2 cells. Protein Eng Des Sel. 2010 Apr;23(4):169-74 Authors: Backovic M, Johansson DX, Klupp BG, Mettenleiter TC, Persson MA, Rey FA Fab molecules are used as therapeutic agents, and are invaluable tools in structural biology. We report here a method for production of recombinant Fab in Drosophila S2 cells for use in structural biology. Stably transfected S2 cell lines expressing the Fab were created ... Sun, 11 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10795.html http://biomarket.jp/modules/d3pipes/article-10797.html Related Articles Single nucleotide polymorphism associated with nonsyndromic cleft palate influences the processing of miR-140. Am J Med Genet A. 2010 Apr;152A(4):856-62 Authors: Li L, Meng T, Jia Z, Zhu G, Shi B Nonsyndromic oral cleft is a common developmental malformation of humans. Embryonic development is regulated by microRNAs. MicroRNA-140-5p (miR-140-5p) was found to regulate palatal development. As sequence variants in miRNA genes are likely to affect miRNA expression and/or maturation ... Sun, 11 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10797.html A) located in precursor miRNA-140. We carried out a case-control analysis in 557 patients with nonsyndromic oral clefts and 306 unaffected controls from west China and found that the frequency of minor allele (A allele) was significantly increased (P = 0.003 after Bonferroni correction) in nonsyndromic cleft palate (NSCP) patients in comparison with that in controls. We constructed expression vectors of primary miRNA-140 (pri-miR-140) with the major and minor alleles of rs7205289. The vectors were transfected into HEK293 cells, and the mature forms of miR-140 were detected by Northern blot. Compared to the vector with the C allele, the vector with the A allele was found to influence the miR-140 processing, resulting in a significant decrease of miR-140-5p and an increase of miR-140-3p. These results suggest that the SNP located in pre-miR-140 contributes to NSCP susceptibility by influencing the processing of miR-140. PMID: 20358594 [PubMed - indexed for MEDLINE] ]]> http://biomarket.jp/modules/d3pipes/article-10796.html Related Articles piggyBac transposon-mediated long-term gene expression in mice. Mol Ther. 2010 Apr;18(4):707-14 Authors: Nakanishi H, Higuchi Y, Kawakami S, Yamashita F, Hashida M Transposons are promising systems for somatic gene integration because they can not only integrate exogenous genes efficiently, but also be delivered to a variety of organs using a range of transfection methods. piggyBac (PB) transposon has a high transposability in mammalian cells in vitro, and has been used for gen ... Sun, 11 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10796.html http://biomarket.jp/modules/d3pipes/article-10794.html Related Articles Heterodimerization of hypothalamic G-protein-coupled receptors involved in weight regulation. Obes Facts. 2009;2(2):80-6 Authors: Rediger A, Tarnow P, Bickenbach A, Schaefer M, Krude H, Gruters A, Biebermann H BACKGROUND: Melanocortin 3 and 4 receptors (MC3R and MC4R) are known to play an essential role in hypothalamic weight regulation. In addition to these two G-protein-coupled receptors (GPCRs), a huge number of other GPCRs are expressed in hypothalamic regions, and some of ... Sun, 11 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10794.html http://biomarket.jp/modules/d3pipes/article-10807.html Related Articles 5th Annual Conference of the Organisation of Oncology and Translational Research. Foreword. Expert Opin Investig Drugs. 2010 Apr;19 Suppl 1:S1-2 Authors: GlÃ?ck S PMID: 20374020 [PubMed - indexed for MEDLINE] Sun, 11 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10807.html http://biomarket.jp/modules/d3pipes/article-10809.html Related Articles Stressful life events, cognitive symptoms of depression and response to antidepressants in GENDEP. J Affect Disord. 2010 Jul 5; Authors: Keers R, Uher R, Gupta B, Rietschel M, Schulze TG, Hauser J, Skibinska M, Henigsberg N, Kalember P, Maier W, Zobel A, Mors O, Kristensen AS, Kozel D, Giovannini C, Mendlewicz J, Kumar S, McGuffin P, Farmer AE, Aitchison KJ BACKGROUND: The occurrence of stressful life events (SLEs) has been shown to predict response to antidepressants; however, ... Sun, 11 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10809.html http://biomarket.jp/modules/d3pipes/article-10811.html Related Articles Pharmacogenetics raises new legal questions. Nat Med. 2010 Jul;16(7):729 Authors: Hutson S PMID: 20613735 [PubMed - in process] Sun, 11 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10811.html http://biomarket.jp/modules/d3pipes/article-10810.html Related Articles Cellular Form of Prion Protein Inhibits Reelin-Mediated Shedding of Caspr from the Neuronal Cell Surface to Potentiate Caspr-Mediated Inhibition of Neurite Outgrowth. J Neurosci. 2010 Jul 7;30(27):9292-9305 Authors: Devanathan V, Jakovcevski I, Santuccione A, Li S, Lee HJ, Peles E, Leshchyns'ka I, Sytnyk V, Schachner M Extension of axonal and dendritic processes in the CNS is tightly regulated by outgrowth-promoting and -inhibitory cues to assure precision of synaptic connection ... Sun, 11 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10810.html http://biomarket.jp/modules/d3pipes/article-10808.html Related Articles Population pharmacokinetics of gemcitabine and its metabolite in Japanese cancer patients: impact of genetic polymorphisms. Clin Pharmacokinet. 2010 Aug 1;49(8):549-58 Authors: Sugiyama E, Kaniwa N, Kim SR, Hasegawa R, Saito Y, Ueno H, Okusaka T, Ikeda M, Morizane C, Kondo S, Yamamoto N, Tamura T, Furuse J, Ishii H, Yoshida T, Saijo N, Sawada J Background and Objective: Gemcitabine (2',2'-difluorodeoxycytidine) is an anticancer drug, which is effective against solid tumours, inc ... Sun, 11 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10808.html A (Ala70Thr)] (64% decrease), heterozygous *3 (17% decrease) and CDA -31delC (an approximate 7% increase per deletion), which has a strong association with CDA*2 [79A>C (Lys27Gln)], and coadministered S-1, an oral, multicomponent anti-cancer drug mixture consisting of tegafur, gimeracil and oteracil (an approximate 19% increase). The estimated contribution of homozygous CDA*3 to gemcitabine clearance provides an explanation for the life-threatening severe adverse reactions, including grade 4 neutropenia observed in three Japanese patients with homozygous CDA*3. Genetic polymorphisms of DCK and SLC29A1 (hENT1) had no significant correlation with gemcitabine pharmacokinetic parameters. Aging and increased serum creatinine levels correlated with decreased dFdU clearance. Conclusion: A population pharmacokinetic model that included CDA genotypes as a covariate for gemcitabine and dFdU in Japanese cancer patients was successfully constructed. The model confirms the clinical importance of the CDA*3 genotype. PMID: 20608756 [PubMed - in process] ]]> http://biomarket.jp/modules/pubmed/article-23777.html 290 new pubmed citations were retrieved for your search.Click on the search hyperlink below to display the complete search results:biological chemistryThese pubmed results were generated on 2010/07/06PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's.These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. Sat, 10 Jul 2010 01:00:11 +0900 http://biomarket.jp/modules/pubmed/article-23777.html http://biomarket.jp/modules/pubmed/article-23782.html 290の新しいpubmed参照はあなたの調査のために取り出された。完全な調査の結果を表示するために次調査のハイパーリンクをつけなさい:生物化学これらのpubmed結果は50年代に戻って生物医学的な記事のための15,000,000の参照に2010/07/06 PubMedの薬の国立図書館のサービスで、含んでいる発生した。これらの参照はMEDLINEおよび付加的な生命科学ジャーナルからある。 PubMedはフルテキストの記事および他の関連資源を提供する多くの場所にリンクを含んでいる。(原文:290 new pubmed citations were retrieved for your search.Click on the ... Sat, 10 Jul 2010 01:00:11 +0900 http://biomarket.jp/modules/pubmed/article-23782.html http://biomarket.jp/modules/pubmed/article-23882.html 122の新しいpubmed参照はあなたの調査のために取り出された。完全な調査の結果を表示するために次調査のハイパーリンクをつけなさい:免疫学これらのpubmed結果は50年代に戻って生物医学的な記事のための15,000,000の参照に2010/07/06 PubMedの薬の国立図書館のサービスで、含んでいる発生した。これらの参照はMEDLINEおよび付加的な生命科学ジャーナルからある。 PubMedはフルテキストの記事および他の関連資源を提供する多くの場所にリンクを含んでいる。(原文:122 new pubmed citations were retrieved for your search.Click on the se ... Sat, 10 Jul 2010 01:00:11 +0900 http://biomarket.jp/modules/pubmed/article-23882.html http://biomarket.jp/modules/pubmed/article-23779.html 498の新しいpubmed参照はあなたの調査のために取り出された。完全な調査の結果を表示するために次調査のハイパーリンクをつけなさい:癌これらのpubmed結果は50年代に戻って生物医学的な記事のための15,000,000の参照に2010/07/06 PubMedの薬の国立図書館のサービスで、含んでいる発生した。これらの参照はMEDLINEおよび付加的な生命科学ジャーナルからある。 PubMedはフルテキストの記事および他の関連資源を提供する多くの場所にリンクを含んでいる。(原文:498 new pubmed citations were retrieved for your search.Click on the search ... Sat, 10 Jul 2010 01:00:11 +0900 http://biomarket.jp/modules/pubmed/article-23779.html http://biomarket.jp/modules/pubmed/article-23781.html Related Articles IMRT Implementation and Patient Specific Dose Verification with Film and Ion Chamber Array Detectors. Gulf J Oncolog. 2010 Jul;1(8):20-27 Authors: Sathiyan S, Ravikumar M, Varatharaj C, Supe SS, Keshava SL Implementation of Intensity Modulation Radiotherapy (IMRT) and patient dose verification was carried out with film and I'mariXX using linear accelerator with 120-leaf Millennium dynamic multileaf collimator (dMLC). The basic mechanical and electrical commissioning and quality ... Sat, 10 Jul 2010 01:00:11 +0900 http://biomarket.jp/modules/pubmed/article-23781.html 95% and 14 patients were with the gamma pixel match of 90-95% with the criteria of 3% delta dose (DD) and 3 mm distance-to-agreement (DTA). Commissioning and quality assurance of dMLC for IMRT application requires considerable time and effort. Many dosimetric characteristics need to be assessed carefully failing which the delivered dose will be significantly different from the planned dose. In addition to the issues discussed above we feel that individual MU check is necessary before the treatment is delivered. Keywords: IMRT, dMLC, Quality Assurance, I'mariXX, DTA, Delta dose. PMID: 20601335 [PubMed - as supplied by publisher] ]]> http://biomarket.jp/modules/pubmed/article-23780.html Related Articles Distinct developmental roles for direct and indirect talin-mediated linkage to actin. Dev Biol. 2010 Jun 28; Authors: Franco-Cea A, Ellis SJ, Fairchild MJ, Yuan L, Cheung TY, Tanentzapf G Transmembrane adhesion receptors, such as integrins, mediate cell adhesion by interacting with intracellular proteins that connect to the cytoskeleton. Talin, one such linker protein, is essential to connect extracellular matrix-bound integrins to the cytoskeleton. Talin can connect to the cyto ... Sat, 10 Jul 2010 01:00:11 +0900 http://biomarket.jp/modules/pubmed/article-23780.html http://biomarket.jp/modules/pubmed/article-23881.html Related Articles Human Wharton's Jelly Stem Cells Have Unique Transcriptome Profiles Compared to Human Embryonic Stem Cells and Other Mesenchymal Stem Cells. Stem Cell Rev. 2010 Jul 3; Authors: Fong CY, Chak LL, Biswas A, Tan JH, Gauthaman K, Chan WK, Bongso A The human umbilical cord that originates from the embryo is an extra-embryonic membrane and the Wharton's jelly within it is a rich source of stem cells (hWJSCs). It is not definitely known whether these cells behave as human embryonic ste ... Sat, 10 Jul 2010 01:00:11 +0900 http://biomarket.jp/modules/pubmed/article-23881.html http://biomarket.jp/modules/pubmed/article-23880.html 関連の記事の診断X線検査および高められた染色体の転置: 3つの調査からの証拠。 RadiatはBiophysを囲む。 7月2010日3日; 著者: Bhatti P、Yong LC、Doody MM、プレストンDL、Kampa DM、Ramsey MJ、区EM、Edwards AA、Ron E、Tucker JDの医学の診断radiologic検査の高められた使用からの潜在的な健康を損う危険性に関するSigurdsonのAJ論争は世間の注目に来た。 私達は染色体の損傷、とりわけ癌の危険性のための可能性としては中間biomarkerである転置が診断X線への露出の後で高められたかどうか、評価したmGyおよそ50のレベルの下で電離放 ... Sat, 10 Jul 2010 01:00:11 +0900 http://biomarket.jp/modules/pubmed/article-23880.html http://biomarket.jp/modules/pubmed/article-23879.html 膵臓の腺癌の処置のための関連の記事の新しい代理店: トンネルの端にライトか。 「2010 ASCO年次総会」のからのハイライト。 シカゴ、IL、米国。 2010年6月4-8日。 JOP. 2010年; 11 (4): 324-7書く: Dimouはの、Syrigos KNのSaif MWの膵臓癌陰気な予想の病気であり、処置の選択は限られている。 新しく活動的な混合物の開発は必須である。 腕間の新しい代理店含まれている臨床腫瘍学(ASCO)の年次総会の最近の2010人のアメリカ人の社会で示されたこといくつかの膵臓癌臨床試験。 IGF-1Rの阻止が有効であるかもしれないし、これがそれ以上の ... Sat, 10 Jul 2010 01:00:11 +0900 http://biomarket.jp/modules/pubmed/article-23879.html http://biomarket.jp/modules/pubmed/article-23883.html Related Articles Comparative studies on the extraction of metagenomic DNA from the saline habitats of Coastal Gujarat and Sambhar Lake, Rajasthan (India) in prospect of molecular diversity and search for novel biocatalysts. Int J Biol Macromol. 2010 Jun 23; Authors: Siddhapura PK, Vanparia S, Purohit MK, Singh SP Extraction of total DNA from a given habitat assumes significance in metagenomics, due to the requirement of inhibitor free and high quality metagenome in good quantity for applications ... Sat, 10 Jul 2010 01:00:10 +0900 http://biomarket.jp/modules/pubmed/article-23883.html http://biomarket.jp/modules/pubmed/article-23921.html Related Articles HLA-A, -B and DRB1 allele and haplotype frequencies in the Mozambican population: a blood donor based population study. Hum Immunol. 2010 Jul 2; Authors: Assane AA, Fabricio-Silva GM, Cardoso-Oliveira J, Mabunda NE, Sousa AM, Jani IV, Ferreira OC, Porto LC The human leukocyte antigens (HLA) has been used for several decades as genetic markers for analyzing diversity of gene pool origin, platelet transfusion, tissue transplantation, disease susceptibility or resistance, and foren ... Sat, 10 Jul 2010 01:00:10 +0900 http://biomarket.jp/modules/pubmed/article-23921.html http://biomarket.jp/modules/pubmed/article-23926.html Related Articles Tafazzin knockdown causes hypertrophy of neonatal ventricular myocytes. Am J Physiol Heart Circ Physiol. 2010 Jul;299(1):H210-6 Authors: He Q Mutation of the mitochondrial protein tafazzin causes dilated cardiomyopathy in Barth syndrome. We employed an adenovirus as a vector to transfer tafazzin small hairpin RNA (shRNA) into neonatal ventricular myocytes (NVMs) to investigate the effects of tafazzin knockdown. The tafazzin shRNA adenovirus consistently knocked down tafazzin mR ... Sat, 10 Jul 2010 01:00:10 +0900 http://biomarket.jp/modules/pubmed/article-23926.html http://biomarket.jp/modules/pubmed/article-23927.html 407の新しいpubmed参照はあなたの調査のために取り出された。完全な調査の結果を表示するために次調査のハイパーリンクをつけなさい:癌これらのpubmed結果は50年代に戻って生物医学的な記事のための15,000,000の参照に2010/07/07 PubMedの薬の国立図書館のサービスで、含んでいる発生した。これらの参照はMEDLINEおよび付加的な生命科学ジャーナルからある。 PubMedはフルテキストの記事および他の関連資源を提供する多くの場所にリンクを含んでいる。(原文:407 new pubmed citations were retrieved for your search.Click on the search ... Sat, 10 Jul 2010 01:00:10 +0900 http://biomarket.jp/modules/pubmed/article-23927.html http://biomarket.jp/modules/pubmed/article-23929.html 407 new pubmed citations were retrieved for your search.Click on the search hyperlink below to display the complete search results:cancerThese pubmed results were generated on 2010/07/07PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's.These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. Sat, 10 Jul 2010 01:00:10 +0900 http://biomarket.jp/modules/pubmed/article-23929.html http://biomarket.jp/modules/pubmed/article-24086.html 206の新しいpubmed参照はあなたの調査のために取り出された。完全な調査の結果を表示するために次調査のハイパーリンクをつけなさい:免疫学これらのpubmed結果は50年代に戻って生物医学的な記事のための15,000,000の参照に2010/07/07 PubMedの薬の国立図書館のサービスで、含んでいる発生した。これらの参照はMEDLINEおよび付加的な生命科学ジャーナルからある。 PubMedはフルテキストの記事および他の関連資源を提供する多くの場所にリンクを含んでいる。(原文:206 new pubmed citations were retrieved for your search.Click on the se ... Sat, 10 Jul 2010 01:00:10 +0900 http://biomarket.jp/modules/pubmed/article-24086.html http://biomarket.jp/modules/pubmed/article-24165.html 202 new pubmed citations were retrieved for your search.Click on the search hyperlink below to display the complete search results:biological chemistryThese pubmed results were generated on 2010/07/07PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's.These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24165.html http://biomarket.jp/modules/pubmed/article-24084.html 202の新しいpubmed参照はあなたの調査のために取り出された。完全な調査の結果を表示するために次調査のハイパーリンクをつけなさい:生物化学これらのpubmed結果は50年代に戻って生物医学的な記事のための15,000,000の参照に2010/07/07 PubMedの薬の国立図書館のサービスで、含んでいる発生した。これらの参照はMEDLINEおよび付加的な生命科学ジャーナルからある。 PubMedはフルテキストの記事および他の関連資源を提供する多くの場所にリンクを含んでいる。(原文:202 new pubmed citations were retrieved for your search.Click on the ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24084.html http://biomarket.jp/modules/pubmed/article-24085.html 209の新しいpubmed参照はあなたの調査のために取り出された。完全な調査の結果を表示するために次調査のハイパーリンクをつけなさい:biomarkerこれらのpubmed結果は50年代に戻って生物医学的な記事のための15,000,000の参照に2010/07/07 PubMedの薬の国立図書館のサービスで、含んでいる発生した。これらの参照はMEDLINEおよび付加的な生命科学ジャーナルからある。 PubMedはフルテキストの記事および他の関連資源を提供する多くの場所にリンクを含んでいる。(原文:209 new pubmed citations were retrieved for your search.Click on the ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24085.html http://biomarket.jp/modules/pubmed/article-24235.html 115の新しいpubmed参照はあなたの調査のために取り出された。完全な調査の結果を表示するために次調査のハイパーリンクをつけなさい:biomarkerこれらのpubmed結果は50年代に戻って生物医学的な記事のための15,000,000の参照に2010/07/08 PubMedの薬の国立図書館のサービスで、含んでいる発生した。これらの参照はMEDLINEおよび付加的な生命科学ジャーナルからある。 PubMedはフルテキストの記事および他の関連資源を提供する多くの場所にリンクを含んでいる。(原文:115 new pubmed citations were retrieved for your search.Click on the ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24235.html http://biomarket.jp/modules/pubmed/article-24162.html Related Articles Genome-wide analysis of aminoacylation (charging) levels of tRNA using microarrays. J Vis Exp. 2010;(40): Authors: Zaborske J, Pan T tRNA aminoacylation, or charging, levels can rapidly change within a cell in response to the environment[1]. Changes in tRNA charging levels in both prokaryotic and eukaryotic cells lead to translational regulation which is a major cellular mechanism of stress response. Familiar examples are the stringent response in E. coli and the Gcn2 stress re ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24162.html http://biomarket.jp/modules/pubmed/article-24163.html 497の新しいpubmed参照はあなたの調査のために取り出された。完全な調査の結果を表示するために次調査のハイパーリンクをつけなさい:癌これらのpubmed結果は50年代に戻って生物医学的な記事のための15,000,000の参照に2010/07/08 PubMedの薬の国立図書館のサービスで、含んでいる発生した。これらの参照はMEDLINEおよび付加的な生命科学ジャーナルからある。 PubMedはフルテキストの記事および他の関連資源を提供する多くの場所にリンクを含んでいる。(原文:497 new pubmed citations were retrieved for your search.Click on the search ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24163.html http://biomarket.jp/modules/pubmed/article-24164.html 497 new pubmed citations were retrieved for your search.Click on the search hyperlink below to display the complete search results:cancerThese pubmed results were generated on 2010/07/08PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's.These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24164.html http://biomarket.jp/modules/pubmed/article-24217.html 11q21.1-11q23.3 Is a site of intrinsic genomic instability triggered by irradiation. Genes Chromosomes Cancer. 2010 Jun 2;49(9):831-843 Authors: Du N, Baker PM, Do TU, Bien C, Bier-Laning CM, Singh S, Shih SJ, Diaz MO, Vaughan AT The chromosome location, 11q21-23, is linked to loss of heterozygosity (LOH) in multiple tumors including those of breast, lung, and head and neck. To examine the process of LOH induction, the H292 cell line (human muco-epidermoid carcinoma) was irradiated or treated w ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24217.html http://biomarket.jp/modules/pubmed/article-24219.html Epigenetic pre-patterning and dynamics during initial stages of mammalian preimplantation development. J Cell Physiol. 2010 Jul 6; Authors: Rasmussen TP, Corry GN Mammals, like all multicellular organisms, develop from a single cell-the totipotent zygote. During preimplantation development and subsequent development in utero, over 200 distinct cell types are established and integrated into the organ systems and tissues of the developing organism. Much of the field of mammalian developmental bio ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24219.html http://biomarket.jp/modules/pubmed/article-24220.html Controlled induction of distributed microdeformation in wounded tissue via a microchamber array dressing. J Biomed Mater Res A. 2010 Jul 6; Authors: Kane BJ, Younan G, Helm D, Dastouri P, Prentice-Mott H, Irimia D, Chan RK, Toner M, Orgill DP Mechanical stimuli are known to play an important role in determining the structure and function of living cells and tissues. Recent studies have highlighted the role of mechanical signals in mammalian dermal wound healing. However, the biological link bet ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24220.html http://biomarket.jp/modules/pubmed/article-24218.html A nonsynonymous polymorphism in IL23R gene is associated with risk of gastric cancer in a Chinese population. Mol Carcinog. 2010 Jul 6; Authors: Chen J, Lu Y, Zhang H, Ding Y, Ren C, Hua Z, Zhou Y, Deng B, Jin G, Hu Z, Xu Y, Shen H Interleukin-23 receptor (IL-23R) is a key element in T helper (Th)17 cell-mediated inflammatory process, which plays an important role in pathogenesis of gastric cancer. Genetic variants of IL-23R have been identified as the predisposing factors for immunopathologic ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24218.html C and rs1884444 T>G of IL-23R and risk of gastric cancer. We found that the variant allele (G) of rs1884444 T>G, with amino acid His substituted by Gln at codon 3, was significantly associated with a decreased risk of gastric cancer [adjusted allelic odds ratio (OR) = 0.78, 95% confidence interval (CI) = 0.68-0.88]. In the stratified analysis, we found that this protective effect of rs1884444 G allele was mainly evident in intestinal-type gastric cancer (adjusted allelic OR = 0.75, 95% CI = 0.65-0.87) other than in diffuse-type gastric cancer (adjusted allelic OR = 0.96, 95% CI = 0.76-1.22). However, we did not find any significant association of rs6682925 T>C with gastric cancer risk. These findings indicate, for the first time, that the nonsynonymous variant rs1884444 T>G of IL-23R may contribute to gastric cancer susceptibility, especially in intestinal-type gastric cancer, in Chinese population. (c) 2010 Wiley-Liss, Inc. PMID: 20607725 [PubMed - as supplied by publisher] ]]> http://biomarket.jp/modules/pubmed/article-24216.html Preclinical assessment of simultaneous targeting of epidermal growth factor receptor (ErbB1) and ErbB2 as a strategy for cholangiocarcinoma therapy. Hepatology. 2010 May 20; Authors: Zhang Z, Oyesanya RA, Campbell DJ, Almenara JA, Dewitt JL, Sirica AE Overexpression of epidermal growth factor receptor (ErbB1) and/or ErbB2 has been implicated in the pathogenesis of cholangiocarcinoma, suggesting that combined ErbB1/ErbB2 targeting might serve as a target-based therapeutic strategy for this highl ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24216.html http://biomarket.jp/modules/pubmed/article-24233.html Down-regulation of MMP-2 through the p38 MAPK-NF-kappaB-dependent pathway by aloe-emodin leads to inhibition of nasopharyngeal carcinoma cell invasion. Mol Carcinog. 2010 Jul 6; Authors: Lin ML, Lu YC, Chung JG, Wang SG, Lin HT, Kang SE, Tang CH, Ko JL, Chen SS Aloe-emodin (AE), extracted from the rhizome of Rheum palmatum, has an anti-proliferative effect on different human cancer cell lines. Nonetheless, the underlying mechanism by which AE inhibits nasopharyngeal carcinoma (NPC) cell invasio ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24233.html http://biomarket.jp/modules/pubmed/article-24229.html Up-regulation of death receptor 4 and 5 by celastrol enhances the anti-cancer activity of TRAIL/Apo-2L. Cancer Lett. 2010 May 31; Authors: Zhu H, Liu XW, Ding WJ, Xu DQ, Zhao YC, Lu W, He QJ, Yang B Our previous study demonstrated that celastrol combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo-2L) exhibited significant synergistic anti-cancer activities, thus we were promoted to investigate the molecular mechanism of this synergy. Here in this study, we show that ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24229.html http://biomarket.jp/modules/pubmed/article-24232.html Development of Non-viral Vector for Cancer Gene Therapy. Yakugaku Zasshi. 2010 Jul;130(7):917-23 Authors: Hattori Y Cancer gene therapy has been intensively developed using non-viral vectors, among which cationic liposomes and nanoparticles are the most investigated. Optimal gene therapy for tumors must deliver plasmid DNA (pDNA) or synthetic small interfering RNA (siRNA) to tumor cells with high efficiency and minimal toxicity. We developed new cationic nanoparticles (NP) composed of cholester ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24232.html http://biomarket.jp/modules/pubmed/article-24230.html Purinergic receptor-mediated rapid depletion of nuclear pAkt depends on PH domain leucine-rich repeat phosphatase (PHLPP), calcineurin, PP2A and PTEN phosphatases. J Biol Chem. 2010 Jul 6; Authors: Mistafa O, Ghalali A, Kadekar S, Högberg J, Stenius U Akt is an important oncoprotein and data suggest a critical role for nuclear Akt in cancer development. We have previously described a rapid (3-5 min) and P2X7-dependent depletion of nuclear phosphorylated Akt (pAkt) and effects on downstream ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24230.html http://biomarket.jp/modules/pubmed/article-24231.html Involvement of caveolin in low K+-induced endocytic degradation of the cell surface hERG channels. J Biol Chem. 2010 Jul 6; Authors: Massaeli H, Sun T, Li X, Shallow H, Wu J, Xu J, Li W, Hanson C, Guo J, Zhang S Reduction in the rapidly activating delayed rectifier K(+) channel current (I(Kr)) due to either mutations in the human ether-a-go-go related gene (hERG), or drug block, causes inherited or drug-induced long QT syndrome (LQTS). A reduction in extracellular K(+) concentration ([K(+)](o)) ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24231.html http://biomarket.jp/modules/pubmed/article-24388.html 213 new pubmed citations were retrieved for your search.Click on the search hyperlink below to display the complete search results:biological chemistryThese pubmed results were generated on 2010/07/08PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's.These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24388.html http://biomarket.jp/modules/pubmed/article-24234.html 213の新しいpubmed参照はあなたの調査のために取り出された。完全な調査の結果を表示するために次調査のハイパーリンクをつけなさい:生物化学これらのpubmed結果は50年代に戻って生物医学的な記事のための15,000,000の参照に2010/07/08 PubMedの薬の国立図書館のサービスで、含んでいる発生した。これらの参照はMEDLINEおよび付加的な生命科学ジャーナルからある。 PubMedはフルテキストの記事および他の関連資源を提供する多くの場所にリンクを含んでいる。(原文:213 new pubmed citations were retrieved for your search.Click on the ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24234.html http://biomarket.jp/modules/pubmed/article-24270.html Related Articles Pericarditis and pleuritis associated with human parvovirus B19 infection in a systemic lupus erythematosus patient. Mod Rheumatol. 2010 Jul 7; Authors: Seishima M, Shibuya Y, Watanabe K, Kato G Human parvovirus B19 (PVB19) infection sometimes shows systemic lupus erythematosus (SLE)-like symptoms. We present an SLE patient showing pericarditis and pleuritis with a fever and an acute swelling of extremities 2 months after the fist consultation. Initially, a diagnosis of SLE exac ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24270.html http://biomarket.jp/modules/pubmed/article-24269.html Related Articles Fournier's Gangrene of the Penis: A Rare Entity. J Cutan Aesthet Surg. 2010 Jan;3(1):41-4 Authors: Talwar A, Puri N, Singh M Fournier's gangrene is a rare, fulminant, but and usually a localized disease of the scrotum and penis, with an occasional extension up to the abdominal wall. The usual organism is an anaerobic streptococcus synergistic with other organisms. A 45-year-old male presented with fever and pain and a brownish-black discolouration of the penis, of four days. Our ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24269.html http://biomarket.jp/modules/pubmed/article-24268.html Related Articles A modified surgical technique for steatocystoma multiplex. J Cutan Aesthet Surg. 2010 Jan;3(1):25-8 Authors: Choudhary S, Koley S, Salodkar A BACKGROUND: Steatocystoma multiplex (SM) is a disorder of the pilosebaceous unit characterized by multiple sebum-containing dermal cysts. Different surgical modalities like cryosurgery, aspiration, surgical excision, incision with a surgical blade or sharp-tipped cautery followed by expression of cyst contents and forceps-assisted removal ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24268.html http://biomarket.jp/modules/pubmed/article-24271.html Related Articles Lysophosphatidylcholine mediated functional inactivation of syndecan 4 results in decreased adhesion and motility of dendritic cells. J Cell Physiol. 2010 Jul 6; Authors: BÃ?hligen J, Himmel M, Gebhardt C, Simon JC, Ziegler W, Averbeck M Following antigen contact, maturation and migration of DCs into lymphatic tissues are crucial to the developing immune response or maintenance of tolerance. Lysophosphatidylcholine (LysoPC) is generated during apoptosis of cells and acts as a ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24271.html http://biomarket.jp/modules/pubmed/article-24267.html Related Articles Biofilms: their role in dermal fillers. J Cutan Aesthet Surg. 2010 Jan;3(1):20-2 Authors: Sadashivaiah AB, Mysore V Fillers are commonly used in several aesthetic indications. Though considered safe, several side effects have been reported. The role of biofilms in the causation of some of these side effects has been elucidated only recently and this article presents a short review of the subject. PMID: 20606988 [PubMed - in process] Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24267.html http://biomarket.jp/modules/pubmed/article-24272.html Related Articles The gut microbiota modulates host energy and lipid metabolism in mice. J Lipid Res. 2010 May;51(5):1101-12 Authors: Velagapudi VR, Hezaveh R, Reigstad CS, Gopalacharyulu P, Yetukuri L, Islam S, Felin J, Perkins R, Borén J, Oresic M, Bäckhed F The gut microbiota has recently been identified as an environmental factor that may promote metabolic diseases. To investigate the effect of gut microbiota on host energy and lipid metabolism, we compared the serum metabolome and ... Sat, 10 Jul 2010 01:00:09 +0900 http://biomarket.jp/modules/pubmed/article-24272.html http://biomarket.jp/modules/pubmed/article-24273.html 260の新しいpubmed参照はあなたの調査のために取り出された。完全な調査の結果を表示するために次調査のハイパーリンクをつけなさい:免疫学これらのpubmed結果は50年代に戻って生物医学的な記事のための15,000,000の参照に2010/07/08 PubMedの薬の国立図書館のサービスで、含んでいる発生した。これらの参照はMEDLINEおよび付加的な生命科学ジャーナルからある。 PubMedはフルテキストの記事および他の関連資源を提供する多くの場所にリンクを含んでいる。(原文:260 new pubmed citations were retrieved for your search.Click on the se ... Sat, 10 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24273.html http://biomarket.jp/modules/pubmed/article-24275.html Related Articles Pro-Inflammatory Effects of Interleukin-17A on Vascular Smooth Muscle Cells Involve NAD(P)H- Oxidase Derived Reactive Oxygen Species. J Vasc Res. 2010 Jul 6;48(1):52-58 Authors: Pietrowski E, Bender B, Huppert J, White R, Luhmann HJ, Kuhlmann CR T cells are known for their contribution to the inflammatory element of atherosclerosis. Recently, it has been demonstrated that the Th17 derived cytokine IL-17 is involved in the pro-inflammatory response of vascular smooth muscle cells ... Sat, 10 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24275.html http://biomarket.jp/modules/pubmed/article-24274.html Related Articles Hepatocyte growth factor and antibodies to HLA and MICA antigens in heart transplant recipients. Tissue Antigens. 2010 Jul 1; Authors: Pavlova YA, Malek I, Honsova E, Netuka I, Sochman J, Lodererova A, Kolesar L, Striz I, Skibova J, Slavcev A Recent unconfirmed literature data suggest that elevated concentrations of the multifunctional cytokine hepatocyte growth factor (HGF) might be a marker of increased incidence of acute rejection after organ transplantation. The aim of this ... Sat, 10 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24274.html http://biomarket.jp/modules/pubmed/article-24301.html Related Articles Specific protein and miRNA patterns characterise tumour-associated fibroblasts in bladder cancer. J Cancer Res Clin Oncol. 2010 Jul 4; Authors: Enkelmann A, Heinzelmann J, von Eggeling F, Walter M, Berndt A, Wunderlich H, Junker K PURPOSE: Tumour development and progression are strongly affected by interaction of tumour cells and tumour stroma. Different tumour models demonstrate a supportive effect of tumour-associated fibroblasts (TAF) on the tumour genesis. Aims of the presen ... Sat, 10 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24301.html http://biomarket.jp/modules/pubmed/article-24300.html Related Articles Let-7 microRNA inhibits the proliferation of human glioblastoma cells. J Neurooncol. 2010 Jul 7; Authors: Lee ST, Chu K, Oh HJ, Im WS, Lim JY, Kim SK, Park CK, Jung KH, Lee SK, Kim M, Roh JK MicroRNAs (miRNAs) are small noncoding RNAs comprising 21-23 nucleotides that regulate gene expression by transcriptionally repressing their complementary mRNAs. In particular, let-7 miRNA has been postulated to function as a tumor suppressor in various cancer cells, but not yet in glioblast ... Sat, 10 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24300.html http://biomarket.jp/modules/pubmed/article-24299.html Related Articles MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration. J Cereb Blood Flow Metab. 2010 Jul 7; Authors: Saugstad JA MicroRNAs are small RNAs that function as regulators of posttranscriptional gene expression. MicroRNAs are encoded by genes, and processed to form ribonucleoprotein complexes that bind to messenger RNA (mRNA) targets to repress translation or degrade mRNA transcripts. The microRNAs are particularly abundant ... Sat, 10 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24299.html http://biomarket.jp/modules/pubmed/article-24302.html Related Articles Transcriptional regulatory networks associated with self-renewal and differentiation of neural stem cells. J Cell Physiol. 2010 Jul 6; Authors: Yun SJ, Byun K, Bhin J, Oh JH, Nhung JH, Hwang D, Lee B Neural stem cells (NSCs) are self-renewing, multipotent cells that can generate neurons, astrocytes, and oligodendrocytes of the nervous system. NSCs have been extensively studied because they can be used to treat impaired cells and tissues or improve regenerative power of degenrati ... Sat, 10 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24302.html http://biomarket.jp/modules/pubmed/article-24298.html Related Articles Nanoparticles Modified With Tumor-targeting scFv Deliver siRNA and miRNA for Cancer Therapy. Mol Ther. 2010 Jul 6; Authors: Chen Y, Zhu X, Zhang X, Liu B, Huang L Targeted delivery of RNA-based therapeutics for cancer therapy remains a challenge. We have developed a LPH (liposome-polycation-hyaluronic acid) nanoparticle formulation modified with tumor-targeting single-chain antibody fragment (scFv) for systemic delivery of small interfering RNA (siRNA) and microRNA (miRNA) into ... Sat, 10 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24298.html http://biomarket.jp/modules/pubmed/article-24304.html Related Articles Intranuclear DNA Release Is a Determinant of Transfection Activity for a Non-viral Vector: Biocleavable Polyrotaxane as a Supramolecularly Dissociative Condenser for Efficient Intranuclear DNA Release. Biol Pharm Bull. 2010;33(7):1218-22 Authors: Yamada Y, Nomura T, Harashima H, Yamashita A, Katoono R, Yui N It has been believed that nuclear gene delivery is the most important process for gene expression, and various non-viral vectors are currently being developed with this assu ... Sat, 10 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24304.html http://biomarket.jp/modules/pubmed/article-24305.html Related Articles Development of Non-viral Vector for Cancer Gene Therapy. Yakugaku Zasshi. 2010 Jul;130(7):917-23 Authors: Hattori Y Cancer gene therapy has been intensively developed using non-viral vectors, among which cationic liposomes and nanoparticles are the most investigated. Optimal gene therapy for tumors must deliver plasmid DNA (pDNA) or synthetic small interfering RNA (siRNA) to tumor cells with high efficiency and minimal toxicity. We developed new cationic nanoparticles (NP) compo ... Sat, 10 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24305.html http://biomarket.jp/modules/pubmed/article-24303.html Related Articles Alpha-fetoprotein producing cells act as cancer progenitor cells in human cholangiocarcinoma. Cancer Lett. 2010 Aug 1;294(1):25-34 Authors: Ishii T, Yasuchika K, Suemori H, Nakatsuji N, Ikai I, Uemoto S We aimed to demonstrate that alpha-fetoprotein (AFP)-producing cells in cholangiocarcinomas possessed cancer stem cell (CSC)-like properties. AFP enhancer/promoter-driven EGFP gene was transfected into human cholangiocarcinoma cell lines. One cell line, RBE, expressed both AFP a ... Sat, 10 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24303.html http://biomarket.jp/modules/pubmed/article-24306.html Related Articles p53 downregulates the gene expression of mitochondrial aconitase in human prostate carcinoma cells. Prostate. 2010 Jul 6; Authors: Tsui KH, Feng TH, Lin YF, Chang PL, Juang HH BACKGROUND: Mitochondrial aconitase (mACON) is regarded as the key enzyme in citrate oxidation in human prostate epithelial cells, and its abnormal expression has been implicated in tumorigenesis of the prostate. Evidence also supports a broad role for the p53 gene in suppressing prostatic tumorigenesis. W ... Sat, 10 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24306.html http://biomarket.jp/modules/pubmed/article-24386.html Related Articles Sphingolipids in Multiple Sclerosis. Neuromolecular Med. 2010 Jul 7; Authors: Jana A, Pahan K Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the CNS. Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), are target cells in MS. Although the etiology of MS is poorly known, new insights suggest oligodendrocyte apoptosis as one of the critical events followed by glial activation and infiltration of lymphocytes and macrophages. A m ... Sat, 10 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24386.html http://biomarket.jp/modules/pubmed/article-24383.html Related Articles Viral Fusion Peptides Induce Several Signal Transduction Pathway Activations That Are Essential for Interleukin-10 and Beta-Interferon Production. Intervirology. 2010 Jul 2;53(6):381-389 Authors: Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S Objectives: The deciphering of intracellular signaling pathways that are activated by the interaction between viral fusion peptides and cellular membranes are important for the underst ... Sat, 10 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24383.html http://biomarket.jp/modules/pubmed/article-24385.html Related Articles TBK1-targeted suppression of TRIF-dependent signaling pathway of toll-like receptor 3 by auranofin. Arch Pharm Res. 2010 Jun;33(6):939-45 Authors: Park SJ, Lee AN, Youn HS Toll-like receptors (TLRs) play an important role in induction of innate immune responses. The stimulation of TLRs by microbial components triggers two branches of downstream signaling pathways: myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain-containing adapter inducing interfero ... Sat, 10 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24385.html http://biomarket.jp/modules/pubmed/article-24384.html Related Articles (1)H, (13)C and (15)N chemical shift assignments for the N-terminal domain of the voltage-gated potassium channel-hERG. Biomol NMR Assign. 2010 Jul 7; Authors: Li Q, Raida M, Kang C The human ether Ã? go-go related gene (hERG) voltage-gated potassium controls the rapid delayed rectifier potassium current (I(ks)) in heart. The N-terminal 135 amino acids (NTD) form a Per-Arnt-Sim (PAS) domain which involves in signal transduction and protein-protein interactions. NTD was shown t ... Sat, 10 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24384.html http://biomarket.jp/modules/pubmed/article-24387.html Related Articles Bacterial stimulus perception and signal transduction: Response to osmotic stress. Chem Rec. 2010 Jul 6; Authors: Krämer R When exposed to osmotic stress from the environment, bacteria act to maintain cell turgor and hydration by responding both on the level of gene transcription and protein activity. Upon a sudden decrease in external osmolality, internal solutes are released by the action of membrane embedded mechanosensitive channels. In response to an osmotic upshift, t ... Sat, 10 Jul 2010 01:00:08 +0900 http://biomarket.jp/modules/pubmed/article-24387.html http://biomarket.jp/modules/d3pipes/article-10784.html Up-regulation of death receptor 4 and 5 by celastrol enhances the anti-cancer activity of TRAIL/Apo-2L. Cancer Lett. 2010 May 31; Authors: Zhu H, Liu XW, Ding WJ, Xu DQ, Zhao YC, Lu W, He QJ, Yang B Our previous study demonstrated that celastrol combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo-2L) exhibited significant synergistic anti-cancer activities, thus we were promoted to investigate the molecular mechanism of this synergy. Here in this study, we show that ... Sat, 10 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10784.html http://biomarket.jp/modules/d3pipes/article-10785.html Purinergic receptor-mediated rapid depletion of nuclear pAkt depends on PH domain leucine-rich repeat phosphatase (PHLPP), calcineurin, PP2A and PTEN phosphatases. J Biol Chem. 2010 Jul 6; Authors: Mistafa O, Ghalali A, Kadekar S, Högberg J, Stenius U Akt is an important oncoprotein and data suggest a critical role for nuclear Akt in cancer development. We have previously described a rapid (3-5 min) and P2X7-dependent depletion of nuclear phosphorylated Akt (pAkt) and effects on downstream ... Sat, 10 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10785.html http://biomarket.jp/modules/d3pipes/article-10786.html Involvement of caveolin in low K+-induced endocytic degradation of the cell surface hERG channels. J Biol Chem. 2010 Jul 6; Authors: Massaeli H, Sun T, Li X, Shallow H, Wu J, Xu J, Li W, Hanson C, Guo J, Zhang S Reduction in the rapidly activating delayed rectifier K(+) channel current (I(Kr)) due to either mutations in the human ether-a-go-go related gene (hERG), or drug block, causes inherited or drug-induced long QT syndrome (LQTS). A reduction in extracellular K(+) concentration ([K(+)](o)) ... Sat, 10 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10786.html http://biomarket.jp/modules/d3pipes/article-10788.html Down-regulation of MMP-2 through the p38 MAPK-NF-kappaB-dependent pathway by aloe-emodin leads to inhibition of nasopharyngeal carcinoma cell invasion. Mol Carcinog. 2010 Jul 6; Authors: Lin ML, Lu YC, Chung JG, Wang SG, Lin HT, Kang SE, Tang CH, Ko JL, Chen SS Aloe-emodin (AE), extracted from the rhizome of Rheum palmatum, has an anti-proliferative effect on different human cancer cell lines. Nonetheless, the underlying mechanism by which AE inhibits nasopharyngeal carcinoma (NPC) cell invasio ... Sat, 10 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10788.html http://biomarket.jp/modules/d3pipes/article-10787.html Development of Non-viral Vector for Cancer Gene Therapy. Yakugaku Zasshi. 2010 Jul;130(7):917-23 Authors: Hattori Y Cancer gene therapy has been intensively developed using non-viral vectors, among which cationic liposomes and nanoparticles are the most investigated. Optimal gene therapy for tumors must deliver plasmid DNA (pDNA) or synthetic small interfering RNA (siRNA) to tumor cells with high efficiency and minimal toxicity. We developed new cationic nanoparticles (NP) composed of cholester ... Sat, 10 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10787.html http://biomarket.jp/modules/d3pipes/article-10792.html Related Articles p53 downregulates the gene expression of mitochondrial aconitase in human prostate carcinoma cells. Prostate. 2010 Jul 6; Authors: Tsui KH, Feng TH, Lin YF, Chang PL, Juang HH BACKGROUND: Mitochondrial aconitase (mACON) is regarded as the key enzyme in citrate oxidation in human prostate epithelial cells, and its abnormal expression has been implicated in tumorigenesis of the prostate. Evidence also supports a broad role for the p53 gene in suppressing prostatic tumorigenesis. W ... Sat, 10 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10792.html http://biomarket.jp/modules/d3pipes/article-10791.html Related Articles Development of Non-viral Vector for Cancer Gene Therapy. Yakugaku Zasshi. 2010 Jul;130(7):917-23 Authors: Hattori Y Cancer gene therapy has been intensively developed using non-viral vectors, among which cationic liposomes and nanoparticles are the most investigated. Optimal gene therapy for tumors must deliver plasmid DNA (pDNA) or synthetic small interfering RNA (siRNA) to tumor cells with high efficiency and minimal toxicity. We developed new cationic nanoparticles (NP) compo ... Sat, 10 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10791.html http://biomarket.jp/modules/d3pipes/article-10790.html Related Articles Intranuclear DNA Release Is a Determinant of Transfection Activity for a Non-viral Vector: Biocleavable Polyrotaxane as a Supramolecularly Dissociative Condenser for Efficient Intranuclear DNA Release. Biol Pharm Bull. 2010;33(7):1218-22 Authors: Yamada Y, Nomura T, Harashima H, Yamashita A, Katoono R, Yui N It has been believed that nuclear gene delivery is the most important process for gene expression, and various non-viral vectors are currently being developed with this assu ... Sat, 10 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10790.html http://biomarket.jp/modules/d3pipes/article-10789.html Related Articles Alpha-fetoprotein producing cells act as cancer progenitor cells in human cholangiocarcinoma. Cancer Lett. 2010 Aug 1;294(1):25-34 Authors: Ishii T, Yasuchika K, Suemori H, Nakatsuji N, Ikai I, Uemoto S We aimed to demonstrate that alpha-fetoprotein (AFP)-producing cells in cholangiocarcinomas possessed cancer stem cell (CSC)-like properties. AFP enhancer/promoter-driven EGFP gene was transfected into human cholangiocarcinoma cell lines. One cell line, RBE, expressed both AFP a ... Sat, 10 Jul 2010 01:00:06 +0900 http://biomarket.jp/modules/d3pipes/article-10789.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-115.html Related Articles [Direct enantioseparation of pantoprazole sodium by high performance liquid chromatography on teicoplanin-bonded chiral stationary phase] Se Pu. 2006 Jan;24(1):46-8 Authors: Ding G, Tang A, Wang J, Cong R, Bao J Teicoplanin-bonded chiral stationary phase was prepared and used for the direct chiral separation of racemic pantoprazole sodium by reversed-phase high performance liquid chromatography (HPLC). The influences of organic modifiers, the composition of mobile phase, the flo ... Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-115.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-220.html Related Articles Central Role of Manganese in Regulation of Stress Responses, Physiology and Metabolism in Streptococcus pneumoniae. J Bacteriol. 2010 Jul 2; Authors: Ogunniyi AD, Mahdi LK, Jennings MP, McEwan AG, McDevitt CA, Van der Hoek MB, Bagley CJ, Hoffmann P, Gould KA, Paton JC The importance of Mn(2+) for pneumococcal physiology and virulence has been studied extensively. However, the specific cellular role(s) for which Mn(2+) is required are yet to be fully elucidated. Here, we analyzed ... Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-220.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-214.html Related Articles Chip-based reversed-phase liquid chromatography-mass spectrometry of permethylated N-linked glycans: a potential methodology for cancer-biomarker discovery. Anal Chem. 2010 Jun 15;82(12):5095-106 Authors: Alley WR, Madera M, Mechref Y, Novotny MV The study of protein glycosylation in biological fluids and tissues has substantial medical importance, as changes in glycan structures have now been associated with a number of diseases. Quantification of glycomic-profile changes is b ... Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-214.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-213.html Related Articles Enzymatic synthesis of new oligosaccharides using mannosyltransferases from Candida species and their NMR assignments. Biol Pharm Bull. 2010;33(5):895-9 Authors: Shibata N, Okawa Y The outer layer of the cell wall of pathogenic fungi, Candida species, consists of mannan, which plays an important role in infection. In this study, we synthesized several oligosaccharides using mannosyltransferases obtained from Candida parapsilosis and Candida albicans. Namely, we synthesized mann ... Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-213.html 2Manalpha1-->3Manalpha1-->2Man and Manalpha1-->3(Manalpha1-->6)Manalpha1-->2Man] from mannotriose, Manalpha1-->3Manalpha1--> 2Man, and mannohexaoses [Manalpha1-->2Manalpha1-->3Manalpha1-->3Manalpha1-->2Manalpha1-->2Man and Manalpha1-->3(Manalpha1-->6)Manalpha1-->3Manalpha1-->2Manalpha1-->2Man] from mannopentaose, Manalpha1-->3Manalpha1-->3Manalpha1-->2Manalpha1-->2Man. The linkage sequence of these oligosaccharides was identified by a sequential (1)H-NMR assignment method combined with rotating frame nuclear Overhauser enhancement spectroscopy and relayed coherence transfer spectroscopy. The steric effect by the alpha-1,6-linked branching mannose residue to the H-1 proton chemical shift of the neighboring 3-O-substituted mannose residue was different from that of the 2-O-substituted mannose residue. These oligosaccharides having novel structures seem to be useful as the substrate or ligand for glycomics. PMID: 20460773 [PubMed - in process] ]]> http://biomarket.jp/modules/pubmed_sugarcomposition/article-219.html Related Articles Chiral-auxiliary-mediated 1,2-cis-glycosylations for the solid-supported synthesis of a biologically important branched alpha-glucan. Nat Chem. 2010 Jul;2(7):552-7 Authors: Boltje TJ, Kim JH, Park J, Boons GJ Solid-phase oligosaccharide synthesis offers the promise of providing libraries of oligosaccharides for glycomics research. A major stumbling block to solid-phase oligosaccharide synthesis has been a lack of general methods for the stereoselective installation of 1,2-cis-gl ... Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-219.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-212.html Related Articles Preparation of regioselectively feruloylated p-nitrophenyl alpha-L-arabinofuranosides and beta-D-xylopyranosides-convenient substrates for study of feruloyl esterase specificity. Carbohydr Res. 2010 Jun 16;345(9):1094-8 Authors: Mastihubov Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-212.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-210.html Related Articles Platform technology to identify potential disease markers and establish heritability and environmental determinants of the human serum N-glycome. Carbohydr Res. 2010 Apr 18; Authors: Tharmalingam T, Mari Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-210.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-208.html Related Articles Glycopeptidome of a heavily N-glycosylated cell surface glycoprotein of Dictyostelium implicated in cell adhesion. J Proteome Res. 2010 Jul 2;9(7):3495-510 Authors: Feasley CL, Johnson JM, West CM, Chia CP Genetic analysis has implicated the cell surface glycoprotein gp130 in cell interactions of the social amoeba Dictyostelium, and information about the utilization of the 18 N-glycosylation sequons present in gp130 is needed to identify critical molecular determinants of its a ... Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-208.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-211.html Related Articles Proteoglycomics: Recent Progress and Future Challenges. OMICS. 2010 May 7; Authors: Ly M, Laremore TN, Linhardt RJ Abstract Proteoglycomics is a systematic study of structure, expression, and function of proteoglycans, a posttranslationally modified subset of a proteome. Although relying on the established technologies of proteomics and glycomics, proteoglycomics research requires unique approaches for elucidating structure-function relationships of both proteoglycan components, ... Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-211.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-207.html Related Articles Altered Serum Glycomics in Alzheimer Disease: A Potential Blood Biomarker? Rejuvenation Res. 2010 Apr 28; Authors: Chen CC, Engelborghs S, Dewaele S, Le Bastard N, Martin JJ, Vanhooren V, Libert C, De Deyn PP Abstract We investigated whether blood N-glycan changes can be used as a diagnostic biomarker for Alzheimer disease (AD). We used DNA sequencer-assisted, fluorophore-assisted carbohydrate electrophoresis (DSA-FACE) technology to assay N-glycans in sera from 79 autopsy-confi ... Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-207.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-209.html Related Articles Mass Spectrometry and Glycomics. OMICS. 2010 May 5; Authors: Zaia J Abstract Glycosylation defines the adhesive properties of animal cell surfaces and the surrounding extracellular environments. Because cells respond to stimuli by altering glycan expression, glycan structures vary according to spatial location in tissue and temporal factors. These dynamic structural expression patterns, combined with the essential roles glycans play in physiology, drive the need for analytical m ... Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-209.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-206.html Related Articles Rescue of Drosophila Melanogaster l(2)35Aa lethality is only mediated by polypeptide GalNAc-transferase pgant35A, but not by the evolutionary conserved human ortholog GalNAc-transferase-T11. Glycoconj J. 2010 May;27(4):435-44 Authors: Bennett EP, Chen YW, Schwientek T, Mandel U, Schjoldager KB, Cohen SM, Clausen H The Drosophila l(2)35Aa gene encodes a UDP-N-acetylgalactosamine: Polypeptide N-acetylgalactosaminyltransferase, essential for embryogenesis and development (J. Biol. ... Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-206.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-204.html Related Articles Developing high-affinity boron-based receptors for cell-surface carbohydrates. Chembiochem. 2010 May 3;11(7):954-7 Authors: Houston TA PMID: 20391454 [PubMed - in process] Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-204.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-199.html Related Articles Synthesis of alkyl and cycloalkyl alpha-d-mannopyranosides and derivatives thereof and their evaluation in the mycobacterial mannosyltransferase assay. Carbohydr Res. 2010 Mar 15; Authors: Pol Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-199.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-202.html Related Articles Chemical approaches to glycobiology. Annu Rev Biochem. 2010;79:619-53 Authors: Kiessling LL, Splain RA Glycans are ubiquitous components of all organisms. Efforts to elucidate glycan function and to understand how they are assembled and disassembled can reap benefits in fields ranging from bioenergy to human medicine. Significant advances in our knowledge of glycan biosynthesis and function are emerging, and chemical biology approaches are accelerating the pace of discovery. No ... Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-202.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-198.html Related Articles Carbohydrate vaccines: developing sweet solutions to sticky situations? Nat Rev Drug Discov. 2010 Apr;9(4):308-24 Authors: Astronomo RD, Burton DR Recent technological advances in glycobiology and glycochemistry are paving the way for a new era in carbohydrate vaccine design. This is enabling greater efficiency in the identification, synthesis and evaluation of unique glycan epitopes found on a plethora of pathogens and malignant cells. Here, we review the progress being made i ... Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-198.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-200.html Related Articles Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC. Glycobiology. 2010 Jul;20(7):865-71 Authors: Nakajima K, Kitazume S, Angata T, Fujinawa R, Ohtsubo K, Miyoshi E, Taniguchi N Nucleotide sugars are important in determining cell surface glycoprotein glycosylation, which can modulate cellular properties such as growth and arrest. We have developed a conventional HPLC method for simultaneous determination of nucleotide sugars. A mixture of nucleotid ... Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-200.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-197.html Related Articles Glycomic Analysis of Sialic Acid Linkages in Glycans Derived from Blood Serum Glycoproteins. J Proteome Res. 2010 May 5; Authors: Alley WR, Novotny MV A number of alterations to the normal glycomic profile have been previously described for a number of diseases and disorders, thus underscoring the medical importance of studying the glycans associated with proteins present in biological samples. An important alteration in cancer progression is an increased level of alpha2,6-sial ... Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-197.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-203.html Related Articles Marine glycobiology: current status and future perspectives. Mar Biotechnol (NY). 2010 Jun;12(3):241-52 Authors: Caldwell GS, Pagett HE Glycobiology, which is the study of the structure and function of carbohydrates and carbohydrate containing molecules, is fundamental to all biological systems.Progress in glycobiology has shed light on a range of complex biological processes associated with, for example,disease and immunology, molecular and cellular communication,and developme ... Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-203.html http://biomarket.jp/modules/pubmed_sugarcomposition/article-196.html Related Articles Enzymatic Oxidation and Separation of Various Saccharides with Immobilized Glucose Oxidase. Appl Biochem Biotechnol. 2010 Mar 27; Authors: Mislovi Fri, 09 Jul 2010 01:00:42 +0900 http://biomarket.jp/modules/pubmed_sugarcomposition/article-196.html