http://biomarket.jp/ バイオ研究支援ビジネスポータルサイト Thu, 11 Mar 2010 07:58:44 +0900 Wed, 03 Mar 2010 17:17:28 +0900 http://backend.userland.com/rss/ XOOPS rssc RSS Center noreply@biomarket.jp (bioassociates) noreply@biomarket.jp (bioassociates) Copyright (c) 2010, bioassociates ja http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5330 Related Articles Phagocytosis mechanism of apoptotic granulosa cells regulated by milk-fat globule-EGF factor 8. Med Mol Morphol. 2009 Sep;42(3):143-9 Authors: Naka M, Kusakabe K, Takeshita A, Nakagawa H, Ito Y, Shibata MA, Otsuki Y In the process of ovary sexual maturation, most immature ovarian follicles degrade into atretic follicles accompanied by apoptosis in granulosa cells. Macrophages can recognize apoptotic cells through specific binding with phosphatidylserine (PS), exposed on the sur ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5330 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5372 Related Articles Transgenic Mice Enriched in Omega-3 Fatty Acids Are More Susceptible to Pulmonary Tuberculosis: Impaired Resistance to Tuberculosis in fat-1 Mice. J Infect Dis. 2010 Jan 6; Authors: Bonilla DL, Fan YY, Chapkin RS, McMurray DN Background. Besides their health benefits, dietary omega-3 fatty acids (n-3 PUFAs) can impair host resistance to intracellular pathogens. Previously, we and others have showed that n-3 PUFA-treated macrophages poorly control Mycobacterium tuberculosis infec ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5372 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5433 Related Articles Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. J Clin Invest. 2009 Dec;119(12):3713-22 Authors: Atabai K, Jame S, Azhar N, Kuo A, Lam M, McKleroy W, Dehart G, Rahman S, Xia DD, Melton AC, Wolters P, Emson CL, Turner SM, Werb Z, Sheppard D Milk fat globule epidermal growth factor 8 (Mfge8) is a soluble glycoprotein known to regulate inflammation and immunity by mediating apoptotic cell clearance. Since fibros ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5433 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5658 Related Articles Effects of oral administration of yam tuber storage protein, dioscorin, to BALB/c mice for 21-days on immune responses. J Agric Food Chem. 2009 Oct 14;57(19):9274-9 Authors: Liu YW, Liu JC, Huang CY, Wang CK, Shang HF, Hou WC Dioscorin, the tuber storage protein of yam, was reported to have immunomodulatory activity in RAW264.7 murine macrophage cell lines ( Food and Chemical Toxicology , 2007 , 45 , 2312 -2318 ). However, the immunomodulatory function of dioscorin after being ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5658 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5732 Computational modeling of the human serum proteome response to colon resection surgery. Anal Chim Acta. 2010 Feb 19;661(1):20-27 Authors: Xu CJ, Hoefsloot HC, Dijkstra M, Havenga K, Roelofsen H, Vonk RJ, Smilde AK Principal component analysis (PCA) is much used in exploring time-course biological data sets, but does not distinguish variation between time and subjects. This study proposes a new integrated approach by combining analysis of variance (ANOVA) and three component modeling methods. Th ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5732 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5777 Proteomic analysis of the effect of storage temperature on human serum. Ann Clin Lab Sci. 2010;40(1):61-70 Authors: Lee DH, Kim JW, Jeon SY, Park BK, Han BG This study examined the effect of storage temperature on the protein profile of human serum. Serum samples were stored for >/=7 days at -80 degrees C, -20 degrees C, 4 degrees C, and room temperature prior to proteomic analysis. Serum protein fractionations by SDS-PAGE, including high and low molecular weight (MW) proteins, showed that seve ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5777 /=7 days at -80 degrees C, -20 degrees C, 4 degrees C, and room temperature prior to proteomic analysis. Serum protein fractionations by SDS-PAGE, including high and low molecular weight (MW) proteins, showed that several bands had different intensities after storage at higher temperatures. Fractionations by 2-dimensional gel electrophoresis (2-DE) indicated that approximately 60 protein spots had changed significantly after storage at higher temperatures. These proteins included C3/C4, alpha2-macroglobulin, and alpha1B glycoprotein, based on identification by MS and MS/MS. The profile of the low MW serum proteins, analyzed using SELDI ProteinChip Arrays (IMAC3 and Q10), was also significantly changed after storage at higher temperatures. These results indicate that the higher storage temperatures have a significant influence on serum protein profiles regardless of MW. Based on these findings, serum specimens should be preferably be stored at -80 degrees C before proteomic analysis. PMID: 20124332 [PubMed - in process] ]]> http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5783 Related Articles Adalimumab for the treatment of psoriasis. Health Technol Assess. 2009 Sep;13 Suppl 2:49-54 Authors: Turner D, Picot J, Cooper K, Loveman E This paper presents a summary of the evidence review group (ERG) report into the clinical and cost-effectiveness of adalimumab for the treatment of moderate to severe plaque psoriasis based upon a review of the manufacturer's submission to the National Institute for Health and Clinical Excellence (NICE) as part of the single technology appr ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5783 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5794 Related Articles Glycome profiling using modern glycomics technology: technical aspects and applications. Biol Chem. 2010 Feb 3; Authors: Vanderschaeghe D, Festjens N, Delanghe J, Callewaert N Abstract Glycomics research has become indispensable in many research fields such as immunity, signal transduction and development. Moreover, changes in the glycosylation of proteins and lipids have been reported in several diseases including cancer. The analysis of a complex posttranslational modification ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5794 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5806 Related Articles A bovine whey protein extract stimulates human neutrophils to generate bioactive IL-1Ra through a NF-kappaB- and MAPK-dependent mechanism. J Nutr. 2010 Feb;140(2):382-91 Authors: Rusu D, Drouin R, Pouliot Y, Gauthier S, Poubelle PE Innate immunity depends on the efficiency of neutrophils to be activated rapidly to restore homeostasis. It can benefit from priming agents that enhance neutrophil capacity to respond more efficiently to a subsequent stimulation. Among natural produc ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5806 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5809 Production of antibodies in plants: status after twenty years. Plant Biotechnol J. 2010 Feb 3; Authors: De Muynck B, Navarre C, Boutry M Summary Thanks to their potential to bind virtually all types of molecules; monoclonal antibodies are in increasing demand as therapeutics and diagnostics. To overcome the overloading of current production facilities, alternative expression systems have been developed, of which plants appear the most promising. In this review, we focus on the expression of mon ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5809 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5808 Related Articles B-1 cells and naturally occurring antibodies: influencing the immunogenicity of recombinant human therapeutic proteins? Curr Opin Biotechnol. 2009 Dec;20(6):715-21 Authors: Sauerborn M, Schellekens H Recombinant human therapeutic proteins are increasingly being used to treat serious and life-threatening diseases like multiple sclerosis, diabetes mellitus, and cancer. An important side effect of these proteins is the development of antidrug antibodies, which can be neutralizing ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5808 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5824 Related Articles From the gamma-glutamyl cycle to the glycan cycle: a road with many turns and pleasant surprises. J Biol Chem. 2009 Dec 11;284(50):34469-78 Authors: Taniguchi N PMID: 19840938 [PubMed - indexed for MEDLINE] Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5824 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5844 The phasevarion: phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes. Nat Rev Microbiol. 2010 Feb 8; Authors: Srikhanta YN, Fox KL, Jennings MP In several host-adapted pathogens, phase variation has been found to occur in genes that encode methyltransferases associated with type III restriction-modification systems. It was recently shown that in the human pathogens Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis phase vari ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5844 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5870 [Analysis of serum protein fingerprints on non-small cell lung cancer lymphatic metastasis.] Zhonghua Yi Xue Za Zhi. 2009 Sep;89(35):2481-2485 Authors: L&#xFC; C, Shen J, Wu N, Zheng QF, Wang J, Yan S, Feng Y, Yang Y OBJECTIVE: To establish a classification model and serum proteomic patterns in non-small cell lung cancer (NSCLC) patients with lymph node metastasis by surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS). METHODS: The relative contents of s ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5870 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5873 Related Articles The promise of glycomics, glycan arrays and carbohydrate-based vaccines. Immunopharmacol Immunotoxicol. 2010 Feb 9; Authors: Lepenies B, Seeberger PH Carbohydrates and glycoconjugates are involved in a number of biological processes including host-pathogen interactions, cell communication, proliferation and differentiation as well as the initiation of immune responses. However, access to synthetic oligosaccharide structures has been limited for long time since no standardized pr ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5873 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5874 Related Articles Comparison of Normalization Methods for the Identification of Biomarkers Using MALDI-TOF and SELDI-TOF Mass Spectra. OMICS. 2010 Feb;14(1):115-26 Authors: Borgaonkar SP, Hocker H, Shin H, Markey MK Abstract Proteomic profiling by mass spectrometry has tremendous potential for identifying disease biomarkers. A key limitation of mass spectrometry is that the information provided on the abundance of the various peptides is only relative. Thus, normalization is typically employed. S ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5874 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5877 Tipifarnib Plus Tamoxifen in Tamoxifen-Resistant Metastatic Breast Cancer: A Negative Phase II and Screening of Potential Therapeutic Markers by Proteomic Analysis. Clin Cancer Res. 2010 Feb 9; Authors: Dalenc F, Doisneau-Sixou SF, Allal BC, Marsili S, Lauwers-Cances V, Chaoui K, Schiltz O, Monsarrat B, Filleron T, Ren&#xE9;e N, Malissein E, Meunier E, Favre G, Roch&#xE9; H PURPOSE: Tipifarnib, a farnesyltransferase inhibitor, has antitumor activity in heavily pretreated metastatic breast cance ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5877 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5888 Never take candy from a stranger: the role of the bacterial glycome in host-pathogen interactions. Future Microbiol. 2010 Feb;5:267-88 Authors: Reid CW, Fulton KM, Twine SM With the comprehensive study and complete sequencing of the Haemophilus influenzae genome in 1995 came the term 'genomics' and the beginning of the 'omics' era. Since this time, several analogous fields, such as transcriptomics and proteomics, have emerged. While growth and advancement in these fields have increased understa ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5888 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5887 GlycoExtractor - a web-based interface for high throughput processing of HPLC-glycan data. J Proteome Res. 2010 Feb 9; Authors: Artemenko NV, Campbell MP, Rudd PM Recently, an automated high-throughput HPLC platform has been developed which can be used to fully sequence and quantify low concentrations of N-linked sugars released from glycoproteins, supported by an experimental database (GlycoBase) and analytical tools (autoGU). However, commercial packages that support the operation of HPLC ins ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5887 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5893 Related Articles Native chromatin preparation and illumina/solexa library construction. CSH Protoc. 2009 Jun 1;2009(6):pdb.prot5237 Authors: Cuddapah S, Barski A, Cui K, Schones DE, Wang Z, Wei G, Zhao K INTRODUCTION High-throughput whole-genome analysis has become a practical and important technique to understand nuclear processes, such as transcription, replication, and genome structure. Though microarrays have been the preferred genome-scale analysis method for over a decade, new technologies ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5893 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5918 Related Articles Managing the risks of IBD therapy. Curr Gastroenterol Rep. 2009 Dec;11(6):509-17 Authors: Seow CH, de Silva S, Kaplan GG, Devlin SM, Ghosh S, Panaccione R Successful management of the patient with inflammatory bowel disease (IBD) involves not only the induction and maintenance of remission, but also the optimization of the benefit-to-risk equation to achieve the greatest gain in quality of life. These risks range from intolerance to prescribed medications to potentially life-thr ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5918 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5926 Xyloglucan endotransglycosylases (XETs) from germinating nasturtium (Tropaeolum majus) seeds: Isolation and characterization of the major form. Plant Physiol Biochem. 2010 Jan 28; Authors: Stratilov&#xE1; E, Ait-Mohand F, Rehulka P, Garajov&#xE1; S, Flodrov&#xE1; D, Rehulkov&#xE1; H, Farka&#x161; V Five forms of xyloglucan endotransglycosylase/hydrolase (XTH) differing in their isoelectric points (pI) were detected in crude extracts from germinating nasturtium seeds. Without further fractionati ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5926 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5927 Biochemical analysis of Lgt3, a glycosyltransferase of the bacterium Moraxella catarrhalis. Biochem Biophys Res Commun. 2010 Feb 11; Authors: Faglin I, Tiralongo J, Wilson JC, Collins PM, Peak IR The lipooligosaccharide (LOS) of Moraxella catarrhalis is unusual in that it lacks heptose. The sugar linking oligosaccharide to Lipid A is a trisubstituted glucose. A single enzyme, Lgt3, is suggested to trisubstitute this core sugar. The lgt3 gene encodes two distinct domains with high similarity to ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5927 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5940 Related Articles B cells from glatiramer acetate-treated mice suppress experimental autoimmune encephalomyelitis. Exp Neurol. 2010 Jan;221(1):136-45 Authors: Kala M, Rhodes SN, Piao WH, Shi FD, Campagnolo DI, Vollmer TL Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) thought to be primarily mediated by T cells. However, emerging evidence supports an important role for B cells in the pathogenesis and inhibition of MS. Glatiramer acetate (GA), a Food and Drug ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5940 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5941 Related Articles Vibrio cholerae O1 Ogawa detoxified lipopolysaccharide structures as inducers of cytokines and oxidative species in macrophages. J Med Microbiol. 2010 Feb;59(Pt 2):158-64 Authors: Paulovicov&#xE1; E, Kov&#xE1;cov&#xE1; E, Bystrick&#xFD; S Multidrug resistance in several strains of Vibrio cholerae has encouraged anti-cholera vaccine developmental attempts using various subcellular moieties. In order to examine the immunological efficacy of detoxified LPS (dLPS)-derived saccharid ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5941 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5955 Related Articles Analysis of the human seminal plasma glycome reveals the presence of immunomodulatory carbohydrate functional groups. J Proteome Res. 2009 Nov;8(11):4906-15 Authors: Pang PC, Tissot B, Drobnis EZ, Morris HR, Dell A, Clark GF A recent analysis of the human sperm N-glycome confirmed the expression of biantennary bisecting type N-glycans and terminal Lewis(x)/Lewis(y) sequences previously implicated in the suppression of the innate and adaptive immune responses, respectively. In t ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5955 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5973 Use of SELDI Mass Spectrometry to Discover and Identify Potential Biomarkers of Toxicity in InnoMed PredTox: a Multi-Site, Multi-Compound Study. Proteomics. 2010 Feb 16; Authors: Collins BC, Sposny A, McCarthy D, Brandenburg A, Woodbury R, Pennington SR, Gautier JC, Hewitt P, Gallagher WM A serious bottleneck in the drug development pipeline is the inability of current preclinical toxicology evaluation methods to predict early on, and with good accuracy, that a drug candidate will have to be re ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5973 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5974 Related Articles Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice. Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):193-9 Authors: Ohmura K, Ishimori N, Ohmura Y, Tokuhara S, Nozawa A, Horii S, Andoh Y, Fujii S, Iwabuchi K, Ono&#xE9; K, Tsutsui H BACKGROUND: Macrophage and lymphocyte infiltration in adipose tissue may contribute to the pathogenesis of obesity-mediated metabolic disorders. Natural killer T (NKT) cells, which inte ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5974 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5976 Human iPS cell-based therapy: Considerations before clinical applications. Cell Cycle. 2010 Mar 2;9(5) Authors: Sun N, Longaker MT, Wu JC Generation of induced pluripotent stem (iPS) cells has revolutionized the field of regenerative medicine. With the exponential increase in iPS cell research in the past three years, human iPS cells have been derived with different technologies and from various cell types. From a translational perspective, however, a number of issues must be addressed before s ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5976 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5978 Progenitor Cells for Regenerative Medicine and Consequences of ART and Cloning-Associated Epimutations. Mol Biotechnol. 2010 Feb 17; Authors: Laprise SL The "holy grail" of regenerative medicine is the identification of an undifferentiated progenitor cell that is pluripotent, patient specific, and ethically unambiguous. Such a progenitor cell must also be able to differentiate into functional, transplantable tissue, while avoiding the risks of immune rejection. With reports detailing aberrant g ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5978 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5977 Induced Pluripotent Reprogramming from Promiscuous Human Stemness Related Factors. Clin Transl Sci. 2009 Apr 1;2(2):118-126 Authors: Nelson TJ, Martinez-Fernandez A, Yamada S, Mael AA, Terzic A, Ikeda Y Ectopic expression of pluripotency gene sets provokes nuclear reprogramming in permissive somatic tissue environments generating induced pluripotent stem (iPS) cells. The evolutionary conserved function of stemness orthologs was here tested through interspecies transduction. A spectrum of HIV-ba ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5977 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5980 Related Articles Sympatric ecological speciation meets pyrosequencing: sampling the transcriptome of the apple maggot Rhagoletis pomonella. BMC Genomics. 2009;10:633 Authors: Schwarz D, Robertson HM, Feder JL, Varala K, Hudson ME, Ragland GJ, Hahn DA, Berlocher SH BACKGROUND: The full power of modern genetics has been applied to the study of speciation in only a small handful of genetic model species--all of which speciated allopatrically. Here we report the first large expressed sequence tag ( ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5980 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5981 Related Articles MicroRNA and tasiRNA diversity in mature pollen of Arabidopsis thaliana. BMC Genomics. 2009;10:643 Authors: Grant-Downton R, Le Trionnaire G, Schmid R, Rodriguez-Enriquez J, Hafidh S, Mehdi S, Twell D, Dickinson H BACKGROUND: New generation sequencing technology has allowed investigation of the small RNA populations of flowering plants at great depth. However, little is known about small RNAs in their reproductive cells, especially in post-meiotic cells of the gametophyte gener ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5981 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5979 Related Articles De novo genome sequence assembly of a filamentous fungus using Sanger, 454 and Illumina sequence data. Genome Biol. 2009;10(9):R94 Authors: Diguistini S, Liao NY, Platt D, Robertson G, Seidel M, Chan SK, Docking TR, Birol I, Holt RA, Hirst M, Mardis E, Marra MA, Hamelin RC, Bohlmann J, Breuil C, Jones SJ Sequencing-by-synthesis technologies can reduce the cost of generating de novo genome assemblies. We report a method for assembling draft genome sequences of eukaryotic organis ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5979 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5982 Related Articles Emerging drugs for small-cell lung cancer. Expert Opin Emerg Drugs. 2009 Dec;14(4):591-606 Authors: Metro G, Cappuzzo F Small-cell lung cancer (SCLC) is a rapidly progressing tumor in which chemotherapy has a limited impact on survival. Unfortunately, little progress has been made in the medical management of SCLC during the last 30 years, which is best exemplified by the fact that standard first-line chemotherapy has remained platinum-based over time. On the other hand, improve ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5982 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5992 Related Articles No Evidence for Clonal Selection due to Lentiviral Integration Sites in Human Induced Pluripotent Stem Cells. Stem Cells. 2010 Feb 17; Authors: Winkler T, Cantilena A, M&#xE9;tais JY, Xu X, Nguyen AD, Borate B, Antosiewicz-Bourget JE, Wolfsberg TG, A Thomson J, Dunbar CE Derivation of induced pluripotent stem (iPS) cells requires the expression of defined transcription factors (among Oct3/4, Sox2, Klf4, c-Myc, Nanog and Lin28) in the targeted cells. Lentiviral or standard retrov ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5992 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5991 Related Articles Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature. 2010 Feb 17; Authors: Agarwal S, Loh YH, McLoughlin EM, Huang J, Park IH, Miller JD, Huo H, Okuka M, Dos Reis RM, Loewer S, Ng HH, Keefe DL, Goldman FD, Klingelhutz AJ, Liu L, Daley GQ Patients with dyskeratosis congenita (DC), a disorder of telomere maintenance, suffer degeneration of multiple tissues. Patient-specific induced pluripotent stem (iPS) cells represent invaluable in ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=5991 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6006 Related Articles Transcriptomic changes arising during light-induced sporulation in Physarum polycephalum. BMC Genomics. 2010 Feb 17;11(1):115 Authors: Barrantes I, Glockner G, Meyer S, Marwan W ABSTRACT: BACKGROUND: Physarum polycephalum is a free-living amoebozoan protist displaying a complex life cycle, including alternation between single- and multinucleate stages through sporulation, a simple form of cell differentiation. Sporulation in Physarum can be experimentally induced by several exte ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6006 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6005 Related Articles DLA-based strategies for cloning insertion mutants: cloning the gl4 locus of maize using Mu transposon tagged alleles. Genetics. 2009 Dec;183(4):1215-25 Authors: Liu S, Dietrich CR, Schnable PS Digestion-ligation-amplification (DLA), a novel adaptor-mediated PCR-based method that uses a single-stranded oligo as the adaptor, was developed to overcome difficulties of amplifying unknown sequences flanking known DNA sequences in large genomes. DLA specifically overcomes the problem ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6005 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6021 Related Articles Increased phosphorylation of vimentin in noninfiltrative meningiomas. PLoS One. 2010;5(2):e9238 Authors: Bouamrani A, Ramus C, Gay E, Pelletier L, Cubizolles M, Brugi&#xE8;re S, Wion D, Berger F, Issartel JP BACKGROUND: Tissue invasion or tissue infiltration are clinical behaviors of a poor-prognosis subset of meningiomas. We carried out proteomic analyses of tissue extracts to discover new markers to accurately distinguish between infiltrative and noninfiltrative meningiomas. M ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6021 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6026 Related Articles Hematopoiesis from pluripotent stem cell lines. Int J Hematol. 2010 Feb 20; Authors: Sakamoto H, Tsuji-Tamura K, Ogawa M Embryonic stem cells (ESCs) can differentiate into various types of hematopoietic cells (HPCs) when placed in an appropriate environment. Various methods for the differentiation of ESCs into specific HPC lineages have been developed using mouse ESCs. These ESC-differentiation methods have been utilized also as an in vitro model to investigate hematopoiesis in ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6026 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6027 Cellular mediators of inflammation: tregs and t(h)17 cells in gastrointestinal diseases. Mediators Inflamm. 2009;2009:132028 Authors: Pandolfi F, Cianci R, Pagliari D, Landolfi R, Cammarota G Human lymphocyte subpopulations were originally classified as T- and B-cells in the 70s. Later, with the development of monoclonal antibodies, it became possible to recognize, within the T-cells, functional populations: CD4(+) and CD8(+). These populations were usually referred to as "helper" and "suppress ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6027 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6036 Related Articles Characterization of specific egg yolk immunoglobulin (IgY) against mastitis-causing Staphylococcus aureus. J Appl Microbiol. 2008 Nov;105(5):1529-35 Authors: Zhen YH, Jin LJ, Guo J, Li XY, Li Z, Fang R, Xu YP AIMS: To evaluate the in vitro activity of egg yolk immunoglobulin (IgY) against mastitis-causing Staphylococcus aureus. METHODS AND RESULTS: Specific IgY was produced by immunizing hens with formaldehyde-killed Staph. aureus, using a bacterial strain known to cause mastit ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6036 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6045 Related Articles Culture of human cells and synthesis of extracellular matrix on materials compatible with direct analysis by mass spectrometry. Analyst. 2010 Mar;135(3):503-11 Authors: Lavigne D, Guerrier L, Gueguen V, Michel JB, Boschetti E, Meilhac O, Letourneur D The extracellular matrix (ECM) is a complex three-dimensional network of macromolecules synthesized by cells and is essential for the structure and the function of a tissue. The aim of our approach was to propose a surface allowing ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6045 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6055 Related Articles Cost-effectiveness of biological therapy for Crohn's disease: Markov cohort analyses incorporating United Kingdom patient-level cost data. Aliment Pharmacol Ther. 2009 Aug;30(3):265-74 Authors: Bodger K, Kikuchi T, Hughes D BACKGROUND: Anti-TNF-alpha agents for Crohn's disease (CD) have good clinical efficacy but high acquisition cost compared to rival drugs. AIM: To assess the cost-effectiveness of infliximab and adalimumab for Crohn's disease from the perspective of the UK NH ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6055 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6073 Related Articles The effect of BMP-2 on micro and macroscale osteointegration of biphasic calcium phosphate scaffolds with multiscale porosity. Acta Biomater. 2010 Feb 19; Authors: Lan Levengood SK, Polak SJ, Poellmann MJ, Hoelzle DJ, Maki AJ, Clark SG, Wheeler MB, Wagoner Johnson AJ It is well established that scaffolds for applications in bone tissue engineering require interconnected pores on the order of 100um for bone growth, and nutrient and waste transport. As a result, most studies of ha ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6073 100um). More recently, researchers have also investigated the role of microporosity in calcium phosphaste (CaP) based scaffolds. Osteointegration into macropores improves when scaffold rods or struts contain micropores, typically defined as pores less than approximately 50um. We recently demonstrated multiscale osteointegration, or growth into both macropores and micropores (<10um), of rods in biphasic CaP (BCP) scaffolds. The combined effect of BMP-2, a potent osteoinductive growth factor, and multiscale porosity has yet to be investigated. In this study, we implanted BCP scaffolds into porcine mandibles for 3, 6, 12, and 24 weeks and evaluated the effect of BMP-2 on multiscale osteointegration. Results showed, for this in vivo model, that BMP-2 influences osteointegration at the microscale, but not at the macroscale. Cell density was higher in the rod micropores for scaffolds containing BMP-2 compared to controls at all time points, but BMP-2 was not required for bone formation in micropores. In contrast, there was essentially no difference in fraction of bone in macropores for scaffolds with BMP-2 compared to controls. Additionally, bone in macropores seemed to have reached steady state by 3 weeks. Multiscale osteointegration results in composites that are fully osteointegrated, with no "dead space," and are likely to have not only a continuous cell network, but also the potential for enhanced load transfer and improved mechanical properties. PMID: 20176148 [PubMed - as supplied by publisher] ]]> http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6074 Related Articles Telomere rejuvenation during nuclear reprogramming. Curr Opin Genet Dev. 2010 Feb 20; Authors: Mari&#xF3;n RM, Blasco MA Reprogramming of adult differentiated cells to a more pluripotent state has been achieved by various means, including somatic cell nuclear transfer (SCNT) and, more recently, by over expression of specific transcription factors to generate the so-called induced pluripotent stem (iPS) cells. Since telomeres play an important role in the maintenance of chromosom ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6074 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6080 Related Articles Defining the healthy "core microbiome" of oral microbial communities. BMC Microbiol. 2009;9:259 Authors: Zaura E, Keijser BJ, Huse SM, Crielaard W BACKGROUND: Most studies examining the commensal human oral microbiome are focused on disease or are limited in methodology. In order to diagnose and treat diseases at an early and reversible stage an in-depth definition of health is indispensible. The aim of this study therefore was to define the healthy oral microbiome using recent ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6080 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6090 Strategies toward CNS-regeneration using induced pluripotent stem cells. Genome Inform. 2009 Oct;23(1):217-20 Authors: Okano H Induced pluripotent stem (iPS) cells are pluripotent stem cells directly reprogrammed from cultured mouse fibroblast by introducing Oct3/4, Sox2, c-Myc, and Klf4. Cells obtained using this technology, which allows the ethical issues and immunological rejection associated with embryonic stem (ES) cells to be avoided, might be a clinically useful source for cell replaceme ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6090 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6094 Related Articles Biologics as treatment for systemic lupus: great efforts, sobering results, new challenges. Curr Drug Discov Technol. 2009 Dec;6(4):252-5 Authors: Schr&#xF6;der JO, Zeuner RA Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by specific organ manifestations and the production of autoantibodies to nuclear antigens. SLE can induce severe organ damage and carries the risk of fatal outcome. During recent years, no major progress has been made regarding new tr ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6094 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6103 Related Articles Lack of a central role for osteoprogenitor cells from the femoral canal in heterotopic ossification of the hip: an experimental study in a rat model. J Bone Joint Surg Br. 2010 Feb;92(2):298-303 Authors: Toom A, Suutre S, M&#xE4;rtson A, Haviko T, Selstam G, Arend A We have developed an animal model to examine the formation of heterotopic ossification using standardised muscular damage and implantation of a beta-tricalcium phosphate block into a hip capsulotomy wound in Wistar ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6103 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6104 Related Articles Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells. FASEB J. 2010 Feb 24; Authors: Mizuno Y, Chang H, Umeda K, Niwa A, Iwasa T, Awaya T, Fukada SI, Yamamoto H, Yamanaka S, Nakahata T, Heike T Induced pluripotent stem (iPS) cells, which are a type of pluripotent stem cell generated from reprogrammed somatic cells, are expected to have potential for patient-oriented disease investigation, drug screening, toxicity tests, and transplantati ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6104 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6107 Related Articles Interaction of DNA/nuclear protein/polycation and the terplexes for gene delivery. Nanotechnology. 2010 Jan 29;21(4):045102 Authors: Shen Y, Peng H, Pan S, Feng M, Wen Y, Deng J, Luo X, Wu C Nuclear transport of exogenous DNA is a major barrier to nonviral gene delivery that needs to be addressed in the design of new vectors. In this study, we prepared pDNA/HMGB1/PEG-PEI terplexes to promote nuclear import. HMGB1 in the terplexes was used to assist the transportation of pDNA in ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6107 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6109 Related Articles Insulin expressed from endogenously active glucose-responsive EGR1 promoter in bone marrow mesenchymal stromal cells as diabetes therapy. Gene Ther. 2010 Feb 25; Authors: Chen NK, Tan SY, Udolph G, Kon OL Advances in islet transplantation have encouraged efforts to create alternative insulin-secreting cells that overcome limitations associated with current therapies. We have recently demonstrated durable correction of murine and porcine diabetes by syngeneic and autologous impla ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6109 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6108 Related Articles Hematopoetic Cell Kinase Associates with the 40S Ribosomal Subunit and Mediates the Ribotoxic Stress Response to Deoxynivalenol in Mononuclear Phagocytes. Toxicol Sci. 2010 Feb 24; Authors: Bae H, Gray JS, Li M, Vines L, Kim J, Pestka JJ The trichothecene deoxynivalenol (DON) binds to eukaryotic ribosomes and triggers p38-driven proinflammatory gene expression in the macrophage - a response that is dependent on both double-stranded RNA-activated protein kinase (PKR) and hematopo ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6108 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6117 Related Articles Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: role of macrophage scavenger receptor class A type I and II. J Allergy Clin Immunol. 2010 Jan;125(1):175-83.e1-11 Authors: Ilchmann A, Burgdorf S, Scheurer S, Waibler Z, Nagai R, Wellner A, Yamamoto Y, Yamamoto H, Henle T, Kurts C, Kalinke U, Vieths S, Toda M BACKGROUND: The Maillard reaction occurs between reducing sugars and proteins during thermal processing of foods. It produces chemic ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6117 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6119 Related Articles Seasonally dynamic fungal communities in the Quercus macrocarpa phyllosphere differ between urban and nonurban environments. New Phytol. 2010 Feb 17; Authors: Jumpponen A, Jones KL Summary *The fungal richness, diversity and community composition in the Quercus macrocarpa phyllosphere were compared across a growing season in trees located in six stands within and outside a small urban center using 454-sequencing and DNA tagging. The approaches did not differentiate between endop ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6119 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6118 Related Articles Metagenomic study of the oral microbiota by Illumina high-throughput sequencing. J Microbiol Methods. 2009 Dec;79(3):266-71 Authors: Lazarevic V, Whiteson K, Huse S, Hernandez D, Farinelli L, Oster&#xE5;s M, Schrenzel J, Fran&#xE7;ois P To date, metagenomic studies have relied on the utilization and analysis of reads obtained using 454 pyrosequencing to replace conventional Sanger sequencing. After extensively scanning the 16S ribosomal RNA (rRNA) gene, we identified the V5 hyp ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6118 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6123 Related Articles Ultrasound-Microbubble-Mediated Intercellular Adhesion Molecule-1 Small Interfering Ribonucleic Acid Transfection Attenuates Neointimal Formation After Arterial Injury in Mice. J Am Coll Cardiol. 2010 Mar 2;55(9):904-913 Authors: Suzuki JI, Ogawa M, Takayama K, Taniyama Y, Morishita R, Hirata Y, Nagai R, Isobe M OBJECTIVES: The purpose of this study was to investigate the efficiency of small interfering ribonucleic acid (siRNA) in murine arteries. We transfected it using a nonvi ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6123 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6124 Related Articles Constitutive HIF-1 activity in malignant melanoma. Eur J Cancer. 2010 Feb 23; Authors: Kuphal S, Winklmeier A, Warnecke C, Bosserhoff AK The hypoxia-inducible factor-1 (HIF-1), which consists of the constitutive HIF-1beta and the oxygen-responsive HIF-1alpha subunit, is the master activator of the cellular transcriptional response to hypoxia coordinating gene expression during reduced oxygen tension. Overexpression of HIF-1 and increased transcriptional activity induced by hypox ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6124 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6126 Related Articles De Novo Metabolic Engineering and the Promise of Synthetic DNA. Adv Biochem Eng Biotechnol. 2010 Feb 26; Authors: Klein-Marcuschamer D, Yadav VG, Ghaderi A, Stephanopoulos GN The uncertain price and tight supply of crude oil and the ever-increasing demand for clean energy have prompted heightened attention to the development of sustainable fuel technologies that ensure continued economic development while maintaining stewardship of the environment. In the face of these enormous ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6126 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6128 Related Articles Molecular Characterization of Varicella Zoster Virus in Latently Infected Human Ganglia: Physical State and Abundance of VZV DNA, Quantitation of Viral Transcripts and Detection of VZV-Specific Proteins. Curr Top Microbiol Immunol. 2010 Feb 26; Authors: Azarkh Y, Gilden D, Cohrs RJ Varicella zoster virus (VZV) establishes latency in neurons of human peripheral ganglia where the virus genome is most likely maintained as a circular episome bound to histones. There is considerable ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6128 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6125 Related Articles Intergenic, gene terminal, and intragenic CpG islands in the human genome. BMC Genomics. 2010;11:48 Authors: Medvedeva YA, Fridman MV, Oparina NJ, Malko DB, Ermakova EO, Kulakovskiy IV, Heinzel A, Makeev VJ BACKGROUND: Recently, it has been discovered that the human genome contains many transcription start sites for non-coding RNA. Regulatory regions related to transcription of this non-coding RNAs are poorly studied. Some of these regulatory regions may be associated with CpG ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6125 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6129 Related Articles Analysis of the Functions of Glycoproteins E and I and Their Promoters During VZV Replication In Vitro and in Skin and T-Cell Xenografts in the SCID Mouse Model of VZV Pathogenesis. Curr Top Microbiol Immunol. 2010 Feb 26; Authors: Arvin AM, Oliver S, Reichelt M, Moffat J, Sommer M, Zerboni L, Berarducci B The two VZV glycoproteins, gE and gI, are encoded by genes that are designated open reading frames, ORF67 and ORF68, located in the short unique region of the VZV genome. Thes ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6129 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6127 Related Articles Varicella-Zoster Virus Open Reading Frame 66 Protein Kinase and Its Relationship to Alphaherpesvirus US3 Kinases. Curr Top Microbiol Immunol. 2010 Feb 26; Authors: Erazo A, Kinchington PR The varicella-zoster virus (VZV) open reading frame (ORF) 66 encodes a basophilic kinase orthologous to the US3 protein kinases found in all alphaherpesviruses. This review summarizes current information on the ORF66 kinase, and outlines apparent differences from other US3 kinases, as well as s ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6127 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6130 Related Articles Rapid Multiplexed Genotyping for Hereditary Thrombophilia by SELDI-TOF Mass Spectrometry. Diagn Mol Pathol. 2010 Mar;19(1):54-61 Authors: Yang S, Xu L, Wu HM Approximately 50% of patients with venous thromboembolism also present with hereditary predisposition. The most common genetic factors are single nucleotide polymorphisms (SNPs) of factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T. Genotyping these SNPs helps clinicians to correctly diagnos ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6130 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6135 Related Articles Involvement of the bone morphogenetic protein system in endothelin- and aldosterone-induced cell proliferation of pulmonary arterial smooth muscle cells isolated from human patients with pulmonary arterial hypertension. Hypertens Res. 2010 Feb 26; Authors: Yamanaka R, Otsuka F, Nakamura K, Yamashita M, Otani H, Takeda M, Matsumoto Y, Kusano KF, Ito H, Makino H Recent genetic studies have uncovered a link between familial and idiopathic pulmonary arterial hypertension (PAH) and g ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6135 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6136 Related Articles Characterization of cyclic acetal hydroxyapatite nanocomposites for craniofacial tissue engineering. J Biomed Mater Res A. 2010 Feb 22; Authors: Patel M, Patel KJ, Caccamese JF, Coletti DP, Sauk JJ, Fisher JP Cyclic acetal hydrogels are a novel group of biomaterials which may facilitate osteogenic differentiation of encapsulated bone marrow stromal cells (BMSCs) because of their neutral degradation products. Here, we have incorporated hydroxyapatite nanoparticles within cyclic a ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6136 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6132 Related Articles The Sequential Production Profiles of Growth Factors and Their Relations to Bone Volume in Ossifying Bone Marrow Explants. Tissue Eng Part A. 2010 Feb 25; Authors: Gurkan UA, Gargac J, Akkus O Osteogenesis is a complex process that involves the synergistic contribution of multiple cell types and numerous growth factors (GFs). In order to develop effective bone tissue engineering strategies employing GFs, it is essential to delineate the complex and interconnected role of GFs in ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6132 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6131 Related Articles Bone morphogenetic protein signaling is involved in human mesenchymal stem cell survival in serum-free medium. Stem Cells Dev. 2009 Nov;18(9):1283-92 Authors: Solmesky LJ, Abekasis M, Bulvik S, Weil M Bone marrow human mesenchymal stem cells (hMSCs) are known to survive in serum-free media, when most normal somatic cells do not survive. We found that the endogenously-activated bone morphogenetic protein (BMP) pathway is involved in this cellular behavior. Under this culture cond ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6131 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6134 Related Articles Bone induction by biomimetic PLGA-(PEG-ASP)n copolymer loaded with a novel synthetic BMP-2-related peptide in vitro and in vivo. J Control Release. 2010 Feb 22; Authors: Lin Z, Duan Z, Guo X, Li J, Lu H, Zheng Q, Quan D, Yang S BMP-2 is one of the most important growth factors of bone regeneration. Polylactide-co-glycolic acid (PLGA), which is used as a biodegradable scaffold for delivering therapeutic agents, has been intensively investigated. In previous studies, we synthesize ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6134 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6138 Related Articles Anodic oxidized nanotubular titanium implants enhance bone morphogenetic protein-2 delivery. J Biomed Mater Res B Appl Biomater. 2010 Feb 22; Authors: Bae IH, Yun KD, Kim HS, Jeong BC, Lim HP, Park SW, Lee KM, Lim YC, Lee KK, Yang Y, Koh JT Implant failure has been attributed to loosening of an implant from the host bone possibly due to poor osseointegration. One promising strategy for improving osseointegration is to develop a functional implant surface that promotes osteoblast ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6138 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6137 Related Articles Repair of large cranial defects by hBMP-2 expressing bone marrow stromal cells: Comparison between alginate and collagen type I systems. J Biomed Mater Res A. 2010 Feb 22; Authors: Chang SC, Chung HY, Tai CL, Chen PK, Lin TM, Jeng LB Despite a wide range of available sources for bone repair, significant limitations persist. To bioengineer bone, we have previously transferred adenovirus-mediated human BMP-2 gene into autologous bone marrow stromal cells (MSC). We have successfull ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6137 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6133 Related Articles Global transcriptomic analysis of murine embryonic stem cell-derived brachyury (T) cells. Genes Cells. 2010 Feb 24; Authors: Doss MX, Wagh V, Schulz H, Kull M, Kolde R, Pfannkuche K, Nolden T, Himmelbauer H, Vilo J, Hescheler J, Sachinidis A Brachyury(+) mesodermal cell population with purity over 79% was obtained from differentiating brachyury embryonic stem cells (ESC) generated with brachyury promoter driven enhanced green fluorescent protein and puromycin-N-acetyltransferase ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6133 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6142 Related Articles AP-1 homolog BZLF1 of Epstein-Barr virus has two essential functions dependent on the epigenetic state of the viral genome. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):850-5 Authors: Kalla M, Schmeinck A, Bergbauer M, Pich D, Hammerschmidt W EBV, a member of the herpes virus family, is a paradigm for human tumor viruses and a model of viral latency amenable for study in vitro. It induces resting human B lymphocytes to proliferate indefinitely in vitro and initially establishes ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6142 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6140 Related Articles Introduction of shRNAs into human NK-like cell lines with retrovirus. Methods Mol Biol. 2010;612:223-31 Authors: Purdy AK, Campbell KS Natural killer (NK) cell lines are difficult to transfect using standard techniques, which limits the ability to establish long-term knockdown of proteins with short-hairpin (sh)RNAs. We have developed a method to stably knockdown protein expression in human NK-like lines by introducing shRNAs in retroviral vectors. After a single transduction w ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6140 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6141 Related Articles Introduction of shRNAs into primary NK cells with lentivirus. Methods Mol Biol. 2010;612:233-47 Authors: Kung SK Natural killer (NK) cells are lymphocytes that provide an important line of defense against viruses and tumors. Technical hurdles in genetic modifications of primary NK cell ex vivo had limited our studies of protein function(s) in NK cell differentiation, acquisition of self-tolerance, and induction of anti-tumor responses. We used VSV-G-pseudotyped, EGFP-expressing ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6141 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6139 Related Articles IgG-single chain Fv fusion protein therapeutic for Alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey. Biotechnol Bioeng. 2010 Feb 15;105(3):627-35 Authors: Boado RJ, Lu JZ, Hui EK, Pardridge WM Monoclonal antibodies (MAb) directed against the Abeta amyloid peptide of Alzheimer's disease (AD) are potential new therapies for AD, since these antibodies disaggregate brain amyloid plaque. However, the MAb is not transported acr ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6139 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6143 Related Articles Gene-specific FACS sorting method for target selection in high-throughput amplicon sequencing. BMC Genomics. 2010 Feb 26;11(1):140 Authors: Sandberg J, Neiman MG, Ahmadian A, Lundeberg J ABSTRACT: BACKGROUND: In addition to shotgun sequencing, next generation sequencing has been shown to be suitable for deep sequencing of many specific PCR-amplified target genes in parallel. However, primer-dimer formation is a common problem in amplicon sequencing since primer-dimers are diffic ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6143 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6144 Related Articles Current and future directions in MS management: key considerations for managed care pharmacists. J Manag Care Pharm. 2009 Nov-Dec;15(9 Suppl A):S2-15; quiz S16-7 Authors: Lipsy RJ, Schapiro RT, Prostko CR BACKGROUND: The management paradigm for multiple sclerosis (MS) continues to evolve and is shifting toward earlier diagnosis, differentiation of patients with varying clinical prognoses, and earlier initiation of treatment in selected individuals. Based on surveys conducted at ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6144 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6149 Reactive oxygen species produced by the knockdown of manganese-superoxide dismutase up-regulate hypoxia-inducible factor-1alpha expression in oral squamous cell carcinoma cells. Free Radic Biol Med. 2010 Feb 23; Authors: Sasabe E, Yang Z, Ohno S, Yamamoto T Hypoxia-inducible factor-1alpha (HIF-1alpha) is a central regulator that controls the hypoxic response of mammalian cells through the induction of various target genes, and its expression contributes to the development and malignant progress ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6149 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6151 Arsenite down-regulates the cytochrome P450 1A1 at transcriptional and post-translational levels in human HepG2 cells. Free Radic Biol Med. 2010 Feb 24; Authors: Anwar-Mohamed A, El-Kadi AO Aryl hydrocarbon receptor (AhR) ligands typified by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and metals, typified by arsenite (As(III)), are environmental co-contaminants and their molecular interaction may disrupt the coordinated regulation of the carcinogen activating enzyme cytochrome P450 1A1 (CYP1A1). ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6151 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6148 VEGF-mediated angiogenesis stimulates neural stem cell proliferation and differentiation in the premature brain. Biochem Biophys Res Commun. 2010 Feb 23; Authors: Sun J, Sha B, Zhou W, Yang Y This study investigated the effects of angiogenesis on the proliferation and differentiation of neural stem cells in the premature brain. We observed the changes in neurogenesis that followed the stimulation and inhibition of angiogenesis by altering vascular endothelial growth factor (VEGF) expression in ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6148 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6152 PIM-1 gene RNA interference induces growth inhibition and apoptosis of prostate cancer cells and suppresses tumor progression in vivo. J Surg Oncol. 2010 Feb 26; Authors: Zhang T, Zhang X, Ding K, Yang K, Zhang Z, Xu Y BACKGROUND: The goal of this study was to investigate the roles of PIM-1 in prostate cancer (CaP) cell proliferation and apoptosis, and to assess the potential of PIM-1 as a target for CaP therapy. METHODS: Using RNAi technology, we knocked down the expression of PIM-1 in PC-3 ce ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6152 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6150 Cigarette smoke particle phase extract induces HO-1 expression in human tracheal smooth muscle cells: Role of c-Src/NADPH oxidase/MAPKs/Nrf2 signaling pathway. Free Radic Biol Med. 2010 Feb 24; Authors: Cheng SE, Lee IT, Lin CC, Kou YR, Yang CM Heme oxygenase-1 (HO-1) is known as an oxidative stress protein that is up-regulated by various stimuli. HO-1 has been shown to protect cells against oxidative damage. Cigarette smoke is a potential inflammatory mediator which causes chronic obstructive ... Wed, 03 Mar 2010 17:17:28 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6150 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6146 [Construction and screening of neurite outgrowth inhibitory 66 eukaryotic expression vectors] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2010 Feb;24(2):185-9 Authors: Li R, Dang X, Li L, Wang K, Bai C, Bao L, Lou G OBJECTIVE: To construct and screen neurite outgrowth inhibitory 66-small interfering RNA (nogo66-siRNA) eukaryotic expression vectors of effective interference, so as to lay a foundation for further reconstruction of related viral vector. METHODS: The nogo66-siRNA fragments were desig ... Wed, 03 Mar 2010 17:17:27 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6146 0.05). CONCLUSION: Nogo66-siRNA eukaryotic expression vector is successfully constructed, it lays an experimental foundation for repair of spinal cord injury. PMID: 20187450 [PubMed - in process] ]]> http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6147 Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage. Arthritis Res Ther. 2010 Feb 26;12(1):R33 Authors: Garcia S, Liz M, Gomez-Reino JJ, Conde C ABSTRACT: INTRODUCTION: Synovial hyperplasia is a main feature of rheumatoid arthritis pathology that leads to cartilage and bone damage in the inflamed joints. Impaired apoptosis of resident synoviocytes is pivotal in this process. Apoptosis resistance seems to involve defects in the extrinsic ... Wed, 03 Mar 2010 17:17:27 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6147 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6145 Related Articles Class III beta-tubulin expression and in vitro resistance to microtubule targeting agents. Br J Cancer. 2010 Jan 19;102(2):316-24 Authors: Stengel C, Newman SP, Leese MP, Potter BV, Reed MJ, Purohit A BACKGROUND: Class III beta-tubulin overexpression is a marker of resistance to microtubule disruptors in vitro, in vivo and in the clinic for many cancers, including breast cancer. The aims of this study were to develop a new model of class III beta-tubulin expression, avoiding th ... Wed, 03 Mar 2010 17:17:27 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6145 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6154 Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR. Bioorg Med Chem. 2010 Feb 10; Authors: Opperman TJ, Williams JD, Houseweart C, Panchal RG, Bavari S, Peet NP, Moir DT, Bowlin TL The bis-indoles are a novel class of compounds with potent antibacterial activity against a broad spectrum of Gram-positive and Gram-negative pathogens. The mechanism of action of these compounds has not been clearly defined. To study the mech ... Wed, 03 Mar 2010 17:17:27 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6154 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6157 Identification of genes specifically expressed during Bacillus cereus growth at low temperature. Appl Environ Microbiol. 2010 Feb 26; Authors: Brillard J, J&#xE9;hanno I, Dargaignaratz C, Barbosa I, Ginies C, Carlin F, Fedhila S, Nguyen-The C, Broussolle V, Sanchis V The mechanisms involved in the ability of B. cereus to multiply at low temperature were investigated. It was assumed that many genes involved in cold acclimation would be up-regulated at low temperature. Recombinase-based in vivo e ... Wed, 03 Mar 2010 17:17:27 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6157 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6156 A Synonymous Mutation in the CFTR Gene Causes an Aberrant Splicing in an Italian Patient Affected by a Mild Form of Cystic Fibrosis. J Mol Diagn. 2010 Feb 26; Authors: Faa' V, Coiana A, Incani F, Costantino L, Cao A, Rosatelli MC Mutations within exons are responsible for aberrant splicing of pre-mRNA in several human disease genes and in some viral systems. Nonsense, missense, and even synonymous mutations can induce aberrant skipping of the mutant exon, producing nonfunctional proteins. In th ... Wed, 03 Mar 2010 17:17:27 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6156 T [Gly893Gly] detected in a patient of Italian descent affected by a mild form of cystic fibrosis, until now mentioned as sequence variation with unknown functional consequences. The study, performed through DNA as well as RNA analyses, shows that this mutation creates a new 5' splice site within exon 15, resulting in a transcript lacking 76 amino acid residues. Although this aberrant splicing causes a shorter exon 15, the downstream exonic sequence from exon 16 to the end of the open reading frame is in frame. This study indicates that apparently neutral polymorphism, which may be erroneously classified as nonpathogenic, may indeed led to aberrant splicing thereby resulting in defective protein. PMID: 20190016 [PubMed - as supplied by publisher] ]]> http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6155 Isolation and Purification of a New Kalimantacin/Batumin-Related Polyketide Antibiotic and Elucidation of Its Biosynthesis Gene Cluster. Chem Biol. 2010 Feb 26;17(2):149-159 Authors: Mattheus W, Gao LJ, Herdewijn P, Landuyt B, Verhaegen J, Masschelein J, Volckaert G, Lavigne R Kal/bat, a polyketide, isolated to high purity (>95%) is characterized by strong and selective antibacterial activity against Staphylococcus species (minimum inhibitory concentration, 0.05 mug/mL), and no resistance was o ... Wed, 03 Mar 2010 17:17:27 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6155 95%) is characterized by strong and selective antibacterial activity against Staphylococcus species (minimum inhibitory concentration, 0.05 mug/mL), and no resistance was observed in strains already resistant to commonly used antibiotics. The kal/bat biosynthesis gene cluster was determined to a 62 kb genomic region of Pseudomonas fluorescens BCCM_ID9359. The kal/bat gene cluster consists of 16 open reading frames (ORF), encoding a hybrid PKS-NRPS system, extended with trans-acting tailoring functions. A full model for kal/bat biosynthesis is postulated and experimentally tested by gene inactivation, structural confirmation (using NMR spectroscopy), and complementation. The structural and microbiological study of biosynthetic kal/bat analogs revealed the importance of the carbamoyl group and 17-keto group for antibacterial activity. The mechanism of self-resistance lies within the production of an inactive intermediate, which is activated in a one-step enzymatic oxidation upon export. The genetic basis and biochemical elucidation of the biosynthesis pathway of this antibiotic will facilitate rational engineering for the design of novel structures with improved activities. This makes it a promising new therapeutic option to cope with multidrug-resistant clinical infections. PMID: 20189105 [PubMed - as supplied by publisher] ]]> http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6153 Related Articles Mutations in the coding regions of the hepatocyte nuclear factor 4 alpha in Iranian families with maturity onset diabetes of the young. Cardiovasc Diabetol. 2009;8:63 Authors: Taghavi SM, Fatemi SS, Rafatpanah H, Ganjali R, Tavakolafshari J, Valizadeh N Hepatocyte nuclear factor 4alpha (HNF4alpha) is a nuclear receptor involved in glucose homeostasis and is required for normal beta cell function. Mutations in the HNF4alpha gene are associated with maturity onset diabetes of the ... Wed, 03 Mar 2010 17:17:27 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6153 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6158 Reprogramming of human fibroblasts to pluripotent stem cells using mRNA of four transcription factors. Biochem Biophys Res Commun. 2010 Feb 24; Authors: Yakubov E, Rechavi G, Rozenblatt S, Givol D Reprogramming of differentiated cells into induced pluripotent cells (iPS) was accomplished in 2006 by expressing four, or less, embryonic stem cell (ESC) - specific transcription factors. Due to the possible danger of DNA damage and the potential tumorigenicity associated with such DNA damage, attemp ... Wed, 03 Mar 2010 17:17:27 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6158 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6159 Ovarian cancer classification based on dimensionality reduction for SELDI-TOF data. BMC Bioinformatics. 2010 Feb 27;11(1):109 Authors: Tang K, Li T, Xiong W, Chen K ABSTRACT: BACKGROUND: Recent advances in proteomics technologies such as SELDI-TOF mass spectrometry has shown promise in the detection of early stage cancers. However, dimensionality reduction and classification are considerable challenges in statistical machine learning. We therefore propose a novel approach for dimensionality red ... Wed, 03 Mar 2010 17:17:27 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6159 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6160 Related Articles Effectiveness of microRNA in Down-regulation of TGF-beta gene expression in digital flexor tendons of chickens: in vitro and in vivo study. J Hand Surg Am. 2009 Dec;34(10):1777-84.e1 Authors: Chen CH, Zhou YL, Wu YF, Cao Y, Gao JS, Tang JB PURPOSE: Transforming growth factor (TGF)-beta is considered to be responsible for the formation of scars such as adhesions around healing digital flexor tendons. We proposed to deliver microRNAs (miRNAs) to silence expression of the TGF-beta ... Wed, 03 Mar 2010 17:17:27 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6160 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6162 Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage. Arthritis Res Ther. 2010 Feb 26;12(1):R33 Authors: Garcia S, Liz M, Gomez-Reino JJ, Conde C ABSTRACT: INTRODUCTION: Synovial hyperplasia is a main feature of rheumatoid arthritis pathology that leads to cartilage and bone damage in the inflamed joints. Impaired apoptosis of resident synoviocytes is pivotal in this process. Apoptosis resistance seems to involve defects in the extrinsic ... Wed, 03 Mar 2010 17:17:27 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6162 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6161 [Construction and screening of neurite outgrowth inhibitory 66 eukaryotic expression vectors] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2010 Feb;24(2):185-9 Authors: Li R, Dang X, Li L, Wang K, Bai C, Bao L, Lou G OBJECTIVE: To construct and screen neurite outgrowth inhibitory 66-small interfering RNA (nogo66-siRNA) eukaryotic expression vectors of effective interference, so as to lay a foundation for further reconstruction of related viral vector. METHODS: The nogo66-siRNA fragments were desig ... Wed, 03 Mar 2010 17:17:27 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6161 0.05). CONCLUSION: Nogo66-siRNA eukaryotic expression vector is successfully constructed, it lays an experimental foundation for repair of spinal cord injury. PMID: 20187450 [PubMed - in process] ]]> http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6163 Related Articles Immunological and therapeutic strategies against salmonid cryptobiosis. J Biomed Biotechnol. 2010;2010:341783 Authors: Woo PT Salmonid cryptobiosis is caused by the haemoflagellate, Cryptobia salmositica. Clinical signs of the disease in salmon (Oncorhynchus spp.) include exophthalmia, general oedema, abdominal distension with ascites, anaemia, and anorexia. The disease-causing factor is a metalloprotease and the monoclonal antibody (mAb-001) against it is therapeutic. MAb-001 ... Wed, 03 Mar 2010 17:17:27 +0900 http://biomarket.jp/modules/d3pipes/index.php?page=clipping&clipping_id=6163 http://biomarket.jp/modules/pubmed/index.php?page=clipping&clipping_id=3867 134 new pubmed citations were retrieved for your search.Click on the search hyperlink below to display the complete search results:signal transductionThese pubmed results were generated on 2010/03/02PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's.These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. Tue, 02 Mar 2010 20:04:20 +0900 pubmed:g10915697:2010030206 Report